UA81235C2 - Catheter composition and uses thereof - Google Patents
Catheter composition and uses thereof Download PDFInfo
- Publication number
- UA81235C2 UA81235C2 UA20040605026A UA20040605026A UA81235C2 UA 81235 C2 UA81235 C2 UA 81235C2 UA 20040605026 A UA20040605026 A UA 20040605026A UA 20040605026 A UA20040605026 A UA 20040605026A UA 81235 C2 UA81235 C2 UA 81235C2
- Authority
- UA
- Ukraine
- Prior art keywords
- catheter
- plasminogen activator
- sample
- effective amount
- test
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 102000009123 Fibrin Human genes 0.000 claims abstract description 30
- 108010073385 Fibrin Proteins 0.000 claims abstract description 30
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229950003499 fibrin Drugs 0.000 claims abstract description 30
- 208000007536 Thrombosis Diseases 0.000 claims abstract description 28
- 230000003385 bacteriostatic effect Effects 0.000 claims abstract description 20
- 102000013566 Plasminogen Human genes 0.000 claims abstract description 13
- 108010051456 Plasminogen Proteins 0.000 claims abstract description 13
- 239000002738 chelating agent Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 69
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 51
- 239000000243 solution Substances 0.000 claims description 51
- 102000001938 Plasminogen Activators Human genes 0.000 claims description 28
- 108010001014 Plasminogen Activators Proteins 0.000 claims description 28
- 229940127126 plasminogen activator Drugs 0.000 claims description 28
- 108010039185 Tenecteplase Proteins 0.000 claims description 26
- 229960000216 tenecteplase Drugs 0.000 claims description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 17
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 13
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- 229960005356 urokinase Drugs 0.000 claims description 12
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 5
- 229960002917 reteplase Drugs 0.000 claims description 4
- 108010051412 reteplase Proteins 0.000 claims description 4
- 239000008215 water for injection Substances 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 101
- 239000000523 sample Substances 0.000 description 90
- 244000005700 microbiome Species 0.000 description 53
- 239000012895 dilution Substances 0.000 description 31
- 238000010790 dilution Methods 0.000 description 31
- 230000000845 anti-microbial effect Effects 0.000 description 27
- 238000002360 preparation method Methods 0.000 description 27
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 26
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 26
- 102000004169 proteins and genes Human genes 0.000 description 26
- 108090000623 proteins and genes Proteins 0.000 description 26
- 230000003287 optical effect Effects 0.000 description 24
- 229960003318 alteplase Drugs 0.000 description 23
- 238000004090 dissolution Methods 0.000 description 22
- 238000004458 analytical method Methods 0.000 description 20
- 230000000694 effects Effects 0.000 description 20
- 208000015181 infectious disease Diseases 0.000 description 19
- 239000003146 anticoagulant agent Substances 0.000 description 17
- 239000000463 material Substances 0.000 description 17
- 238000010899 nucleation Methods 0.000 description 17
- 238000003860 storage Methods 0.000 description 16
- 239000002054 inoculum Substances 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 239000003085 diluting agent Substances 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 13
- 230000003480 fibrinolytic effect Effects 0.000 description 13
- 238000011010 flushing procedure Methods 0.000 description 13
- 239000003242 anti bacterial agent Substances 0.000 description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 11
- 230000002421 anti-septic effect Effects 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 229960002897 heparin Drugs 0.000 description 11
- 229920000669 heparin Polymers 0.000 description 11
- 239000002245 particle Substances 0.000 description 11
- 229940127219 anticoagulant drug Drugs 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 238000011534 incubation Methods 0.000 description 10
- 239000012460 protein solution Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 9
- 238000005119 centrifugation Methods 0.000 description 9
- 239000011521 glass Substances 0.000 description 9
