UA47832U - method for delay of processes of skin ageing and rejuvenation - Google Patents

Abstract

A method for delay of processes of skin ageing and rejuvenation comprises the intradermal administration of hyaluronic acid preparation. A preparation which addition contains sodium succinate, amber acid, sodium chloride and water for injections, is administered.

Description

increasing the activity of fibroblasts. Autoregulation collagen fibers of the synthesis of endogenous hyaluronic acid and elastin become less dense and poorly matrinized with organoslots and other extracellular components. Production of strong collagen fibers of the dermis. When hyaluronic acid is injected into the skin, which prevents stretching and tearing of the elas- skin, the intercellular retinal fibers are restored, the resistance of iron and its properties such as plasticity and the connective tissue system to mechanical and chemical turgors of the tissues is slowed down, and the water balance is restored. as a result of this, tissue damage is significantly reduced, ensuring receptor-mediated healing. The number of structural glycoproteins decreases - stimulation of skin cells, including fibroblasts, and colloidal masses accumulate in the dermis, which increases the endogenous synthesis of molecules. Yes, they give the skin a yellowish tint. finally, there is stimulation of differentiation

At the same time, human skin suffers from the destruction of fibrocytes into fibroblasts, mediated by ultraviolet radiation, which inevitably stimulates collagen and elastinogenesis, stimulation that accompanies our lives every day. The most angiogenesis (see Stroitelev V., Fedorishchev I. aggressive factors that lead to stimu- Hyaluronic acid in medical and cosmetic aging process are factors in external urinary preparations // Cosmetics and Medicine. 2000. rows, among which on in the first place, free ra- - Mo 3. - pp. 21-30; Maiagazzo 5. oi yyyyszvye aidtepiadicals, which are formed from chemically neutral Mop // Ip: Oeptaioiodu, Mozbu. - 2008. - Moi. Me 2. - b oxygen under the action of ultraviolet and ionizing 2369-84). radiation, chemical pollution in the surrounding environment, smoking, alcohol, the action of some processes of skin aging and rejuvenation by means of other medicines (see Boldyrev A.A., Kyavyaryat E.I. ., Ilyukha V.A. Biomembranology. - Petro- a preparation of hyaluronic acid (sodium hyaluronan - zavodsk: Izd-vo Kar NC RAS, 2006. - 226 p.). tu) of non-animal origin, identical to its own

Age-related hyaluronic acid of human skin plays a significant role in skin aging (see changes in the microcirculatory channel of the skin. With age pErulumlu. tavzri.gy/La! vuviet.avr). Namely, the preparation reduces the number of capillaries per unit of area, rate IaI-Zuviet "m 1.8 95 of the Riiodep company (Italy). capillary walls thicken, life deteriorates. division and reduces - single use, the size is filled with a preparation, a muscle distoma gradually develops, which does not need to be diluted and is ready for trophism, the face changes shape, the skin acquires use. This drug is registered in Ukraine - parchment shade. In case of violation of microcirculation - registration certificate Me 7551/2008. culation, the thickness of all skin layers decreases. The shortcomings of the prototype include the fact that other

Thus, the main pathogenetic metradermal introduction of a monocomponent prehanism of skin aging is. Hyaluronic acid parath (sodium hyaluronate) - a violation of the optimal water balance in the skin, although it leads to the replenishment of the deficiency of hya-skin, due to a decrease in the amount of hyaluronic acid in the tissues, elimination of dehydration in the skin and a decrease in its ability to retain the skin, strengthening of endogenous synthesis to absorb water, which in turn leads to dehydration of luronic acid and collagen through the mechanism of skin sagging and loss of its tone. Slowing down of syn-stimulation of proliferation and migration of fibroblasts, collagen and elastin thesis, reducing the amount but does not provide a comprehensive effect on various collagen and elastin fibers, which is the cause of the pathogenesis of skin aging, namely restores to the loss of elasticity and elasticity of the skin; digestive and antioxidant effects. - suppression of the processes of tissue metabolism. The basis of a useful model is the task, namely, the reduction of cellular respiration, trans- creation of a method of slowing down the processes of aging of the ion port, protein synthesis, reduction of skin formation and rejuvenation, in which through intrader-

ATP; small introduction of a complex agent containing - the action of free radicals that damage the cells' hyaluronic acid, sodium succinate and cystic membranes, which leads to the destruction of cells, amber lot, an improvement in the state of collagen destruction is achieved; which damage the DNA of cells, which also leads to their death due to the activation of skin microcirculation processes. This leads to disorders of tissue metabolism and antioxidant protection of skin microcirculation, deterioration of the color effect and provides a complex effect on the texture of the face, and premature aging of various links of the pathogenesis of skin aging, which causes the skin in general. until restoration of firmness and elasticity

In order to slow down the aging processes of the skin, the level of hydration and tone, color and rejuvenation, intradermal injections of facial texture, elimination of signs of aging and hyaluronic acid preparations are performed (see Lopatina N. we, which determines its high effectiveness.

