UA26742C1 - - Google Patents

Description

18. A composition capable of using the types of emulsions, gels, foaming compounds, non-specific immunostimulation, ointments and fatty carriers. containing a pharmaceutical active ingredient 23. The composition according to item 21 or item 22, an ingredient and physiologically acceptable, characterized by the fact that the carrier, filler and/or filler, additionally contains, to a lesser extent, что актинннкм ре, one herbal extract and/or, according to the less active ingredient, one flavoring substance - a peat extract containing no more than 70% and web.96 of inorganic salts, especially 24. Composition pop. 18, except for sodium chloride, calculated on a dry basis, which includes the substance, and the bioactive product is a sterile alcoholic herbal extract - capable of inducing cytokines! i composition in the amount of 0.01 - the compound, and the carrier contains a gel layer that corresponds to the amount of the disintegrating agent, and the weight corresponds to 90-99.99% by weight of the carriers, fillers, liquid mixture to the gelling agent, m/or additives is about 90 :94 to Za:6., 19. The composition of item 18, i.e. part 1, Priopritet item 150791. according to the fact that the carrier is items 1 - 24. a mixture of lactose and lubricating substances, 2 Priority from 16032941 lol and the weight loss of the active ingredient in points 15, 16, 21-23. ratio to the carrier is 1:9-1:19. With Priority no. 170591 according to , 20, Composition according to item 18 or item 19, items 15, 16, 21-23. I am sorry for the fact that 4 Priority ot030691 is filled in the form of tablets or capsules. points 15, 16, 21-23. 21. The composition according to item 18, that is, BPrioritetzhkh ot 160381 is based on the fact that it contains items 21-23. carriers and/or other additives, ordinary bPrioritet ot 16.03.91 for cosmetic preparations, and mentioned in items 21-23, that bisrsactive product from peat with 7. Priority ot 10.06.9891 po is present in the composition in the amount of 0, 01 - items 21-23. and 1 wt. Z6, in particular 0.05-0.1 wt. b5, pri- 85Prioritet ot 10.06.91 lo than the composition is intended for treatment of items 21-23. and for the body, namely for the skin, hair or teeth. paragraphs 21-23. 22. Composition pop. 21, about tlicha: M: Priority from 17.05.91 according to the content of points 21-28. about specified bi-active product from peat 1. Priority from 17063941 according to a concentration of 0.05-1 wt.9, and carriers of clauses 21-23. and/or vibrational additives from groups, so-

The invention relates to the chemical and various methods of the production of lime and the pharmaceutical industry, peat fermentation using, first of all, to new bisactive, various extraction media, as well as to products obtained from peat, and to the combined use of such extracts, containing - bam of obtaining such products. 5, obtained from peat, are bireactive

The invention also relates to pharmaceutical ingredients for pharmaceutical and cosmetic and cosmetic compomatic purposes. 7 of the articles containing these products, M Kk "One of such well-known methods for the production of pharmaceutical and/or cosmetic compositions described in Polish, containing 10 inventions to the patent Me 124110 (Spetisa!) 788542). Correspondingly, ductine obtained from peat with the same lime method is biactive

7 and 25742 8 products! obtained from peat with the help of acidification of the hydrolyzate, separation of non-primary and alkaline water-soluble solid parts with subsequent hydrolysis of air-dry unsettled solid and secondary alkalinization, and the peat material, then carried out by acidification of the pure liquid phase, acidification of the hydrolyzed in this way, removal of inert substances from the used lyzate and separation of the insoluble part by extraction of the organic dissolved solid part with a subsequent second separator, and subsequent treatment by alkalization, acidification of the pure melted liquid phase containing non- (transparent) liquid phase and removal of organic salts and ballast substances extracted from peat with the help of alcohol - 10 bioactive ingredients. .voy or zfirnoy zkstraktsii, V ukadasny - The known method of obtaining a pharmaceutical and the aqueous phase of an organic pharmaceutical composition capable of in- zxtraktsii is a liquid bibactivnym to induce cytokines! and it is useful for uluch- a product obtained from peat. hay therapeutic treatment outside

A well-known liquid product, which 15 wounds or varicose ulcers, especially, is a solution of peat-derived varicose ulcers of the lower parts of the legs, pre-active ingredients, is highly concentrated. obtained in the composition of the extract or herbal composition with the above-mentioned link on pol- racts, a gelling agent, and the printed description of the invention to the patent, and the ingredients. It becomes unstable when stored in a well-known composition capable of long-term exposure and, in addition, nonspecific immunostimulation. . carrier, filler m/or additive,

Being a voluminous product, it is not easy to use. they appear to be stable and can be

A bisactive product is also known, 30 easily introduced into pharmaceutical or animal-derived from peat, a method of obtaining veterinary products, as well as into cosmetics, a method of obtaining pharmaceutical Czech preparations! both in a solid form and in a composition capable of inducing cy- and in the form of any convenient solution. tokin, and a composition capable of carrying- In particular, what concerns the use of non-specific immunostimulation. Use of peat-derived bio-calcium

Mashkovsky M.D., Lekarstvennne sredst- product for pharmaceutical purposes, t.a. va, M., Medicine, 1989, part |, p. 33-76 for obtaining pharmaceutical compounds (prototype). "Zytsy, then there was an urgent need

A well-known bi-active product, an aid in the development of a solid mold, would be suitable for the rolling of peat and used for 40 times; for those guys. non-specific immunostimulation, since the preliminaries, the sva- are a mixture of active torzanne with a concentration of known water ingredients and inorganic salt solution obtained from bioactive peat. lei The slurry is obtained by the method of preventive substances and its desalination, which does not matrivate the primary alkaline hyd- 45 gave positive results in connection with the role of the peat material. With the occlusion of active ingredients in the acidification of the hydrolyzate, the deposition of the non-crystallisable solid phase, the vis" of the soluble part is the following reducing the bislogic acid by acid alkalinization, and then by acidifying the pure liquid phase, it is very difficult to find a suitable method for turning ballast liquid substances into a powder using the composition. Neonium extraction with an organic solvent was found to be positive, and the subsequent processing of the final result can be achieved by adding a liquid phase containing inorganics to the concentration of liquid compositional salts and curing from peat 55 first dilute several times, bisactive ingredient!, i.e. will dilute one volume of the composition

A well-known method of obtaining bioactive water, an active product from peat, with a certain amount of water is considered.

AND

"а 25742 10 specific immunostimulation, with a concentration of no more than 70 weight 96, from a self-dissolving mixture of active peat on dry matter; the stage of final ingredients and inorganic concentration and purification. ley, obtained by the method, considering The dilution of the demineralized primary alkaline hydrolysis 5 is carried out at a ratio of 1:5 to raw peat material, oxidized 18, and the dilution solution is desalted hydrolyzate, the separation is dissolved to the preferred content of the liquid part with the subsequent addition of inorganic salts no more than 60 nes.95 by alkalization and then acidification based on the calculation of the dry substance. pure liquid phase, removal of ballast 10 In addition, the method of additional sonic substances with the use of extrac- holds the stage of sterilization and/or drying with an organic solvent, and then, where the concentrated and purified freezing treatment of the remaining liquid solution is sterilized and/or subjected to phase, soda rusting inorganic salts spray drying. and the extraction of bisactive ingredients from peat. For that reason, the slurry is passed through the dry substance through a sponge, and the so-called ceramic filter under the action of holding salts is provided by means of 20 reduced pressure, ploluchaya pure dilution of the indicated liquid phase, defiltrate of the mentioned liquid phase, co-mineralized water with subsequent holding of inorganic salts and bisbac - by reverse osmosis to reduce the sodretic ingredient!. the absorption of salts in the product. Sterilization is carried out by means of

The product is in the form of a water 25 membrane filter. solution or dried powder. In addition, the solution is subjected to

The content in the product of inorganic alcohol drying at a temperature at which salts does not exceed 6095. enters about 180 and exits about.

In addition, when the product is in the in the form of a 195-foot aqueous solution, it has 30. because in the method of obtaining far-

When the product is in the form of a con-maceutical composition capable of concentrated solution, this solution is useful for improving external therapeutic treatment of wounds or varicose ulcers. especially up to 1.09 g/ml, and the content in it of dry varicose veins of the lower parts of the legs, pre-substances is not less than 5 wt.95. looking at the connection induces

The specified task is solved also by our cytokines bibsactive material so. that the method of obtaining a bisoactive herbal extract or herbal product from peat, providing 40 rakts, a gelling agent, and secondly, primary alkaline hydrolysis of sulfur humus with ingredients, according to the invention, of the peat product, followed by raising, sterile aqueous solution acidification hydrolyzate, the separation of the inert product obtained from peat, the fermentation of solid parts, followed by secondary alkalization containing no more than 7095 inorganic salts, and then 45 salts, especially sodium chloride, from the acidification of the pure liquid phase, the removal of dry matter , COMBINE the inert substances using sterile alcohol extraction with an organic solvent, racto, after which the liquid mixture is pre- and subsequent processing of the remaining water into a gel-like form by means of an additional liquid phase) containing an inorganic addition of a gel-forming agent. which salts and extraction from peat bisac- As a gelling agent, a tive ingredient, according to the invention, is added, preferably a colloidal niyu provides for the following dopol-silica, and the weight ratio nitelne stage, the dilution stage, in the liquid mixture to the gelling agent in which the mentioned solution is diluted 55 is 90-94:10-6. demineralized water; the stage of post- To obtain a pharmaceutical-grade desalination, in which the solution in the form of an ointment is added to the gel, the solution is subjected to a reverse-dissolving agent, preferably colloid osmosis for desalination of the solution, silica, and inorganic salts are removed by weight addition of a liquid mixture to a gelling agent

1: 25742 12 and the agent is about 30:2, and the indicated bi-active product is obtained from it, the gel is ground in this way with pre-peat, the composition contains in a concentrated sterilized base weighing 0.05-1 wt., and the carriers and /or a dose containing a mixture of fatty compounds selected from the groups), consisting of substances such as zucirin and petroleum jelly, in 5 aqueous solutions of alcohols, all types of gel-to-liquid ratios by weight, commulsies, gels, foaming compositions of component 32 -34:68:656. and fatty carriers,

