CN101511411B

CN101511411B - A medical delivery system with flexible blocking element

Info

Publication number: CN101511411B
Application number: CN2007800328673A
Authority: CN
Inventors: A·V·克里斯琴森
Original assignee: Novo Nordisk AS
Current assignee: Novo Nordisk AS
Priority date: 2006-07-15
Filing date: 2007-07-15
Publication date: 2012-02-15
Anticipated expiration: 2027-07-15
Also published as: CN101489607A; CN101511411A; CN101489607B

Abstract

A medical delivery system (200) having a container (202) and a dosing assembly (204), where the container is fastenable to the dosing assembly by a movement comprising a translatory movement followed by a rotational movement. One of the container and the dosing assembly comprises one or more blocking elements (207) movable between a blocking position and a non-blocking position responsive to the rotational movement. Each blocking element is able to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system.

Description

Medical delivery system with flexible stop member

Technical field

The present invention relates to a kind of medical delivery system, comprise container and proportioner.Especially, the present invention relates to a kind of medical delivery system, wherein in this container and the proportioner comprises another the flexible stop member that is suitable for meshing in this container and the proportioner.In addition, the present invention relates to a kind of container and proportioner, wherein each is applicable to according to medical delivery system of the present invention.

Background technology

Usually, for the good medical transmission equipment that is easy to by the acceptance of given patient colony is provided, in delivery system, set sizable difference so that patient uses.Along with the increase of commercial transmission system quantity, distributed the medicament storage pipe or the container of number of different types.Great majority in the container of these types are different in all fields.

Each medicament reservoir can be filled with the medicine of a kind of particular type of from a large amount of different pharmaceuticals, selecting, also can in this container, load the variety classes (for example quick or protamine zine insulin) of similar medicine and the variable concentrations of every kind of specific medication simultaneously.

In addition, can introduce different container volumes, thereby come each container of personalized customization, and then customize this transmission system to specific user's needs.The variation of container volume can provide through length or the diameter that changes this container.These change the corresponding change of the proportioner comprising medical delivery system usually, thereby the specific stroke that driver part is provided is to penetrate medicine or to provide optional proportioning accuracy from container.Can also realize for the further differentiation between the different pharmaceutical container through the design requirement of each particular transport system, for example the sliding friction demand of set piston in this container.

In order to distinguish more used vessel, developed a plurality of container coding systems, it mainly is based on the medicine that electronic reading transmits particular type with the specific container of identification so that through dedicated transmissions equipment and realizes.Following mechanical coding system is known in the art:

US5611783 relates to a kind of pen-type injection device, the near-end that comprises the far-end with ampoule and have batching setting and driving mechanism.This near-end and far-end have interlocking bayonet socket coupling device.Provide projection to form pattern, guarantee that a kind of specific far-end only can be used for connecting a kind of specific proximal.

WO03/017915A1 discloses a kind of cartridge case, has the far-end that has been equipped with mechanical coding.This mechanical coding has the form of circular projection, and wherein this circular outer diameter is exclusively used in the certain concentration that is included in the insulin in this cartridge case.

US5693027 discloses and a kind ofly has been used to make standard cartridge to be applicable to the vinyl cover of selected syringe.This vinyl cover can have a device, and it is used for when the cartridge case with syringe assembles and the corresponding intrument wedge shape in the syringe meshes so that it can not rotate.

US6648859B2 discloses a kind of cartridge case device that is used for the reusable lip pencil device of medical transmission pen.Intersect to use in order to eliminate, this lip pencil device and this cartridge case are wedge shapes, and the screw thread that promptly they can be through correspondence and groove, engage threads and groove, snap or a pair of projection that cooperates with reverse Luer-Lock mode realize screw-threaded engagement.This component is selected to prevent and the use that intersects of other devices that for example the gradient of this screw thread is formed certain angle so that only match rather than other devices with another corresponding parts.

Another kind of prior art system is disclosed in DE20110690.

The purpose of a preferred embodiment of the present invention provides a kind of alternative of known system.In addition, the purpose of a preferred embodiment of the present invention provides a kind of medical delivery system with many possible coding structures.

In addition; The purpose of a preferred embodiment of the present invention provides a kind of coding system; Wherein the container when predetermined medical delivery system intercouple with proportioner/when separating; Though the compatible container of many groups, in the proportioner specific selection why, the user can experience essentially identical fastening motor performance.In addition, the purpose of a preferred embodiment of the present invention provides a kind of system with container/proportioner of many different codings, obtains one simultaneously and has reduced the possible robust system of mechanical breakdown.

In addition, the purpose of a preferred embodiment of the present invention provides a kind of fixed mechanism directly perceived that is used for container is fixed to proportioner.

Summary of the invention

In first aspect; The present invention relates to a kind of medical delivery system; Comprise :-container; Comprise being suitable in cavity, loading the shell of medicine and being arranged to slidably piston that the volume that this piston can move to reduce this cavity towards outlet also passes through this outlet discharge with this medicine on distal direction;-proportioner has the container reception cavity, be used at least in part this container being received in wherein and with this container be coupled to this proportioner so that the driving device of this proportioner at the move up piston of this container of this far end party.Wherein, This proportioner has formed first clamp device; Second clamp device that is used to mesh this container to be to be fixed to this proportioner with this container, wherein should fixing motion comprises along first move to axial, subsequently for around this relative rotary motion of first.Wherein, This proportioner comprises one or more stop members; Wherein said one or more stop member can move towards the second position from primary importance; Wherein when this primary importance this stop member with respect to said first diameter of axle in extending to said container reception cavity; This stop member is radially outward moved when this second position, and wherein this stop member can move to the said second position from said primary importance in response to said relative rotary motion, has prevented simultaneously when being applied in axial force, to move to the said second position from said primary importance; And wherein this container comprises the chamber wall part, and it is formed with axially extended breach, is used to receive the stop member of said predetermined quantity, and makes this vessel axis in being inserted into said container reception cavity.

