UA135017U - METHOD OF BIOPHORESIS OF WOUND SURFACES BY VITAMIN B6 BY AEROGEL BANDINGS WITH SILVER HEMISPHERE - Google Patents

Abstract

A method of biophoresis of wound surfaces with vitamin B6, which consists in applying two electrodes of dissimilar metals to the wound and connecting them with an electric conductor, which causes a unidirectional circular motion of electrons and a constant galvanic current of 5-80 μA. An airgel bandage (based on amorphous silicon dioxide) with silver hemispheres containing silicone tubes inside, through which vitamin B6 is injected, is applied to the wound surface.

Description

The useful model belongs to the field of medicine, namely to general surgery, combustiology, traumatology, polytrauma and can be used for the purpose of adapting a skin graft on a wound bed, as well as in the treatment of wound defects with damage to the skin and underlying tissues.

The known method is as follows: for the purpose of biophoresis, two electrodes made of dissimilar metals are applied to the affected limb or part of the body and connected by an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current with a strength of 5-80 μA appears. The current ionizes liquid therapeutic substances, gives unidirectional ions movement, which is used for therapeutic purposes (1-21.

The disadvantage of the known method is the impossibility of controlling the dosage of the medicinal substance, namely the preparation of vitamin Bb directly during the process of biophoresis of the wound surface, and the wound dressing does not provide optimal pressure on the wound. When applying a gauze bandage, it is impossible to qualitatively fill the entire wound surface by repeating its relief, and it is also impossible to introduce a therapeutic agent, vitamin Bb, into the wound directly without removing the gauze bandage, and the wound bandage does not provide constant antiseptic conditions.

The basis of the useful model is the task of eliminating the shortcomings of the method of controlling the dosage of the substance during the process of biophoresis of the wound surface.

The task is solved by the fact that the method of biophoresis of wound surfaces with vitamin Bb, which consists in applying two electrodes made of dissimilar metals to the wound and connecting them with an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current with a strength of 5-80 μA. An airgel bandage (based on amorphous silicon dioxide) with silver hemispheres, containing silicone tubes inside, through which vitamin Bb is administered, is applied to the wound surface.

Airgel (based on amorphous silicon dioxide) is a unique material - a gel in which the liquid phase is completely replaced by a gaseous one. This material has a record low density and exhibits a number of unique properties: hardness, transparency, heat resistance, etc. Airgel belongs to the class of mesoporous materials, with the structure of a tree-like network of nanoparticles 2-5 nm in size and pores up to 100 nm in size combined into clusters (I3-6). Also, aerogels have good thermal insulation and hygroscopic properties, they are transparent and through them the state of the wound bed and the features of the wound process are clearly visible. Silicone tubes (through which they are introduced

zo therapeutic agents) are located in the thickness of the airgel bandage, they have one external outlet on the surface of the bandage and pores in its base, from where the Vb gradually enters the wound.

The use of vitamin Bb stimulates metabolic and regenerative processes in the wound, reduces the intensity of the inflammatory process. Which, in turn, improves microcirculation in the tissues and shortens the course of the phases of the wound process, prevents drying of the wound (7-9). And the silver hemispheres in the airgel bandage provide constant antiseptic conditions for wound surfaces.

The method is carried out as follows: wound defects are first treated with dry sterile napkins, maximally adsorbing the wound contents, then the wound is treated with sterile napkins moistened with an aqueous solution of chlorhexidine. After treatment of wound defects, the wound is covered with a sterile napkin and an airgel bandage based on amorphous silicon dioxide with silver hemispheres is placed on top of it. A medical substance, namely vitamin Bb, is injected directly into the silicone tubes of the airgel bandage. After the introduction of vitamin Bb into silicone tubes, one tube remains connected to the syringe, and the other is closed with a stopper. An electrode (anode) is placed on top of the plate.

During biophoresis, the anode (positive electrode) is placed over the wound defects, and the cathode (negative electrode) is placed under the affected area (extremity) or on the opposite side of the anode.

The strength of the current that acts on wound defects is from 5 to 80 μA, the current ionizes vitamin Bb, gives ions unidirectional movement into the wound for therapeutic purposes. Without stopping the treatment procedure of biophoresis, after the end of vitamin Bb, you can wash the wound surface with an antiseptic solution by injecting it with a syringe through a silicone tube into an airgel bandage, having previously removed the plug. Under the action of galvanic current, part of the drug will fall directly to the wound surface through the pores in the lower surface, and part will leave the cavity of the plate through the outlet tube.

So, the method of biophoresis of wound surfaces with vitamin Bb airgel bandages based on amorphous silicon dioxide enables control over its introduction during the wound galvanization procedure, and, if necessary, allows to increase the dose of the drug directly during the procedure. The method improves the deposition of antiseptic and vitamin Bb in the wound tissues, stimulates microcirculation in the affected tissues, reduces microbial contamination of secretions from the wound, and the silver hemispheres create permanent antiseptic conditions in the wound, which allows shortening the patient's stay in hospital treatment.

Sources of information: 1. Lisovska T.V., Husakivska O.V. Biophoresis and biopuncture of biological medicine preparations as an alternative to traditional treatment of chronic endometritis // Ukrainian medical almanac. - 2012. - Volume 15, Issue 6. - P. 107-108. 2. por/lLymly gadiiz.ru/K/radez/eIesitorpogeviv.pPIti.

Z. Ma, N.5.; Rhemovi, U.N.; Ushiyep, A. ZANegeg, S.M. Aotryieg 5itsiaiop oi teANapidAai! zi Ashte-rgorepu heyiIayop5pir oi aegode!5. U. Mop-Aguzi. ZoiiAv 2001, 285, 216-221. 4. Eyettegpipod, A.; EpAKe, U. Zaaiipud rgoregie5z apA v5igiAiiige oi aegodei!5. 9). ZoI-Se! 5AI.

TeApNpoi. 1997, 8, 781-788. 5. perz:/Lymly.zrgipdefgotezziopa!.Ae/ep/hemiem/-oi-aegode!I-bazeA-taietgiaIv-ip-bioteAiAai!- arriiAayopv/11742122. 6. pen /mlum.taAri.Aot/Loigpai/deiI5/5reliai izzuez/aegodeiv. 7. nerve //uveozmya. tsal/irgagu/biopitiApa-iOI-myatipim-ia-miatiporoAirpin-5roishk-432.piti. 8. Gubsky Yu.I. Biological chemistry: Textbook. Kyiv-Ternopil: Ukrmedknyga, 2000. - 508 p. 9.-pyr://teAiiA!Tz.yAo peyip Aeh/miAi romia7ok/0-24.

Claims (1)

USEFUL MODEL FORMULA The method of biophoresis of wound surfaces with vitamin Bb, which consists in the fact that two electrodes made of dissimilar metals are applied to the wound and connected by an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current with a strength of 5-80 μA appears, which is characterized by that an airgel bandage (based on amorphous silicon dioxide) with silver hemispheres containing silicone tubes inside, through which vitamin Bb is administered, is applied to the wound surface.