UA123865C2 - Визначення та лікування дефіциту гормону росту - Google Patents

Визначення та лікування дефіциту гормону росту Download PDF

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Publication number
UA123865C2
UA123865C2 UAA201803953A UAA201803953A UA123865C2 UA 123865 C2 UA123865 C2 UA 123865C2 UA A201803953 A UAA201803953 A UA A201803953A UA A201803953 A UAA201803953 A UA A201803953A UA 123865 C2 UA123865 C2 UA 123865C2
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UA
Ukraine
Prior art keywords
growth
response
serum
testing
peak
Prior art date
Application number
UAA201803953A
Other languages
English (en)
Ukrainian (uk)
Inventor
Майкл Торнер
Original Assignee
Люмос Фарма, Інк
Аммонетт Фарм Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Люмос Фарма, Інк, Аммонетт Фарм Ллк filed Critical Люмос Фарма, Інк
Publication of UA123865C2 publication Critical patent/UA123865C2/uk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/61Growth hormones [GH] (Somatotropin)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
UAA201803953A 2015-09-21 2016-09-21 Визначення та лікування дефіциту гормону росту UA123865C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562221191P 2015-09-21 2015-09-21
US201662289221P 2016-01-30 2016-01-30
PCT/US2016/052800 WO2017053373A1 (en) 2015-09-21 2016-09-21 Detecting and treating growth hormone deficiency

Publications (1)

Publication Number Publication Date
UA123865C2 true UA123865C2 (uk) 2021-06-16

Family

ID=58276481

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201803953A UA123865C2 (uk) 2015-09-21 2016-09-21 Визначення та лікування дефіциту гормону росту

Country Status (23)

Country Link
US (4) US9763919B2 (enExample)
EP (3) EP3352752B1 (enExample)
JP (5) JP6816149B2 (enExample)
KR (4) KR20250102122A (enExample)
CN (2) CN116459250A (enExample)
AU (5) AU2016328969B2 (enExample)
CA (1) CA2998523C (enExample)
CY (1) CY1125183T1 (enExample)
DK (2) DK3352752T3 (enExample)
ES (2) ES2967259T3 (enExample)
FI (1) FI3939590T3 (enExample)
HR (1) HRP20220317T1 (enExample)
HU (2) HUE057831T2 (enExample)
IL (1) IL258224B (enExample)
LT (1) LT3352752T (enExample)
PL (2) PL3939590T3 (enExample)
PT (2) PT3352752T (enExample)
RS (1) RS62988B1 (enExample)
SG (2) SG10202010598SA (enExample)
SI (1) SI3352752T1 (enExample)
SM (1) SMT202200167T1 (enExample)
UA (1) UA123865C2 (enExample)
WO (1) WO2017053373A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220142989A1 (en) * 2015-09-21 2022-05-12 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency
AU2016328969B2 (en) * 2015-09-21 2020-10-08 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency
US11234969B2 (en) * 2016-01-30 2022-02-01 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency
US10288629B1 (en) * 2017-12-19 2019-05-14 Aeterna Zentaris, Inc. Method of assessing growth hormone deficiency in humans by a macimorelin containing composition
KR102880573B1 (ko) 2018-08-20 2025-11-04 베서, 파마 엘엘씨 칸나비노이드의 생성 공정
US11644474B2 (en) * 2020-07-22 2023-05-09 Æterna Zentaris Gmbh Use of macimorelin in assessing growth hormone deficiency in children
GEAP202516774A (en) 2022-11-03 2025-06-25 Lumos Pharma Inc Compactable oral formulations of ibutamoren

