US20030004466A1 - Disposable, pre-filled drug cartridge - Google Patents
Disposable, pre-filled drug cartridge Download PDFInfo
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- US20030004466A1 US20030004466A1 US09/932,043 US93204301A US2003004466A1 US 20030004466 A1 US20030004466 A1 US 20030004466A1 US 93204301 A US93204301 A US 93204301A US 2003004466 A1 US2003004466 A1 US 2003004466A1
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- drug cartridge
- barrel
- tubular barrel
- distal end
- medication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2433—Ampoule fixed to ampoule holder
- A61M2005/2437—Ampoule fixed to ampoule holder by clamping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2492—Ampoule holder connected to rest of syringe via snap connection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6036—General characteristics of the apparatus with identification means characterised by physical shape, e.g. array of activating switches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
Abstract
Description
- The present invention generally relates to drug delivery devices, and more specifically relates to disposable, pre-fillable drug cartridge for use with a reusable body portion of an injection device for injecting drugs or medicaments into patients which are commonly known in the field as pens.
- Hypodermic syringes are used to deliver selected doses of medication to patients. The prior hypodermic syringe includes a syringe barrel having opposed proximal and distal ends. A cylindrical chamber wall extends between the ends and defines a fluid receiving chamber. The proximal end of the syringe barrel is substantially open and receives a plunger in sliding fluid tight engagement. The distal end of the syringe barrel includes a passage communicating with the chamber. A needle cannula may be mounted to the distal end of the syringe barrel, such that the lumen of the needle cannula communicates with the passage and the chamber of the syringe barrel. Movement of the plunger in a proximal direction draws fluid through the lumen of the needle cannula and into the chamber. Movement of the plunger in a proximal-to-distal direction urges fluid from the chamber and through the lumen of the needle cannula.
- Medication to be injected with the prior hypodermic syringe often is stored in a vial having a pierceable elastomeric seal. Medication in the vial is accessed by piercing the elastomeric seal with the needle cannula. A selected dose of the medication may be drawn into the chamber of the syringe barrel by moving the plunger a selected distance in a proximal direction. The needle cannula may be withdrawn from the vial, and the medication may be injected into a patient by moving the plunger in a distal direction.
- Some medication, such as insulin is self-administered. The typical diabetes patient will require injections of insulin several times during the course of a week or day. The required dose of insulin will vary from patient to patient, and for each patient may vary during the course of the day and from day to day. Usually, each diabetes patient will establish a regimen that is appropriate for his or her own medical condition and for his or her lifestyle. The regimen typically includes some combination of a slow or medium acting insulin and a faster acting insulin. Each of these regimens may require the diabetes patient to periodically self-administer insulin in public locations, such as places of employment or restaurants. The required manipulation of the standard hypodermic syringe and vial can be inconvenient and embarrassing in these public environments. Examples of syringes are described in U.S. Pat. Nos. 5,250,037 (Bitdinger) and 5,667,495 (Bitdinger), and an example of a filler for mixing insulins is described in U.S. Pat. No. 5,542,760 (Chanoch), the disclosures of which are hereby incorporated by reference in their entirety.
- Medication delivery pens have been developed to facilitate the self-administration of medication. An example of one such medication delivery pen is described in U.S. Pat. No. 5,279,585 (Balkwill), which includes a vial holder into which a vial of insulin or other medication may be received, the disclosure of which is hereby incorporated by reference in its entirety. The vial holder is an elongate generally tubular structure with proximal and distal ends. The distal end of the vial holder includes mounting means for engaging a double-ended needle cannula. The proximal end also includes mounting means for engaging a driver and dose setting apparatus as explained further below. A disposable vial for use with the vial holder includes a distal end having a pierceable elastomeric seal that can be pierced by one end of a double-ended needle cannula. The proximal end of this vial includes a plunger slidably disposed in fluid tight engagement with the cylindrical wall of the vial. This medication delivery pen is used by inserting the vial of medication into the vial holder. A pen body then is connected to the proximal end of the vial holder. The pen body includes a dose setting apparatus for designating a dose of medication to be delivered by the pen and a driving apparatus for urging the plunger of the vial distally for a distance corresponding to the selected dose. Other examples of pens are described in U.S. Pat. Nos. 5,645,534 (Chanoch), 5,582,598 (Chanoch) and 5,569,214 (Chanoch), the disclosure of which are hereby incorporated by reference in their entirety.
- The user of the pen mounts a double-ended needle cannula to the distal end of the vial holder such that the proximal point cannula of the needle cannula pierces the elastomeric seal on the vial as described, for example, in U.S. Pat. No. 5,549,575 (Giambattista et. al.), the disclosure of which is hereby incorporated by reference in its entirety. The user then selects a dose and operates the pen to urge the plunger distally to deliver the selected dose. The user then removes and discards the needle cannula, and keeps the medication delivery pen in a convenient location for the next required medication administration. The medication in the vial will become exhausted after several such administrations of medication. The user then separates the vial holder from the pen body. The empty vial may then be removed and discarded. A new vial can be inserted into the vial holder, and the vial holder and pen body can be reassembled and used again as explained above.
