UA77816C2 - 1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors - Google Patents
1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors Download PDFInfo
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- UA77816C2 UA77816C2 UA20041210642A UA20041210642A UA77816C2 UA 77816 C2 UA77816 C2 UA 77816C2 UA 20041210642 A UA20041210642 A UA 20041210642A UA 20041210642 A UA20041210642 A UA 20041210642A UA 77816 C2 UA77816 C2 UA 77816C2
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- alkyl
- general formula
- compounds according
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- compounds
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- 239000003446 ligand Substances 0.000 title abstract description 6
- 101000783645 Homo sapiens Adenosine receptor A3 Proteins 0.000 title abstract description 3
- 102000046278 human ADORA3 Human genes 0.000 title abstract description 3
- 125000003363 1,3,5-triazinyl group Chemical class N1=C(N=CN=C1)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 47
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- -1 /M-(di)-alkyl(1-3C) Chemical group 0.000 claims description 18
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- 208000035475 disorder Diseases 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 239000000651 prodrug Substances 0.000 claims description 7
- 229940002612 prodrug Drugs 0.000 claims description 7
- 125000005322 morpholin-1-yl group Chemical group 0.000 claims description 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical class CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077310 | 2002-05-30 | ||
| PCT/EP2003/050203 WO2003101980A1 (en) | 2002-05-30 | 2003-05-28 | 1,3,5-triazine derivatives as ligands for human adenosine-a3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77816C2 true UA77816C2 (en) | 2007-01-15 |
Family
ID=29595045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041210642A UA77816C2 (en) | 2002-05-30 | 2003-05-28 | 1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1513827A1 (pt) |
| JP (1) | JP4590260B2 (pt) |
| CN (1) | CN1329388C (pt) |
| AR (1) | AR040231A1 (pt) |
| AU (1) | AU2003250232B2 (pt) |
| BR (1) | BR0304925A (pt) |
| CA (1) | CA2484981C (pt) |
| HK (1) | HK1075045A1 (pt) |
| HR (1) | HRP20040970A2 (pt) |
| IL (1) | IL164240A (pt) |
| MX (1) | MXPA04011948A (pt) |
| PL (1) | PL372418A1 (pt) |
| RU (1) | RU2312859C2 (pt) |
| UA (1) | UA77816C2 (pt) |
| WO (1) | WO2003101980A1 (pt) |
| ZA (1) | ZA200408029B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005009980A1 (en) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| WO2005028467A1 (en) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| BR112014032873B1 (pt) | 2012-07-04 | 2019-02-12 | Agro-Kanesho Co., Ltd. | Derivado de éster de ácido 2-aminonicotínico, e, bactericida |
| GB201810668D0 (en) | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226735D0 (en) * | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
| DE19735800A1 (de) * | 1997-08-18 | 1999-02-25 | Boehringer Ingelheim Pharma | Triazine mit adenosinantagonistischer Wirkung |
| JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
-
2003
- 2003-05-28 RU RU2004138803/04A patent/RU2312859C2/ru not_active IP Right Cessation
- 2003-05-28 PL PL03372418A patent/PL372418A1/xx not_active Application Discontinuation
- 2003-05-28 EP EP03755982A patent/EP1513827A1/en not_active Withdrawn
- 2003-05-28 MX MXPA04011948A patent/MXPA04011948A/es active IP Right Grant
- 2003-05-28 UA UA20041210642A patent/UA77816C2/uk unknown
- 2003-05-28 AU AU2003250232A patent/AU2003250232B2/en not_active Ceased
- 2003-05-28 JP JP2004509671A patent/JP4590260B2/ja not_active Expired - Fee Related
- 2003-05-28 BR BR0304925-6A patent/BR0304925A/pt not_active IP Right Cessation
- 2003-05-28 CN CNB038090937A patent/CN1329388C/zh not_active Expired - Fee Related
- 2003-05-28 WO PCT/EP2003/050203 patent/WO2003101980A1/en active Application Filing
- 2003-05-28 CA CA2484981A patent/CA2484981C/en not_active Expired - Fee Related
- 2003-05-30 AR ARP030101920A patent/AR040231A1/es unknown
-
2004
- 2004-09-23 IL IL164240A patent/IL164240A/en not_active IP Right Cessation
- 2004-10-05 ZA ZA200408029A patent/ZA200408029B/xx unknown
- 2004-10-15 HR HR20040970A patent/HRP20040970A2/xx not_active Application Discontinuation
-
2005
- 2005-08-22 HK HK05107314A patent/HK1075045A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4590260B2 (ja) | 2010-12-01 |
| CN1329388C (zh) | 2007-08-01 |
| AU2003250232B2 (en) | 2008-09-11 |
| IL164240A0 (en) | 2005-12-18 |
| RU2004138803A (ru) | 2005-06-10 |
| IL164240A (en) | 2010-12-30 |
| JP2005531600A (ja) | 2005-10-20 |
| RU2312859C2 (ru) | 2007-12-20 |
| HRP20040970A2 (en) | 2005-06-30 |
| AR040231A1 (es) | 2005-03-23 |
| AU2003250232A1 (en) | 2003-12-19 |
| WO2003101980A1 (en) | 2003-12-11 |
| PL372418A1 (en) | 2005-07-25 |
| CN1646520A (zh) | 2005-07-27 |
| EP1513827A1 (en) | 2005-03-16 |
| ZA200408029B (en) | 2005-10-06 |
| CA2484981C (en) | 2011-07-26 |
| CA2484981A1 (en) | 2003-12-11 |
| BR0304925A (pt) | 2004-09-28 |
| MXPA04011948A (es) | 2005-03-31 |
| HK1075045A1 (en) | 2005-12-02 |
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