UA99766C2 - НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ, ВИСОКООЧИЩЕННЫЙ, СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА АЛЬФА С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ действием, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ - Google Patents
НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ, ВИСОКООЧИЩЕННЫЙ, СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА АЛЬФА С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ действием, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ Download PDFInfo
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- UA99766C2 UA99766C2 UAA201015114A UAA201015114A UA99766C2 UA 99766 C2 UA99766 C2 UA 99766C2 UA A201015114 A UAA201015114 A UA A201015114A UA A201015114 A UAA201015114 A UA A201015114A UA 99766 C2 UA99766 C2 UA 99766C2
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Abstract
Изобретение относится к новому функционально активному, высокоочищенному, стабильному конъюгату интерферона альфа с полиэтиленгликолем, представленному одним позиционным изомером ПЭГ-NH, с уменьшенной иммуногенностью, с пролонгированным биологическим действием, пригодному для медицинского применения, с улучшенными фармакокинетическими параметрами, общей формулы:, (I)где:n - целые значения от 227' до 10000, так что молекулярная масса ПЭГ составляет приблизительно 10000-40000 Da;m - целое число ≥ 4;IFN - естественный или рекомбинантный полипептид, который имеет активность ИФН-альфа,и к иммунобиологическому средству на его основе. Также изобретение относится к лекарственным средствам, которые содержат заявленн�
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| RU2515913C1 (ru) * | 2013-03-22 | 2014-05-20 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | ГИБРИДНЫЙ БЕЛОК, ОБЛАДАЮЩИЙ ПРОЛОНГИРОВАННЫМ ДЕЙСТВИЕМ, НА ОСНОВЕ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА АЛЬФА-2 ЧЕЛОВЕКА (ВАРИАНТЫ), СПОСОБ ЕГО ПОЛУЧЕНИЯ И ШТАММ Saccharomyces cerevisiae ДЛЯ ОСУЩЕСТВЛЕНИЯ ЭТОГО СПОСОБА (ВАРИАНТЫ) |
| EA021643B1 (ru) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Монопегилированный интерферон-альфа линейной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа |
| EA021610B1 (ru) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Жидкое противовирусное лекарственное средство |
| CN103463623B (zh) * | 2013-09-03 | 2015-09-09 | 长春海伯尔生物技术有限责任公司 | 一种聚乙二醇干扰素注射液及其制备方法 |
| RU2554761C1 (ru) * | 2014-05-13 | 2015-06-27 | Закрытое акционерное общество "Сибирский центр фармакологии и биотехнологии" | Противоэнтеровирусное и иммуностимулирующее средство |
| RU2572800C1 (ru) * | 2014-09-22 | 2016-01-20 | Закрытое Акционерное Общество "Биокад" | Новый состав, содержащий конъюгат пэг и интерферон-альфа-2бета, обладающий сниженной болезненностью при введении |
| EA029498B1 (ru) * | 2015-11-24 | 2018-04-30 | Учреждение Белорусского государственного университета "Научно-исследовательский институт физико-химических проблем" (НИИ ФХП БГУ) | ПРОТИВООПУХОЛЕВОЕ СРЕДСТВО НА ОСНОВЕ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА АЛЬФА-2b В ВИДЕ МИКРОЧАСТИЦ ДЛЯ ПАРЕНТЕРАЛЬНОГО ПРИМЕНЕНИЯ |
| RU2678332C1 (ru) | 2017-09-08 | 2019-01-28 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") | Пегилированный интерферон лямбда, обладающий высокой биодоступностью при пероральном применении, и способ его получения |
| AU2021258734A1 (en) * | 2020-04-20 | 2023-01-05 | Altum Pharmaceuticals Inc. | Recombinant interferon |
| CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| JP2758154B2 (ja) * | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| RS20050202A (en) * | 2002-09-09 | 2007-08-03 | Nektar Therapeuticals Al.Corporation, | Water-soluble polymer alkanals |
| RU2311930C2 (ru) * | 2004-04-30 | 2007-12-10 | Закрытое акционерное общество "ВЕРОФАРМ" | Пэгилированный интерферон для борьбы с вирусной инфекцией |
| CA2572751A1 (en) * | 2004-06-30 | 2006-01-12 | Egen Corporation | Pegylated interferon alpha-1b |
| US7872082B2 (en) * | 2005-07-19 | 2011-01-18 | Nektar Therapeutics | Method for preparing polymer maleimides |
| JP2009541333A (ja) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
| CN101491682A (zh) * | 2008-04-30 | 2009-07-29 | 北京凯正生物工程发展有限责任公司 | 聚乙二醇化重组人干扰素ω偶合物及其制备工艺 |
| CN101591387A (zh) * | 2008-05-28 | 2009-12-02 | 中国人民解放军军事医学科学院微生物流行病研究所 | 聚乙二醇化重组人干扰素ω偶合物 |
| CN101514229B (zh) * | 2009-04-03 | 2012-05-09 | 海南四环心脑血管药物研究院有限公司 | 人干扰素α衍生物及其聚乙二醇化修饰物 |
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- 2010-09-24 WO PCT/RU2010/000529 patent/WO2012011836A1/en active Application Filing
- 2010-09-24 SG SG2013003801A patent/SG187117A1/en unknown
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- 2010-09-24 PE PE2013000084A patent/PE20131034A1/es not_active Application Discontinuation
- 2010-09-24 CU CUP2013000013A patent/CU24193B1/es active IP Right Grant
- 2010-12-15 UA UAA201015114A patent/UA99766C2/ru unknown
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- 2011-07-19 CN CN201110214149.6A patent/CN102617736B/zh not_active Expired - Fee Related
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| CU20130013A7 (es) | 2013-04-19 |
| EA020257B1 (ru) | 2014-09-30 |
| KR101586372B1 (ko) | 2016-01-18 |
| HK1170504A1 (zh) | 2013-03-01 |
| MX2011007458A (es) | 2012-01-19 |
| KR20130056885A (ko) | 2013-05-30 |
| BRPI1101565A2 (pt) | 2012-12-04 |
| ECSP13012398A (es) | 2013-05-31 |
| SG187117A1 (en) | 2013-02-28 |
| CN102617736B (zh) | 2015-11-25 |
| CN102617736A (zh) | 2012-08-01 |
| CR20130021A (es) | 2013-02-20 |
| WO2012011836A1 (en) | 2012-01-26 |
| RU2010129824A (ru) | 2012-01-27 |
| DOP2013000002A (es) | 2013-09-15 |
| PE20131034A1 (es) | 2013-09-27 |
| AR087227A1 (es) | 2014-03-12 |
| CO6680611A2 (es) | 2013-05-31 |
| NI201300008A (es) | 2014-05-26 |
| UY33525A (es) | 2012-02-29 |
| CU24193B1 (es) | 2016-09-30 |
| MY168784A (en) | 2018-12-04 |
| RU2447083C1 (ru) | 2012-04-10 |
| EA201100809A1 (ru) | 2012-01-30 |
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