- The above described reusable medication delivery pen is effective and much more convenient for self-administration of medication than the typical hypodermic syringe and separate medication vial. However, it has been found that there is a need for additional features and improvements for such a medication delivery pen. For example, with the increased use of pens for self-injection of drugs other than insulin, there is a need to prevent cross-use of insulin pens with other drugs and/or cross-use of drug cartridges with other pens. The problems associated with cross-use could also pose a potential hazard, where the dose dials of the pens are different, which might result in the administration of the wrong dosage of the drug. This is particularly hazardous where an overdose of insulin could lead to hypoglycemia and ER treatment.
- Thus, there has been a need for a pen, as well as a drug cartridge assembly, which would eliminate the problems and limitations associated with the prior devices discussed above, most significant of the problems being cross-use of the pen with other drug cartridge assemblies and/or cross-use of the drug cartridge assembly with other pens.
- In contrast to the prior devices discussed above, it has been found that a pen particularly suited for use in reducing or otherwise eliminating cross-use can be constructed in accordance with the present invention. Specifically, the pen and the drug cartridge assembly of the present invention are keyed, i.e., they have a connection interface which mechanically prevents the cross-use of cartridge assemblies among designated pens by, for example, using matching threads, bayonets or snap fits on the pen and the holding sleeve of the drug cartridge assembly. Also, the cartridge assembly can have an embedded drug cartridge, not readily separable from each other.
- Another object of the present invention is to improve the design of the drug cartridge and holder sleeve so that they are a single integral unit for containing the drug, with a rubber septum for multiple needle penetrations along with a standard thread to attach the pen needle. On the far end of the pen needle thread, a connection interface prevents connection to pens other than the one for which use of the drug container is designed. In this way, the drug cartridge assembly will have minimal dead space and an insert molded rubber septum.
- The various features, objects, benefits, and advantages of the present invention will become more apparent upon reading the following detailed description of the preferred embodiment(s) along with the appended claims in conjunction with the drawings, wherein like reference numerals identify corresponding components, and:
- FIG. 1 is a top view of the injection pen of the present invention, with FIG. 1A being a end view;
- FIG. 2 is a cross-sectional view of the injection pen shown in FIG. 1 with the lead screw retracted;
- FIG. 3 is a partial, cross-sectional view of the injection pen similar to FIG. 2 with the lead screw retracted and a drug vial retained therein;
- FIG. 4 is an exploded, side view of the cartridge assembly of the present invention and the drug cartridge and the corresponding portion of the pen shown in FIG. 3;
- FIG. 5 is a partial, cross-sectional view of the cartridge assembly shown in FIG. 4 assembled;
- FIG. 6 is a partial, cross-sectional view of an alternative embodiment of the cartridge assembly of the present invention;
- FIG. 7 is a partial, cross-sectional view of another alternative embodiment of the cartridge assembly of the present invention;
- FIG. 8 is a partial, cross-sectional view of yet another alternative embodiment of the cartridge assembly of the present invention; and
- FIG. 9 is a partial, cross-sectional view of yet another alternative embodiment of the cartridge assembly of the present invention.
- The medication delivery pen of the present invention is illustrated in FIGS. 1 through 5, with the pen being generally designated10. As shown in FIGS. 1-3, the pen includes a
pen body assembly 12, acartridge assembly 14 and acap 16, with the cartridge assembly being situated between the body assembly and thecap 16 and typically having sufficient medication for several doses. The pen body assembly and the cartridge assembly are keyed, i.e., they have a connection interface which mechanically prevents the cross-use of cartridges among designated pens by, for example, threadedly engaged by corresponding threads and grooves, bayonet threads and grooves, snap fits or a pair of lugs that mate in a reverse Luer-lock manner. In addition, all of these elements have a generally cylindrical configuration and are arranged coaxially from opposed proximal anddistal ends pen 10 respectively to define a generally cylindrical housing which can easily be handled by a patient or medical attendant. - Referring to FIGS. 1 and 2, and in greater detail in FIG. 3, the
body assembly 12 is used to set a desired dose of medication to be delivered by thepen 10 and includes an advancing member preferably in the form of alead screw 22 with adistal end 24 movable in the distal direction based on the dose set by a dose setting mechanism within thepen body 12. The dose setting mechanism determines the distance through which leadscrew 22 is to be moved during the injection of medication by thepen 10. It is understood, however, that variations from this preferred embodiment may be provided, and are considered to be within the scope of the subject invention. Particularly, the specific construction of thepen body 12, including the mechanisms for advancing the lead screw, may include those, for example, disclosed in U.S. Pat. Nos. 5,279,585 (Balkwill), 5,279,586 (Balkwill), 5,549,575 (Giambattista et al.), 5,569,214 (Chanoch), 5,582,598 (Chanoch) and 5,645,534 (Chanoch), and co-pending U.S. patent application Ser. No. 08/314,179 (Chanoch et. al.), the disclosures of which are hereby incorporated by reference in their entirety. Accordingly, the particular pen body is not essential to the present invention and is merely a matter of choice. - As shown in FIGS.1-3, and in greater detail in FIGS. 4 and 5, the