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650597A4 (en) 1992-06-29 1996-12-18 Univ South Florida DIAGNOSTIC METHOD FOR EVALUATING THE AETIOLOGY OF MINOR GROWTH.
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ES2275313T3 (es) 1997-08-22 2007-06-01 Kaken Pharmaceutical Co., Ltd. Derivados de amida como promotores de la liberacion de la hormona del crecimiento.
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
AR029941A1 (es) 2000-06-13 2003-07-23 Zentaris Gmbh Compuestos utiles para elevar el nivel plasmatico de la hormona del crecimiento y las composiciones farmaceuticas que las contienen
WO2005027894A1 (en) * 2003-09-19 2005-03-31 Pfizer Health Ab Enhanced method of treatment of growth disorders
US7674913B2 (en) 2003-11-12 2010-03-09 Phenomix Corporation Heterocyclic boronic acid compounds
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
US20150119327A1 (en) * 2012-04-25 2015-04-30 The Regents Of The University Of California Drug screening platform for rett syndrome
AU2016328969B2 (en) * 2015-09-21 2020-10-08 Lumos Pharma, Inc. Detecting and treating growth hormone deficiency

Also Published As

Publication number Publication date
IL258224B (en) 2021-10-31
US20190015394A1 (en) 2019-01-17
AU2025237934A1 (en) 2025-10-16
CA2998523C (en) 2023-08-01
KR20220047407A (ko) 2022-04-15
PT3939590T (pt) 2024-01-23
AU2024201658B2 (en) 2025-10-30
AU2020233715A1 (en) 2020-10-22
US9763919B2 (en) 2017-09-19
HUE057831T2 (hu) 2022-06-28
CN108348501A (zh) 2018-07-31
AU2021254600A1 (en) 2021-11-18
KR102560838B1 (ko) 2023-07-27
US20250213536A1 (en) 2025-07-03
SG10201902424TA (en) 2019-04-29
JP2024026112A (ja) 2024-02-28
CY1125183T1 (el) 2023-06-09
AU2016328969A1 (en) 2018-04-26
FI3939590T3 (fi) 2023-12-14
AU2020233715B2 (en) 2021-09-30
JP7104768B2 (ja) 2022-07-21
AU2016328969B2 (en) 2020-10-08
DK3939590T3 (da) 2023-12-18
US10105352B2 (en) 2018-10-23
KR20180082428A (ko) 2018-07-18
US20170079961A1 (en) 2017-03-23
KR20230116961A (ko) 2023-08-04
HUE065224T2 (hu) 2024-05-28
US10898472B2 (en) 2021-01-26
AU2024201658A1 (en) 2024-04-04
EP4296679A3 (en) 2024-04-10
ES2908423T3 (es) 2022-04-29
EP3352752A1 (en) 2018-08-01
SI3352752T1 (sl) 2022-05-31
SMT202200167T1 (it) 2022-05-12
KR102385669B1 (ko) 2022-04-13
EP3939590B1 (en) 2023-11-29
ES2967259T3 (es) 2024-04-29
SG10202010598SA (en) 2020-11-27
PL3352752T3 (pl) 2022-04-19
JP7724831B2 (ja) 2025-08-18
JP7389862B2 (ja) 2023-11-30
KR20250102122A (ko) 2025-07-04
CN116459250A (zh) 2023-07-21
EP3352752B1 (en) 2021-12-22
US20180071266A1 (en) 2018-03-15
JP6816149B2 (ja) 2021-01-20
IL258224A (en) 2018-05-31
LT3352752T (lt) 2022-04-11
JP2022163012A (ja) 2022-10-25
JP2021063096A (ja) 2021-04-22
JP2018529766A (ja) 2018-10-11
EP3352752A4 (en) 2019-06-12
EP4296679A2 (en) 2023-12-27
JP2025170274A (ja) 2025-11-18
PL3939590T3 (pl) 2024-03-25
RS62988B1 (sr) 2022-03-31
HRP20220317T1 (hr) 2022-05-13
WO2017053373A1 (en) 2017-03-30
PT3352752T (pt) 2022-03-09
HK1263178A1 (zh) 2020-01-31
AU2021254600B2 (en) 2024-02-15
CA2998523A1 (en) 2017-03-30
NZ741142A (en) 2025-05-02
DK3352752T3 (da) 2022-02-28
EP3939590A1 (en) 2022-01-19

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