- 230000002792 vascular Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 102000008946 Fibrinogen Human genes 0.000 description 8
- 108010049003 Fibrinogen Proteins 0.000 description 8
- 241000233866 Fungi Species 0.000 description 8
- 239000004599 antimicrobial Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 229940012952 fibrinogen Drugs 0.000 description 8
- 239000003527 fibrinolytic agent Substances 0.000 description 8
- 229940012957 plasmin Drugs 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 238000007865 diluting Methods 0.000 description 7
- 238000001631 haemodialysis Methods 0.000 description 7
- 230000000322 hemodialysis Effects 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
- 108090000190 Thrombin Proteins 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000502 dialysis Methods 0.000 description 6
- 238000001990 intravenous administration Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 229960004023 minocycline Drugs 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 239000008223 sterile water Substances 0.000 description 6
- 238000007920 subcutaneous administration Methods 0.000 description 6
- 229960004072 thrombin Drugs 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 5
- 239000012470 diluted sample Substances 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 229920002223 polystyrene Polymers 0.000 description 5
- 239000012898 sample dilution Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 4
- 239000003708 ampul Substances 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000011088 calibration curve Methods 0.000 description 4
- 229960003260 chlorhexidine Drugs 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 239000012925 reference material Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010064687 Device related infection Diseases 0.000 description 3
- 206010062506 Heparin-induced thrombocytopenia Diseases 0.000 description 3
- 101000817629 Homo sapiens Dymeclin Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229960004676 antithrombotic agent Drugs 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- -1 citrate Chemical class 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000012417 linear regression Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 2
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 229940123150 Chelating agent Drugs 0.000 description 2
- 108010015899 Glycopeptides Proteins 0.000 description 2
- 102000002068 Glycopeptides Human genes 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000008228 bacteriostatic water for injection Substances 0.000 description 2
- 239000003637 basic solution Substances 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 208000028208 end stage renal disease Diseases 0.000 description 2
- 201000000523 end stage renal failure Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229940006607 hirudin Drugs 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 229960003600 silver sulfadiazine Drugs 0.000 description 2
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012430 stability testing Methods 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 229960004267 taurolidine Drugs 0.000 description 2
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 description 2
- 229950007343 taurultam Drugs 0.000 description 2
- 230000001732 thrombotic effect Effects 0.000 description 2
- 229960000187 tissue plasminogen activator Drugs 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000012224 working solution Substances 0.000 description 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- OOIBFPKQHULHSQ-UHFFFAOYSA-N (3-hydroxy-1-adamantyl) 2-methylprop-2-enoate Chemical compound C1C(C2)CC3CC2(O)CC1(OC(=O)C(=C)C)C3 OOIBFPKQHULHSQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- FFRVQTGCNAGNJO-UHFFFAOYSA-N 2-(4-fluorophenyl)-2-pyrrolidin-1-ylethanamine Chemical compound C=1C=C(F)C=CC=1C(CN)N1CCCC1 FFRVQTGCNAGNJO-UHFFFAOYSA-N 0.000 description 1
- MVQXBXLDXSQURK-UHFFFAOYSA-N 2-aminoethanesulfonamide Chemical class NCCS(N)(=O)=O MVQXBXLDXSQURK-UHFFFAOYSA-N 0.000 description 1
- 208000010470 Ageusia Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000032840 Catheter-Related Infections Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002306 Glycocalyx Polymers 0.000 description 1
- 102000007625 Hirudins Human genes 0.000 description 1