cartridge assembly 14 is divided into two parts, i.e., anupper vial retainer 30 and alower vial retainer 32, with the lower vial retainer defining avial retaining cavity 34 formed in the lower vial retainer. As explained further herein, oneend 36A of theupper vial retainer 30 is preferably dimensioned and configured to threadedly engage oneend 38A of thelower vial retainer 32 and theother end 36B of the lower vial retainer is configured to securely but releasably engage a needle cannula assembly (not shown). The particular needle cannula assembly is not essential to the present invention and may include the type disclosed in co-pending U.S. patent application No. (P4059) filed on Sep. 12, 1997 and entitled “PEN NEEDLE ASSEMBLY,” the disclosure of which is hereby incorporated by reference in its entirety. The upper andlower retainers - The
cartridge assembly 14, as shown in FIGS. 34 and 5, includes a drug vial orcartridge 40, with thecavity 34 dimensioned and configured to securely receive and retain the drug cartridge therein. Thedrug cartridge 40 includes a generally tubular barrel 42 with a distal end 44A defined by an inwardly convergingshoulder 46 and an openproximal end 44B. Asmaller diameter neck 48 projects distally from theshoulder 46 of the barrel 42, and is provided with a large diameter annular bead (not shown) extending circumferentially thereabout at the extreme distal end of the neck. A pierceable and resealable elastomeric seal or septum 50 is securely mounted across the open distal end defined by theneck 48. The seal 50 is held in place by ametallic sleeve 52 which is crimped around the circumferential bead at the distal end of theneck 48. Medication is pre-filled into thedrug cartridge 40 and is retained therein by an elastomeric stopper orplunger 54. Theplunger 54 is in sliding fluid-tight engagement with the tubular wall of the barrel 42. Distally directed forces on theplunger 54 urge the medication from the pen as explained further below. - The portion of the
lower retainer 32 defining thecavity 34 is of substantially uniform diameter which is slightly greater than the diameter of the vial barrel 42. The interior of theupper vial retainer 30 includes an inwardly extending annual portion or stop 60 dimensioned to prevent thedrug cartridge 40 from moving within thevial retainers drug cartridge 40 is inserted into thecavity 34 and thevial retainers drug cartridge 40 is securely held in thecavity 34 at the openproximal end 44B of the tubular barrel 42 by theannual stop 60. More particularly, theneck 48 and crimpedmetallic sleeve 52 of thedrug cartridge 40 are inserted in a proximal to distal direction into the open proximal end of thelower retainer 32 with the crimpedmetallic sleeve 52 eventually passing entirely into thelower retainer 32, which will require entry of the crimped metallic sleeve into the portion thereof for mounting the needle cannula assembly. Then, with thevial retainers drug vial 40 abuts thestops 60 of theupper vial retainer 30. - Preferably, when using standard drug vials or
cartridges 40, thevial retainers cartridge assembly 14 with thedrug vial 40 secured therein may disposed of after being used. - The
pen body assembly 12 includes an array ofthreads 62 for threaded engagement with the threadedother end 36B of theupper vial retainer 30, and when threadedly engaged, theplunger 54 is disposed in sliding fluid tight engagement in thecartridge assembly 40. As shown in FIG. 3, thelead screw 22 initially is disposed substantially adjacent theplunger 54 of thedrug cartridge 40. The portion ofdrug cartridge 40 between theplunger 54 and the seal 50 is filled with amedication 66. In this way, advancement of theplunger 54 causes themedication 66 to be forced from thedrug cartridge 40 through the needle cannula - Preferably, the
pen body assembly 12 is reusable and thedrug cartridge 40 in thecartridge assembly 14 will contain a volume ofmedication 66 sufficient for administration of several doses. After exhaustion of themedication 66, thecartridge assembly 14 will be threadedly disengaged frompen body assembly 12 and thedrug cartridge 40 discarded. A new assembly containing a drug cartridge may then be mounted to the reusablepen body assembly 12. - The assembled reusable
pen body assembly 12 andcartridge assembly 14 may be stored until a selected dose of medication is required. Just prior to use, a needle cannula assembly may be threadedly engaged todistal end 38B ofcartridge assembly 14. This threaded engagement will cause a proximal tip of a needle cannula to the pierce the seal 50 and provide communication withmedication 66. - A desired dose of medication may be set by rotating a
dose knob 70 located at thedistal end 20 of the pen which will cause advancement of thelead screw 22 into thecavity 34 of thecartridge assembly 14. When the desired dose is set, injection is achieved by merely pushing onactuator button 72 and thelead screw 22 will be advanced axially intocartridge assembly 14. This axial advancement oflead screw 22 causesdistal end 24 thereof to come in contact with theplunger 54 and urge the plunger distally into thedrug cartridge 40, and hence causes themedication 66 to be injected through the needle cannula. Injection will be terminated when thedose knob 70 is fully depressed into engagement with thepen body assembly 12. - Upon completion of the injection, the needle cannula assembly may be disengaged from the
