UA135013U - METHOD OF BIOPHORESIS OF WOUND SURFACES BY VITAMIN B2 BY AEROGEL BANDINGS WITH SILVER HEMISPHERE - Google Patents

Abstract

The method of biophoresis of wound surfaces with vitamin B2 is that two electrodes of dissimilar metals are applied to the wound and connected by an electrical conductor, which causes a unidirectional circular motion of electrons and there is a direct galvanic current of 5-80 μA, according to the utility model. the wound surface is applied an airgel bandage (based on amorphous silicon dioxide) with silver hemispheres containing silicone tubes, through which vitamin B2 is injected.

Description

The useful model belongs to the field of medicine, namely to general surgery, combustiology, traumatology, polytrauma, and can be used for the purpose of adapting a skin graft on a wound bed, as well as in the treatment of wound defects with damage to the skin and underlying tissues.

As the closest analogue, the following method was chosen: for the purpose of biophoresis, two electrodes made of dissimilar metals are applied to the affected limb or part of the body and connected with an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current of 5-80 μA appears . The current ionizes liquid medicinal substances, gives ions unidirectional movement, which is used for therapeutic purposes (1-2).

The disadvantage of the known method is the impossibility of controlling the dosage of the medicinal substance, namely the preparation of vitamin B2 directly during the process of biophoresis of the wound surface, and the wound dressing does not provide optimal pressure on the wound. When applying a gauze bandage, it is impossible to qualitatively fill the entire wound surface, repeating its relief, and it is also impossible to introduce the therapeutic agent, vitamin B2, into the wound directly without removing the gauze bandage, and the wound bandage does not provide constant antiseptic conditions.

The basis of a useful model is the task of eliminating the above-mentioned shortcomings.

The task is solved by conducting a method of biophoresis of wound surfaces with vitamin B2, which consists in applying two electrodes made of dissimilar metals to the wound and connecting them with an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current with a strength of 5-80 μA appears , according to a useful model, an airgel bandage (based on amorphous silicon dioxide) with silver hemispheres, containing silicone tubes inside, through which vitamin B2 is injected, is applied to the wound surface.

Airgel (based on amorphous silicon dioxide) is a unique material - a gel in which the liquid phase is completely replaced by a gaseous one. This material has a record low density and exhibits a number of unique properties: hardness, transparency, heat resistance, etc. Airgel belongs to the class of mesoporous materials, with the structure of a tree-like network united into clusters of nanoparticles 2-5 nm in size and pores up to 100 nm in size (I3-6). Also, aerogels have good thermal insulation and hygroscopic properties, they are transparent and through them the state of the wound bed and the features of the wound process are clearly visible. Silicone tubes (through which they are introduced

zo therapeutic agents) are located in the thickness of the airgel bandage, they have one external outlet on the surface of the bandage and pores in its base, from where B2 gradually enters the wound.

The use of vitamin B2 stimulates metabolic and regenerative processes in the wound, reduces the intensity of the inflammatory process. Which, in turn, improves microcirculation in the tissues and shortens the course of the phases of the wound process, prevents drying of the wound (7-9). And the silver hemispheres in the airgel bandage provide constant antiseptic conditions for wound surfaces.

The method is carried out as follows: wound defects are first treated with dry sterile napkins, maximally adsorbing the wound contents, then the wound is treated with sterile napkins moistened with an aqueous solution of chlorhexidine. After treatment of wound defects, the wound is covered with a sterile napkin and an airgel bandage based on amorphous silicon dioxide with silver hemispheres is placed on top of it. A medical substance, namely vitamin B2, is injected directly into the silicone tubes of the airgel bandage. After the introduction of vitamin B2 into silicone tubes, one tube remains connected to the syringe, and the other is closed with a stopper. An electrode (anode) is placed on top of the plate.

During biophoresis, the anode (positive electrode) is placed over the wound defects, and the cathode (negative electrode) is placed under the affected area (extremity) or on the opposite side of the anode.

The strength of the current that acts on wound defects is from 5 to 80 μA, the current ionizes vitamin B2, gives ions unidirectional movement into the wound for therapeutic purposes. Without stopping the treatment procedure of biophoresis, after the end of vitamin B2, you can wash the wound surface with an antiseptic solution, injecting it with a syringe through a silicone tube into an airgel bandage, having previously removed the stopper. Under the action of galvanic current, part of the drug will fall directly to the wound surface through the pores in the lower surface, and part will leave the cavity of the plate through the outlet tube.

Therefore, the method of biophoresis of wound surfaces with vitamin B2 airgel bandages based on amorphous silicon dioxide enables control over its introduction during the wound galvanization procedure, and if necessary, allows to increase the dose of the drug directly during the procedure. The method improves the deposition of antiseptic and vitamin B2 in the wound tissues, stimulates microcirculation in the affected tissues, reduces microbial contamination of secretions from the wound, and the silver hemispheres create constant antiseptic conditions in the wound, which makes it possible to shorten the patient's stay in hospital treatment.

Sources of information: 1. Lisovska T.V., Husakivska O.V. Biophoresis and biopuncture of biological medicine preparations as an alternative to traditional treatment of chronic endometritis //Ukrainian medical almanac. - 2012. - Volume 15, Issue 6. - P. 107-108. 2. por/lymly gadiiv.rulik/radez/eIestorpogezviv. pPiti

Z. Ma, N.5.; Rhemovi, U.N.; Ushiyep, A. ZANegeg, S.M. Aotryieg 5itsiaiop oi teANapidAai! zigyAshte-rgorepu heiIayopz5pir oi aegode!5. U. Mop-Aguzi. 5oiAv. - 2001. - 285. - 216-221. 4. Eyettegpipod, A.; EpAKe, U. ZAaiipd rgoregieez apA vzigiAtshge oi aegode!5. U. ZoI-be! 5AI.

TeAnNpo). - 1997. - 8. - 781-788. 5. pre :/Llymlmu. vrhipdegrgoiezziopa!.Av/ep/hemivm-oi-aegode!-bazeA-taiegia!5-ip-biotelAiAai!- arriiAayopv/11742122 b. per /Luimly.taAri.Aot/oigpai/dei5/5relia!. izvyez/ayegodeiv 7. pybrv5 //uzeozuya. tsalirgagu/biopitiApa-go!-myatipim-ia-miatiporoAiBpin-5roishk-432.piti 8. Gubskyi Y.I. Biological chemistry: Textbook. - Kyiv- Ternopil: Ukrmedknyga, 2000. - 508 p. 9. per://teAiA!yz.yAo2.peipAeh/lAi rom|ia2oK/0-24

Claims (1)

USEFUL MODEL FORMULA The method of biophoresis of wound surfaces with vitamin B2, which consists in the fact that two electrodes made of dissimilar metals are applied to the wound and connected with an electrical conductor, which causes a unidirectional circular movement of electrons and a constant galvanic current of 5-80 μA appears, which is characterized by that an airgel bandage (based on amorphous silicon dioxide) with silver hemispheres containing silicone tubes inside, through which vitamin B2 is injected, is applied to the wound surface.