According to the present invention, extend axially the distribution of breach through changing stop member and corresponding along this medical delivery system coupling unit profile, can obtain the different coding variant.Thereby can guarantee the container of first medical delivery system is encoded so that it can not be fixed on the proportioner of second medical delivery system.Similarly, can guarantee the container of second medical delivery system is encoded so that it can not be fixed on the proportioner of first medical delivery system.Therefore, this medical system according to the present invention has improved user security, because have only predetermined container can be connected to specific proportioner.Thereby this proportioner can be set to the medicine that uses predefined type and/or concentration, and the container that the medicine of other concentration or type is housed then can not be connected to this proportioner.

System according to the present invention has such advantage: though comprise an adapter with comprise move axially and subsequently the situation that for example rotatablely moves in bayonet joint under so that this container is fixed to this proportioner, also can reduce to extend axially the size of the coding characteristic that breach limits by this.This just provides the possibility of more different vessels codings.In addition, because the space that coding characteristic of the present invention needs is still less, thus need be with respect to the fixed convex addressable part than the system of wide-angle notch, the part that comprises the coding system of this breach can be made more stable.According to the present invention, can come encoding device through position of rotation that changes one or more stop members and the position of rotation that correspondingly changes corresponding one or more breach.Yet even for the system of different coding, this is used for container and proportioner coupling and isolating whole particular user interface with it can be consistent.This often uses the transmission system of a plurality of different codings for needs is particularly advantageous with the user who uses dissimilar medicines.

In full text of the present invention, term " medical delivery system " is appreciated that any system that can drug administration comprises the medicament that flows.The example of medical delivery system is for example AutoPen (TM) of pump mechanism, dosimeter, lip pencil dosimeter, electronic dosimeter and automatic injector.

The present invention can be used for all kinds of medical delivery systems that can the drug conveying in the container be given the user, and this container is conditioned to be coupled to the proportioner of this transmission equipment.This transmission equipment can comprise any transmission equipment that is used for percutaneous, subcutaneous, intravenous, intramuscular or pulmonary administration.

As used herein, term " medical " is to have contained any medicine, and comprising can be through the transmitting device for example mobile medicament carried with controlled manner of hollow syringe or conduit, for example liquid, solution, gel or fine suspension.And the freeze-dried drug of before administration, being dissolved into liquid form is also contained by above-mentioned definition.Representative drugs comprises for example other materials of peptide, protein (for example insulin, para-insulin and C peptide) and hormone, biological acquisition or activating agent, the medicament based on hormone and gene, nutrient formulation and solid-state (preparation) or liquid form of medicine.

The cavity of this container or apotheca can piston forms with being arranged to slidably by one or more sidewalls of this shell of tank.In most embodiment, at least a portion of this container is annular, and forms a cylindrical cavity to hold this piston.The far-end of this container can comprise a sealing gasket, is used for being passed to pass through transmitting device for example sleeve pipe or the intravital medicine of conduit discharge side by sleeve pipe.The far-end of this container can be fit to be connected to clamping to be had on the telescopic support.For example, the far-end of this container can comprise screw thread, and it is suitable for corresponding threaded engagement with this support so that can this rack screw be fixed on this container.Alternatively, the far-end of this container can be fit to be coupled to injection device.

The outlet of this container can be fit to sleeve pipe or needle tubing or needle hub or injection device matches or by its qualification, perhaps any other is suitable for the medicine in this container is carried out the fluid-transporting tubing that fluid obtains.

The driving device of this proportioner can comprise and is adapted at the move up piston rod of this piston of far end party.This piston rod can comprise the parts harder than this piston; It is fit to be preferably most of adjacent with at least a portion of this piston near-end opposite face; Compare thereby directly engage this piston, can the power that this piston rod is applied on this rigid element be applied on the more large tracts of land of this piston proximal end face with this piston rod.

This proportioner has formed one first clamp device, and it engages with second clamp device of this container during this container is fixed to proportioner.In one embodiment, the near-end opposite face of first clamp device of this proportioner engages with the far-end opposite face of second clamp device of this container.

Be used for the coupling process that this container is coupled to proportioner can comprise carry out simultaneously axially with rotatablely move for example screw.By rotatablely moving of this axial and generation of carrying out simultaneously that rotatablely moves less than a week, for example less than 120 degree,, for example spend less than 60 for example less than 90 degree, for example, for example spend less than 20 less than 30 degree.When the near-end opposite face of this first clamp device engaged with the far-end opposite face of this second clamp device, this container can be so that this container relative to each other advances with this proportioner with respect to summoning to court of proportioner.

In first embodiment, first clamp device of this proportioner forms a groove, and it is fit to receive projection or convex parts that second clamp device by this container forms.During this container was fixed to proportioner, most of near-end opposite face of first clamp device of this proportioner engaged with most of far-end opposite face of this container.Motion that should be predetermined is limited the shape on this at least one composition surface.In another embodiment, this second clamp device forms for example two, three or four of a plurality of projections, and this first clamp device forms the corresponding a plurality of grooves that are fit to this engages.