cartridge assembly 14 and safely discarded. Thecap 16 may be mounted overcartridge assembly 14, and thepen 10 may be stored or carried in a convenient location until the next dose of medication is required. A subsequent dose of medication will be set in exactly the manner as described above. However, for such a subsequent dose, theplunger 54 will be in a partly advanced position as a starting point. Dose setting and injections can be carried out until all ofmedication 66 has been used. Thecartridge assembly 14 may then be threadedly disengaged frompen body assembly 12, and slidably separated from thelead screw 22 and discarded in order to be replaced as described above. - FIG. 6 shows an alternative embodiment of the cartridge assembly114 which is disposable and includes an
upper vial retainer 130 and alower vial retainer 132. In this embodiment, once adrug cartridge 140 is placed in thecavity 134, thevial retainers empty drug cartridge 140 may be disengaged from the pen body assembly and safely discarded. - FIG. 7 shows another alternative embodiment of the
cartridge assembly 214 which is disposable and is in the form of a single integral unit having a generallytubular barrel 242 with adistal end 244A defined by an inwardly convergingshoulder 246 and an openproximal end 244B. Asmaller diameter neck 248 projects distally from theshoulder 246 of thebarrel 242, and is provided with a pierceable and resealable elastomeric seal orseptum 250 securely mounted across the open distal end defined by theneck 248. Medication is pre-filled into theintegral cartridge assembly 214 and is retained therein by an elastomeric stopper orplunger 254. Theplunger 254 is in sliding fluid-tight engagement with the tubular wall of thebarrel 242. Distally directed forces on theplunger 254 urge the medication from the pen as explained interconnection with the preferred embodiment. In this embodiment, theproximal end 244B of theintegral cartridge assembly 214 includebayonet threads 280 which are engageable with correspondinggrove 282 formed in the distal end of thepen body 212. Thedistal end 244A of the tubular barrel is configured to securely but releasably engage a needle cannula assembly (not shown). - The
cartridge assembly 214 shown in FIG. 7 may be assembled and pre-filled by any suitable means, including those disclosed, for example, in U.S. Pat. Nos. 5,279,585 (Balkwill), 5,531,255 (Vacca), 5,519,984 (Veussink et al.), 5,373,684 (Vacca), 5,207,983 (Liebert et al.) 4,718,463 (Jurgens, Jr. et al.). and 4,628,969 (Jurgens, Jr. et al.), and PCT Application No. WO 94/13328 (Hagen) the disclosures of which are hereby incorporated by reference in their entirety. - FIG. 8 shows yet another alternative embodiment of the
cartridge assembly 314 which is disposable and includessingle vial retainer 332. However, a stop has been situated in thedistal end 338B of thevial retainer 332 which permit thedrug cartridge 340 to be inserted into the cavity 334 in one direction but resists removal of the drug cartridge, i.e., the insertion force is less than the removal force. Specifically,protrusions 360 project inwardly and extend along theneck 348 of thedrug cartridge 40 to securely retain it in the cartridge assembly. In this way, upon utilization of the medication, thedrug cartridge assembly 314 along with theempty drug cartridge 340 may be disengaged from the pen body assembly and safely discarded. - FIG. 9 shows yet another alternative embodiment of the
cartridge assembly 414 which is disposable and includes single vial retainer in which a flexible vial ordrug container 440 such as a pouch can be inserted into the cartridge assembly. Attached by treads or the like to theend 438B of the cartridge assembly is acannula 490 having a double endedneedle 492. In this way, upon movement of the plunger orstopper 454, the proximal end of theneedle 492 pierces the drug container to permit the drug to be released therefrom as the container collapses The particular material of which the cartridge assembly is made is not essential to the present invention but preferably includes a polymeric material such as polycarbonate. However, the particular material is a matter of choice depending upon availability, the manufacturing process used and the intended use of the cartridge assembly. For example, where thecartridge assembly 214 is pre-filled with the medication, the polymeric material must be compatible with the medication contained therein. - It should be appreciated from the detailed description of the preferred embodiments, that the particular means by which the
pen body assembly 12 and the cartridge assembly are keyed, i.e., engaged so as to reduce or otherwise eliminate cross-use is essential and may be threadedly engaged by corresponding threads and grooves, bayonet threads and grooves, snap fits or a pair of lugs that mate in a reverse Luer-lock manner. In this way, thepen body assembly 12 includes either a female or male mating member and thecartridge assembly 14 includes a corresponding female or male mating member engageable with one another for interconnecting the two assemblies, with the mating members selected so as to prevent cross-use with other assemblies, e.g., the pitch of the threads may be angled so as to mate only with one another and not with other assemblies. - Also, the cartridge holder sleeve can have an embedded cartridge, not readily separable from each other as described in connection with one alternative embodiment. In addition, the drug cartridge can be designed as a single integral unit for containing the drug as described in connection with another alternative embodiment.