- 108010007267 Hirudins Proteins 0.000 description 1
- 241001446467 Mama Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 description 1
- 238000013494 PH determination Methods 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 235000011449 Rosa Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- RXDLGFMMQFNVLI-UHFFFAOYSA-N [Na].[Na].[Ca] Chemical compound [Na].[Na].[Ca] RXDLGFMMQFNVLI-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000019666 ageusia Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000000941 anti-staphylcoccal effect Effects 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 208000016063 arterial thoracic outlet syndrome Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960000958 deferoxamine Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- WQABCVAJNWAXTE-UHFFFAOYSA-N dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 description 1
- 229960001051 dimercaprol Drugs 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 206010014665 endocarditis Diseases 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- 229940009626 etidronate Drugs 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 210000004517 glycocalyx Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 239000002897 polymer film coating Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 description 1
- ACTRVOBWPAIOHC-XIXRPRMCSA-N succimer Chemical compound OC(=O)[C@@H](S)[C@@H](S)C(O)=O ACTRVOBWPAIOHC-XIXRPRMCSA-N 0.000 description 1
- 229960005346 succimer Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000021476 total parenteral nutrition Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 210000002620 vena cava superior Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33336901P | 2001-11-26 | 2001-11-26 | |
PCT/US2002/037878 WO2003045466A2 (en) | 2001-11-26 | 2002-11-25 | Catheter composition and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
UA81235C2 true UA81235C2 (en) | 2007-12-25 |
Family
ID=23302492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA20040605026A UA81235C2 (en) | 2001-11-26 | 2002-11-25 | Catheter composition and uses thereof |
Country Status (28)
Country | Link |
---|---|
US (3) | US20030206906A1 (ja) |
EP (1) | EP1455858A4 (ja) |
JP (1) | JP4458240B2 (ja) |
KR (2) | KR20100102745A (ja) |
CN (1) | CN100478027C (ja) |
AR (1) | AR037437A1 (ja) |
AU (2) | AU2002365408B2 (ja) |
BR (1) | BR0215098A (ja) |
CA (1) | CA2467645C (ja) |
CO (1) | CO5580795A2 (ja) |
EA (1) | EA007594B1 (ja) |
EC (2) | ECSP045123A (ja) |
HR (1) | HRP20040502A2 (ja) |
HU (1) | HUP0600436A3 (ja) |
IL (2) | IL162083A0 (ja) |
IS (1) | IS7275A (ja) |
ME (1) | ME00015B (ja) |
MX (1) | MXPA04004948A (ja) |
MY (1) | MY140404A (ja) |
NO (1) | NO331700B1 (ja) |
NZ (1) | NZ533029A (ja) |
PL (1) | PL371760A1 (ja) |
RS (1) | RS46204A (ja) |
TW (1) | TWI262794B (ja) |
UA (1) | UA81235C2 (ja) |
UY (1) | UY27550A1 (ja) |
WO (1) | WO2003045466A2 (ja) |
ZA (1) | ZA200404024B (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2467645C (en) | 2001-11-26 | 2017-01-17 | Genentech, Inc. | Composition for removing fibrin-bound blood clots from a catheter |
US7128923B2 (en) * | 2003-03-31 | 2006-10-31 | Procyte Corporation | Preserved and stable compositions containing peptide copper complexes and method related thereto |
CN101563100B (zh) | 2006-08-28 | 2013-08-07 | 李季男 | 用于预防和治疗牙周病、改善牙周创伤愈合以及促进口腔健康的新药物靶标 |
DK2056865T3 (en) | 2006-08-28 | 2014-03-24 | Omnio Healer Ab | Hitherto unknown medicinal products for the prevention and treatment of gum disease, improvement of healing of gums in the gums and promotion of dental and oral health |
JP5871449B2 (ja) * | 2006-11-07 | 2016-03-01 | ジェネンテック, インコーポレイテッド | 組織プラスミノゲン活性化因子バリアントの使用 |
JP5642540B2 (ja) | 2007-06-01 | 2014-12-17 | アロウ・インターナショナル・インコーポレイテッドArrow International, Inc. | 組み合わされた線維素溶解性および抗菌性のカテーテル、およびその使用 |
ES2728785T3 (es) * | 2007-09-07 | 2019-10-28 | United Therapeutics Corp | Soluciones tampón con actividad bactericida selectiva contra las bacterias gramnegativas y métodos para usarlas |
US9333280B2 (en) | 2009-02-25 | 2016-05-10 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
US8545459B2 (en) * | 2009-02-25 | 2013-10-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
US20110213025A1 (en) * | 2009-08-10 | 2011-09-01 | Proviflo, Llc | Catheter Lock Solutions Utilizing Tocopherol and Mid-Chain Fatty Acids |