The herbal extract is selected from the group - The composition additionally contains, at least one herbal extract of tansy, calendula extract, rosemary extract, and/or at least one aromatic herb, marigold extract, extract of the leaf is a fermenting substance. In addition, the composition includes stenoi, horsetail extract, leaf extract, sedum leaf extract, alcoholic herbal extract and stinging nettle, germ extract, a sterile solution of wheat germ, aloe extract, thyme extract, and the carrier contains gelobyan , Fuller's herbal extract. disintegrating agent, and the weight ratio is

Slytherin and/or a sterile solution of a liquid mixture to a gel-forming flavoring compound, the preferred agent is from 90:94 to 94:65, titively selected from the groups consisting of menthol, thymol, mint), lemon and 20 we have developed a method by which Kk is added to the liquid mixture with the help of zqualipta. which can be obtained separately

The bioactive product obtained from the bisactive peat product, otly peat, is a peat extract with the above advantages in the form of concentrated water with the same characteristics. From a concentrated aqueous solution or a dried powder, which preferably contains non-bopeorganic salts - mainly 60 wt.95% of inorganic salts per sodium chloride containing dry substance. . bioactive ingredient from peat! with

The specified problem is also solved by diluting the mentioned solvent because in the composition capable of 30 ra demineralized water, i.e. Disinfect non-specific immunostimulatory water, followed by an ob- - tsium containing pharmaceu- tically active osmosis, concentration and physiological purification of the active ingredient. The solvent-acceptable carrier and filler obtained in this way can be easily transformed into an additive, according to the invention, an active and solid product, a suitable ingredient is a bi-active product for the necessary purposes, by means of a peat product containing no more 70 rilization and spray drying. Weight: 95% of organic salts, especially if the amount of water is added. of sodium chloride, calculated on a dry basis, is carried out several times, a substance, and a bioactive product 40 preferably from 5 to 5 times, oh, if it is capable of inducing cytokines! and the components of the concentrated solution, which are present in the composition in the amount of 0.01, must be diluted. 95 wt. 45 documents with a description of the invention to the

As a carrier, the composition of the sodertent of Poland Mo 124110 consists of rye mixed with lactose and lubricating substances, the final organic residues are removed, and the weight ratio of the active ingrevorite from the post-extraction aqueous dient to the carrier is 1:9-1;:19, phases) , separated by insoluble times

The composition is made in the form of 50 tablets with the help of low-dose filtration or capsules. nom davleniiy due to baked kgerami-

In addition, the composition contains nocturnal material diluted with solvents and/or other additives, ordinary substances in several times the volume for cosmetic preparations, and with the addition of distilled water and its processing, a bisactive product from peat is obtained by means of desalination with with help

There is a composition in the amount of 0.01-reverse osmosis for the separation of 1 wt.95, in particular 0.05-9.1 wt.95, tributary mineral salts, mainly the composition is intended for the removal of sodium chloride, in in the form of permeate. Then for the body, namely for the skin, hair or the desalination solution is concentrated, teeth, cleaned with the help of centrifugation and sterilized by filtration through a membrane of a well-known product, such as a chemical early filter, for example, a "soap" filter, so and on a wider lipor" range of anticancer activity.

Obtaining a microbiological clean- An example of obtaining a product according to a patent solution in an optional order of 5th Polish Me 124110, can be subjected to spraying One kilogram of air-dry torso. From a sterile product, the liquid phase is crushed and extracted, or a solid one is used, it can be made by mixing 8 liters of 0.1-8.095 aqueous Rastmetik, pharmaceutical, or Vetenor MasA for 36 hours with a combinar composition . At a temperature of 10 nits and at a constant temperature, it is optional, concentrated and stirred. Then the alkaline extract of the cleaning solution can be used - they are centrifuged to separate the solid particles: without sterilization and spraying, after which it is acidified with salt drying; in the forehead with a suitable dilute acid to a pH value of approximately 2 flax as a component in many 15 and leave for 12 hours. Forming cosmetic compositions. at the same time, the precipitate is separated, and the transparent solution is treated with sodium hydroxide

Preferably, at the spray stage, until the pH value of 9 is reached, after complete drying, the temperature at the inlet is filtered again. Further, the filtrate is cooled to about 180, and the temperature of 20 is again acidified with hydrochloric acid and the result is about 30. center at reduced pressure to

In accordance with the Polish patent, 1/2 of the initial volume of acidified hydrolyzate can be achieved. A concentrated solution of neutralizing peat, which is characterized by salting with sodium hydroxide and steaming with a solution of ash substances in the amount of 25 to dryness. Extraction of the dry mass is 8-3096, the degree of decomposition is up to 30-7095, and it is carried out with hydrogen ethanol. The extract is separated by the value of ri, equal to 3.5-7.0, from the fatty residue and non-organic soots by secondary hydrolysis in an aqueous solution. Then the extract is concentrated until it contains alkaline substances at the values of the moment when the salts begin to precipitate

pH from 9.0 to 14.0 and temperatures from 16 to 60. 30 days in the sediment. The precipitate is separated, and half-

After separation of the precipitate, the filtrate is concentrated in this way, the filtrate is then acidified to the pH value, the filtrate is diluted with a 1:1 mixture of ethanol 3.0-1.0, after which it is concentrated and neutralized with sulfur, chloroform, benzene, or and again concentrate the dolacetate. The precipitate that fell out the second time is dry. Dry 35 inorganic salts obtained in this way are filtered again, the filter mass is then extracted with 40-80% of water, and the aqueous filtrate is concentrated with ethanol at a temperature of 30-60. ruyut to half the relative volume

After separation from the ballast extract of its original value, the centrifuge substances are concentrated until they are diluted and filtered. Transparent filtration of half the volume of the original 40 is subjected to a chromatograph on a column with values. The residue is extracted with ethanol, Biogel P-2 minus 400 mem (sroy) with mixing with a second organic solvent as a solvent, using water as a solvent, such as zephyr, chloroform, or 1095 aqueous ethanol, and the fractions, o6-benzene, ethyl acetate, and CO ot 1: modulating anticancer activity, so- to 1:3. Then the aqueous layer is concentrated and taken. to half of the initial volume, cent- The resulting preparation is sorifugurated and separated on columns with hygroscopic, amorphous substance cellulose or biogel, using a brownish color containing water or 1096 water. It is water-soluble and can be dissolved in 5-1095% ethanol, methanol or 50% in organic solvents - acetone, alcohol. After carrying out acid hydro-

Selectivnog udalenie obtka soli lysa it gives a positive reaction or acids are carried out with the help of ion exchange, when the interaction is a group of reagents, a different technique. I use it to determine the presence of

The product obtained in accordance with the specified 55 chars - glucose, galactose, arabinose, in addition to glucuronic acid, rhamnose, xylopolysaccharides, certain minerals, b-deoxyglucose and 2-deoxyglucose salts. The IR spectrum is typical for polysaccharides, the final product obtained in this way. After calcination at 700'C by semi-method, the corresponding sol is distinguished, making up to 6-1095 percent of the initial mass and containing oxygen. The product obtained after such a state of metals, among which such findings are obtained by spray drying, is in the form of oxides of Mo, SiA, Co, M, Mp, Ma, C, M, in the form of a powder, and therefore especially non-metallic oxides, sredy ditsya for the preparation of some Far- which should be noted oxidation of R. 5 maceutical compositions. Nayiboleev

Although the method according to the invention has been described, the preferred product of this type is combined with the method and the product referred to as -. lasno to the description of the invention in the patent "To RAE. To Rgeragayop" To! RAD?

Polish Mo 124110, its use was not registered trade limited to such a combination, but the brand name of Togi Sogrogtayop, Mudiapa 2, but it is applicable in the context of the method of sale - Uumgosiam, Roiapa. chenie isolated from peat bisactively - In this article, the invention of this product from a highly concentrated product is described. ley, mainly sodium chloride, 15 The present invention is also related to bioactive peat fertilizer to pharmaceutical compositions, ingredients containing as an active ingredient

The bioactive substance obtained from peat, the bioactive product obtained from peat, which is referred to in this product, described above, in particular, invented, do not contain more than 70 wt.96, 20 duct containing not more than 70 wt.95, preferably not more 60 wt.9a, not more than 60 wt.zo, inorganic salts, mainly chlorine salts, mainly sodium chloride. Since in the optimal sodium chloride, on dry solids Duct is the desired concentration for you, together with a pharmaceutical acceptable sodium chloride as low as possible, 25 mm carrier. Obtained from peat. the main image for the pharmaceutical bisactive product contained in such and such cosmetic applications and pharmaceutical compositions, pradmenpiy, where necessary! higher TRs are respectfully indicated by higher concentrations, i.e. for facial care, that is. Pharmaceutical preparation! soder- the most suggestive are those obtained from peat, bioactive, and low concentrations of sodium chloride, the product and pharmaceutics, and such as 5595 and even lower, especially the carrier, preferably by weight if it is possible to obtain it by means of ratios of about 1:5 to 1: 25, and the most advanced stage of dilution and reverse osmosis. preferably between 1:9 and 1:19.