In a second embodiment, this groove is formed by container, and projection is formed by proportioner.In the 3rd embodiment, this container forms the combination of groove and projection, and its corresponding projection and groove that is fit to form with this proportioner engages.

In full text of the present invention, it is relevant with first and second clamp devices that term " groove " and " projection " only are used for, and " breach " only is used for relevant with second portion stretched-out coding mechanism with the joint/receiving mechanism of this rotary part with " protuberance ".Yet " groove ", " breach " and " depression parts " should be regarded as synonym, and " protuberance ", " projection " and " convex parts " should be regarded as synonym.

This first and second clamp device can be fit to can discharge or permanent mode engages.Even when this clamp device was fit to engage with the permanent engagement mode, the present invention also can strengthen the for example safety in manufacture process before final this medical transmission equipment of assembling with respect to mixing.

In one embodiment, the quantity of this stop member is selected as one, two, three, four or five, and wherein each all is fit to engage the breach of the correspondence/cooperation/coupling of this second portion.Yet the main purpose of this stop member is prevention or limits vessel axis in the container reception cavity that gets into this proportioner.Above-mentioned term " correspondence/cooperation/coupling " must not represented the joint that shape matches, and promptly this breach can be than this stop member wideer (on peripheral direction).

In one embodiment; This breach ratio stops parts wideer (circumference); Move in this breach thereby make this stop member to rotate; Thereby make that when this protuberance is received in the breach this second portion can rotate with respect to this rotatable part, and does not need this stop member is moved to its second position from its primary importance.

In further embodiments, this stop member and breach can have essentially identical periphery width.Alternatively, this stop member can be slightly wideer than this breach.

In one embodiment, this first and second clamp device and this stop member and breach are fit to make this first and second clamp device at least partly to engage, so that this stop member can be received in this breach.In other words; When being fixed to this container on the proportioner; This stop member can not be received in this breach, otherwise (this first or second clamp device) projection is just at least partly received in (another of said first or second clamp device) this groove.

In one embodiment, this proportioner forms these one or more stop members.In certain embodiments, this stop member extend in the container reception cavity to stop that the vessel axis that is not allowed to is to entering.In further embodiments, this stop member radially outward stretches out to stop that the proportioner that is not allowed to is coupled in the container that a shape matches, and this vessel is useful on the cavity of at least a portion that receives this proportioner therein.In further embodiments, this stop member is formed by this container, and wherein this stop member is radially inside or protruding from chamber wall.In these embodiment, this proportioner has the axially extended breach that is used to correct container coding.

Other embodiment comprise medical transmission equipment, wherein this container and proportioner each all have one or more stop members so that received by the breach that extends axially accordingly of another part.

In one embodiment, this transmission system comprises two or more stop members.These two or more stop members can for example be used to be provided at the asymmetric coding system that is provided with around the circumferential section of this coupling interface by with irregular mutual spacing setting.

In one embodiment, this container comprises that being arranged to apart from the distance of this container near-end is second clamp device of X1.This second clamp device can be provided so that cooperate with the depression parts of this proportioner by the convex parts.The axial length of convex parts can be expressed as thickness t 1.In this system, these one or more breach have surpassed distance X 1+t1.In certain embodiments, said one or more breach distance of expression in the eyes on distal direction has surpassed X1+t1 for example 50%, 75%, 100%, 150%, 200% or 300%.

In certain embodiments, this second clamp device is set at the most proximal end of this container.

In one embodiment, these one or more breach are formed that to compare with adjacent part be vertical breach of depression.In this structure, this breach may be provided in the thickness of the chamber wall minimizing partly of this container.In further embodiments, this container provides the center cavity that is arranged in this container proximal face, and wherein this breach radially extends and extends radially outwardly into this external container from the center cavity of this container.Thereby this breach can be formed in the opening that forms on this container side wall.

In one embodiment, this container comprises cartridge holder and the cartridge case that forms said cavity.This second clamp device can form or be connected to this support by this cartridge holder.In addition, this breach/stop member can be formed by this cartridge holder.This cartridge case and cartridge holder can be two independent parts, and cartridge case can be remained in this cartridge holder by friction.In one embodiment, this cartridge case is processed by glass, and cartridge holder is processed to protect this glass ampoules by non-glass materials.This cartridge case can immovably be remained in the cartridge holder impaired to prevent.Even will this cartridge case be removed from cartridge holder, can not it be installed different instruments once more with hands.This just provides an advantage, and promptly when this cartridge case was drained, this cartridge holder just can not be used again, and therefore can not the cartridge case with wrong drug be inserted in this cartridge holder and through the use proportioner and distribute.This cartridge holder and cartridge case can form a global facility, promptly constitute the parts that need not engage.This global facility can form a mechanograph, its by synthetic resin for example cyclic olefine copolymer for example Topas (R) process or process by polypropylene.Yet, can use to be suitable for any material that the long time storage is installed in the specific medication in this container.

In one embodiment, this second clamp device is associated with the near-end of this container.In further embodiments, this second clamp device is associated in the position of giving set a distance from this container proximal extension, for example between this near-end and the far-end midway or nearer apart from this container far-end.In further embodiments, this second clamp device is associated with the far-end of this container.