- While the preferred embodiments of the present invention have been described so as to enable one skilled in the art to practice the device of the present invention, it is to be understood that variations and modifications may be employed without departing from the concept and intent of the present invention as defined in the following claims. The preceding description is intended to be exemplary and should not be used to limit the scope of the invention. The scope of the invention should be determined only by reference to the following claims.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/932,043 US6648859B2 (en) | 1997-09-29 | 2001-08-17 | Disposable, pre-filled drug cartridge |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US93977697A | 1997-09-29 | 1997-09-29 | |
US93947997A | 1997-09-29 | 1997-09-29 | |
US30846699A | 1999-08-26 | 1999-08-26 | |
US09/932,043 US6648859B2 (en) | 1997-09-29 | 2001-08-17 | Disposable, pre-filled drug cartridge |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US30846699A Continuation | 1997-09-29 | 1999-08-26 |
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US20030109834A2 US20030109834A2 (en) | 2003-06-12 |
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US09/932,043 Expired - Lifetime US6648859B2 (en) | 1997-09-29 | 2001-08-17 | Disposable, pre-filled drug cartridge |
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US (1) | US6648859B2 (en) |
EP (1) | EP0941133B1 (en) |
JP (1) | JP3414760B2 (en) |
AU (2) | AU9202398A (en) |
DE (1) | DE69823481T2 (en) |
DK (1) | DK0941133T3 (en) |
WO (2) | WO1999016485A1 (en) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008000827A1 (en) * | 2006-06-30 | 2008-01-03 | Novo Nordisk A/S | A medical delivery system comprising a coding mechanism |
WO2008059063A1 (en) * | 2006-11-17 | 2008-05-22 | Novo Nordisk A/S | A medical delivery system comprising a coding mechanism between dosing assembly and medicament container |
WO2008071804A1 (en) * | 2006-12-15 | 2008-06-19 | Novo Nordisk A/S | A medical delivery system comprising a container and a dosing assembly with radially moving fastening means |
WO2009049885A1 (en) * | 2007-10-17 | 2009-04-23 | Haselmeier Gmbh | Injection device with reset of the piston rod caused by cartridge exchange |
US20090259197A1 (en) * | 2006-07-15 | 2009-10-15 | Novo Nordisk A/S | Medical Delivery System with Flexible Blocking Element |
US20090281505A1 (en) * | 2006-07-15 | 2009-11-12 | Novo Nordisk A/S | Medical Delivery System with Asymmetrical Coding Means |
US20100004603A1 (en) * | 2001-08-27 | 2010-01-07 | Novo Nordisk A/S | Cartridge And Medical Delivery System Accommodating Such Cartridge |
US20100010455A1 (en) * | 2006-08-28 | 2010-01-14 | Novo Nordisk A/S | Medical Delivery System Adapted to be Locked Axially and Unlocked Rotationally |
US20100106099A1 (en) * | 2006-12-21 | 2010-04-29 | Novo Nordisk A/S | Syringe Device |
US20100160894A1 (en) * | 2006-06-30 | 2010-06-24 | Julian Joseph F | Automatic injection device |
US20110046567A1 (en) * | 2008-01-28 | 2011-02-24 | Novo Nordisk A/S | Injection device for performing medical injections |
US20110046566A1 (en) * | 2006-11-21 | 2011-02-24 | Novo Nordisk A/S | Medical Delivery System Comprising Locking Ring with L-Shaped Grooves |
US20110054414A1 (en) * | 2009-04-29 | 2011-03-03 | Abbott Biotechnology Ltd. | Automatic Injection Device |
US20110152781A1 (en) * | 2008-07-15 | 2011-06-23 | Shl Group Ab | Medicament Delivery Device |
US20110178500A1 (en) * | 2009-12-15 | 2011-07-21 | Shang Sherwin S | Firing button for automatic injection device |
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US8162887B2 (en) | 2004-06-23 | 2012-04-24 | Abbott Biotechnology Ltd. | Automatic injection devices |
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US8708968B2 (en) | 2011-01-24 | 2014-04-29 | Abbvie Biotechnology Ltd. | Removal of needle shields from syringes and automatic injection devices |
US20140194827A1 (en) * | 2013-01-09 | 2014-07-10 | Pei-Hsin Hsu | Disposable pre-filled syringe |
JP2015504748A (en) * | 2012-01-25 | 2015-02-16 | ノボ・ノルデイスク・エー/エス | Drug ejection device with cartridge fixing characteristics |
US9180244B2 (en) | 2010-04-21 | 2015-11-10 | Abbvie Biotechnology Ltd | Wearable automatic injection device for controlled delivery of therapeutic agents |
US9265887B2 (en) | 2011-01-24 | 2016-02-23 | Abbvie Biotechnology Ltd. | Automatic injection devices having overmolded gripping surfaces |
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WO2020187876A1 (en) * | 2019-03-20 | 2020-09-24 | Sanofi | Container retaining member, drug delivery device and method |
US10806867B2 (en) | 2011-01-24 | 2020-10-20 | E3D Agricultural Cooperative Association Ltd. | Injector |
