UA7182U - Biologically active preparation "gumosvit" - Google Patents

Abstract

The biologically active preparation contains sodium humate, the medicinal tea "11 tigers", and the water.

Description

Description of the invention

The useful model relates to biotechnology and veterinary medicine and can be used for 2 complex prevention, treatment of a number of diseases of animals and birds.

Known biologically active preparations of plant origin | patents of Ukraine Mo10057, 1996; Mo17228, 1997), which are produced by the extraction method and administered intramuscularly.

But these drugs are not effective enough, have a more targeted effect and are used for the appropriate species of animals. 70 The closest in terms of technical solution are preparations based on sodium humate, but it, stimulating the body's immune system, does not have a wide spectrum of action, taking into account the sexual functions of females and males of animals and birds.

Therefore, the task of a useful model is to improve the biologically active drug, the method of its manufacture and use, in which the spectrum of complex action is expanded with the increase of sexual functions, which makes it possible to increase physiological activity, especially under adverse environmental conditions.

The task is solved by the fact that the biologically active drug /Humosvit", the method of its manufacture and use as a stimulant of reproductive and milk-forming functions, which includes sodium humate, according to a useful model, additionally contains tea,11 (Kdege" with this ratio of components: pharmacy tea, 11 iidegv" 1.50-1.65 sodium humate 0.15-0.05 water 98.35-98.30.

Tea is extracted 11 (dege) with bidistilled water with exposure for 40-10 minutes at a temperature of 98-29 and gradual cooling to room temperature of 20-26.

Mix filtered tea extract 11 (idegv) with 0.195 sodium humate solution in a ratio of 1:1.

The ready packaged drug is autoclaved. The ready-made biologically active drug "Humosvit" is administered at the rate of 0.1 ml per kg of body weight to the animal 1-4 times for 1-7 days.

Additional administration of tea extract, 11 Kdegv, to the solution of sodium humate enhances the complex effect of the drug with a clearly expressed improvement of the sexual functions of the animal organism.

Extraction in bidistilled water improves the solubility of the components, which increases the concentration of active substances in the extract. --

Mixing tea extract with sodium humate solution in a ratio of 1:11 is optimal, which has been confirmed experimentally.

The introduction of the ready-made bioactive drug "Humosvit" subcutaneously in a dose of OM ml per kg of body weight is optimal, which has been confirmed experimentally.

Examples of specific implementation. "

Sodium humate powder is dissolved in bidistilled water at the rate of 0.1 g of dry drug per 99.9 ml of water in one container.

In the second container, tea extract is prepared as follows: 15 g of dry tea, 11 (degv) of the company "EGEMEM TISEK5 s RIZREMZAKM CO "TO" is poured with boiling water, the temperature of which is 96-98 2C, and with constant stirring, the mixture is kept for 45 minutes. which gradually cools down.

The mixture is filtered first through asbestos and then through millipore filters.

The extract obtained by this method is mixed with a 0.195 sodium humate solution in a ratio of 1:1 and packaged in sterile glass vials or ampoules, and then autoclaved for 45 minutes. it. Control of the biologically active effect of the drug and its quality was carried out by injecting 0.5 ml of the drug into the lymphatic bag of male frogs with an exposure lasting 1 hour. Then, every hour, a sample was taken from the male's cloaca and the presence of spermatozoa was monitored under a microscope. Their absence means that the drug is not active. of 20 The biologically active drug "Humosvit" administered to male frogs caused the appearance of sperm in the frog's cloaca after 1 hour, and the maximum increase in their number was observed after 3-4 hours.

Application of the biologically active drug Humosvit".

Example 1.

Experiments were conducted on 3 groups of 4-month-old calves:

WITH; o55 1-control, the calves of which were injected with 0.8595 sodium chloride solution; 2-experimental group, whose calves were injected with the drug "Humosvit"; C-experimental group - whose calves were injected with a 0.195 sodium humate solution. The injection was carried out subcutaneously in the neck area.

Indicators that characterize the body's immune system were monitored.

The data are presented in Table 1: 60 hematopoiesis in 4-month-old calves

Mo Groups of animals Number of heads | Doses, Multiplicity 65 In the group, ml of injection, days of erythrocytes, hemoglobin, Ileukocytes, million/mm C g/l thousand/mm C -D-

1.1 -a control (0.8595 solution 4 02/08 vleyuso obstv2 ego. 02/80 vaeyuli field ttogoya

With Z-I-experimental (0.195 solution of humate 4 and sy?

The data in Table 1 indicate that the optimal dose of the drug "Humosvit" (0.1 ml per 1 kg of body weight) under the conditions of 1-2 times subcutaneous administration increases the parameters characterizing the processes of hematopoiesis and strengthens the immunity of animals. Increasing the dose to 0.12 ml and above, as well as the frequency of administration, is impractical, since the increase in indicators is not significant.

Example 2

Experiments were carried out on 2 groups of Simmental cows: 1-control, 2-experimental, which cows were injected with "Humosvity" at a dose of 0.1 ml per 1 kg of body weight 2 times.

The results of the research are shown in Table 2: 2 of

The data in Table 2 indicate an increase in milk yield by 12.7 0.895, milk fat by 0.1-0.0395 and milk protein by 0.1-0.0495 g)

Example 3. "-

Experiments were conducted on cows with ovarian hypoplasia due to nutritional deficiency.

The cows of the first group were injected with a physiological solution of sodium chloride, and the second group - the drug "Humosvit" in the village. a dose of O.ml per kg of body weight.

The results of the experiment are shown in table 3: they are not " - her 13.02.03 16.02.03 19.02.03 20.02.03 » with NNYA NBN ONY SHON MB " of physiological solution) (Dospidna (introduction of I5mliolov Tumosvt) 121.14 18 - and From the data of table Z it can be seen that after 6-7 days, the cows of the experimental group came to heat, and during the gynecological examination, an increase in the size of the follicles in the ovaries was found in them, which contributed to further ovulation. In cows of medium fatness, ovulation occurred after the third administration of the drug (ee) "Humosvit", that is, 6-7 days after the introduction of "Humosvit" at the rate of 0.1 ml per kg of body weight.

Kz 50 The use of the drug stimulates the metabolism and strengthens the immunity of animals. "Humosvit" increases milk productivity of cows by 12.7-0.895, milk fat content by 0.1-0.0395, protein concentration in milk by 0.1-0.04905, prevents infertility by stimulating the functions of the reproductive system of females and has a positive effect on spermatogenesis in males.

Su;

Claims (1)

The formula of the invention is a biologically active preparation containing sodium humate, which is distinguished by the fact that it additionally contains pharmacy tea "11 (idegv)" with such a ratio of components, mass 90: 60 pharmacy tea "11 iidegv" 1.50-1.65 sodium humate 0.15-0.05 water 98.35-98.30. b5 Official Bulletin "Industrial Property". Book 1 "Inventions, useful models, topographies of integrated microcircuits", 2005, M 6, 15.06.2005. State Department of Intellectual Property Ministry of Education and Science of Ukraine. - with so «- cha - with ;" -I - (ee) Kz 50 Su; 60 b5