If the method is limited to the stages of concentration and purification, then the product belongs to the preparation method and is made by concentrating or thickening the pharmaceutical composition containing it in a solution. "Concentrated peat-derived from peat bioactive professional extract", which is referred to in the duct in the form of a gel. 40 This method differs in that the dark-brown liquid with a density of 1.02-1.09 g/ml is mixed with an alcoholic herbal extract and contains at least 5 units of sterile glycerin. wt.?5 dry solids. The hydrogen content is preferably the chloride ion of dry solids pre-centrifuged with a solution of the precursors, calculated as the mass of the component ground into powder obtained and not higher than 7095, preferably not from peat bisactive product and more 5095, and the pH value is 195 with an aqueous solution of menthol, and the half-solution is 5.0-6.5, usually 6.0. does not apply a liquid composition in the form of a gel, and, for example, for a certain cosmetic by weight, the ratio of the liquid technical use of the mentioned composition to silica is 90:10 of the concentrated peat extract. to 94:6. It is preferable to

On the other hand, the stage of sterilization in the form of a powder may be mandatory, in part or in a concentrated form, if the product is intended for the bisactive TP product. preparation of pharmaceutical compositions. The present invention is also related to

In this case, it is especially preferable to the method of preparation of pharmaceutical -

Dust-drying, if it is not mandatory to extract bisactive product from peat, it is in the form of an ointment. This method is distinguished by the fact that the healing mud, known and studied, is a sterile herbal extract of the plant, which is used as a biologically soluble material and is combined with a sterile soluble and microbiological source of powder obtained from walking; due to its content of peat, a bisactive product , the resulting mixture of 5 nutritious and stimulating components is turned into a gel with the help of dotov, it will have the healing effect of the addition of colloidal silica, and on the body of a person and a mammal; bisactive compositions contain an elevated mixture of fatty components, and breakable substances in proportions such as zucerin (eiseple) and vaseline, which are preternatural for living organisms; therefore, it is possible to respectfully and seriously consider the liquid as an explanation of the useful of components to silica about 30:20 vozlejstvia kosmetikeshk them and pharmaceutical gel to fatty components from 32:68 to chemical preparations containing polu- 34:56, Here are also the preferred 15 peat actin products: and the use of 8 high-quality compositions. A particularly good effect of rose-shaped or concentrated when applied new cosmetic products obtained from topher bibactive offers is observed in the case when in the TR duct. compositions are also present in May

Cosmetic preparation containing 20 extracts. The selection of a suitable herbal can include herbal extract, and also the extract is based on a well-known ordinary and other additional and enriched compounds, the use of such extracts in the composition, the flavoring component, and the carriers with a change in activity, acceptable for cosmetologists and therefore, it will adapt to the goals, contain a bioactive product obtained from the tor- 25 content of cosmetic preparations in accordance with the requirements and needs of patients. The present invention is characterized by the following examples: 0.10 wt. 95. Example 1. Based on 1000 kg

Carriers can be used with water-based solutions of air-dry, unrefined peat-based alcohols, all types of emulsions, material treated with tar, napgels, foam-forming compositions of rimers, according to the technology of Polish and fatty carriers. Using the Mo patent 124110, a solution of one specific carrier, selected from 35 extracts from peat, bioactive ingredients from the group of the above-mentioned substances, dients in a saturated aqueous solution, allows to make different types of sodium chloride in the amount of about 10 liters. metic preparations in accordance with the Solution filtered through a sintering ke- invention, such as tonic ramic material when the product is lowered, creams, balm, milk for 40 pressed in order to clean it skin cleansing, etc., for everyday before desalination. The preparation of such body care, as well as shampoos, in particular, the pure solution contains hair substitutes, foaming agents about 9595 Mass of dry mass. Dry oil for baths, all with additives obtained from it, is about 32% by weight of the solution. peat bioactive products. 45 The volume of the pure solution is approx

Extraction from peat is more bioactive than 7 l. products (abbreviated peat extraction, the clean solution is diluted 5-6 times), obtained from the original unpurified distilled water, and in the diluted peat material, such as 50 is carried out using the reverse osmosis method of balancing the amount of myosmosis and using the 0235 device. BI, AB, Ge, Mo, Mp, Si, 5, ralnyh salts - mainly MaSi -

Mi, Sa, DIA and Ma; organic compounds are separated in the form of permeate. Desalted salt, such as amino acids in a free composition, contains approximately 65-7095 of the form and type of salts; polysaccharide, sodium chloride in solid form. Obtained - partially decomposed/reacted - in this way, a solution with a volume of 6- in the case of hydrolysis - to deoxysaccharide - 7 l is concentrated 4-5 times in a rotary dov and/or aminosaccharides. Peat, often - the Bissni evaporator to obtain a concen-

nshnnnshnnnlnlnltltlLllLlzhlLlLllLOLOTSDCD0ГВШООООООООООООООООООООООООООООООООООООО 19 25742 20 rirovano rastnor, containing causes of varicose ulcers! legs Ulcers were treated - 2095 dry exudates. The product is treated with a gel preparation, while the resulting concentrated solution treats and cleans the affected skin around them, using a centrifuge, and washes it with ointment. It is believed that the addition of cop-

Non-flammable (flow separator), and then 5 steroloid silica promotes filtration through the rum filter and drying, while tra-

Withering, withering and elimination of peat ingredients

The resulting microbiologically clean solutions are responsible for the treatment and do not dry out the spraying effect of the drug. Fat component! by drying in an Appluygo dryer at a temperature of 10, they help to preserve the elasticity of the crust of the tour at the exit of 90 and temperature, established wound (scab) and skin. The obtained re-infused at the entrance, 18070. The results are compared with the results of the odorous powder equal to approximately 200 g, treatments on the control group of patients

Example 2. The product, which is treated with a new method, as in example 1, is used to prepare 15 from a group of patients suffering from pharmaceutical compositions in the form of disease for many months, gels and ointments, which also contain herbs (sometimes years) without noticeable improvement. extract, which synergistically strengthens patients who have undergone treatment, and the effect of treatment for some diseases is similar to the invention. bathroom For example, gel and ointment from varicose veins - 20 show the best results! already in the

Noah's ulcer; The legs are treated as follows for the first few weeks: 20 g of horse chestnut extract with a control group of patients, 10 g of kale extract, Example 3. Products, preparation of dulia, 60 g of glycerin, 0.01 g of TTR in the form of example 1 is used to prepare the powder obtained as described above in 25 nia pharmaceutical compositions in the form of example 1, 0.1 g of salicylic acid, 1.0 tablets or granules, which are placed in g of distilled water and 8 .8 g of Aegobia? capsule. Colloidal silica is used for Sterile obtained from peat preparation in the form of a gel. bisactive composition in pide powder

The liquid (non-volatile) ingredients are combined with the carrier in a weighted volume and sterilized before use with the aid of 1:9. As a quality carrier, heating with a reflux refrigerator is used MUMATEKhe (trade name within two hours, Herbal extracts of the product Firm Eastman-Kodak), the mixture is combined with glycerin and hydrogen, dissolve lactose and lubricants in TTR weight, as well as with menthol, and Kk is obtained in a ratio of 44:1. Lactose is gradually added with creamers particles of 50 mesh and MUMATEKHU TI melt with constant stirring, which are crushed in such a way that approx.

In a similar way, 7095 of their weight passes through the composition in the form of an ointment, using a total of 100 meshes. From a part of the resulting mixture, the blowing ingredient: 20 g of the extract of cashew- 40 of the active composition and the carrier form a horse's pelvis (prrosasialaseoi5), 10 g of tablets , containing 5 mg of active ingredients

Extract of capendula, 0.1 g of salicylic redients. The total mass of each tablet of acid), 0.1 TR in the form of a powder, loluchen- is 50 mg. The second part of the mixture as described above in example 1, m 2.0 cm of the actinic composition and the carrier of the grains of "degovia" (colloidal silica). 45 is diluted using 0.5 ztanol (40 vol.965). 8 as fatty components of the granule are passed through a sieve and a mixture of the following substances is used: 22 g, if necessary, painted, and zazucerin (eisegipe) and 45.98 g of vaseline, then mixed into capsules in such a

Herbal extracts are sterilized by heating, so that each capsule contains the power of heating with a reversible refrigerator- 50 5 mg of active ingredients for approximately 2 hours. Liquid TITR is used in a mixture with a carrier, which ingredients are carefully combined in a ratio of 1:19. with silica to obtain a gel, which Tablets, obtained as indicated, are, in turn, ground with water, tested for the purpose of measurement with liquid components, cooled to room temperature for 55 days in an artificial disintegration. With gastric juice at a temperature of 37-20, a stable ointment is poured, which does not disintegrate using the YegleKa equipment. Yskusst- is divided when stored. Venous gastric juice is prepared as follows-

Gel and ointment obtained as indicated: 2.0 g of sodium chloride, 3.2 g above, simultaneously used for lepepsin, dissolved in 7 ml of hydrochloric acid

oil and add distilled water to a clean (clear) liquid without up to a total volume of 1000 ml. The pH value of any solid substances. They have a yellow color of the obtained solution. The pH value is 4.28 and 1.2. Tablet disintegration time, ztanol content - 45.92 vol.95. A dinner with a diameter of 5.1 mm and a total mass of 5. The acidity, which is considered to be 0.0498 g, would be minutes. of salicylic acid, makes

The following examples relate to many cosmetic preparations containing at least 0.1 wt.9%, namely 0.23 wt.95%. When stored for 12 months according to the present invention, the device has not changed any - different compositional forms and 10 specified characteristics. And creations for various applications, Example 5. The procedure containing the bisactive healing additive described above in Example 4, with the same ingredients obtained from peat, is followed. with the difference that instead of an extract of

Among the other descriptions are such preparations), masks and aromatizing compositions as tonics, balm, 15 TOPAMA H4AZOV use flower extract, cream, milk, shampoos, foaming nail polish and composition RIMO5 H4ab25 bath products, etc. (also a product of ERabtuk 5upivyukomzhm

Example 4. In a reaction vessel, 7araspozhusp RoPepa-Agot) with the same equipment with a stirrer, place 150 g of chamomile extract obtained in the same molar and volumetric proportions. The preparation of the tonic ractsygey of the chamomile flower solution is suitable for dry and tender skin: water 1:1, and 1 g of TTR melts, as described in the skin. It is also pure liquid. 50 tU without any solid particles is added to the resulting mixture. The value of glycerin. Three ingredients are mixed until the pH is 4.30, the total content is to obtain a homogeneous mixture. Darkness 25% ethanol 45.82 vol. 90 and oxygen, so the vessel is poured with a second concentration of 0.27 vol. 96. When stored in a liquid mixture. It includes 12 months, the drug does not change, it consists of 340 g of a solution of ethanol:water 95:5, 1 g of sleep properties, as well as the drug, salicylic acid and 0.5 g of menthol. Two preparations according to example 4. The mixture is mixed to form a single 30 Example 6. The procedure of the native solution is repeated. After that, add:- from example 4, except that they pour 3 g of the flavoring composition instead of the chamomile extract, choose the extract

TIAMA NiAZOV. TNAMA N4AZOV are produced by sage leaves, and instead of TISHAM by Rartuk duct BZupisiukozhm 2araspozhusn NIAZO8 they choose a flavoring compound

