UA124263U - METHOD OF CORRECTION OF SUBSTANCE EXCHANGE AND STIMULATION OF LACTATING BREED PRODUCTIVITY UNDER TECHNOGENIC LOAD - Google Patents

Abstract

A method of correction of metabolism and stimulation of the productivity of lactating cows under conditions of anthropogenic loading involves the introduction into the diet of trace elements and vitamins. A mixture of trace elements in the form of compounds with the essential amino acid methionine and fat-soluble vitamins is used, with the following ratio of components (per kg of body weight per day): copper methionate - 0.1 mg, iron methionate - 0.1 mg, cobalt methionate - 0, 05 mg, vitamin D3 - 0,15 g, vitamin E - 0,05 mg.

Description

The useful model belongs to the field of animal husbandry, in particular to the feeding and hygiene of farm animals, namely to methods of eliminating the adverse effect of man-made environmental pollution on the organism of lactating cows in the conditions of farms with different forms of ownership.

Objects of production and industry, agriculture, energy and transport consume a significant amount of natural resources in the process of their functioning. At the same time, harmful substances harmful to the natural environment are released into the environment.

Man-made products entering the biosphere overload, in particular, when they get into living organisms, they cause serious metabolic disorders, which can lead to irreversible changes in the form of mutagenic and carcinogenic effects. Therefore, in recent years, methods have been developed aimed at correcting and preventing metabolic disorders of the animal body in conditions of man-made stress.

Known methods (Tairova A. The use of chitinous preparations in chronic intoxication of cows with salts of heavy metals. / A. Tairova. // Dairy and meat cattle breeding. - 2002. - Mo 1. - P. 31-34; Method of removal of radionuclides and salts of heavy metals from the human and animal body, patent of Ukraine Mo 10482; Shaposhikov AA Natural mineral sorbent for cows and calves / AA Shaposhikov, VD Bukhanov, AV Posokhov //

Zootechniya. - 2003. - Mo 2. - P. 15-17; Method of correction of metabolism, stimulation of productivity and reproductive capacity in lactating cows in conditions of man-made environmental pollution, patent of Ukraine Mo 4165; The method of correcting the metabolism in the body of lactating cows and normalizing the content of heavy metals in milk in the conditions of man-made pollution of the environment with lead and zinc salts, patent of Ukraine Mo 31714; The method of reducing the level of lead in the blood and milk of man-made cows, patent KO 2245030) include the use of adsorbents.

The disadvantages of the known methods are a rather limited scope of application, since they are designed to remove toxic substances from the body, however, they are not aimed at the actual correction of biochemical processes in the body, changed as a result of the action of toxic substances.

Known methods (I.A. Likasova, Kinetics of heavy metals in the animal organism against the background of licorice root application. / I.A. Likasova, M.I. Rabynovich // Veterinaria - 1999. - Mo 3. - S.

From 45-47; T.G. Andrianova. Treatment and prevention of intoxication of broiler chickens with lead and cadmium compounds // Veterinaria. - 2005. - Mo. 8. - P. 54-56; The method of treatment of hepatosis of dairy cows in the conditions of technogenic provinces with an excess of lead, nickel and cadmium, patent KO Mo 2599499) involves the use of various pharmaceutical preparations.

The disadvantages of known methods are their insufficient efficiency.

The closest analogue to the proposed method is the method of correction of mineral metabolism in cows in the conditions of the biogeochemical province (patent KO Mo 2494732), which includes the daily introduction into the basic diet of animals of a complex of salts of trace elements - sulfates of copper, manganese, zinc, and simultaneous use inside with feed anti-stress drug "Selerol" in a dose of 20-23 ml per head once every 30-31 days, every month, during the period of use of cows. The method ensures an increase in the speed and efficiency of the normalization of indicators of mineral metabolism in cows and an increase in indicators of milk productivity.

The claimed method and the prototype have common essential features, namely: it includes the use of trace elements and vitamin E to correct the metabolism of cows.

The disadvantages of the prototype are that microelements are used in the form of inorganic compounds that are poorly assimilated in the animal's body.

The proposed method eliminates the shortcomings of the prototype and provides a reduction in the intake of heavy metals and correction of the metabolism of the cows' body in conditions of man-made load, stimulates productivity improvement.

