US1920926A - Mineral oil emulsion - Google Patents

Mineral oil emulsion Download PDF

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Publication number
US1920926A
US1920926A US493922A US49392230A US1920926A US 1920926 A US1920926 A US 1920926A US 493922 A US493922 A US 493922A US 49392230 A US49392230 A US 49392230A US 1920926 A US1920926 A US 1920926A
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United States
Prior art keywords
mineral oil
emulsion
jelly
agar
oil
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US493922A
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Noonan Harry
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DRUG PRODUCTS CO Inc
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DRUG PRODUCTS CO Inc
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Publication date
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Priority to US493922A priority Critical patent/US1920926A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Definitions

  • the invention relates to mineral oils and more particularly to emulsions of highly refined mineral oils for internal use.
  • An object of the invention is to provide such 5 a composition which is palatable and pleasant,
  • a further object is to provide a composition which is readily miscible with the intestinal contents and assists in the formation of a soft fecal mass, and which contains no sugar.
  • mineral oils and more particularly the highly refined mineral oils in common use at the present time for internal administration as lubricants may be emulsified by a jelly made from psyllium seed, agar agar and gelatin by intimate mixture therewith and by passing through a colloid mill.
  • the intimate mixture of the psyllium seed jelly and mineral oil may be accomplished by shaking, mixing and grinding or homogenization and thereby eliminate the use of such emulsifying agents as Acacia or tragacanth which are ordinarily used in forming emulsion of mineral oils in aqueous vehicles.
  • the psyllium seed jelly and agar agar act to greatly enhance the lubrication value of the emulsion and the gelatin acts to increase the stability of the composition.
  • the mineral oil may be present in varying proportions. In practice it has been found that an emulsion containing 70% of mineral oil by volume is very satisfactory for internal use. The proportion of the elements forming the jelly may also be varied and other materials having similar properties to those mentioned may be used .to form the jelly. The following proportions of the above named materials in con- 40 junction with a 70% volume content of mineral oil have been found to form a suitable colloidal emulsion: 6 of 1% of psyllium seed jelly, of
  • colloidal emulsion provides a homogeneous mass
  • the agar agar ingredient in conjunction with the mineral oil serves an additional function of being a laxative.
  • the emulsion may be readily formed by mixing the mineral oil with the psyllium seed jelly base and then passing the mixture through a colloid mill which causes complete dispersion of the oil and presents a finished product in a colloidal form.
  • Emulsions formed in accordance with this invention are cream-like in appearance and taste, are palatable and effective in internal use as a mechanical lubricant and remedy for constipation.
  • the mineral oil used is preferably one which has been highly refined for internal use.
  • the mineral oil emulsion may be made as heretofore stated, or the ingredients may be varied. For somewhat obstinate cases of constipation with gastro-intestinal hyperacidity, a mechanical lubricant which is mildly laxative is desirable and one which contains no sugar.
  • An emulsion containing the following ingredients has been found to work out well in practice: mineral oil 50%; milk of magnesia 8%; glycerin 5%; and 20% of jelly containing psyllium seed, agar agar and sodium benzoate. This emulsion is colloidal in form and pleasant to take. It normalizes peristalsis by modifying the intestinal bulk and consistency so that the feces are easily expelled.
  • the emulsion of your! applicant is an oil-in-water type of colloidal emulsion with a homogeneous and fine dispersion.
  • colloidal oil-in-water emulsion In the preparation of the colloidal oil-in-water emulsion, use is made as above mentioned of the colloid mill which intimately mixes the highly refined mineral oil together with the jelly of the ingredients and proportions thereof, as before set forth, into a homogeneous colloidal emulsion wherein the dispersed phase, namely oil,- is both uniform and fine in size.
  • the colloid mill which intimately mixes the highly refined mineral oil together with the jelly of the ingredients and proportions thereof, as before set forth, into a homogeneous colloidal emulsion wherein the dispersed phase, namely oil,- is both uniform and fine in size.
  • a laxative comprising a colloidal oil-inwater type mineral oil emulsion comprising a homogeneous and fine dispersion of substantially 70% by volume of a highly refined mineral oil in 105 a jelly comprising substantially of 1% of psyllium seed, substantially of 1% agar agar and substantially 7/ of 1% gelatine.
  • a colloidal oil-in-water type mineral oil emulsion comprising a homogeneous and fine dispersion of substantialLv 70% by volume of a highly refined mineral oil in a jelly comprising substantially of 1% of psyllium seed, substantially of 1% agar agar and substantially 7/ 100 of 1% gelatine, the above said proportions being adapted to form an emulsion of a homogeneous and line dispersion.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Edible Oils And Fats (AREA)

