UA78774C2 - Dipyridodiazepinones as inhibitors of reverse transcriptase - Google Patents
Dipyridodiazepinones as inhibitors of reverse transcriptase Download PDFInfo
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- UA78774C2 UA78774C2 UA20041008768A UA20041008768A UA78774C2 UA 78774 C2 UA78774 C2 UA 78774C2 UA 20041008768 A UA20041008768 A UA 20041008768A UA 20041008768 A UA20041008768 A UA 20041008768A UA 78774 C2 UA78774 C2 UA 78774C2
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- 239000003921 oil Substances 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 description 1
- 238000005949 ozonolysis reaction Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- WLHPCEJPGLYEJZ-UHFFFAOYSA-N prop-2-enyltin Chemical compound [Sn]CC=C WLHPCEJPGLYEJZ-UHFFFAOYSA-N 0.000 description 1
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960004556 tenofovir Drugs 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36797102P | 2002-03-27 | 2002-03-27 | |
| PCT/CA2003/000418 WO2003080612A1 (en) | 2002-03-27 | 2003-03-24 | Dipyridodiazepinones as reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78774C2 true UA78774C2 (en) | 2007-04-25 |
Family
ID=28454858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041008768A UA78774C2 (en) | 2002-03-27 | 2003-03-24 | Dipyridodiazepinones as inhibitors of reverse transcriptase |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6706706B2 (de) |
| EP (1) | EP1495024B1 (de) |
| JP (1) | JP4344246B2 (de) |
| KR (1) | KR20040095338A (de) |
| CN (1) | CN1318420C (de) |
| AR (1) | AR039142A1 (de) |
| AT (1) | ATE421963T1 (de) |
| AU (1) | AU2003215466A1 (de) |
| BR (1) | BR0308704A (de) |
| CA (1) | CA2479216C (de) |
| DE (1) | DE60326035D1 (de) |
| EA (1) | EA007920B1 (de) |
| EC (1) | ECSP045316A (de) |
| ES (1) | ES2321828T3 (de) |
| HR (1) | HRP20040886A2 (de) |
| IL (1) | IL163598A0 (de) |
| MX (1) | MXPA04009444A (de) |
| MY (1) | MY135166A (de) |
| NO (1) | NO20044043L (de) |
| NZ (1) | NZ535911A (de) |
| PE (1) | PE20040305A1 (de) |
| PL (1) | PL371048A1 (de) |
| RS (1) | RS81704A (de) |
| TW (1) | TW200408641A (de) |
| UA (1) | UA78774C2 (de) |
| UY (1) | UY27734A1 (de) |
| WO (1) | WO2003080612A1 (de) |
| ZA (1) | ZA200406610B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1610782A1 (de) * | 2003-03-27 | 2006-01-04 | Boehringer Ingelheim International GmbH | Antivirale kombination eines dipyridodiazepinons und einer weiteren antiretroviralen verbindung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705499A (en) | 1995-10-06 | 1998-01-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection |
| TWI270547B (en) | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
| US6716836B2 (en) | 2001-03-22 | 2004-04-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
| US6673791B2 (en) | 2001-07-30 | 2004-01-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
-
2003
- 2003-03-04 US US10/379,448 patent/US6706706B2/en not_active Expired - Lifetime
- 2003-03-24 UA UA20041008768A patent/UA78774C2/uk unknown
- 2003-03-24 AT AT03744749T patent/ATE421963T1/de active