Roiepa-Agota (factory of synthetic aro- 35 item GECA 90368 (RoPepa-Agogaa, matting substances RoPepa-Agota, Var-Uuagzam. Extract of the leaves of sage polusawa, Poland). The solution is then brought to tea rooms with the extraction of dry leaves of sage with a total volume of 1000 ml , adding 454.5 g of ethanol at 50'C, and it has a brown-" distilled water, mixing it color, the characteristic smell of sage, we continue until it forms a density of 0.91650-0.9503, it contains 52-th homogeneous mixture. In the above-mentioned B5z0 ztanol. The resulting agent for the ear method is used 8695th glycerin, and for the skin it is especially suitable for fatty menthol and water in accordance with the required skin. It is pure and homogeneous Polish RIagtasorea ERIM is a solid liquid that has a dark yellow zero in a concentration of 9595 in accordance with 45 color, the value of pA, the content of ethanol and Polish industrial standards, acidity are recognized as similar values

BM-75/6193-01. according to the composition of the skin care agent

The peat extract used in Example 4 is dark-cinnamon: Example 7. The following composite liquid with a density of 1.020-50 is a particularly effective gel-1.090 g/ml, m dry solids content for the prevention or treatment of sostanlyast not menvee 595, zchana- rhodontosis, g: the pH of the 15th aqueous solution is equal to Chamomile extract. 34.0 '5.0-6.5. Chamomile extract is a beautiful brown liquid with a density of 55. Salicylic acid 0.3 0.9150-0.9503 g/ml and the content of menthol, 02 zero 52-50 vol.95, TR 01

Tonic preparations, obtained as described above, are suitable for flax gel 8 quality for all types of skin. They represent the main Tires 23 2bt42 24

Example 8.8, a reaction vessel of 0.9160-0.9503 g/ml and a volume of 2000 ml, equipped with mechaninol 55 g... with a Czech stirrer, is carefully introduced. The resulting preparation is suitable for all components!: type of hair It is pure M 270 g of chamomile extract, obtained as a transparent liquid without any 5090-nm yellow-brown solid parts from the extraction of chamomile flowers, with ethanol; The extract appears red-co- pH value, ethanol content, total . with a permanent liquid having a density of 0.9150-0.9503 g/ml, as well as a stability after 12 months of storage, remaining approximately 55 vol.; 10 are unchanged and have the same amount of glycerin, 8655, according to the requirements, as in the preparation described in the application of Roy Rpagtasorea ERIM; re 6.

Example 10. The procedure described, obtained by extracting the roots in example 8, is repeated with similar results from the medicinal mylanka I096-nkm. The only difference is that the extract is red-brown, the density is composed of chamomile and TIPAMA H4AZOV composition is 0.9530-0.9810 g/ml, and the content is tannin drops - approximately 75 each; I also flavored the composition, 1.0 g of the invented concentrated 20 KEEGTA 90368 (a product of the same Gabguk peat extract, which was Bupistukozh 2garaspomus RoPep-Agopt) in a dark brown liquid with a plot of the same sequence and in the same density of 1.02-1.09 g/ml, contains non-free, used herbal tea 295 manov hChlopmda, which calculated extract has an olive-pink color, is filtered by sodium chloride, content 25 density 0.9150-0.9503 g/ml and the content of dry solids, the composition is not limited to ethanol, approximately 55 06.95. The preparation is 595, the value of the 19th water rat is suitable for all types of hair. of the extract solution is 6.0. Example 11. Learned cosmetic

The name is more than an ingredient! tidatel-koe-'molochko is a dispersion of fatty acids but mixed. Tula, on the other hand, is filled with substances that act both chemically and mechanically on the skin. In fact, salicylic acid in 260 g of Z55 is due to the convenient way of applying it. To the mixed solution, add 383 g of distilled water and 5 g of leather for a better interaction of the liquid.

Н4А308 and mix until it dissolves. They easily penetrate into the deep layer of the homogeneous solution, and thus prevent

The drug is subjected to analysis and preservation of the skin due to age. Kosye //-. in bottles for retail trade, metic milk is mainly used in a volume of 200 ml. The resulting preparation 40 is used for cleaning dry and delicate skin. aggressive volatile oils, including an opalescent liquid, which often contains approximately 45 06.95% ethanol; other herbal extracts, such as natural pH equal to 4.5; normal acidity, 45% camomile or from the extract of the germ, which is calculated according to salicylic wheat), the addition of bireactive products obtained from toric acid, amounting to at least 0.1 wt...

The product is suitable for light hair. tic milk is even more painful and enhances "7 The quality of the drug has a long-lasting positive effect. In particular, the months of storage remain unchanged. 50 the composition of the new product is as follows:

Example 9. Repeat the procedure, that '0.05 - described in example 8, with the exception of Aloe extract 20.00 instead of chamomile extract and Glycerin 3.00. TCAMA NAME composition is used in 55 Zucerin 2.00 of the same sequence ssotnoshe - White paraffin oil: horsetail horsetail extract and aromatic oil 1.00, tying composition RIMO5 H4Ab25, Tristilamine 1.00

Herbal extract of horsetail is a herb for cattle? (colloidal brown liquid with the density of silica) 4.00

23 and 25742 26

Example 12 Improved resolution of 1-8 weight 90, salicylic acid and that: after reduction, the used TTR is observed with menthol in a water-alcohol solution, and carefully selected. Nocturnal nourishing and restorative 5 goths, thyme, aloes and similar creams of TTR are used in the amount of 0.01 part of Dobank medicinal plants 1.00 weight 956 and combinations with herbs. (the choice depends on the type of skin for which the cream is intended due to its effect on elasticity) sometimes it accelerates the application of the drug at least 0.05-1.00 wt. 96, 10 on the face, as well as its penetration into an antibacterial preparation in the deeper layer of the skin, enhancing the effect of 0.05-1.00 wt.%, synthetically, the healing effect of active aromatizing compositions in a peat composition and herbal thickened 0.01-0.05 weight 95 and fatty carriers. The preferred recipe is in the form of an aqueous emulsion, consisting of the following, weight 97.00-99.50 weight 95 of the entire composition PR 0.10

It is necessary so that the fatty composition would be a good carrier for active ingredients Glycerin 500 redienton and so that; she was pleasant - Menthol oo my for the skin. Preferably, it is 20 Salicylic acid 0.10 diluted with emulsion (all quantities are given in Ztanol (conc. 9590) 10.00 wt. 95) 35-45 sugar, 8-14 vaseline, flavoring 2.5-4 olive oil, 6-10 glycerin composition 0.0 and 35-40 code. Preferable herbs - Distilled water, these extracts are flower extract - 25 addition to 100.00 marigolds, chamomile extract, extract Example 14. Thyme shampoo composition, etc. prepare in accordance with the current

Preferable recipes are - recipe, g (nes.9o) . the following, by weight: Tranyan extract I 1 recipe 30 Fuller's 15.0 (7.5)

Zucerin 395.00 Leaf extract

Vaseline 11.50 stinging nettle 20.0 (10.0)

Olive oil 3.13 SAMA! 5855-11

Glycerin 7.80 (detergent) 30.0 (15.0)

Water 38.00 35 SAMA! MO-3

MIRASIMA (antibacte- o (detergent) 20.0 (10.0) I , in Vial drug) 0.40 Avzeripa (aseptin) 0.4 (0.2) te 0.05 Ztanol 1.6 (0.8)

Extract of nails 010 VNOMOROII.

Synthetic flavors - 40 /" preservative) 0.04 (0.02) leavening agent sodium chloride 6.0 (3.0)

Total , 100.00 Boda 106.96 (53.48) 2 recipe Total 200.0 (100.0)

Zucerin 47.00 Kc 92 parts by weight indicated below

Vaseline 8.50 45 shampoo compositions add 8 weight

Olive oil 3.08 parts of TTR to obtain 100 weight

Glycerin 7.90 parts of the shampoo according to the invention

Water 38.00 niu Bbmesto extract of burning leaves

MIRASIMA (antibacterial! can be used; other real drug) 0.40 50 herbal extract.

TR 0.05 Primer 15. The following is being prepared

Chamomile extract 0.02 Chamomile composition, g:

Synthetic aromas - extract of horse's salivary substance 0.05 chestnut 15.60

Total 100.00 55 Cuticle extract 22.00

Prim mer 13 Preparation for pri- SAMA. 585-11 30.00 change after shaving contains TR in SAMA! MO-3 20.00 the quality of the peat extract and the amount of Azeriipa (aseptin) 040 and 0.01-71 wt.u5, extraction of the extract! in Ztanol 1.60 in the amount of 1-30 wt. 95, glycerin in kol- VROMOROY. and 0.04

Sodium chloride 6.00 is useful for side products

Water. 106.95 salt use and salt quality for

In total; 200.00 baths, as they can provide additional

Example 16. Toothpaste has a meaningful beneficial effect on standard TTR diet as a concentrated 5-activity bath salt. By-products of peat extract in the amount of 0.01 - the product is tested with the corresponding o00 - 0.10 wt. b5, safflower oil or their combination according to its chemical and physical position or other fruit essence properties in the Balneological Institute - calichestvo 1-10 wt. , glycerin in a cat and in Poznań, in Poland, for the improvement of the personality 5-10 weight, herbal extracts 10 possibilities of its use in cosmetics, in the amount of 0.10-10 weight. and cleaners of quiet baths. Since the test substance in the amount of 20-35 wt.95, no carriers and bleaching substances in the desired properties of the product were found by blood tests, it was allowed to use it for 1-2 wt. cos-

Titanium dioxide can be used for 15 practical purposes. . used as a whitening component, the following is preferred; th recipe, g:

TR by itself can serve as an antibacterial additive; an extract containing sage leaves, chamomile or flowers, but 20 occluded TR 97.00 is used as a useful herbal extract. Oil or a composition that

The preferred recipe is the following essential oils 3.00 g: Measure 18, New balm for

Precipitated 25 hairs contain TTR in the amount of 9.01-1 calcium carbonate "150.00 wt.bo, herbal extract in the amount

Magnesium carbonate 60.00 0.01-10 wt.9o6, anti-electrostatic

Glycerin ' 70.00 component! in the amount of 3-4 weight,.9b, com-

Herbal extract 5.00 elements that prevent excessive drying of hair and skin

Titanium dioxide 10.00 z" to 2 web.b5o, glycerin in the amount of 1-5 " - to etc. essence) 5.00 total 100 weight 95.