Description

Patented Aug. 1, 1933 UNITED STATES MINERAL OIL EMULSION Harry Noonan, to The Drug White Plains, N. Y., assignor Products Co., Inc., Long Island City, N. Y., a Corporation of New York No Drawing. Application November 6, 1930 Serial No. 493,922
3 Claims. (01. 107-56) The invention relates to mineral oils and more particularly to emulsions of highly refined mineral oils for internal use.
An object of the invention is to provide such 5 a composition which is palatable and pleasant,
one that has great powers of internal lubrication, and one in which the consistency of the mineral oil is not afiected.
A further object is to provide a composition which is readily miscible with the intestinal contents and assists in the formation of a soft fecal mass, and which contains no sugar.
It has been discovered that mineral oils and more particularly the highly refined mineral oils in common use at the present time for internal administration as lubricants may be emulsified by a jelly made from psyllium seed, agar agar and gelatin by intimate mixture therewith and by passing through a colloid mill. The intimate mixture of the psyllium seed jelly and mineral oil may be accomplished by shaking, mixing and grinding or homogenization and thereby eliminate the use of such emulsifying agents as Acacia or tragacanth which are ordinarily used in forming emulsion of mineral oils in aqueous vehicles.
The psyllium seed jelly and agar agar act to greatly enhance the lubrication value of the emulsion and the gelatin acts to increase the stability of the composition.
In the emulsion the mineral oil may be present in varying proportions. In practice it has been found that an emulsion containing 70% of mineral oil by volume is very satisfactory for internal use. The proportion of the elements forming the jelly may also be varied and other materials having similar properties to those mentioned may be used .to form the jelly. The following proportions of the above named materials in con- 40 junction with a 70% volume content of mineral oil have been found to form a suitable colloidal emulsion: 6 of 1% of psyllium seed jelly, of
1% of agar agar, 7/100 of 1% of gelatine, 5%
of glycerine, and a water quantity of 100% with sodium benzoate as a preservative. Such a colloidal emulsion provides a homogeneous mass,
which is both palatable and pleasant. Moreover, the agar agar ingredient in conjunction with the mineral oil serves an additional function of being a laxative.
As heretofore stated the emulsion may be readily formed by mixing the mineral oil with the psyllium seed jelly base and then passing the mixture through a colloid mill which causes complete dispersion of the oil and presents a finished product in a colloidal form. Emulsions formed in accordance with this invention are cream-like in appearance and taste, are palatable and effective in internal use as a mechanical lubricant and remedy for constipation. The mineral oil used is preferably one which has been highly refined for internal use.
The mineral oil emulsion may be made as heretofore stated, or the ingredients may be varied. For somewhat obstinate cases of constipation with gastro-intestinal hyperacidity, a mechanical lubricant which is mildly laxative is desirable and one which contains no sugar. An emulsion containing the following ingredients has been found to work out well in practice: mineral oil 50%; milk of magnesia 8%; glycerin 5%; and 20% of jelly containing psyllium seed, agar agar and sodium benzoate. This emulsion is colloidal in form and pleasant to take. It normalizes peristalsis by modifying the intestinal bulk and consistency so that the feces are easily expelled.
In cases of chronic constipation or intestinal stasis, more pronounced laxative action is often required in addition to lubrication. The
following is another way of mixing the ingredients to accomplish this result: mineral oil 70%, caromel 2 /270 and a jelly made from psyllium seed of 1%, agar agar i o% of 1%, gelatine 7/100 of 1%, glycerine 5% and water quantity sufiicient ad 100% with sodium benzoate as a preservative, phenolphthalein a laxative and any suitable flavoring substance.
It is to be noted that the emulsion of your! applicant is an oil-in-water type of colloidal emulsion with a homogeneous and fine dispersion.
In the preparation of the colloidal oil-in-water emulsion, use is made as above mentioned of the colloid mill which intimately mixes the highly refined mineral oil together with the jelly of the ingredients and proportions thereof, as before set forth, into a homogeneous colloidal emulsion wherein the dispersed phase, namely oil,- is both uniform and fine in size.
I claim:
1. A laxative comprising a colloidal oil-inwater type mineral oil emulsion comprising a homogeneous and fine dispersion of substantially 70% by volume of a highly refined mineral oil in 105 a jelly comprising substantially of 1% of psyllium seed, substantially of 1% agar agar and substantially 7/ of 1% gelatine.
2. A colloidal oil-in-water type mineral oil emulsion comprising a homogeneous and fine dispersion of substantialLv 70% by volume of a highly refined mineral oil in a jelly comprising substantially of 1% of psyllium seed, substantially of 1% agar agar and substantially 7/ 100 of 1% gelatine, the above said proportions being adapted to form an emulsion of a homogeneous and line dispersion.
3. A colloidal oil-in-water type mineral oil
US493922A 1930-11-06 1930-11-06 Mineral oil emulsion Expired - Lifetime US1920926A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2717839A (en) * 1951-11-09 1955-09-13 Seeger Refrigerator Co Heat conductive mastic
FR2128075A1 (en) * 1971-03-03 1972-10-20 Adeline Andre Magnesium chelates of aliphatic amides - as laxative enemas
EP0007619A2 (en) * 1978-07-25 1980-02-06 The Wellcome Foundation Limited Galactomannan polysaccharide gum formulation containing gellation inhibitor
WO1991015117A1 (en) * 1990-04-05 1991-10-17 Basic Bio Systems, Inc. Film-forming proteinaceous emulsion
US5399350A (en) * 1990-04-05 1995-03-21 Nurture, Inc. Proteinaceous oil spill dispersant
US5910317A (en) * 1988-01-11 1999-06-08 The Procter & Gamble Company Mixed compositions for treating hypercholesterolemia

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2717839A (en) * 1951-11-09 1955-09-13 Seeger Refrigerator Co Heat conductive mastic
FR2128075A1 (en) * 1971-03-03 1972-10-20 Adeline Andre Magnesium chelates of aliphatic amides - as laxative enemas
EP0007619A2 (en) * 1978-07-25 1980-02-06 The Wellcome Foundation Limited Galactomannan polysaccharide gum formulation containing gellation inhibitor
EP0007619A3 (en) * 1978-07-25 1980-02-20 The Wellcome Foundation Limited Polysaccharide gum formulation containing gellation inhibitor
US5910317A (en) * 1988-01-11 1999-06-08 The Procter & Gamble Company Mixed compositions for treating hypercholesterolemia
WO1991015117A1 (en) * 1990-04-05 1991-10-17 Basic Bio Systems, Inc. Film-forming proteinaceous emulsion
US5399350A (en) * 1990-04-05 1995-03-21 Nurture, Inc. Proteinaceous oil spill dispersant

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