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WO2023025973A1 (en) * | 2021-08-23 | 2023-03-02 | Gerencia Regional de Salud de Castilla y León | Drug housing device |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE251478T1 (en) | 1998-07-08 | 2003-10-15 | Novo Nordisk As | A DISCHARGE DEVICE AND ASSOCIATED CARTRIDGE |
US6822639B1 (en) | 1999-05-25 | 2004-11-23 | Silverbrook Research Pty Ltd | System for data transfer |
US8518328B2 (en) * | 2005-12-27 | 2013-08-27 | Honeywell International Inc. | Fluid sensing and control in a fluidic analyzer |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
NL1016298C2 (en) * | 2000-09-29 | 2002-04-03 | Sgt Exploitatie Bv | Vial, method for using a vial for analysis on a sample, as well as a system for performing the method according to the invention using a vial according to the invention. |
GB0129171D0 (en) * | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
EP2210634A1 (en) | 2009-01-22 | 2010-07-28 | Sanofi-Aventis Deutschland GmbH | Drug delivery device dose setting mechanism |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
DE102004009434A1 (en) | 2004-02-24 | 2005-12-15 | Boehringer Ingelheim International Gmbh | atomizer |
GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
GB2414406B (en) | 2004-05-28 | 2009-03-18 | Cilag Ag Int | Injection device |
GB2414409B (en) | 2004-05-28 | 2009-11-18 | Cilag Ag Int | Injection device |
GB2414401B (en) | 2004-05-28 | 2009-06-17 | Cilag Ag Int | Injection device |
GB2414775B (en) | 2004-05-28 | 2008-05-21 | Cilag Ag Int | Releasable coupling and injection device |
GB2414402B (en) | 2004-05-28 | 2009-04-22 | Cilag Ag Int | Injection device |
GB2414403B (en) | 2004-05-28 | 2009-01-07 | Cilag Ag Int | Injection device |
GB2414400B (en) | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
EP1804865B1 (en) | 2004-10-21 | 2009-09-30 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
DE102004061094A1 (en) * | 2004-12-18 | 2006-06-22 | Aixtron Ag | Deposition of single layers, on a flat or structured substrate, uses a limiter to stop the deposition automatically when the layer is closed |
GB2424836B (en) | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2424835B (en) | 2005-04-06 | 2010-06-09 | Cilag Ag Int | Injection device (modified trigger) |
GB2425062B (en) | 2005-04-06 | 2010-07-21 | Cilag Ag Int | Injection device |
GB2424838B (en) | 2005-04-06 | 2011-02-23 | Cilag Ag Int | Injection device (adaptable drive) |
GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
US8561854B2 (en) * | 2005-08-01 | 2013-10-22 | Rich Products Corporation | Dispensing device for viscous materials |
US8297481B2 (en) | 2005-08-01 | 2012-10-30 | Rich Products Corporation | Dispensing device |
DE602005018480D1 (en) | 2005-08-30 | 2010-02-04 | Cilag Gmbh Int | Needle device for a prefilled syringe |
US20110046059A1 (en) * | 2005-09-06 | 2011-02-24 | Zelos Therapeutics, Inc. | Pharmaceutically acceptable formulations/compositions for peptidyl drugs |
US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
US7485153B2 (en) * | 2005-12-27 | 2009-02-03 | Honeywell International Inc. | Fluid free interface for a fluidic analyzer |
US8182767B2 (en) * | 2005-12-27 | 2012-05-22 | Honeywell International Inc. | Needle-septum interface for a fluidic analyzer |
ATE458517T1 (en) | 2006-05-16 | 2010-03-15 | Novo Nordisk As | TRANSMISSION MECHANISM FOR AN INJECTION DEVICE |
JP5253387B2 (en) | 2006-05-18 | 2013-07-31 | ノボ・ノルデイスク・エー/エス | Injection device with mode locking means |
GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438591B (en) | 2006-06-01 | 2011-07-13 | Cilag Gmbh Int | Injection device |
GB2438593B (en) | 2006-06-01 | 2011-03-30 | Cilag Gmbh Int | Injection device (cap removal feature) |
EP2040780B1 (en) * | 2006-07-03 | 2016-01-06 | Novo Nordisk A/S | Coupling for injection devices |
CN101511411B (en) * | 2006-07-15 | 2012-02-15 | 诺沃-诺迪斯克有限公司 | A medical delivery system with flexible blocking element |
WO2008056443A1 (en) * | 2006-11-07 | 2008-05-15 | Yoshio Oyama | Ampule guide and medical solution dosing unit |
US7988668B2 (en) * | 2006-11-21 | 2011-08-02 | Medtronic, Inc. | Microsyringe for pre-packaged delivery of pharmaceuticals |
CN101605569B (en) | 2007-02-05 | 2012-09-05 | 诺沃-诺迪斯克有限公司 | Injection button |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
WO2009117420A1 (en) | 2008-03-17 | 2009-09-24 | Jesse Bunch | Multi-mode syringe |
GB2461086B (en) | 2008-06-19 | 2012-12-05 | Cilag Gmbh Int | Injection device |
GB2461085B (en) | 2008-06-19 | 2012-08-29 | Cilag Gmbh Int | Injection device |
GB2461089B (en) | 2008-06-19 | 2012-09-19 | Cilag Gmbh Int | Injection device |
GB2461087B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
GB2461084B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Fluid transfer assembly |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