CN103083726A (zh) * | 2013-03-04 | 2013-05-08 | 昆明市第一人民医院 | 一种肝脏组织脱细胞液 |
US10456570B2 (en) | 2015-06-11 | 2019-10-29 | Proviflo, Llc | Graft-port hemodialysis systems, devices, and methods |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI831484L (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
US5000185A (en) * | 1986-02-28 | 1991-03-19 | Cardiovascular Imaging Systems, Inc. | Method for intravascular two-dimensional ultrasonography and recanalization |
US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
GB8820945D0 (en) * | 1988-09-07 | 1988-10-05 | Smith & Nephew | Medical articles |
FR2661790B1 (fr) * | 1990-05-03 | 1995-08-25 | France Etat | Dispositif d'amplification tres large bande continu-hyperfrequences, notamment realisable en circuit integre. |
WO1991017724A1 (en) * | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5399158A (en) * | 1990-05-31 | 1995-03-21 | The United States Of America As Represented By The Secretary Of The Army | Method of lysing thrombi |
US5363754A (en) * | 1991-09-03 | 1994-11-15 | Grainco Queensland Co-Operative Association Limited | Apparatus for preparing animal feedstuff from cotton seed |
JPH05291891A (ja) * | 1992-02-14 | 1993-11-05 | Ricoh Co Ltd | 一次乱数パルス列発生回路装置 |
AU664469B2 (en) * | 1992-06-03 | 1995-11-16 | Genentech Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
US5688516A (en) * | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
US5362754A (en) | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
HUT74690A (en) | 1993-11-24 | 1997-01-28 | Du Pont Merck Pharma | Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
US5509896A (en) * | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
US5772640A (en) * | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
CA2178541C (en) * | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US5932299A (en) * | 1996-04-23 | 1999-08-03 | Katoot; Mohammad W. | Method for modifying the surface of an object |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
US5837688A (en) * | 1996-11-27 | 1998-11-17 | Gelfand; Mathew I. | Use of thrombolytic reagents for prevention of vascular disease |
WO1998028326A1 (en) | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
GB9626795D0 (en) * | 1996-12-23 | 1997-02-12 | Geistlich Soehne Ag | Combating infection in delivery systems |
US5981826A (en) * | 1997-05-05 | 1999-11-09 | Georgia Tech Research Corporation | Poly(vinyl alcohol) cryogel |
JPH10328293A (ja) | 1997-06-04 | 1998-12-15 | Unitika Ltd | 医療用具及びその製造方法 |
US6206914B1 (en) * | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
US6166007A (en) * | 1998-07-02 | 2000-12-26 | Sodemann; Klaus | Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof |
US6174537B1 (en) * | 1998-09-25 | 2001-01-16 | Becton, Dickinson And Company | Catheter flush solution and method for its use |
BR0010380A (pt) * | 1999-03-11 | 2002-03-26 | Du Pont Pharm Co | Método, composição farmacêutica, kit e uso de uma combinação para prevenção e tratamento de diversas disfunções tromboembólicas e métodos de tratamento de trombose em mamìferos |
EP1161279A1 (en) | 1999-03-11 | 2001-12-12 | Du Pont Pharmaceuticals Company | Treatment of thrombosis by combined use of a factor xa inhibitor and aspirin, tissue plasminogen activator (tpa), a gpiib/iiia antagonist, low molecular weight heparin or heparin |
CA2302720C (en) | 1999-03-29 | 2009-07-14 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Anticoagulant/sterilizing compositions and methods |
US6187768B1 (en) * | 1999-06-01 | 2001-02-13 | Becton, Dickinson And Company | Kit for flushing medical devices and method of preparation |
EP1060747A3 (en) * | 1999-06-16 | 2001-12-05 | New York Blood Center, Inc. | Fibrin(ogen) degradation and clot lysis by fibrinolytic metalloproteinase |
US6592564B2 (en) * | 1999-07-23 | 2003-07-15 | Vasca, Inc. | Methods and kits for locking and disinfecting implanted catheters |
US6350251B1 (en) * | 2000-01-18 | 2002-02-26 | Biolink Corporation | Biocidal locks |
US20010031981A1 (en) * | 2000-03-31 | 2001-10-18 | Evans Michael A. | Method and device for locating guidewire and treating chronic total occlusions |
ATE394134T1 (de) | 2000-05-10 | 2008-05-15 | Ash Access Technology Inc | Kathetersperrlösung mit photo-oxidant |
US6772640B1 (en) * | 2000-10-10 | 2004-08-10 | Mks Instruments, Inc. | Multi-temperature heater for use with pressure transducers |