Water 400.00 ZB As an anti-static agent

Dye The following component of this balm contains . quantities of trimethylamine alcohol solution and salt

Example 17. Preparation of ammonium chloride salt obtained from fats for baths. In the method of obtaining vydelen-amines of animal origin; into a bibactive product made from peat, as a thickener, which plays a role in the present invention, and often as a stabilizing agent - space when transformed into a liquid form! in technical alcohol; as an agent, a pre-powder, there is a stage of desalination that prevents excessive drying, in which sodium chloride separates hair and skin - vegetable oils, as a by-product. In the higher plane, the cosmulshymynate by-product 9595 is simultaneously recognized as a constituent agent; and glycerin - for lightening sodium chloride; the second is the mineral application and absorption of the balm, the salts that separate it are recognized especially by its active ingredients, i.e. b Calcium salts, magnesium salts, I oskovnoMm TTR and herbal extracts. Since the acidic chloride and sulfate salt environment prevents the reproduction of bacteria, the products also contain some organo- balsam in accordance with the invention. also preservative, within the crystal structure: quiet lime under the name VNOMOROI. and aro-inorganic salts. 55 matting composition.

These organic compounds are preferably the following components of TTR and are recognized - the middle recipe, weight 95; of others - by polysaccharides, amino acid-Alcohol solution, fulvic acids (Mis acids) m.t.p. trimethylamine and salts

The presence of these components in brines is ammonium chloride 3-4

29 25742 zo

Cosmetic alcohol 3-4 ducts of the present invention, that is. to their 0.01-10 bireactive characteristics and to the

The thickened herbal content of these products, in particular, extract! 0.01-10 s from the point of view of their use in

Glycerin 1.5 5 honest pharmaceutical preparations, Yes-

Vegetable oils The following juices will be used up to 2 lei

Citric or fumaric acid: uric acid. 01 TTR OF THAT RA? - peat preparation (torveOoMOROI. 0, cow brand Peat Corporation, Wroclaw,

Aromatizyruyushchaya 10 Mudiapa Street 2, Poland). composition 0.3 IEM - interferon, exists in the form

Distilled water Up to 100 ubiquitous cytokine (tissue hormone).

Example 19. Cosmetic masks Genya IEM are present in all cells. they are known as cosmetic pre- IEM is mainly induced by protein paraths, serving for many purposes. 15 or glycoproteins. Substances, stimulants

Due to the fact that healing muds that stimulate IEM genes to produce IEMs, they are called inducers with beneficial effects. The process of the body and the body, it is also possible to apply IEM, is regulated by the high-precision biochemical complex that remains after the extraction, which is obtained with the help of a simple process; detection! negative and positive regulatory genes for the separation of bioactive inputs, control

Some of them are peat compositions for IEM cosmetic products. Nebolshie ko-cheskh tselya, Ostavcysya posle zkstraklychestva THEM can be produced sponsii peat contains rastnor of active bodies, cheaply, without any detectable which are released in the process of another 25 inductor. Such IEMs are sometimes called "typical hydrolysis due to unusual M", but due to the high sorption capacity of thorium, IEMs exist in nature in three phases after neutralization. It is possible to use it as a useful TEM-c (or leukocyte) as a component of cosmetic masks. With this - 30 IeM-V (fibroplastic) and the enrichment remaining after zxset - IEM (immune). peat fractions with a large amount of cen- IEM-se and IEM-D belong to type I-IEM, their components add natural light, and IEM - to type NAM. The main biological actions of mud and the humic acid fraction of IM are compounds that naturally have anti-viral, anti-proliferative (proto-peat, and they are separated in the process of receiving) and immunomodulating action of peat particles. . Various compositions of alkaline hydrolyzate are available for sale. Forms and EM in the form of natural and recombination are tested in the above-mentioned binary preparations, and they are used in

Balneological Institute and find 40 quality drugs for the treatment of tumors suitable for cosmetic use, viral and some other diseases. lazy

The following is recommended. - cytolytic T-lymphocyte. composition, g: MK-cells - naturally, cell-cells

Obtained after 45 lers, peat extraction 160.00 Sh-1, 0-2 - good lime inter-

Natural healing leukinia, mud or peat that stimulates the proliferation of 20.00 T-cells and other lymphoid cells,

Fraction of humic including B-cells. acid 10.00 50 NRMI 1640 - tissue culture (medium)

Magnesium carbonate 10.00 for the lysis of human leukocytes and !

Zinc oxide 500 dr. (abbreviation of Nozmeiya Ragk Metogia!

DCitric acid Inziyshiye, Vochayu). or similar to it 01 ROS - fetal calf serum

Herbal extract 55 (for analysis with leukocytes, it is necessary to check the herbal Bo

The material in the form of a powder may contain mitogenic substances,

Distilled water imitating the action of interleukins).

The following provisions and explanations of EMSU - zncephalomyocarditis virus, refer to the biological aspect of the moss virus (Motsve risogpa khmigui5), nepa- ,

31 265742 32 togenic for a person, it is often used in a certain amount and cytokised as a virus with a control non. infected in biological anapyses. Tolerance to the inductor - naz-

A-549 - the adenocarcinogenic cell line is also hyporeactive. human nom - used in biological 5 Occurs after the introduction of a single dose and IRM analyzes due to its high inducer, for example, after 20 hours of sensitivity to IEM c, b and in the Line of action of RVY. on the inductor (for example, rus is recommended for such use); cells stop further examination by experts of the IEM (World Organization of IEM. Hyporeactive state of healthcare, Geneva), after IM-10, it usually lasts about 7 days. It is standardization. it can be full or partial. Such

MT - bromide 3-14,5-dimethylthidzol - reactivity makes therapeutic 2-ily-2,5-diphenyl-tetrazolium difficult. The reagent is used as a strong inducer and/or de-used to measure cell lysis, making it ineffective. Weak IEM - or cell growth in certain bislogs - 15 inducer! either they do not induce hyporeactive analyses, with the help of the scanned State, or the tolerance of a clear UEIT (Napshep et al., is insignificant.

Igaglopo!i, Met, 1980, 119, 203-210). Some natural medicines, such as muscle cell line, made from medicinal plants, commonly used for the analysis of human or muscle EM and TME, are regulated by immunomodulating properties. we. TE gives the impression of one

TME - tumor necrosis factor, cy- of them. TTR changes many different toxins (relatively small protein, immune functions of myo mi and myo. It is very sensitive to proteolytic initiates balanced immune enzymes), produced by monocytes 25 stimulation by means of the ability to carry and macrophages (TME - also known as specific activation of all effectors - tumor necrosis factor cachectin, transport pathways (C04-helper, weakly CO5-sup-. causing cachexia (exhaustion) in humans and spring, STI, MK-cells. and activated-, animals), produced after a stimulated macrophage ) without cytotoxicity for viruses with GRO (lipopolysaccharides), 30 normal tissues. bacteria and many other agents, TR is a tonic vehicle, toxic for many infections, effective for healing common wounds. Low-viruses of cells and newly formed TTR doses of cells weakly stimulate produna; it can also play the role of factor 1-1 and І(/-2. High doses of the mortar for fibroblasts are associated with inflammation and inhibit the synthesis of cytokines, inflammatory reactions. ) is produced by T-tni through the following methods: cells and some other cells - RVI from the blood of healthy eye donors

We. washed with the help of treatment with chloride am

RVI - leukocytes of peripheral chromonia. The cultural environment is the ARMY, separated from the light layer of the crown - 1640 plus 1095 ES5. Cultivate the clot (honey - leukocyte film) at a rate of 8.108 cells/ml for 20 hours (intermediate phase between red blood cells at 37,595 С, antiviral activity (blood) cells and plasma), interferon activity is analyzed by cycle

RVI reactivity. of individual donors of 45 topical inhibitory effects on various cytokine inducers of EMSTU in human AbB49 cells. It also gives the impression that it depends on the he- they use the MT method to measure the linetic system of palm trees. They beat the iden- sis of cells. tificator! TME activity is measured in cells of high-responding and low-responding responders. Zto 50 929. To determine the type of IEM, it also applies separately to the sensitivity of the RBI. EM samples are processed differently on TtTR. with anti-IEM serums for 1 hour.

Variations of individual responses to the induction of their antiviral activity are compared with IEM or TME inducers, which are more clearly defined as untreated drugs. 55 Again, they show that the TR of stimulants, and not very strong inducers, leads to the production of xenogeneic interferants such as viruses, which causes inflammation (IEM) and tumor necrosis factor (TE). due to the fact that the reactions to a weaker inducer, Syavet, corresponded to the dose. tor was of the "all or nothing" type. 33 its biological activity as an immunorespiratory tract and varicose ulcer stimulating and cytokine inducer. lower legs, additional treatment

They observed a significant deviation in the vaginal mucosa and periodontal disease on the TTR of leukocytes of each donor of the disease. blood RAI of several donors turned out to be 5 of the clinically observed immunological tolerances. Therefore, TTR can be used in zhet are a reflection of the genetic quality of the immunomodulator in the support-fong. general therapy of some tumor diseases

They use a potent polyclonal. TR is taken orally (tablets of lonal antiserum, such as an-10 5 mg) or locally, ti-IEM-s (Satei), anti-IEM-a and y (Natamua). Especially relevant and important are K. Rapiez and anti -IEM (Sapiei) is not aware of the fact that RVI treated with TTR of antiviral activity in the body during 20 hours at 37C does not give RVI larvae treated during a hyporeactive state, as they are TR. 15 retain the ability to produce IEM

The results of analyzes of neutralization after induction by means of MOU turn out to be similar to prints (MemsazNtse Oezease Migiz - Newcastle finger of each individual donor crab-pathogenic virus), very strong inv. In other words, the proportions of the IEM conductor types.