Contemporary trends in biorevitalization. The task is solved by the fact that

Journal of aesthetic medicine. 2008; 1:34-6.). methods of slowing down skin aging processes and

The literal translation of the word biorevitalization is "bio-rejuvenation by intradermal feeding" ("bio-renewal" or "bio-restoration of the preparation of hyaluronic acid, according to the useful skin by biological methods") (see models, the drug is introduced, which additionally contains mmliu.siIipisas.gy). The main purpose of this technique is sodium succinate, succinic acid, sodium chloride to replenish the hydration reserve of tissues and water for injections. creation of natural conditions in the skin for functioning - The method is carried out as follows. cells and, thus, activation of the mechanism

The following techniques are used to slow down the processes of skin aging and the background recording of the microcirculation index (PM) of rejuvenation: women D. was 4.08. - papule technique: the drug is injected by mic- After carrying out the procedure with the use of roinjections until the appearance of small papules, the diameter of the single-component hyaluronic acid drug is 1-2 mm at a distance of 0.5-1 cm. The needle is inserted into you using the papule technique , on the back-upper third of the dermis to a depth of 2-3 mm, with a cut of the wound of the wrist of the right hand, the index of microcirculation is upward; was 16.54. - linear technique (tracking and tunneling) is used after the procedure with the application of a complex product containing hyaluronic acid to reinforce the sagging contour. The needle is inserted parallel to the skin, to the entire lot, sodium succinate and succinic acid, lengthwise, to a depth of 2-3 mm. The needle is made straight using the papule technique, movements are made on the back side (with the tunnel technique) and the needle is shaken in the wrist of the left hand PM was 25.94. sides (with tracing technique). The introduction of the preparation is prescribed to the woman, according to the method that the rat is carried out retrogradely in the dermis, when it is expressed. The drug was administered intradermally with daily needles. by means of micro-injections to the emergence of small ones

In all patients, the state of microcyrpapules with a diameter of 1-2 mm at a distance of 0.5-1 cm in the skin circulation during intradermal injection of the comb zone of the face and neck was examined. The needle was inserted into the verplex preparation containing hyaluronic acid in the third of the dermis to a depth of 2-3 mm, with a chisel cut, sodium succinate and succinic and mountain acids. Procedures were performed 1 time in 2 weeks, the comparison drug - monocomponent pre-patient received 6 procedures. In the dynamics of the suspension of hyaluronic acid. When studying the basis of this method, the following were observed: improved blood flow, tissue perfusion of the general type, increased elasticity of tissues (microcirculation index - PM). At the first visit, the smoothing of surface wrinkles, brightening was determined by the background indicator of the microcirculation of the skin of the face and neck, which was noted after (PMI) before the study and determined by taking two procedures. By the end of the course, after intradermal administration of the drug, the elasticity of the tissues increased, the skin became more elastic on the back side, surface wrinkles and wrists smoothed out (15-16 injections on the skin with an area of 3 by 3 cm). the expressiveness of deep wrinkles was significantly reduced

The skin was treated with 2 95 hydrogen peroxide solution, on the forehead, bridge of the nose; postostosis has passed, 0.1 was administered intradermally (intradermally), the "bags" under the eyes have decreased. The skin of the face with ml of the drug before the formation of a papule with a diameter of up to Z turned pink, the tone is even. Side effects, irritation - mm. After the injections, the skin was treated again with skin care, no allergic reactions were noted. sour cream The indicator of microcirculation was determined during the following observation, the effect of restoring the physiological functions of the skin (PMe1) obtained by using a complex product on the left hand, as well as PM when using monocompo- was stable. nent preparation of hyaluronic acid - on pra- Example 2. eyelashes (PMf'i1). Study of skin microcirculation Woman T., 40 years old. The skin of the face, neck, and hands was monitored by the method of laser doppler flow, dehydrated; forehead, chin - flaking. umetry (DDF) on the LAKK-01 device (NPP "Lazma", Reduced turgor of tissues and lethargy of the skin around