The basis of the useful model is the task of developing a new, more effective way of correcting the metabolism and stimulating the productivity of lactating cows in conditions of man-made stress, due to the introduction into the diet of trace elements related to essential amino acids and fat-soluble vitamins, simple and convenient to use.

The technical result is achieved by using a mixture of trace elements in the form of compounds with the essential amino acid methionine and fat-soluble vitamins, with the following ratio of components (per kg of body weight per day): copper methionate - 0.1 mg, iron methionate - 0.1 mg, methionate cobalt - 0.05 mg, vitamin Dz - 0.15 g, vitamin E - 0.05 mg.

The technical result of the claimed method is determined by the role of biogenic metals bound to essential amino acids and fat-soluble vitamins in the metabolism of lactating cows, as well as their influence on the assimilation, neutralization and removal of toxic substances from the body, in particular, heavy metals and oxidants of external and internal origin.

Yes, it is known that iron participates in hematopoiesis, respiration, redox reactions and immunobiological processes; is part of the blood and more than a hundred enzymes; contained in the structure of a number of proteins, and, first of all, hemoglobin, is present in another protein - myoglobin, where it serves to create an oxygen reserve in the body; is included in the structure of cytochromes, which participate in the processes of energy accumulation, released during the final stages of biological oxidation; as part of catalase protects organs from the harmful effects of toxic hydrogen peroxide.

Copper is part of many enzymes and biologically active metalloproteins, participates in tissue respiration; synthesis of collagen and elastin; is a component of cytochrome C of the electron transport chain; important for the processes of growth and reproduction, pigmentation, as it is part of melanin; necessary for the formation of hemoglobin; promotes the transfer of iron to the bone marrow and its transformation into an organically bound form; stimulates the maturation of reticulocytes and their transformation into erythrocytes.

Cobalt, together with iron and copper, participates in hematopoietic processes (stimulates the production of erythrocytes in the bone marrow, participates in the assimilation of iron); regulates some functions of the central nervous system; normalizes metabolism (in close interaction with vitamin

C, folic acid and vitamin B5) and stimulates the growth of bone tissue; participates in the synthesis of vitamin Vig2, DNA and RNA; normalizes the activity of the pancreas and is important for the formation of thyroid hormones; characterized by antisclerotic effect; increases immunity (increases the phagocytic activity of leukocytes) and has an antitumor effect; plays an important role in the processes of recovery of the body after serious diseases.

Methionine is an indispensable, limiting amino acid in the synthesis of milk, a universal donor of methyl groups in methylation reactions, promotes the formation and exchange of choline, vitamin B, folic acid, together with which it improves the use of feed lipids by animals. Methionine belongs to lipotropic substances that prevent the development of fatty hepatodystrophy. Its methyl groups participate in the synthesis of phospholipids, part of which is used by the liver for regeneration processes, and the bulk of them is constantly supplied to other organs and tissues with the blood stream. Methionine promotes the synthesis of choline, which forms choline phosphatides with triacylglycerols

Zo (lecithin) and ensures a constant outflow of lipids from the liver into the bloodstream, preventing the development of fatty dystrophy.

Vitamin Dz affects the growth and proliferation of cells, the immune system, the functional activity of some organs, in particular the mammary gland and ovaries, regulates the synthesis of lipids, hormones, and promotes protein biosynthesis. At the same time, vitamin Dz, due to the great need for it in lactating cows, is practically absent in feed.

Vitamin E is a powerful antioxidant necessary for the normal functioning of the reproductive and immune systems, improves cell nutrition, has a beneficial effect on peripheral blood circulation, prevents the formation of blood clots and strengthens vessel walls, is necessary for tissue regeneration, ensures normal blood clotting, lowers blood pressure, supports nerve health, ensures muscle function, prevents anemia; it protects other fat-soluble vitamins from destruction by oxygen, contributes to the assimilation of vitamin A, participates in the formation of collagen fibers of the intercellular substance, the biosynthesis of heme and proteins, the formation of gonadotropins and the development of the placenta.

In conditions of man-made pollution, the introduction of microelements (iron, copper and cobalt) into the body prevents the entry of heavy metals in particular into tissues and organs through the gastrointestinal tract, as they are antagonists in the competition for receptors on epitheliocytes, which ensure the capture and subsequent absorption of divalent metals. that come with feed. In addition, the intensity of assimilation of metals in the gastrointestinal tract increases in the presence of their connection with ligands, especially with amino acids. In turn, the well-known antioxidant - vitamin E (tocopherol) prevents the development of oxidative stress and, like vitamin D, contributes to increasing the productivity of lactating cows.