- 2003-03-24 CA CA002479216A patent/CA2479216C/en not_active Expired - Fee Related
- 2003-03-24 AU AU2003215466A patent/AU2003215466A1/en not_active Abandoned
- 2003-03-24 EA EA200401193A patent/EA007920B1/ru not_active IP Right Cessation
- 2003-03-24 NZ NZ535911A patent/NZ535911A/en unknown
- 2003-03-24 PL PL03371048A patent/PL371048A1/xx not_active Application Discontinuation
- 2003-03-24 BR BR0308704-2A patent/BR0308704A/pt not_active IP Right Cessation
- 2003-03-24 RS YU81704A patent/RS81704A/sr unknown
- 2003-03-24 ES ES03744749T patent/ES2321828T3/es not_active Expired - Lifetime
- 2003-03-24 EP EP03744749A patent/EP1495024B1/de not_active Expired - Lifetime
- 2003-03-24 IL IL16359803A patent/IL163598A0/xx unknown
- 2003-03-24 WO PCT/CA2003/000418 patent/WO2003080612A1/en not_active Ceased
- 2003-03-24 MX MXPA04009444A patent/MXPA04009444A/es active IP Right Grant
- 2003-03-24 JP JP2003578366A patent/JP4344246B2/ja not_active Expired - Fee Related
- 2003-03-24 DE DE60326035T patent/DE60326035D1/de not_active Expired - Lifetime
- 2003-03-24 CN CNB038064634A patent/CN1318420C/zh not_active Expired - Fee Related
- 2003-03-24 KR KR10-2004-7015370A patent/KR20040095338A/ko not_active Ceased
- 2003-03-24 HR HR20040886A patent/HRP20040886A2/xx not_active Application Discontinuation
- 2003-03-25 PE PE2003000297A patent/PE20040305A1/es not_active Application Discontinuation
- 2003-03-25 TW TW092106631A patent/TW200408641A/zh unknown
- 2003-03-25 MY MYPI20031046A patent/MY135166A/en unknown
- 2003-03-25 UY UY27734A patent/UY27734A1/es not_active Application Discontinuation
- 2003-03-26 AR ARP030101047A patent/AR039142A1/es not_active Application Discontinuation
-
2004
- 2004-08-19 ZA ZA200406610A patent/ZA200406610B/en unknown
- 2004-09-24 NO NO20044043A patent/NO20044043L/no not_active Application Discontinuation
- 2004-09-27 EC EC2004005316A patent/ECSP045316A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0308704A (pt) | 2005-01-04 |
| IL163598A0 (en) | 2005-12-18 |
| RS81704A (sr) | 2006-12-15 |
| CN1642956A (zh) | 2005-07-20 |
| ES2321828T3 (es) | 2009-06-12 |
| US6706706B2 (en) | 2004-03-16 |
| AU2003215466A1 (en) | 2003-10-08 |
| CA2479216A1 (en) | 2003-10-02 |
| EP1495024B1 (de) | 2009-01-28 |
| CN1318420C (zh) | 2007-05-30 |
| ECSP045316A (es) | 2004-10-26 |
| JP4344246B2 (ja) | 2009-10-14 |
| NO20044043L (no) | 2004-09-29 |
| ATE421963T1 (de) | 2009-02-15 |
| JP2005521699A (ja) | 2005-07-21 |
| PL371048A1 (en) | 2005-06-13 |
| EA007920B1 (ru) | 2007-02-27 |
| CA2479216C (en) | 2009-08-18 |
| AR039142A1 (es) | 2005-02-09 |
| EA200401193A1 (ru) | 2005-04-28 |
| UY27734A1 (es) | 2003-10-31 |
| MY135166A (en) | 2008-02-29 |
| US20030195197A1 (en) | 2003-10-16 |
| DE60326035D1 (de) | 2009-03-19 |
| NZ535911A (en) | 2007-08-31 |
| PE20040305A1 (es) | 2004-06-28 |
| KR20040095338A (ko) | 2004-11-12 |
| HRP20040886A2 (en) | 2005-06-30 |
| MXPA04009444A (es) | 2005-06-08 |
| HK1079194A1 (en) | 2006-03-31 |
| EP1495024A1 (de) | 2005-01-12 |
| WO2003080612A1 (en) | 2003-10-02 |
| TW200408641A (en) | 2004-06-01 |
| ZA200406610B (en) | 2006-05-31 |
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