US8764425B2 (en) | 2009-02-12 | 2014-07-01 | Picolife Technologies, Llc | Mold for making a membrane for use with a flow control system for a micropump |
US9457150B2 (en) * | 2009-06-01 | 2016-10-04 | Sanofi-Aventis Deutschland Gmbh | Biasing mechanism for a drug delivery device |
EP2724739B1 (en) | 2009-07-30 | 2015-07-01 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
JP2013506460A (en) | 2009-09-30 | 2013-02-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Methods and assemblies for drug delivery devices |
CA2778859A1 (en) * | 2009-10-30 | 2011-05-05 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
US9623184B2 (en) * | 2009-12-04 | 2017-04-18 | Becton, Dickinson And Company | Cartridge for containing and dispensing a medicament |
DK3539595T3 (en) | 2010-01-22 | 2022-09-19 | Sanofi Aventis Deutschland | ENCODED CARTRIDGE HOLDER AND ATTACHMENT DEVICE ACTIVATED BY CARTRIDGE SIZE |
CN104474610B (en) * | 2010-02-01 | 2018-09-14 | 赛诺菲-安万特德国有限公司 | Cartridge-holder, drug delivery device and the method for being fixed on cylindrantherae in cartridge-holder |
RU2012138044A (en) | 2010-03-25 | 2014-04-27 | Нью Инджекшн Системз Лтд | SPRAYER |
US9022988B1 (en) | 2010-05-07 | 2015-05-05 | Kavan J. Shaban | System and method for controlling a self-injector device |
US20130204187A1 (en) * | 2010-08-06 | 2013-08-08 | Sanofi-Aventis Deutschland Gmbh | Method and system for retaining a cartridge in a holder |
US9687612B2 (en) | 2010-11-08 | 2017-06-27 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism and drug delivery device |
TWI464002B (en) | 2010-11-08 | 2014-12-11 | Shl Group Ab | Container holder assembly and medicament delivery device assembly |
WO2012084930A1 (en) * | 2010-12-21 | 2012-06-28 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with housing comprising frangible zone |
US20130261552A1 (en) * | 2010-12-21 | 2013-10-03 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with housing comprising frangible zone |
US20130274661A1 (en) * | 2010-12-21 | 2013-10-17 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with housing comprising frangible zone |
CA2821943A1 (en) * | 2010-12-22 | 2012-06-28 | Sanofi-Aventis Deutschland Gmbh | Dedicated cartridge |
US20140012205A1 (en) * | 2011-03-23 | 2014-01-09 | Sanofi-Aventis Deutschland Gmbh | Drug Delivery Device with Pivoting Protective Cap |
WO2013009897A1 (en) | 2011-07-11 | 2013-01-17 | Medpro Safety Products, Inc. | Fluid delivery device and methods |
US20140155834A1 (en) * | 2011-07-15 | 2014-06-05 | Michael Harms | Locking Interface, Cartridge Holder and Drug Delivery Device Comprising a Locking Interface |
US8771229B2 (en) | 2011-12-01 | 2014-07-08 | Picolife Technologies, Llc | Cartridge system for delivery of medicament |
US8790307B2 (en) | 2011-12-01 | 2014-07-29 | Picolife Technologies, Llc | Drug delivery device and methods therefor |
MX2014007375A (en) | 2011-12-29 | 2014-08-22 | Novo Nordisk As | Torsion- spring based wind-up autoinjector pen with dial - up/dial - down dosing mechanism. |
AU2013224349A1 (en) | 2012-02-24 | 2014-08-21 | Novo Nordisk A/S | Drug delivery device with front loading feature |
US10130759B2 (en) | 2012-03-09 | 2018-11-20 | Picolife Technologies, Llc | Multi-ported drug delivery device having multi-reservoir cartridge system |
DK2836259T3 (en) * | 2012-04-11 | 2016-09-12 | Sanofi Aventis Deutschland | CARTRIDGE HOLDER AND pen-like INJECTOR |
US9883834B2 (en) | 2012-04-16 | 2018-02-06 | Farid Amirouche | Medication delivery device with multi-reservoir cartridge system and related methods of use |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US10245420B2 (en) | 2012-06-26 | 2019-04-02 | PicoLife Technologies | Medicament distribution systems and related methods of use |
GB2505162A (en) * | 2012-07-11 | 2014-02-26 | Max Doughty | Injector with hook locking system for casing |
WO2014080020A1 (en) | 2012-11-23 | 2014-05-30 | New Injection Systems Ltd | Auto-injector assembly |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
GB2517896B (en) | 2013-06-11 | 2015-07-08 | Cilag Gmbh Int | Injection device |
GB2515032A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Guide for an injection device |
GB2515039B (en) | 2013-06-11 | 2015-05-27 | Cilag Gmbh Int | Injection Device |
GB2515038A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Injection device |
EP3166566B1 (en) * | 2014-07-10 | 2019-10-16 | AbbVie Inc. | Systems and methods for tubing delivery |
HUE054412T2 (en) | 2016-05-16 | 2021-09-28 | Haemonetics Corp | Sealer-less plasma bottle and top for same |
US11648179B2 (en) | 2016-05-16 | 2023-05-16 | Haemonetics Corporation | Sealer-less plasma bottle and top for same |
US10926025B2 (en) | 2016-09-15 | 2021-02-23 | Tandem Diabetes Care, Inc. | Vial supporter for medicament pump |