Russia) according to the method of Bieyapouzka A. and co-authors of the eyes, in the area of the forehead and bridge of the nose. Wrinkles of the corners (see Kumegpto N.O. OzsiPayop ip She pitap siape- eyes and lower eyelids. siv riooa repiviop v5idpa! toaiiea ru epaoineiiit- The background record of PM of patient T. was 7.49. ipderepaepi mazoadiagayugv. // Misgtomazs. Nev. 1999. After carrying out the procedure with the application

Mau, 57(3): 298) in addition to V.V. Sydorov. (see monocomponent preparation of hyaluronic acid - "Laser Doppler flowmetry of microcirculation, using the technique of papules, on the back circulation of blood" edited by A.I. Krupatkin, wound of the wrist of the right hand, indicator of microcirculation

V.V. Sydorova. Guide for doctors, ODO was 9.56. "Medicine", 2005. - 256 p.), with data processing according to After the procedure using the Tankanag method A.V. and Chemeris N.K. (see Tan- a complex agent containing hyaluronic acid, A.V., Chemeris, N.K. Application of wavelet, sodium succinate and succinic acid, transformations for the analysis of LDffFf-grams // Mate- using the technique of papules , on the back side of the rial 4 of the All-Russian Symposium on May 14-16, the wrist of the left hand PM increased to 17.59. 2002. The use of LDF in medical practice - The woman was prescribed the procedure, according to the method that ticks. Pushino, 2002. - p. 28-38). declares The drug was administered intradermally

We give concrete examples of the implementation of microinjections to the emergence of small sobu. papules with a diameter of 1-2 mm at a distance of 0.5-1 cm in the

Example 1. blemish areas of the skin of the face. The needle was inserted into the upper

Woman D., 45 years old. The face is pale, pasty, a third of the dermis is exposed to a depth of 2-3 mm, with a cut of the skin under the eyes; skin with a yellowish-earthy color. The procedures were performed once every 2 weeks, with a shade. The elasticity of soft tissues is reduced, the skin is only on the course of the procedure. dry, thinned, lethargic, especially in the area below. The effect was observed already after the first evaluation of the face and neck. Deep and superficial wrinkles were firmly fixed after the second, when wrinkles in the corners of the eyes, on the forehead, in the area of the lower eyelids, there was a marked improvement in tissue turgor, the skin, transverse neck wrinkles, fan-shaped wrinkles became more "alive", juicy, elastic, more upper lip general appearance improved. By the end of the course

application of a complex preparation - skin of elasny technique. Procedures were performed 1 time in 2 tic, smooth. Wrinkles in the corners of the eyes were smoothed out - weeks, on average, each person was relaxed, in the area of the lower eyelids they became less noticeable; from 3 to 6 procedures. A significant effect was observed: a significant tendency to even out the skin color already after the first procedure and permanently fixed the face. Side effects, skin irritation, sya after the second. All subsequent administrations were carried out and no allergic reactions were noted. in order to support the result obtained, which

During further observation, the result was expressed in a decrease in the number of small wrinkles, the effect of restoration of the physiological functions of the skin, some smoothing of large ones, revitalization of far- was stable. skin condition It should be noted that the procedures

Example 3. carried out well, neither during their implementation, nor on

Woman M., 52 years old. The skin is dry, lethargic, moaning - there were no signs of intolerance. shena Tissue turgor is sluggish. Deformation of the upper and lower eyelids ("bags" under the eyes). when comparing the microcirculation index after

Deep and superficial wrinkles of the forehead, the corners of the eyes, the use of the prototype method and the neck method; hirsutism of the upper lip. is declared, with the background indicator noted

The background PM of patient M. was 3.45. its likely increase in all patients, but at

After carrying out the procedure with the application of the claimed method, the value of the monocomponent preparation of hyaluronic acid microcirculation index was probably higher, using the papule technique, on the back drain than when using the prototype method. When the wrist of the right hand was injured, the index of microcirculation after tradermal administration of the complex was 15.77. containing hyaluronic acid, sodium succinate