US20050215978A1 (en) * | 2001-05-25 | 2005-09-29 | Ash Stephen R | Method of enhancing catheter patency using a citrate salt catheter lock solution |
CA2467645C (en) | 2001-11-26 | 2017-01-17 | Genentech, Inc. | Composition for removing fibrin-bound blood clots from a catheter |
US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
DE60311958T2 (de) | 2003-02-03 | 2007-11-08 | Polaschegg, Hans-Dietrich, Dr. | Zusammensetzung zur Prävention von Infektionen durch subkutane Prothesen |
US7696182B2 (en) | 2004-11-02 | 2010-04-13 | Nd Partners, Llc | Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin |
US7749529B2 (en) | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
JP5871449B2 (ja) | 2006-11-07 | 2016-03-01 | ジェネンテック, インコーポレイテッド | 組織プラスミノゲン活性化因子バリアントの使用 |
-
2002
- 2002-11-25 CA CA2467645A patent/CA2467645C/en not_active Expired - Lifetime
- 2002-11-25 HU HU0600436A patent/HUP0600436A3/hu unknown
- 2002-11-25 IL IL16208302A patent/IL162083A0/xx unknown
- 2002-11-25 EA EA200400712A patent/EA007594B1/ru not_active IP Right Cessation
- 2002-11-25 JP JP2003546965A patent/JP4458240B2/ja not_active Expired - Lifetime
- 2002-11-25 US US10/304,666 patent/US20030206906A1/en not_active Abandoned
- 2002-11-25 EP EP02791318A patent/EP1455858A4/en not_active Withdrawn
- 2002-11-25 KR KR1020107019474A patent/KR20100102745A/ko not_active Application Discontinuation
- 2002-11-25 AU AU2002365408A patent/AU2002365408B2/en not_active Ceased
- 2002-11-25 WO PCT/US2002/037878 patent/WO2003045466A2/en active Application Filing
- 2002-11-25 PL PL02371760A patent/PL371760A1/xx unknown
- 2002-11-25 ME MEP-2008-80A patent/ME00015B/me unknown
- 2002-11-25 NZ NZ533029A patent/NZ533029A/en not_active IP Right Cessation
- 2002-11-25 KR KR10-2004-7007931A patent/KR20040054803A/ko active IP Right Grant
- 2002-11-25 MX MXPA04004948A patent/MXPA04004948A/es active IP Right Grant
- 2002-11-25 RS YU46204A patent/RS46204A/sr unknown
- 2002-11-25 UA UA20040605026A patent/UA81235C2/uk unknown
- 2002-11-25 CN CNB028275578A patent/CN100478027C/zh not_active Expired - Fee Related
- 2002-11-25 BR BR0215098-0A patent/BR0215098A/pt not_active IP Right Cessation
- 2002-11-26 UY UY27550A patent/UY27550A1/es not_active Application Discontinuation
- 2002-11-26 TW TW091134325A patent/TWI262794B/zh not_active IP Right Cessation
- 2002-11-26 AR ARP020104542A patent/AR037437A1/es unknown
- 2002-11-26 MY MYPI20024411A patent/MY140404A/en unknown
-
2004
- 2004-05-20 IL IL162083A patent/IL162083A/en not_active IP Right Cessation
- 2004-05-21 IS IS7275A patent/IS7275A/is unknown
- 2004-05-24 ZA ZA2004/04024A patent/ZA200404024B/en unknown
- 2004-05-26 EC EC2004005123A patent/ECSP045123A/es unknown
- 2004-05-26 EC EC2004005123F patent/ECSDI045123S/es unknown
- 2004-06-03 CO CO04052140A patent/CO5580795A2/es not_active Application Discontinuation
- 2004-06-04 HR HRP20040502 patent/HRP20040502A2/hr not_active Application Discontinuation
- 2004-06-25 NO NO20042693A patent/NO331700B1/no not_active IP Right Cessation
-
2006
- 2006-06-23 US US11/426,283 patent/US20060257390A1/en not_active Abandoned
- 2006-06-23 US US11/426,263 patent/US7829082B2/en not_active Expired - Lifetime
-
2008
- 2008-07-15 AU AU2008203131A patent/AU2008203131A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7829082B2 (en) | Catheter composition and uses thereof | |
EP2440261B1 (en) | A catheter locking solution having antimicrobial and anticoagulation properties | |
WO2000072906A1 (en) | Kit for flushing medical devices and method of preparing the flushing solution | |
CN108697826A (zh) | 导管封管液及导管封管法 | |
WO2008019083A2 (en) | Antimicrobial therapy for indwelling catheters and for sanitizing surfaces | |
US6174537B1 (en) | Catheter flush solution and method for its use | |
JP2005517460A (ja) | 光酸化剤を含むカテーテルロック溶液 | |
JP5464147B2 (ja) | 酢酸を含有する血管内留置カテーテルのロック溶液及び該ロック溶液を収納した容器 | |
JP5417691B2 (ja) | 弱酸を含有する血管内留置カテーテルのロック溶液 | |
US8864742B2 (en) | Catheter locking composition | |
JP2009242347A (ja) | 酸性ヘパリン水溶液を調製し、保存するための容器、および酸性ヘパリン水溶液の調製方法 | |
Parker | IV devices and related infections: causes and complications | |
JP2024526885A (ja) | 抗菌性カテーテルロック溶液としての使用のための16%クエン酸ナトリウム溶液 | |
Sol et al. | Long-term complications of central venous catheters in children | |
SITES | Antibiotics in Laboratory Medicine |