In one embodiment, these one or more breach are from the proximal extension of this container.In further embodiments, this breach extends and further extends towards far-end from the sidewall sections of this container away from this near-end.

As stated, at least a portion of said predetermined motion can be carry out simultaneously axially with rotatablely move.In addition;-this first and second clamp device; With stop member and/or in the breach at least one of each in-this rotatable part and the second portion can be fit to stop in this predetermined motion axially and/or a part that rotatablely moves; Thereby stop this container to be coupled to proportioner, only if: each in-this first and second clamp device forms a predictive encoding shape, and/or-in this stop member and/or the breach each form a predictive encoding shape.

In addition; One or more in-this first and/or second clamp device; And/or-one or more coding shape in this stop member and/or the breach can by following at least one form: the circular degree of this first and second clamp device; The axial length of this first and second clamp device, the circumferential position of the radial width of this first and second clamp device and this first and second clamp device.

Therefore, can recognize that medical delivery system according to the present invention provides a plurality of coding shapes, wherein each may be used to represent different character.For example, first predetermined characteristic that this first and second clamp device can be used to represent this medicine is its kind for example, and second predetermined characteristic that the position of rotation of this stop member can be used to represent this medicine is its concentration for example.Other can be through the example of the characteristic represented of coding shape: men's/lady's medicine, and child/adult's medicine, preventative/curative drug, slow release/active remedy.

Alternatively, the position of rotation of this first and second clamp device and this stop member can be multiple, thereby if one of them breaks down, another will be guaranteed only can be fastened to each other with predetermined container and proportioner.Therefore, owing to these two kinds multiple coding shapes provide higher level of security.

One embodiment comprises :-the first container, have any one of above-mentioned characteristic and/or parts, this first container is fit to be fixed to first proportioner with any one above-mentioned characteristic and/or parts; With-the second container, have any one of above-mentioned characteristic and/or parts, this second container is fit to be fixed to second proportioner with any one above-mentioned characteristic and/or parts; Wherein, First clamp device of-this proportioner; Second clamp device of-this container and-in this stop member and the/breach each at least one be fit to prevent that this first proportioner and second container are fastened to each other, and prevents that this second proportioner and first container are fastened to each other.

In addition, this first container is coupled to first proportioner and separates required predetermined motion and this second container is coupled to second proportioner and to separate required predetermined motion substantially the same.

In second aspect, the present invention relates to a kind of (being arranged for) container that is suitable for being used in according to the medical delivery system of first aspect present invention.

Can recognize, can comprise of the present invention any characteristic and/or parts according to first aspect according to the present invention of second aspect.Especially, the container of this second aspect can comprise any characteristic and/or the parts according to the container of first aspect present invention.

In the third aspect, the present invention relates to a kind of proportioner that is applicable to according to the medical delivery system of first aspect present invention.

Can recognize, can comprise of the present invention any characteristic and/or parts according to first aspect according to the present invention of the third aspect.Especially, the proportioner of this third aspect can comprise any characteristic and/or the parts according to the proportioner of first aspect present invention.

Description of drawings

Illustrate in greater detail the present invention below with reference to accompanying drawings, wherein:

Fig. 1 shows the medical delivery system of prior art,

Fig. 2 and 3 shows the container coupled system of prior art,

Fig. 4 a, 4b, 4c show according to two of first aspect present invention specific container coupled systems,

Fig. 5 discloses the container coupled system according to second embodiment of the invention,

Fig. 6 a discloses the container coupled system according to third embodiment of the invention,

Fig. 6 b and 6c disclose two kinds of alternate Vessel Design according to third embodiment of the invention,

Fig. 7 a, 7b, 7c, 7d and 7e disclose according to the container coupled system of fourth embodiment of the invention and

Fig. 8 a and 8b show the container coupled system according to fourth embodiment of the invention.

Fig. 1 discloses a kind of medical delivery system that constitutes injection pen 1, comprises the container part 2 that medicine is housed, and it is fit to be fixed to proportioner 4.In the illustrated form, proportioner 4 has constituted a mechanism that is used for being provided with the given dose of the medicine of injection vessel 2.This container 2 comprises a distal portions of opening, but it is by 5 sealings of puncture through seal parts.This container also comprises slidably the piston of installing 11, and it is fit to when on distal direction, piston 11 being applied external force the distal portions East China towards this container 2.Typically, carry medicine through the needle tubing 3 that is fixed to releasedly on container 2 distal portions.When container 2 is coupled to proportioner 4, is passed on the piston 11 by 7 externally applied forces of driving device of proportioner, thereby the medicine in the container 2 is discharged through needle tubing 3.

In institute's diagrammatic sketch, container 2 is cartridge holder 2 " limit, it is fit to receive the cartridge case 2 ' that medicine is housed, for example normal glass pipe.This container 2 has the clamp device (not shown) so that container 2 is fixed on the proportioner 4 of this injection pen.

The clamp device of this container 2 is fit to engage the clamp device of proportioner 4, and this coupling can provide permanent coupling so that cartridge case can not remove, thereby forms a prepackage pen, can be dropped after its medicine in cartridge case is drained.

Alternatively, the clamp device of the clamp device of container 2 and proportioner 4 can form releasable the connection, and it provides the possibility of after previous empty is dropped, utilizing a new container to reuse this proportioner.

