UA19318A - Method for human mno2-dismutase obtaining - Google Patents

Method for human mno2-dismutase obtaining

Info

Publication number
UA19318A
UA19318A UA4355336A UA4355336A UA19318A UA 19318 A UA19318 A UA 19318A UA 4355336 A UA4355336 A UA 4355336A UA 4355336 A UA4355336 A UA 4355336A UA 19318 A UA19318 A UA 19318A
Authority
UA
Ukraine
Prior art keywords
dismutase
obtaining
human
mno2
kdna
Prior art date
Application number
UA4355336A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Хекль Конрад
Спевак Вальтер
Остерманн Елінборг
Цефель Андреас
Кристек Едельтрауд
Маурер-Фогі Інгрід
Йозефа Віхе-Кастанон Марія
Стратова Крістіан
Гауптманн Рудольф
Original Assignee
Берінгер Інгельгейм Інтернаціональ Гмбх
Берингер Ингельгейм Интернациональ ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берінгер Інгельгейм Інтернаціональ Гмбх, Берингер Ингельгейм Интернациональ ГмбХ filed Critical Берінгер Інгельгейм Інтернаціональ Гмбх
Publication of UA19318A publication Critical patent/UA19318A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal

Abstract

The invention relates to biotechnology and genetic engineering, in particular, tp methods for obtaining of human MnO2-dismutase for therapeutic use, e.g., as anti-inflammatory agent. A method comprises the isolation of mRNA from placental or hepatic human tissues, obtaining of poly (A)+RNA, synthesizing of two-stranded kDNA, construction of kDNA bank, isolation of DNA sequence and coding of Mn2O-dismutase.
UA4355336A 1987-03-14 1988-03-14 Method for human mno2-dismutase obtaining UA19318A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873708306 DE3708306A1 (en) 1987-03-14 1987-03-14 Human manganese superoxide dismutase (hMn-SOD)

Publications (1)

Publication Number Publication Date
UA19318A true UA19318A (en) 1997-12-25

Family

ID=6323067

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4355336A UA19318A (en) 1987-03-14 1988-03-14 Method for human mno2-dismutase obtaining

Country Status (4)

Country Link
DE (1) DE3708306A1 (en)
SU (1) SU1741610A3 (en)
UA (1) UA19318A (en)
ZA (1) ZA881743B (en)

Also Published As

Publication number Publication date
SU1741610A3 (en) 1992-06-15
ZA881743B (en) 1989-11-29
DE3708306A1 (en) 1988-09-22

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