IEMs induced by each individual, 20 Attached table, 1-23 are significantly different. The division of RVI into various biological, for example, viscous (anegepa) and non-viscous psychological, hematological, and imi- (popadepti) fractions can strengthen the immunological generalization, these tables have induced cytokine synthesis, are quite clear and can serve

Hyporeactivity (tolerance) to the source of information for the biologist, the induction of IEM by means of MOU, which leads to sleepiness and biologics, is observed within 20 hours after the sleep activity of TR. primary stimulation of REI with the help of It should be noted that the concentration

PR, is either minimal, or there are no active ingredients in pharmacists. Bbe Seven packages of batches of 30 technical preparations, as indicated in point

TTR, tested in the RVI of a person in the category of 12 formulas; inventions, perhaps due to IEM and TME inducers, were more active than in cosmetic compositions in terms of induction of IEM and/ (as indicated in point 13) in snow with salt or TME. Optimum concentration of TR by blowing causes. for the induction of IEM, 300-100 ng/ml 35 Pharmaceutical preparations! also prepare for the induction of TME - 100-200 udg/ml, in unit dosages, where the content

A dose of 209 ng/ml may be subtoxic - the active ingredients are below the threshold for RVI, however, the synthesis of TME by rapid control, for example, with tablets, is much faster than the synthesis of IEM, where the concentration is selected accordingly - it is faster than growth a small cytotoxic tablet containing 40 effective daily dose (or its part)

The active ingredient can be made from the above. water about the fact that the active principle of pharmaceuticals, TTR-based pharmaceutical preparations, for example, TTR, in granules with which the immunoactive fraction of capsule filling, preferably extracted peat, containing organic matter is the main only 5 wt. 95 in order to obtain a sufficient size of the tablet and acid, reducing the acid, substances that correspond to the operation of amino acids, m mineral salts, which are on the apparatus that makes the capsule including microelements, LDBO for 50 wires. Votnkh sosStavliaet » 2400 mg/kg reg 05. Another reason was that pain

No mutagenic, no genotoxic, or embryotoxic pharmaceutical drugs were found to be taken internally, and an active ingredient, no teratogenic or carcinogenic dient spreads throughout the body. activity of TTR, TTR does not block any 55 Although it reaches skin cells in very allergenic properties, and also does not have low concentrations, the therapeutic effect is significant. properties, in addition, cosmetic compositions

Therapeutic indications include this - in contrast to fFpharmaceuticals - chronic and recurrent inflammation Czech drugs - used in non.

35 25742 In controlled concentrations, it should have a lower content - locally, with varying degrees of penetration of the active ingredient. novenia to different cells.

Some compositions, such as Naxnen, as in the case of toothpaste-shampoo, which dissolves almost immediately, which is in contact with the saliva, are not in contact with the body or the oral cavity, where the penetration by the hair lasts for a short period of active ingredients for a significant amount of time, we can contain correspondingly lighter than when in contact with the skin, but more of a healing component; other concentrations of active ingredients can be used several times a day and later - 10 points below.

Table 1

Acute toxicity. TTR taken orally affects the biochemical parameters of the blood of rabbits

Dose Day Define parameters!

Half tr, issle- Creatinine, Total protein, | / z-globulin, g/kg dosage mg 96 g/l g 96 o 0.0 0 1.09-0.03 b5.053.49 0.53-0.00 7 1.0320.02 62.0- 0.53 0.56-0.01

Female 20 0; 1.06:5:0.01 58V,0-1.46 0.50-0.02 7 1.1420.38 57.8-1.54 0.54-0.01 at 0.95:0, 12 70.3х3.52 0.55-0.00 7 0.9430.13 60.02, 34 0.57-0.00 оо о 0.80-0.11 73.8-3.23 0.72 --0.06

And 7 0.82:0.13 75.3-1.02 0.79-0.03

Male 2.0 0 0.8850.05 64.6-2.86 052-010 7 1.24530.34 64.6-2.03 0.67-0.07 o 0.85-0.03 58.5: :3.19 0.57-0.02 ! 7 104-012 57.6:4.658 0.56-0.01

Table 2

Acute toxicity. The effect of TTR administered orally on the activity of transaminases in the serum of rabbits

Dose day

Pol tr, issle- Alanin Asparagin

EE Che cheya raza ME" raza ME" 0.0 0 8.b7k1.20 22.3352.60 7 9.67250.33 28.67-3.75

Female 2.0 0 10.3351.765 18.33-4 09 . 7 12.3353.52 20.00-5.03 . 5 o0 11.33--1.56 22.33-3.52 7 11.00-3.05 20.67-4.66 ! , 0.0 o 10.335:1.76 23.0053.05 7 12.00:х:2.64 25.67--417

Male 20 (o; 9.00-1.00 18.00--1.52 7 9.0020.57 270.56-3.52 50 0 8.00:1.00 18.00--1.00 7 11.3321.66 23.00-:1.99 x - (approx. trans. IM - ME - immunizing unit). ,

nnshshnshshnshyashzhNnLzhyazhShyaA OO OO OO OO A O LO I A A I LO LO LEAD OO LO V

Table 3

Acute toxicity. The influence of oral TR on the hematological parameters of rabbits. Dose Day | Defined parameter

Paul tr, | Mosle- ' 0 dova- Hemoglobin. Hematocrit, Deikopyt Red blood cell g/kg | nia mg 95 95 x 103 x 105 o (c) 12.4-0.44 З8.3-1.85 7.32-0.43 5.2130.20 7 11.8-0.63 37.7- 1.20 65.30-0.66 511-011

Sdmka/) 2.0 o 11,550.31 zB5.7-0.88 5.8930.58 5.86b0.55 7 12.3-30.48 38.3-0.66 5.40, 76 5.69350 ,11 (9, 12.3-0.14 40.7-2.6 7.35:0.99 5.42-0.20 7 11.5-0.23 37.350.33 85551.79 5.0850.19 at 12,020.85 37.3x1.20 11.10:0 63 4.53:0.25 7 11.9--0.61 35,721.85 10.80-0.94 4.54-0.19

Males 2.0 o 12.8-:0.265 43.7-4.80 9.94-2.00 4.46-0.65 7 11.8--0.39 34.72.02 11.06: :1.08 5.37-0.56

12.7--0.63 38.72.40 9.521.36 4.595-0.16 7 10.6--1.04 4.052.08 8.87--41.73 B. 72-0.56

Table 4, Acute toxicity. The effect of oral TTR. per mass of rabbit organs /

The mass of the organ, 95, is the total mass

Legkov 0.72-50.8 | 06150.17 | 0.67-0.07 1 0.56:0.05 | 0.5450.09 | 0.7120.14

Heart 0.2350.01 1 0.22:0.021 0025:0.03 | 0.24-0.02 1 0.23:0.013 023500

Spleen 0.057:0.0110.051-0.0010.07950.021 005-001 | 0.0620.01 | 0.0450.01

Liver 2.8550.15 | 3,02-50,08 1 3,220,37 | 2.82-0.09 | 2.77:0.28 1 3.1250.06

Kidney 0.5930.03 1 0.52-0.02 1 0.50250.01 1 0.48-0.03 | 0.55:0.01 | 0.4930.03

Adrenal gland 0.016-0.011 0.01550.01 1О0.020--0.0110.013-0.01 10.013-0.02 0.012-50.0

Ovaries with uterus! 0.58-50.04 | 0.3950.02 1 0.60-0.04 - - -

Seeds - - - 0.30-0.01 KG 0.3230.03 1 0.3620.02

- 39 25742 40th; Table 5 7 Chronic toxicity. Effect of oral TTR on hematological parameters: rabbits

Dose Day Defined parameters

Paul | tt, that GU -

And dova hemoglobin, Hematocrit, Leukocyte Rrythrocyte g/kg niya mg 96 oo x 103 x 109

Males 00 o 12.2-0.05 zv 2-e1.71 9.33-0.79 v. 10-0.56

From 12.3:50.15 40.7-0.33 vUzh1 18 65.34-0.23

And b 3,030.55 41.7x1.30 o.58-1.12 7.32:50.70. , 12 13.5--0.19 40, 730.67 12310 6.30--0.46

Males 50 o 12,930.55 35,751.82 7.5220.78 514-0.47

C - - - - b ro 19.3-0.35 41.032, 0 8.08-1.17 6.38-0.11 , 12 13.70, 39.3-0.94 a,361.01 6b ,19-0,19

Males 150 o 14.20-0.21 36.721.81 819520.16 " in.3az0.16 "

From 11.0550.26 38.5:1.53 8.83-0.78 5.68--0.40

I 6 12.40-0.63 37.3x51.45 8.18-0.06 b,84-50.10 12 13.70-0.32 39.0-0.58 8.24-0.04 b, 54-0.54

Female| 00 |; 12.6-0.27 40.2-0.83 7.07--1.18 5.5320.17

From 12.1:023.,. 39,830.72 8.16--1.01 5B.74-0.12 b 12.430.86 42.3-1.20 9.78:1.59 5.863:0.24 12 12.5-0.87 37 ,7-218 10.90-52.16 4.60:0.29

Female 50 о 132-120 35.0н1.7О 744098 547060 a shi 7 Y 7 . in 13.0-0.55 39,321.20 7.25:0.96 7.08 with 30.94 . 12 12.8-0.21 37.7-4.33 9.3150.35 5.02-0.32

Female| 150 0 15.2-1.15 38.31.40 8.50-0.54 609-008

Z 131110 47.0-42.80 810w0.76 5, 85-0.57 6 12.5-0.82 41.0w1.15 b.85-0.31 5, 613030 12 13.1-0.70 41.0-1.00 8.15--1.68 5, 92-0.13 1 1

Y pya-t p-- - 5 5 Z z m them 839 more B z tost sh) shchi 5 i. F -y a "Z ri: v! g- more sh w Z 8 -

Obov, - - ha iya 02 o- vZVye I-th di 8 z 3 Z

Vkhve g 5ypasho xx color 85 with your and gvOopIND " bot o zho i o v v t vyv Z 5 ze

VV V | and to her doFI Z5 | pcs w what X o

Va EE -E a 858 B |vazh o bozh yv|o 88. be o vy Fo - M t - i 55 x z87 8 x

Zh what - more Q: I in and 5 in U E pzhh go b" -

EE x 5 o uch E t E . ". -

WITH

With and in Io- Na Shto, not 5: tu mo vi yah

Z l - 3 Fo ost y Zh

A t V de 588 - SYA that vo in Sho-E

KE MOm FV FU Them

For 9 - o Fo -58 NU vo i « 5. o - - i

In | in 55th I oyu 5 r Mbh M Vl ee 5 ge) oyu Fo ZHE

WHAT 0 - F 55 -

BO v z u same tot vol v oh bo voy v h bi - o - tyu vl ob . ik x 5 55: oh Z tA What F Fi in F i x Mo Oh zbi 2 b - Fo so Fi i what 8 z -k - 58. av o o Vosl E . -e yuFtm than FF Z . -E Fo Fo bo so ne ie I":

Sh. Mr

With, I'll have them in n-' that at 2 o'clock 5, of bl still would EE! o m - . E | F

M so ah Bo M Sho g o i 1 to 8 -

E byu u bo os cha . ko " At Zhov ra E mol that Za t. ich She) ro i - chn ich - I «Ж with V. su sug9o Ii .