According to above-mentioned universal transmission equipment notion, the last state defending party to the application of this area syringe device is labeled as "

4 ".This equipment provides a kind of lasting proportioner, and it is fit to receive the discardable cartridge case of being changed by the user easily.This specific coupling mechanism that is used for cartridge holder is coupled on the proportioner of

4 provides a kind of easy, directly perceived and coupling reliably.Fig. 2 and 3 shows the concrete diagram of the selection part of 4 relevant with the coupling of this cartridge holder and proportioner.Fig. 2 and 3 syringe device 100 comprise proximal part 104 and distal portions 102.In use, this proximal part 104 has constituted the part of proportioner, and it comprises and is used for discharging a spot of driving device (not shown) from syringe device 100.The driving device of this proximal part 104 is included in the piston rod (not shown) that extends along central shaft 106 in the cartridge case reception cavity 150 of this proximal part 104.In use, distal portions 102 has constituted the part of container, has to be used to hold the for example shell 102 of cartridge case (not shown) of bin.In addition, this distal portions 102 can be adapted at the far-end support of this distal portions 102 or connect the needle tube device (not shown).

This distal portions 102 comprises two convex parts or the projection 110 that is arranged on distal portions 102 each side.These projections 110 are used for the matching track through the groove 112 that projection 110 is advanced to formation proximal part 104, and this distal portions 102 is fixed to proximal part 104.This groove 112 is formed in the cartridge case reception cavity 150 on the inner surface of this proximal part 104.Inclined plane shape protuberance 114 through adjacent radially extend into the given shape that forms each groove 112 in the cartridge case reception cavity 150.Each groove is formed by the first of the opening with the axial entering that is used to receive distal portions 102, during with distal portions 102 correct alignment, makes this projection 110 get into corresponding opening with this proximal part 104 of box lunch.The opening of this groove 112 is promptly limited by near-end opposite face 115 corresponding to moving to the inclined-plane in the groove gradually along the inner rim direction.This set provides the fastening motion between far-end and

proximal part

102 and 104, comprises that inside relatively moves, and axial and rotation combination motion subsequently, and is last with the independent end that rotatablely moves.

Fig. 4 a and 4b disclose the cutaway view according to the coupling unit of first embodiment of medical delivery system of the present invention.Here, 200 expression medical delivery systems comprise container 202 (having omitted for simplicity, the far-end of this container in the drawings) and proportioner 204 (only disclosing the specific part that relates to this distal portions).This proportioner 204 comprises first clamp device 212, forms groove, is used to receive the convex parts or the projection that have formed second clamp device 210 that on container 202, provides.The groove of this first clamp device 212 has formed an opening, when container 202 by correct alignment during with axial entering cartridge case reception cavity 250, the convex parts of this second clamp device 210 can insert in this opening.Through this projection being advanced in this groove so that the far-end opposite face of this projection (second clamp device 210) 211 engages the near-end opposite face 215 of these grooves (first clamp device 212), thereby can container 202 be fixed on the proportioner.Based on the relative rotation between this proportioner 204 and the container 202, because the joint between this far-end opposite face 211 and the near-end opposite face 215, this proportioner 204 is relative to each other drawn with container 202.Because the angle of this groove, these two parts only can relative to each other rotate limited angle, promptly less than a week.

In the embodiment shown, secure component 210 is selected as two pairs with 212 different right quantity.Yet secure component 210 can be selected as 1 to 6 pair with 212 different right quantity.And the peripheral distribution of this secure component can be organized as along peripheral uniform distribution, perhaps can inhomogeneous and asymmetric distribution.

As syringe device 100; Medical delivery system 200 can be fit to, and comprises inside axially-movable relatively separately through a fastening sequence, then is axial and the rotation combination motion; Be to rotatablely move separately at last, thereby container 202 is coupled to proportioner 204.Alternatively, this fastening sequence can comprise motion to axial, then is independent rotatablely moving, and promptly forms the bayonet socket coupling of a routine.

Fig. 4 a also shows two spring members 207, will combine Fig. 4 b to describe now.This two spring members 207 are processed by spring steel, and it is bent or is folded to form hinge portion 205.These two spring members are fixed to proportioner 204 like this, and promptly the end of this spring members 207 extend into container reception cavity 250, thereby form stop member 206.Each stop member 206 is moved to the second deviation position (not shown) from the first non-deviation position (resting position shown in Fig. 4 b), and at this moment this stop member 206 is outwards moved by the center from container reception cavity 250.This stop member is formed and is arranged to, when when near-end applies power above that, stop any moving basically along axial direction from far-end.Shown in specific embodiment in, this be through with this stop member be sized on axial direction, be rigidity and unbending the realization.

The quantity of the stop member in a specific medical delivery system can be selected as 1 to 4 or more a plurality of independent stop members.

Shown in Fig. 4 b, this container 202 has from this container near-end at the upwardly extending axial gap 220 of far end party.Preferably, the quantity of this axial gap 220 is corresponding to the quantity of stop member 206.This axial gap 220 along container 202 outer peripheral portions with respect to the angular orientation of second clamp device 210 of container 202 corresponding to the angular orientation of this stop member 206 with respect to first clamp device, 212 formed openings.Thereby when the register of the groove 212 in the convex parts of container 202 210 and the proportioner 204, this breach 220 aligns with stop member 206.