PE20211202A1 (en) | 2017-08-24 | 2021-07-05 | Novo Nordisk As | COMPOSITIONS OF GLP-1 AND ITS USES |
EP3980099A1 (en) * | 2019-06-05 | 2022-04-13 | Sanofi | Medicament container |
EP4041350A1 (en) * | 2019-10-08 | 2022-08-17 | Novo Nordisk A/S | Dose sensing module with friction enhancing means |
AU2020406018A1 (en) * | 2019-12-18 | 2022-08-11 | Sanofi | Cartridge assembly for a drug delivery device and drug delivery device |
PE20221575A1 (en) | 2020-02-18 | 2022-10-06 | Novo Nordisk As | PHARMACEUTICAL FORMULATIONS |
EP4319843A1 (en) * | 2021-04-07 | 2024-02-14 | medmix Switzerland AG | Drug delivery device |
EP4070832A1 (en) | 2021-04-07 | 2022-10-12 | medmix Switzerland AG | Keyed connectors |
WO2022228934A1 (en) * | 2021-04-28 | 2022-11-03 | Shl Medical Ag | A component and a sub-assembly for a medicament delivery device |
WO2022233755A1 (en) * | 2021-05-03 | 2022-11-10 | Sanofi | Housing components for an injection device |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2685878A (en) * | 1953-04-24 | 1954-08-10 | Sr David Walter Seifert | Capsule type dental syringe |
FR1320820A (en) * | 1962-01-29 | 1963-03-15 | Improvements to injection devices | |
US4718463A (en) | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US4628969A (en) | 1985-12-20 | 1986-12-16 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
GB8713810D0 (en) * | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
FR2633520B1 (en) * | 1988-06-30 | 1992-04-30 | Brunel Marc | SYRINGE OF THE TYPE COMPRISING A SINGLE USE INJECTION NEEDLE, PARTICULARLY FOR THE DENTAL FIELD |
SE9002510D0 (en) | 1990-07-26 | 1990-07-26 | Kabivitrum Ab | APPARATUS FOR CONTROLLED DELIVERY OF LIQUIDS |
DE4025717A1 (en) * | 1990-08-14 | 1992-02-20 | Hoechst Ag | SYRINGE RACK |
US5207983A (en) | 1992-01-29 | 1993-05-04 | Sterling Winthrop Inc. | Method of terminal steam sterilization |
US5279586A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
AU5898794A (en) | 1992-12-14 | 1994-07-04 | Mallinckrodt Medical, Inc. | Methods of producing prefilled delivery devices without exterior or interior contamination |
US5373684A (en) | 1992-12-14 | 1994-12-20 | Mallinckrodt Medical, Inc. | Process and apparatus used in producing prefilled, sterile delivery devices |
US5250037A (en) | 1992-12-18 | 1993-10-05 | Becton, Dickinson And Company | Syringe having needle isolation features |
US5383865A (en) * | 1993-03-15 | 1995-01-24 | Eli Lilly And Company | Medication dispensing device |
US5725508A (en) | 1994-06-22 | 1998-03-10 | Becton Dickinson And Company | Quick connect medication delivery pen |
US5645534A (en) | 1994-06-24 | 1997-07-08 | Becton Dickinson And Company | Time of last injection indicator for medication delivery pen |
US5549575A (en) * | 1994-09-13 | 1996-08-27 | Becton Dickinson And Company | Cartridge retainer assembly for medication delivery pen |
US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
US5569214A (en) | 1994-09-20 | 1996-10-29 | Becton Dickinson And Company | Dose setting knob adapter for medication delivery pen |
US5558259A (en) * | 1994-09-27 | 1996-09-24 | Izzo Systems, Inc. | Golf bag with dual carrying straps |
US5519984A (en) | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
US5667495A (en) | 1995-04-21 | 1997-09-16 | Becton Dickinson France S.A. | Backstop device for a syringe |
US5674204A (en) * | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
US5542760A (en) | 1995-09-26 | 1996-08-06 | Becton Dickinson And Company | Syringe filler for mixing insulins |
US5931817A (en) | 1997-09-12 | 1999-08-03 | Becton Dickinson And Company | Pen needle assembly |
-
1998
- 1998-08-21 WO PCT/US1998/017409 patent/WO1999016485A1/en active Application Filing
- 1998-08-21 AU AU92023/98A patent/AU9202398A/en not_active Abandoned
- 1998-09-21 DK DK98948380T patent/DK0941133T3/en active
- 1998-09-21 WO PCT/US1998/019649 patent/WO1999016487A1/en active IP Right Grant
- 1998-09-21 EP EP98948380A patent/EP0941133B1/en not_active Expired - Lifetime
- 1998-09-21 JP JP52026999A patent/JP3414760B2/en not_active Expired - Lifetime
- 1998-09-21 AU AU94964/98A patent/AU9496498A/en not_active Abandoned
- 1998-09-21 DE DE69823481T patent/DE69823481T2/en not_active Expired - Lifetime
-
2001
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Also Published As
Publication number | Publication date |
---|---|
JP3414760B2 (en) | 2003-06-09 |
EP0941133B1 (en) | 2004-04-28 |
AU9496498A (en) | 1999-04-23 |
US6648859B2 (en) | 2003-11-18 |
JP2002509469A (en) | 2002-03-26 |
DE69823481D1 (en) | 2004-06-03 |
DE69823481T2 (en) | 2005-04-14 |
US20030109834A2 (en) | 2003-06-12 |
WO1999016487A1 (en) | 1999-04-08 |
AU9202398A (en) | 1999-04-23 |
DK0941133T3 (en) | 2004-08-02 |
EP0941133A1 (en) | 1999-09-15 |
WO1999016485A1 (en) | 1999-04-08 |
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