43 25742 44 ! Table 7

Bliyanie TTR nas the number of lymphocytes and the percentage content of T-lymphocytes (E-sockets) and B-lymphocytes (EAS-sockets) in the peripheral blood of rabbits

SHY SLIV NYSLII DRINK NS SNY NAAN

Control 6.6 5.o0 19.0 20.1 421 42.3 1 ml ЕВ5 2-20 -1.9 5 35.5 6.3 -2.05 тв 6.6 5.4 19.2 27.1 43 .7 47.7 (opt 1) -1.5 -14 41 32 -2.6 4.9 mg/kg per day

M x, tv 6.0 6.8 17.0 24.8 41.6 41.0 (opium 1) -1.0 -0.6 -1.9 2.9 1.3 21 5 mg/kg

PE n - the number of researched animals;

RVB5 - phosphate buffer solution; 0 - before the introduction of TIR, b - b days after the introduction of TIR, x - statistically significant deviation at p « 0.05 in relation to the value before the introduction of TIR,

X, 7 statistically significant deviation at p is 0.05 compared to the control group.

Table 8

The number of splenocytes after long-term TR therapy

TR 10 mg/kg TTR 50 mgkg

Time Control day day of entry p-10 p-10 week in weeks | RES/105 splenocyte Jewish | poison | yazhden | tjedene | anger | T-deer

From Z67157 156541 1120-328: | 33652407 772-236 151557 5 572134 1382547 1528-3467 292-827 12395280 232590 7 5188-45 13340 6391367 159544 72232587 141-563 а 466-185 175275 39594 132-356 412138 167-62 12 28718 1532350 287-131 156-395 З75х130 157-689 "Statistically significant deviation at p" 0.05 compared to the control group.

III

Table with

The concentration of anti-5NVS (195 75) antibodies during long-term TTR therapy

TTR 10 mg/kg TTR 50 mg/kg

Time Control day day and vBedeniya p-10 ' p-10 pos t in weeks byu, pr

From ZB 2136 1 880-097 9.20-1.467 1 820-040 1 6.901.37 5B.8231.40 | 6b5051.00 | 7.70-40.84 | 9.10--2.027 | 7.70-0.647 | 9,332,907 7 3.50-50.48 | 52030.74 | 4,4051,117 | 410-083) 3,500,837 | 3.5521.21 9 3.20:1.40 r 4.66-1.24 | 3.50-1.28 | 4.00-0.83 | 2,901.22 | 6b,3351.52 12 A, 800.74 r A 401.01 1 51151.09 1 5.5051.51 1 5.11-1.19 1 6.101.74 z Statistically significant deviation at p « 0.05 compared with a control group. And and, ! The table is right

The concentration of anti-ZNVS (75) antibodies during long-term TR therapy

TT 10 mg/kg TTR 50 mg/kg injection dose TR Hemagglutinin, Id, titer in C 1.75.40.60 1 6.37-0.85 | 320:0.877 1,501.70 AND 3.80-0.877 | 4.9050.74" 5 2.5050.70 | b12-51.16 | 2.2050.97 | 570-1.10 | 2.30541.41 | 5.3350.74

I 7 1.0050.89 | 3.8051.09 1 0.60-0.80 | 2.5051.117 1 0.55:0.83 | 2.5530.68" . and 9 0.40-0.48 1 366-124 ! 030-064 1 3253096 oo 4.3351.94 12 0.80-0.97 | 3.80-0.76 | 1 Table

Immunomodulatory effect of TTR (550)

The dose of RESLO 96 in-|YHemagglutinin" | Hemagglutyte sppenocyte! gave type 195 -- 75 nin "type 75 mg/kg 4th day where 4th day 7th day

Control Zo 4695111 | 13.5532 5.11 V.2--1.8 0.5 10 9977-1359 15.651.4 b, -1.0 84-11 10 8397177 20374, bach 1.0 9.77:51.4 i, 50 10 746-129 23.24, 727506 9.87:1.4 10.0 10 795-129 18.47-4.0 9.37-1.8 10.41, 25.0 10 560-145 16.372 ,5 B1-y1 9.57-1.1 10 40057 14.7-4.0 5.3--1.0 65.7-1.9 then 10 3757-67 11.37-22 | 5.1:5:0.8 5.716 250.0 10 3057267 9.57-2.0 48-11 5.3 -1.7 " Statistically significant deviation with the overall comparison 0.05 (1 - test

student); 7" Yua, title. !

Table 12

VEvedig TTR daily in 3 doses 4th day after - immunization 5AVS 10th day after immunization BNVO

Dose TR RESLOYE Hemagglutinin Hemagglutinin to od, titer (ro, titer oplen- 2 2

E-socket

Control 1 1x0.3 ml 15 13.73, 4695125 | 5.y21.3 oakh1.0 Z.8-1.3 841.6

Control 1

Хх0 1 ml 15 15,334.0 | 5795143 | 61-11 0О.6-0.9 901.7 | 8.5B-1.8 2.5 mg/kg 1x0.3 ml 15 19.47-3.8 3 8547-1901 7.41, Ty 104161 981.2 2, mg/kg 3x01 ml 15 19.075.01 7597139 | 7.1y-0.8 | 0.550.8 93.5-1.0 9.02-2.0 19 mg/kg 1x0.3 ml 15 19.57-54.1| 7951021 700.7 1 0851.0 104416 941.0 10 mgux

ZhoO1 ml 15 17.5:3.7 | 656128 | 7,571.4 1,312 8.9--1.8 8.8--1.5 . Table 13

The effect of oral TTR for 12 weeks on the immunological response of mice immunized with ZABS

Non-RES/102 hemagglutinin RES/1097 hemagglutinin

From 15.2:3.8 1 56556 1 6.0:50.9 | 1.51.3 114.7-3.4| 2556-67 | 8.7--1.0 7.9-1.0 gats, 110357 517Й17.5750.5| 2,902 123.57-3.7|I 4067-88 | 10,471.2 | 9.77 -1.0 13.82.4 | 422-653 510.9 0) 12.7x2.11 209541 7.1-1.4 B, 7-1.6 23, 07-6.1 1 9337248 1 7beige1.5 | 2.7y-1.5120.5y2.7y 43086 11.0 w1.2 | 11.0751.0 7 12.82.9 | 495585 | 4Aba1,1 | 0.5:0.9 114.055.1| 245348 | 88-16 7.551.6 20.5"w5.3 |11120w214| 7.970, 12.17w1.5 126.9-:7.7 4377-1171 11.37--1.0 1 10.30 4

From 150521 5331-67 |6,250.8 1 05:00, 114,152.8| 294-581 871.5 841.5 18.67-2.8 11049184 7.77-0.7| 1.9:51.2 118.2y53.4|515735301 11.9y-0.8 | 10.5751.0 12 1 155052.6 1 5735143 | 721.0 | 141.2 |18.32.6 1 25658 75-11 7.1-0.8 14.1-2.7 | 7705132 7,251.4 | 1.7х51.7 |19,054.1| 294-655 | 11.8y5041 106710 " Statistically significant deviation at p - 0.05 compared to the control group. There were 40 animals in each group and

Table 14

The influence of storage conditions on the activity of TTR from the point of view of its formation ability

E-socket at

Initial dose with room temperature activity temperature | temperature ac i to e | The temperature drops in the dark

Control in 13.5--2.4 12.8.52.3 12.8:2.3 12.8-2.3

OT mg/kg 8 15.8341.7 16.153.04 15.1x2.9 16.0-5.5 1 mg/kg 8 18.0-0.87 19.84, 15.322.8 19.8552.77 mg /kg 8 20.4534.27 18.054.57 16.832.4 16.9-5.57 "Statistically significant deviation at c - 0.5 in comparison with the control group.

Table ii5

The influence of storage conditions on the activity of TTP from the point of view of the number of cells producing antibodies of type 195

RES/109 splenocytes

After two months of storage at le Nachalnaya | three | yumeatoi | that activity | temperature | at temperature time y to e | The temperature is in the darkness of the world

Control 5! 571-695 514-128 5id-128 514128 01 ms/kg 8 744-144 10392326 "7185135 1002-2107 1 MMGUGUG 8 1204-1557 10263147 " Statistically significant deviation at c - 0.5 in comparison with the control group,

ay z-y y 2 Ek Iz sh kozh E i | In :

I sh t Z . ".

With Ge) - 5 hours

EU Z

F Z o o

And x Y g ' so so so 00 x that in | x ! m Z v o u 5

F o.

E- t sl t J z o t- 0 vya v i v v | aBvVIІ in | in ne ho o i" o Z U 15

Z tyu t E Z o Ge) di "SHE x "yusht f Ф 5 Z b Fyuvo - E . 8 12251 в ше жена ши шишки ши в : a -e- Ж и Й y :

F t I sl them te 4 o zy V Z

BZ and | - Rg i vne F g o 5 chi in g g) (45) sh

E- Z b b as z KU ' - (voy Fi Z F, v. et z y 8 ii vel k i v ||| 9 z

Z - x

And: | o li sh t vypt| и Gu F : х с во 2 7 ш e IEBKIv| 885) from ee "7Ж 835 F -

From zve) in . B: 5 "x |Vyuvo| | жх18І z

EK inIx1 a

And. web and va 5 and vaz a 5 Z

Z 5 z he pt vi) o Z . aphid 4; . Zh KE 5 z

Bl tp vv ro - tv chu 2 in z and z it,

Z 8 OO ve Z v -yooyayooshy -y F 5 NYA - shoyu xx - - tet - E.Zh. - Eh v ne Z F t» ach F y !

What F 9 2rI9e 5

"or ovi tin yuviinkk 5525 Sh with ah in -i same yu r? with

Ian

Z Z x E rya F d) 2 x so so 00 so a | - :

З же ж г z) o y o t o o : s t .

