UA86574C2 - Фторированные производные бензотиадиазина, способ их получения и фармацевтическая композиция, которая их содержит - Google Patents

Фторированные производные бензотиадиазина, способ их получения и фармацевтическая композиция, которая их содержит

Info

Publication number
UA86574C2
UA86574C2 UAA200500666A UAA200500666A UA86574C2 UA 86574 C2 UA86574 C2 UA 86574C2 UA A200500666 A UAA200500666 A UA A200500666A UA A200500666 A UAA200500666 A UA A200500666A UA 86574 C2 UA86574 C2 UA 86574C2
Authority
UA
Ukraine
Prior art keywords
optionally substituted
group selected
benzothiadiazines
fluorinated
derivatives
Prior art date
Application number
UAA200500666A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пьер Франкотт
Пьер Фрекен
Тюльйо Паскаль Де
Бернар Пиротт
Пьер Лестаж
Лоранс Данобер
Даниэль-Энри Кеньяр
Пьер Ренар
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of UA86574C2 publication Critical patent/UA86574C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62C—FIRE-FIGHTING
    • A62C13/00—Portable extinguishers which are permanently pressurised or pressurised immediately before use
    • A62C13/76—Details or accessories
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Management (AREA)
  • Business, Economics & Management (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Соединения формулы (І):, (І)где:Rпредставляет собой монофтор- или полифторалкильную или монофтор- или полифторциклоалкилалкильную группу,Rпредставляет собой атом водорода или группу, выбранную из алкиламинокарбонила или необязательно замещенного алкила,Rпредставляет собой атом водорода или галогена или группу, выбранную из циклоалкила или необязательно замещенного алкила,от Rдо R, которые могут быть одинаковыми или отличаться, каждый представляет собой атом или группу, выбранную из атомов водорода и галогена и групп нитро, циано, алкилсульфонила, гидрокси, алкокси, необязательно замещенного алкила,а также их аддитивные соли с фармацевтически приемлемой кислотой или основой, и их оптические изомеры, когда они существуют.
UAA200500666A 2004-01-26 2005-01-25 Фторированные производные бензотиадиазина, способ их получения и фармацевтическая композиция, которая их содержит UA86574C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0400689A FR2865474B1 (fr) 2004-01-26 2004-01-26 Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
UA86574C2 true UA86574C2 (ru) 2009-05-12

Family

ID=34630671

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200500666A UA86574C2 (ru) 2004-01-26 2005-01-25 Фторированные производные бензотиадиазина, способ их получения и фармацевтическая композиция, которая их содержит

Country Status (20)

Country Link
US (1) US7268129B2 (ru)
EP (1) EP1557412A1 (ru)
JP (1) JP4291786B2 (ru)
KR (1) KR100668195B1 (ru)
CN (1) CN1308317C (ru)
AR (1) AR047455A1 (ru)
AU (1) AU2005200311A1 (ru)
BR (1) BRPI0500235A (ru)
CA (1) CA2492161C (ru)
EA (1) EA009698B1 (ru)
FR (1) FR2865474B1 (ru)
GE (1) GEP20063960B (ru)
HK (1) HK1079778A1 (ru)
MA (1) MA27545A1 (ru)
MX (1) MXPA05001019A (ru)
NO (1) NO20050391L (ru)
NZ (1) NZ537877A (ru)
SG (1) SG113569A1 (ru)
UA (1) UA86574C2 (ru)
ZA (1) ZA200500774B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2012020848A1 (en) 2010-08-10 2012-02-16 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN102977054A (zh) * 2012-12-12 2013-03-20 中国药科大学 一类选择性α2A受体激动剂的治疗阿尔茨海默病用途
CN114230471B (zh) * 2021-11-09 2024-01-26 河北科技大学 一种3,4-二氯-2-氟苯胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488049A (en) * 1993-12-10 1996-01-30 Fidia - Georgetown Institute For The Neuro-Sciences Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
US6083947A (en) * 1996-01-29 2000-07-04 The Regents Of The University Of California Method for treating sexual dysfunctions
WO1998012185A1 (en) * 1996-09-17 1998-03-26 The Regents Of The University Of California Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
ZA991301B (en) * 1998-02-18 1999-09-13 Neurosearch As Glutamate receptor modulators.
FR2801587B1 (fr) * 1999-11-30 2002-01-11 Adir Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003005978A1 (en) * 2001-07-10 2003-01-23 Sven Jarby Remedy against skin diseases
FR2833950B1 (fr) * 2001-12-21 2005-12-16 Servier Lab Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2856064B1 (fr) * 2003-06-13 2005-08-19 Servier Lab Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
KR100668195B1 (ko) 2007-01-11
JP2005232166A (ja) 2005-09-02
ZA200500774B (en) 2005-08-10
NZ537877A (en) 2005-10-28
BRPI0500235A (pt) 2005-09-06
MA27545A1 (fr) 2005-10-03
EP1557412A1 (fr) 2005-07-27
HK1079778A1 (en) 2006-04-13
MXPA05001019A (es) 2007-11-14
GEP20063960B (en) 2006-11-10
AU2005200311A1 (en) 2005-08-11
CN1308317C (zh) 2007-04-04
CN1680343A (zh) 2005-10-12
NO20050391D0 (no) 2005-01-25
US7268129B2 (en) 2007-09-11
SG113569A1 (en) 2005-08-29
EA009698B1 (ru) 2008-02-28
FR2865474A1 (fr) 2005-07-29
CA2492161C (fr) 2010-06-22
AR047455A1 (es) 2006-01-18
JP4291786B2 (ja) 2009-07-08
EA200500072A1 (ru) 2005-08-25
KR20050077028A (ko) 2005-07-29
CA2492161A1 (fr) 2005-07-26
US20050165008A1 (en) 2005-07-28
NO20050391L (no) 2005-07-27
FR2865474B1 (fr) 2008-06-13

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