The breach 220 of this container 202 is fit to when this container is axially inserted the container reception cavity of proportioner 204, receive stop member 206.In the embodiment shown, when this container was axially inserted the container reception cavity, the peripheral dimension of the shape of this breach 220 or breach 220 was fit to when this fastening motion begins angular movement, this stop member applied power.Thereby this container partly applies power at the contiguous chamber wall of a breach, thereby in response to the angular movement of container 202 with respect to proportioner 204, this stop member 207 is radially outward moved from primary importance.

Fig. 4 c shows second variant of the first embodiment of the present invention, and wherein medical delivery system 200 ' is fit to handle and the second different medicine of medical delivery system 200 handled first medicines.Here, breach 220 ' different with respect in the angular motion of second clamp device 210 ' of container 202 ' and the container 202.The same with medical delivery system 200, axial gap 220 ' along the outer peripheral portion of container 202 ' with respect to the orientation of second clamp device 210 ' of container 202 corresponding to the angular orientation of stop member 206 ' with respect to the opening of first clamp device 212 '.Therefore, container 202 ' can fully axially be inserted in the container reception cavity 250 ' of proportioner 204 ', and can as this specific fastening motor process limits, rotate.

In order to prevent the different vessels medicine and not match or unallowed proportioner is obscured; According to the medicine of adorning in each cartridge case, each is had specific coding characteristic second clamp device 210,210 ' that for example distributes distribute specific coding characteristic with breach 220,220 ' container 202,202 '.Equally, each proportioner 204,204 ' have specific corresponding codes characteristic for example first clamp device 212,212 ' with stop member 206,206 '.

For container 202 ' is inserted in the container reception cavity 205, the register that forms in can first clamp device 212 with second clamp device 210 ' of container 202 ' and proportioner 204.Yet, when satisfying this condition, can not the breach 220 ' of container 202 ' be alignd with the stop member 206 of proportioner 204.Because stop member 206 can be resisted axial force and not be moved; So the proximal edge portion of container 202 ' will be stopped so that container 202 ' axially gets in the container reception cavity 250, not be the right type that is coupled to proportioner 204 thereby the user is easy to judge container 202 '.Can the identical condition of application in the proportioner 204 ' if the user attempts container 202 is inserted into.Similarly, two devices 204 and 204 ' are designed to repel the cartridge holder with breach.And through correct design container 202 and 202 ', for example second clamp device 210 and 210 ' can guarantee that container 202 and 202 ' is not compatible with the proportioner that is designed to receive the cartridge case with breach.A kind of man-to-man encoding scheme so just is provided, has prevented that medicine from obscuring.

According to the present invention, the addressable part that can guarantee container for example breach 220 is designed to the slit that extends axially of relative narrower, thereby a kind of strong container can be provided, and has reduced the required area of reserving for coding.And this design has been guaranteed can be through providing possible positions, angle in a large number for the addressable part that is limited breach 220, thereby obtain a large amount of different codings.

Shown in Fig. 4 a optimum, this container reception cavity 250 forms inner rim zone 240, connects by first clamp device, 212 formed each opening.This zone 240 provides a guide surface, is used for when the user attempts container 202 and proportioner 204 carried out inside rotation and align, guiding the proximal end face part of second clamp device 210.

The proximal end face part of this second clamp device 210 can be fit to divide at a distance of distance X 1 with the proximal end of this container.In some embodiments of the invention, reduced this distance X 1, perhaps final, the proximal end face of this second clamp device defines the near-end of this container.Through locating this stop member 206; Make the distal portions of stop member 206 on proximal direction, surpass distance X 1 away from this zone 240; This has just guaranteed when the user carries out with container 202 and proportioner 204 that the first time, initial angle was alignd, can not partly control this stop member 206 through the most proximal end of this container.Simultaneously, the distal portions of this stop member 206 preferably is fit to, and this level arrival begins the fastening motion in this angle as first and second clamp devices limit before, makes stop member 206 stop that the cartridge case of mistake axially gets into.Therefore, the breach 220 of correct container 202 is designed to and can fully axially be inserted in the container reception cavity 250.Yet when these demands of investigation, preferably, the far-end of this closed block 206 is fit to as much as possible near above-mentioned distance X 1.

Typically; If limit the axial length that this forms the convex parts of second clamp device 210 with parametric t 1, this container moves to the position (corresponding to the position in zone 240) of first clamp device 212 and is approximately the twice of parametric t 1 or more towards the line shaft that complete on position moves to moving from inlet point.

In the time of near the distal portions of this stop member is set at regional 240, this breach 220 is preferably the minimum length with twice t1 order of magnitude.Yet, if this fastening motor process comprise combination axially with rotatablely move, so should the minimum notch length can be shorter.Typically, this breach will be greater than t1 from the axial length of the near-end of container 202, and final, if the convex parts of second clamp device be fit to this container near-end at a distance of certain distance, then the axial length of this breach will be longer.Typically, notch length will be greater than parametric t 1, for example t1+30%, for example t1+50%, for example t1+100%, for example t1+200%, for example t1+300%.

According to a second embodiment of the present invention, Fig. 5 shows a kind of medical delivery system 300 with container 302 and proportioner 304.For simplicity, only comprised the part that relates to this flexibility addressable part.This container 302 has second clamp device, and proportioner has the first corresponding clamp device.Yet these characteristics are not comprised among the figure shown in Figure 5.This container corresponds essentially to the described container of first embodiment, thereby has one or more breach 320 to cooperate with stop member 306.In this embodiment, stop member 306 comprises the spring steel of a bending, has two ends 308, and each end is coupled in the recess 309 of proportioner 304.