Ha o ts in F - F ovo B in Bo. And a ho o g. There are 2

There is at 5 - o r -

Zh. shchi 155 gi rogyu Fo v 5 o Fo yu V x vv v

Z om V : o»vaz Z | With i tp o ovoovi1i7?i1 5 a il tyu Х х х a |5Б5BB|В8И| z 5 8 - no F y z y ! pu 5 is in Z r x |bsv»| o Z E s o |BEvy|VI| and 5 5 oto" in a

E: shh -

In | with with ooo! ?iI g | 5

SHE oo a | o e |BBBBIVI 3815 8 / . d - 8 4 E 835 2 in -

WHAT! V. 8 pi --y вх г гЗ y ! oebtro vv F oo shchi 2, in what vB55-A 5 5 , i» t 15 Z i o. and E in , - shi rovo|i 5 gu . - 3; And 85 Z - still foreheads of St. Z to 85 Fo

I: Dos and weights Oh g, - -

Becky wee and shen a What

And - -and ' - ra | grgde 68

. Table 18

Hematological parameters: healthy Lobrovolets before and after two weeks of taking TTR at a dose of 1 mg/day

Parameter

She is the bottom chic of wearing a VOS

Red blood cells x 106 4.445046 4.32-0.45 4.32-0.32 4.1850.32

Hemoglobin g/dL 12,452.5 11.9--2.8 12.8-0.8 11.58--0.6

Blood hematocrit Z8.1-65.7 Z8.0-6.3 ZB.72.1 38.15-1.6

Leukocyt " a x 103 dl 525-059 527:0.8 53-06 4.85--0.6

Neutrophils that B2,bBa12 "57.ba11 54,252,5 55, Oz3,6

Lymphocyte

Fo 26.0x57.5 30.458.5 34.04 1 s 32.45,

Thrombocytium and x 10 l 220540.4 214535.8 2215380 214396

Blood sediment

MmMm/1 time 7.858 5.6-1.9 7.822.7 6.8-3.1

Table 19 "Biochemical parameters in healthy volunteers before and after a two-week intake of TTR at a dose of 1 mg/day

Parameter 7791 for 17010 | as

Total beef g/l 72.8:1.76 68.4253.2 73.8-1.92 70-55

Albumin 90 653.232.5 63.8--2.3 63.6-:1.8 64.4521

Globulin a 195 3.1-0.4 3-05 2.8:0.5 2,850.45

Globulin is 290 5.9551.9 6.8-1.5 6.9350.9 6b.9-0.9

Globulin in 95 14.4:22 14.2-1.5 13.3-1.9 15.2--1.3

Globulin xu 955 12.2-1.5 12.1-1.3 13.750.9 12.33-1.0

Yes g/l 10.3321.1 10O.251.0 11.7-1.6 11.1-53.4 "Yes g/l 1.8::06 1.9-0.5 1.850.5 195 -055

YM g/l 1,450.3 1.4-0.2 1.1-0.2 1,140.4

Complement C3 g/l 11501 11-50, 1.150.2 0.202

CA complement g/l 0.250.5 9.320.04 02-00 020.03

Alanine M/l 34,250,05 0,3-0,04 302582 31232

Asparagine m/p 32.8-4A 40.2-6.6 30.4-7.1 Z9.5-5.6 and

Claims (1)

Y I vv KZDO B Kt ! - STATE PATENT DESCRIPTION TO THE PATENT OFFICE; y i o ON THE INVENTION I nin rn z sty livo agaminiv vase potna navan (54) BISAACTIVE PRODUCT OBTAINED FROM PEAT, METHOD OF ITS OBTAINMENT, METHOD OF OBTAINING PHARMACEUTICAL COMPOSITION CAPABLE OF INDUCING CYTO- KINES, AND COMPOSITION WHICH INDUCES CYTOKINES IMMUNOSTIMULATION (21) 93121756 with a ganic solvent, and then - (22) 03.04.92. processing of the remaining liquid phase. ! (24) 12.11.99 containing inorganic salts and (31) 31104098.8, Р 2901078, Р 290283, bisactive peat treatment Р290508, Р 290509, Р 290510, Р 290606, dient, differing in theme, Р 2902907, Р80 , R 290693, R 290694, that it contains no more than 70% by weight of R 290695 inorganic salts, especially sodium chloride (32) 16.03.91, 15.07.91, 17.05.91, ria, based on dry matter, at- 03.06.91, 03.06.91, 03.06.91, 10.06.91, with which the salt content is ensured 10.06.91, 10.06.91, 17.06.91, 17.06.91, by diluting the specified Jewish 17.06.91 koi phases of lemineralized water with (33) ER, RI, RI. RI, RI, RI., RI, RI. RI, RI, followed by reverse osmosis for sleep - RI, RI. decrease in salt content in the product. Ge, (56) PCT/ERO2/00491 (03.04.92) . , 2. Produktlo p. The reason is that it is in the form of SU (56) 1. RI, 124110, 1979, in an aqueous solution or dried powder. 2. ZU, 1826908 AZ, 1993. roshka, Z. Muravyov I.A. Medicine technology, Z. Produktlo p. ii ilid, otlyz - M., Medicine, 1971, p. 275. I am grateful for the contents of 7 4. Mashkovsky M.L. The medicinal value of the organic salts in it does not exceed the means. - M., Medicine, 1989, part |, bo. | and with 33-76 (prototype). 4. Product according to any of the Japanese. 1-3, o t- o (72) Tolpa Stanislan (RI), Ritter Stanis- similar to what is happening - lava (RE), Kukla Ryshard (RI), Skrzyzhevsk - when the product is in the form of the 195th IIh ka Malgorzhata (RI), Tomkov Stanislav (RI), aqueous solution, it has a pH of 5.0 to Jersh Tadeusz (RI.) 6.5 preferably around 6. ko (73) PEAT ESTABLISHMENT (NO) z. The product according to any one of claims 1-4, 0 in which case, (57) 1. Bisactive product, obtained when the product is in the form of a concentration of peat, used for an unspecified solution, sot and! of the Czech immunostimulation, it is a dark brown liquid that is a mixture of active peat ingredients with a specific density of 1.02 to 1.09 C of nutrients and inorganic salts, half g/ml, and the content of dry substances in it is determined by the method providing not less than 5 web.95. primary alkaline hydrolysis of sulfur 6. A method of obtaining bisactive pro-peat material, acidification of hydroduct from peat, which includes perlyzate, separation of insoluble temporary alkaline hydrolysis of raw cake with subsequent secondary alkalinization of the product, followed by acidification, and then by acidification of the pure hydrolyzate, separation of the non-liquid phase, removal of the ballast parts and subsequent substances with the use of extraction or secondary alkalization, and then . With І 265742 4 acidification of pure liquid phase, impact or herbal extracts, gelation of inert substances with the used forming agent, and the second injection of extractive organic solvents, distinguished by the theme, ritel, and subsequent treatment with sterile hydrogen a solution of the bi-activated liquid phase" containing a product obtained from peat, non-organic salts, and bioactive ingredients extracted from inorganic peat containing 7095 bioactive ingredients, especially sodium chloride, from growing themes , что предусматри- couple of dry matter, combine with the following additional stages: with sterile alcohol herbal extract - the dilution stage, in which the mentioned, after which the liquid mixture is transferred, the solution is diluted in demineralized gel form by adding bath code; the stage of the subsequent de-gelling agent. salting, in which the dilution solution 13. The method according to claim 12 for obtaining the flavor is subjected to reverse osmosis for a medicinal composition in the form of a gel, desalting of the solution, and non-organizing, characterized by the fact that nic salts are added, the gelling agent is removed to a concentration, preferably no more 70 wt. 95, calculated on the basis of dry collomanic silica, and the weight of the substance; I compared the concentration stage of the liquid mixture to the gel treatment. to the buzzing agent is 90-94:10-6., 7. Method of pop. b, I distinguish - 14. The method according to claim 12 for obtaining far-Schi is that the dilution of the demycifying composition in the form of an ointment, diluted with water, is carried out at the rate of 1:5 to 1:28, and The gelling agent is added in a fractionated manner, the pre-solution is desalted preferably with colloidal silica, the content of inorganic salts is lower than the weight ratio of the liquid grease is no more than 60 wt.95, based on the calculation of the dry to gelling agent, it is the surrounding substance. lo 30:2, and the gel obtained in this way B. The method of pop. beat 7, but they are rubbed with pre-sterilizing Soya, which additionally contains a basic ointment containing a mixture of stable sterilization and/or dry fat components, such as sugar, concentrated and cleansing food, and petroleum jelly, in the weight ratio of the gel to the solution, sterilize and/or expose the liquid component to 32-34:68:56. spray drying, 15. Method according to any of claims 12-14, 8. The method according to any one of claims 6-8, 0, which is characterized by the fact that after the extract is selected from the groups consisting of organic solvent extraction, horse chestnut extract, calendula extract, chamomile extract, The extract is poured from the aqueous phase, which for the marigolds, the sage leaf extract, is passed through a sintering ceramic filter, the extract is filtered under reduced pressure, and the horsetail, the extract of the leaves of the burning water pressure, obtaining a clean filtered drink. the extract of grown wheat, the so-called liquid phase, containing the extract of aloes, thyme extract, herbal salts, and the bibactive extract of Fulleva's ingredient. dient 16, The method according to any of claims 12-15, 10. According to item C, I distinguish - it is distinguished by the fact that it contains glycerin and/or a sterile solution and is sterilized by means of a membrane filter. mattifying combinations, prefer- 11. Method of pop. With or 10, btly - thoroughly collected from groups), consisting of a solution of menthol, thymol, mint, lemon and Zzek - are subjected to spray drying at a lime, which is added to the liquid mixture - the temperature at the entrance is about 1800 and on you are yields about 90. 17. The method according to any one of claims 12-16, 12. The method of obtaining a pharmaceutical product is distinguished by the fact that it is a composition capable of inducing a bisactive product obtained from torcytokines; and useful for improving tefa, which is an extract of peat in the therapeutic treatment of external wounds or in the form of a concentrated aqueous solution of varicose ulcers, especially varicose ulcers, or a dried powder that provides the lower parts of the legs, preferably contains no more than 60 cytokine-inducing compounds вес.б95 of inorganic salts, from the calculation of bioactive material with herbal extract - on dry matter. AND