After the procedure with the use of succinic acid in order to slow down the pro-complex product containing hyaluronic acid for skin aging and rejuvenation, probable lot, sodium succinate and succinic acid, increasing the microcirculation index (PM) by removing the papules technique, on the back side due to dilatation of the precapillary sphincter of the wrist of the left hand PM increased to 28.52. teres, which is connected with its more pronounced vaso-

The woman was prescribed procedures in a way that has a dilating effect due to the effect on the applicant. The drug was injected intradermally, active mechanisms of regulation of microcirculation (endo-using linear technique (tracking and tunnel-telial, myogenic, neurogenic). well). The needle was inserted parallel to the skin, for the entire length of it. It is known that succinic acid is universal, to a depth of 2-3 mm, straight lines were made with the needle, and the intermediate metabolite that is formed was shaken to the sides. The introduction of the drug during the interconversion of carbohydrates, proteins, and fats was carried out in the dermis retrogradely, when it was removed from plant and animal cells. Transformation of the needle. Procedures were performed 1 time in 2 weeks, succinic acid in the body is associated with pro- the patient received 6 procedures. duction of energy necessary to ensure life

The effect was manifested already after the second procedure: activity. As the load on the skin increased, the turgor of the tissues was noted to improve. The power of the system is a pink shade that gave the face a fresh look of products that use succinic acid. By the end of the course application, the complex is hundreds of times superior to all other systems. of the drug - the turgor of the tissues is satisfactory, the skin- Sodium succinate (sodium salt of amber is elastic, juicy: the acids have noticeably decreased) provides a powerful restorative and "bags" under the eyes. Deep wrinkles have become less antioxidant effects, effectively blocks free expressed, and surface radicals in the corners of the eyes, provides an effect on the processes of exchange smoothed out. The face has acquired healthier light substances in the skin: cellular and tissue appearance is strengthened, the skin is brighter, pinker, reduction, ion transport, protein synthesis, as well as sagging manifestations of hirsutism of the upper lip. stimulating the production of energy (ATP), which

Unpleasant subjective sensations, side effects mean its high efficiency in the best effects were not noted. With further restoration of cells, improvement of the state of microcirculation, the obtained effect of restoration of skin physiology, which, in turn, leads to the skin's protective functions, was stable. renewal of its firmness and elasticity, tone, co-

The claimed method was used in 64 facial hair and texture, removal of signs of persons aged 40 to 58 years (57 women and 7 men - aging and fatigue.). It should be noted that among 57 women, 48 were thus due to the intradermal shaft in the perimenopausal period, when the signs of the introduction of a complex preparation containing skin aging began to manifest themselves with greater hyaluronic acid, sodium succinate and acid. Indications for carrying out an amber treatment, which provides an effect simultaneously on the fool were signs of physiological skin aging, which are three pathogenetic mechanisms of skin aging: expressed in the appearance of wrinkles, and in people over 50 1) maintaining an optimal water balance years - and deep, in the loss of skin elasticity , appearance in the skin due to the replenishment of the amount of hyaluronic individual pigmentation. In 17 people, the procedure of provo-acid in the skin, elimination of skin dehydration. She used the papule technique, and in 47 - the linear technique of strengthening the endogenous synthesis of hyaluronic acid (tracking and tunneling). A total of 47 procedures were performed using the papule technique and 219 - by means of fibroblast lineage and migration;

2) activation of the processes of tissue metabolism, color and texture of the face, prevention of - in particular, strengthening of cellular respiration, transport of rare aging of the skin in general. ions, protein synthesis, increased ATP formation; Each component of the complex acts purposefully

3) antioxidant effect, neutralization of the action of vano and is based on the pathogenetic mechanisms of free radicals that damage cellular mem- aging.

And thanks to the synergistic action of the specified combrans, at the same time, all opponents are disturbed in the cells, a complex of physiological mine processes is ensured, which lead to the destruction of cells; effects that lead to the restoration of physiologically-destroying collagen; damage the DNA of the cells, which are responsible for the properties of the skin, which contributes to the slowing down and also leads to their death.

This leads to the acceleration of its aging and rejuvenation processes. improving the state of skin microcirculation, improving The method can be applied in clinics of

thetic dermatology and medical cosmetology.

Computer layout D. Sheverun Signature Circulation 26 approx.

Ministry of Education and Science of Ukraine

State Department of Intellectual Property, str. Urytskogo, 45, Kyiv, MSP, 03680, Ukraine

SE "Ukrainian Institute of Industrial Property", str. Glazunova, 1, Kyiv - 42, 01601