In the time of in being coupled to proportioner 304; Parts 306 form stop member, and it has a moveable part, and this moveable part has the first non-deviation position (resting position; Corresponding to orientation shown in Figure 5); At this moment the core of this stop member 305 extend in the container reception cavity 350, and this moveable part is moved to the second deviation position (not shown), and at this moment this stop member 306 outwards moves from the center of this container reception cavity 350.Stop member 306 according to this embodiment is to carry out rotatablely moving from the primary importance to the second position around the axle perpendicular to first longitudinal axis that passes this center basically.This stop member 306 and the installation in proportioner 304 thereof are formed and are arranged to, when above that along this axial direction from far-end when near-end applies power, stop any of this stop member 306 to move basically.Shown in the specific embodiment, this be through with stop member 306 be sized on a direction of principal axis, be substantially rigid and unbending the realization.When being inserted into container 302 in the container reception cavity 350 with the breach 320 that cooperates with stop member 306; And when container 302 is rotated with respect to proportioner; If through this stop member, then this stop member 306 or its part are outwards promoted on radial basically direction the sidewall sections of this container 321 during this rotation.

The motion of stop member 306 is by additional unshowned guide surface restriction, and it stops the core of this stop member 306 on proximal direction, to move.This can realize that through a not shown part of proportioner it is set at container reception cavity 350 inside.And, can to cooperate this stop member be pushed to its resting position through the guide surface that forms proportioner 304, thereby this non-deviation position is provided with this stop member.

Fig. 6 a shows the 3rd embodiment, and notion with shown in Figure 5 is consistent basically for it.Equally, stop member 406 can be processed by the steel wire of bending.In use, this steel wire has two free ends, can be installed in the groove 409 that on this axial direction, extends.Shown in Fig. 6 b, 6c and 6d; The axial gap 420 of container 402 can be formed by inclination or curved surface, so that when this stop member 406 of sidewall sections 421 controls outwards moves, realize adjacent sidewall sections 421 and the joint between this stop member 406.

According to each embodiment of the present invention, the breach 220,320,420,520 of this container can be taked many multi-form, and they also all drop in the scope of accompanying claims.And breach 420 can form all center cavity (it is fit to receive the driving device of proportioner 404) from this container towards the outward extending opening of periphery wall radial surface of container 402.Alternatively; Particular design according to this stop member 406 and proportioner 404; This breach is not to extend to outside wall surface from the inner chamber of this container fully, but can form the sunk area in this wall portion, thereby forms the zone with the littler thickness of wall adjacent area.

Fig. 7 a-7e shows the different embodiment of container and proportioner; This proportioner has the stop member 506 of the integral part of the container reception portion that forms this proportioner; Wherein this stop member 506 forms a permission along the crooked flexible portion of a hinge portion, and this hinge portion is formed by the hinge that the axle that extends with this central axes along rotates.Alternatively, because the flexible nature of this stop member self, this whole stop member part can be out of shape.In the embodiment shown, for stop member 506 is pushed to its resting position, promptly this center stop member extends in the container reception cavity, and the spring members 507 that this compliant member has connection is used for applying inside power to stop member 506.

Fig. 7 b shows and similar structure shown in Fig. 7 a, but near two stop members 506 that are set at here this container perimeter part need form the breach 520 of two correspondences so that correctly engage in this container.These demands in the embodiment shown in Fig. 7 b, have been satisfied.Fig. 7 c shows these parts, and wherein this container is inserted in the container reception cavity fully, but before this locking, has carried out relative rotation.

Fig. 7 e and 7d show the detail of proportioner, more particularly, show the distal face of stop member 506.If the proximal edge portion of container is contacted the distal face of this stop member 506 by the accident rotation, outwards move in order to stop stop member 506, this stop member can have groove 508, and the edge part of this container can be pressed into wherein.Alternatively, can form projection 509, it is fit to this cartridge case center ratio nearer with the container inner wall surface apart.Through these projections, this stop member can be locked in its first (static) position, thereby only accepts correct container.

Fig. 8 a and 8b show another embodiment, and wherein spring members 607 can be set to stop member 606.Here, the shape of this spring members is convenient to this spring members 607 is correctly inserted and remains in the groove that forms in the proportioner.The intrinsic flexibility of this spring members 607 has formed primary importance, and at this moment an end of this spring members 607 extends in this cartridge case reception cavity.When the container 602 with coupling breach 620 was rotated alignment, this container 602 can be moved axially in the container reception cavity 650 of proportioner 604.This particular state has been shown in Fig. 8 b.When these two parts were rotated relative to each other, the flexibility of this stop member 606 made this wall part 621 move through this stop member 606.

Other unshowned embodiment comprise that the container part of medical delivery system has the technical scheme of the compliant member of the above-mentioned stop member of one or more formation.In this configuration, this proportioner need be equipped with corresponding breach this proportioner is assigned to each specific container.

The front has provided some preferred embodiments, and what still should stress is that the present invention is not limited to these, but can realize with other modes that are limited in the theme in the following claim.Accompanying drawing discloses medical delivery system of the present invention with injection pen form, yet transmission equipment that this is specific and shape thereof never are to be used for limiting the present invention who limits like claim.