Thus, correction of metabolism in lactating cows and stimulation of productivity in conditions of man-made pollution of the environment is carried out thanks to the rapid entry into the body of a mixture of methionates of iron, copper and cobalt, antioxidant vitamin E and vitamin Dz.

So, the given information explains the obtaining of the technical result of the claimed method.

When conducting a patent information search, the authors and the applicant found a technical solution (Method of correction of mineral metabolism in cows in the conditions of a biogeochemical province, patent KO Mo 2494732), which contains the largest number of essential features common to the claimed one and includes the use of trace elements to correct the metabolism of cows and vitamin E.

However, the presence of the specified features common to the prototype is not sufficient to obtain the technical result provided by the claimed method. The applicant did not find any technical solutions that, based on the set of features, completely correspond to the claimed method.

In the patent and scientific and technical information, no technical solutions were found, which would describe information about the features that distinguish the claimed from the prototype and ensure the achievement of a technical result by using a mixture of trace elements in the form of compounds with the essential amino acid methionine and fat-soluble vitamins, while ratios of components (per kg of body weight per day): copper methionate - 0.1 mg, iron methionate - 0.1 mg, cobalt methionate - 0.05 mg, vitamin Dz - 0.15 g, vitamin E - 0.05 mg .

The declared useful model belongs to the field of animal husbandry, in particular, feeding and hygiene of farm animals, namely to methods of eliminating the adverse effect of man-made environmental pollution on the body of lactating cows in the conditions of farms with different forms of ownership, and therefore meets the criterion of a useful model - "industrial suitability".

Thus, the declared technical solution meets all the conditions of patentability of a utility model in accordance with Article 7 of Section II of the Law of Ukraine "On the Protection of Rights to Inventions and Utility Models" Мо 1771 - Ш - 2000.

Procedure for implementing the method.

The declared method is carried out as follows: - in a farm that keeps cattle and is in the zone of man-made pollution, in particular by heavy metals, the required amount of a mixture of microelements - methionate of iron, copper and cobalt and vitamins is calculated, depending on the number of lactating cows that must be purchased; - before feeding, the mixture of microelements is diluted with a small amount of water and added to the container where the combined feed is steamed; - vitamins are added to compound feed with trace elements, mixed and fed to lactating cows daily, once a day.

The effectiveness of the claimed method and its advantages over the prototype have been confirmed

With an example of specific use.

An example of a specific application of the claimed method.

The experiments were carried out in the peasant union "Vyhoda" of the Stryi district of the Lviv region.

The farm borders the international highway and the gas station. Excessive intake of heavy metals, in particular lead with feed, is indicated by the level of lead in the blood of cows, which is an average of 32.8 μgob.

For the experiment, 10 cows of the black and spotted breed of 4-5 lactations were selected, from which 2 experimental groups of five heads were formed. Cows of the control group received only the basic ration, and the experimental group - combined feed with microelements and vitamins. Milk productivity and the average level of lead in milk were determined in cows during the lactation period.

The results of the table indicate the advantage of the claimed method. In particular, particularly noticeable differences are manifested in the two groups of animals regarding the level of milk productivity and the concentration of lead in milk.

Table

The level of milk productivity and the content of heavy metals in the milk of cows in conditions of man-made pollution (p-5) head), kg

Milk fat, kg 77777771 1111117171891111 1111107

Thus, in the cows of the experimental group, the milk productivity was higher by 14 95, and the level of lead in milk was lower by 27 95 in comparison with the control group.

This result is explained by the optimal concentration of the components of the mixture, which ensured their maximum assimilation and allowed to fully and purposefully act on the metabolism in the body of cows.

Therefore, the research results obtained in the example of a specific implementation of the method confirm its effectiveness.

Claims (1)

USEFUL MODEL FORMULA The method of correcting the metabolism and stimulating the productivity of lactating cows in conditions of man-made load, which includes the use of trace elements and vitamin E, which is characterized by the use of a mixture of trace elements in the form of compounds with the essential amino acid methionine and fat-soluble vitamins, with such a ratio of components (per kg of body weight day): copper methionate 01 mg iron methionate 0 1 mg cobalt methionate 0.05 mg vitamin Dz 015 g vitamin E 0.05 mg.