Claims

1. medical delivery system comprises:

-container comprises being suitable in cavity, loading the shell of medicine and being arranged to slidably piston that the volume that this piston can move to reduce this cavity towards outlet also passes through this outlet discharge with this medicine on distal direction;

-proportioner has the container reception cavity, be used at least in part this container being received in wherein and with this container be coupled to this proportioner so that the driving device of this proportioner at the move up piston of this container of this far end party,

Wherein, This proportioner limits first clamp device; This first clamp device is fit to second clamp device of this container of engagement so that this container is fixed to this proportioner, wherein should fixing motion comprises along first move to axial, subsequently for around this relative rotary motion of first;

Wherein, This proportioner comprises one or more stop members; Each stop member can move towards the second position from primary importance; Wherein when this primary importance this stop member with respect to said first diameter of axle in extending to said container reception cavity; This stop member is radially outward moved when this second position, and wherein this stop member can move to the said second position from said primary importance in response to said relative rotary motion, is prevented from simultaneously when being applied in axial force, moving to the said second position from said primary importance; And

Wherein this container comprises the chamber wall part, and it is formed with axially extended breach, is used to receive the stop member of said predetermined quantity, and makes this vessel axis in being inserted into said container reception cavity.

2. medical delivery system as claimed in claim 1, wherein this container limits a plurality of wall parts, is used to limit breach, and wherein at least one wall part is fit to when this container rotates with respect to proportioner, stop member radially outward moved.

3. according to claim 1 or claim 2 medical delivery system, wherein this stop member is parallel to said first turning cylinder with respect to one and is rotatably mounted, and perhaps is rotatably mounted along an axle that tilts with respect to said turning cylinder.

4. according to claim 1 or claim 2 medical delivery system; Wherein this stop member is an inflexible basically compliant member when this stop member is applied axial force; And wherein when when the container part with respect to the rotation of this proportioner applies power, this stop member can be crooked in the radial direction.

5. according to claim 1 or claim 2 medical delivery system, wherein said breach is to be exclusively used in the drug type that is filled in the said container with respect to the position of said second clamp device.

6. according to claim 1 or claim 2 medical delivery system, wherein this stop member stops that being restricted to unallowed container gets into, thereby has prevented that the container that is not allowed to from participating in the said relative rotary motion.

7. according to claim 1 or claim 2 medical delivery system, wherein this second clamp device comprises at least one the convex component that limits from said first extended projection.

8. according to claim 1 or claim 2 medical delivery system, wherein this second clamp device is set at the near-end of said container.

9. according to claim 1 or claim 2 medical delivery system, wherein this second clamp device is set at the far-end of said container.

10. according to claim 1 or claim 2 medical delivery system, the quantity that wherein is formed on the said breach in this container is 1,2,3,4 or 5.

11. medical delivery system according to claim 1 or claim 2, wherein this container comprises a plurality of said breach, and wherein said breach is distributed in around said first by irregular.

12. medical delivery system according to claim 1 or claim 2, wherein this shell of tank comprises the cartridge holder that is suitable for accepting cartridge case.

13. medical delivery system according to claim 1 or claim 2; Wherein should fixing motion comprise simple axially relative motion along first; Then be carry out simultaneously to axial with rotatablely move, be simple then around said first rotation relative motion.

14. a container that is used for like the described medical delivery system of claim 1-13, this container comprises:

Shell is adapted at being filled with in the bin medicine, and it has a quilt open distal end that can pierce through film phonograph seal and the brake that is slidingly installed that is fit to through the driving device driving of this proportioner;

Near-end has second cavity of the driving device that is suitable for accepting this proportioner;

Second clamp device is through comprising along first move to axial and be coupled to first clamp device of proportioner releasedly around a series of the moving of this relative rotary motion of first subsequently;

Wherein this second clamp device comprises at least one convex component, and it has is arranged to and the near-end of this container far-end opposite face at a distance of first distance, and said far-end opposite face can be fixed to the near-end opposite face of the correspondence of this proportioner, and

Wherein this container comprises one or more breach; Wherein at least one breach extends upward the distance greater than said first distance from the near-end of this container in far end party, and this breach has formed an open area that extends radially outwardly into this external container from said second cavity.

15. container as claimed in claim 14, wherein at least one said convex component is formed by the radially extension projection that the most proximal end at this container provides.

16. like claim 14 or 15 described containers, at least one in wherein said one or more breach is from the proximal extension certain distance of this container, this distance surpasses said first distance 50%.

17. container as claimed in claim 16, at least one in wherein said one or more breach are from the proximal extension certain distance of this container, this distance surpasses said first distance 75%.

18. container as claimed in claim 17, at least one in wherein said one or more breach are from the proximal extension certain distance of this container, this distance surpasses said first distance 100%.

19. container as claimed in claim 18, at least one in wherein said one or more breach are from the proximal extension certain distance of this container, this distance surpasses said first distance 150%.

20. container as claimed in claim 19, at least one in wherein said one or more breach are from the proximal extension certain distance of this container, this distance surpasses said first distance 200%.

21. container as claimed in claim 20, at least one in wherein said one or more breach are from the proximal extension certain distance of this container, this distance surpasses said first distance 300%.

22. like claim 14 or 15 described containers; Wherein this container comprises the cartridge holder that is suitable for accepting cartridge case; Wherein when this cartridge case is inserted into wherein; The proximal extension of this cartridge holder surpasses the near-end of this cartridge case, thereby makes said one or more breach that an opening that extends radially outwardly into this cartridge holder outside from said second cavity is provided.