UA120919U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. In the serum of the patient determine the polymorphism of the eNOS T786C gene, the content of thrombomodulin, pyridinoline, homocysteine, with homozygous carrier 786-CC, thrombomodulin levels> 5 ng / ml, pyridinoline> 8 ng / ml, homocytogenes.

Description

A useful model belongs to medicine, in particular to therapy and rheumatology, and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (Okorokov A.N.

Diagnosis of diseases of internal organs. - M.: Med. lit., 2003. - Vol. 6. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, the polymorphism of the nitric oxide synthase gene (6ЕМО5 T786C), the content of thrombomodulin, pyridinoline, and homocysteine is determined in the patient's blood serum by arteriography. With homozygous carrier 786-SS, levels of thrombomodulin »5 ng/ml, pyridinoline 28 ng/ml, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmo5 T786C gene is determined, and the content of thrombomodulin, pyridinoline, and homocysteine is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin 25 ng/ml, pyridinoline 28 ng/ml, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method

Patient B., 40 years old, was hospitalized for rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed. There are no signs of atherosclerosis. The emo gene polymorphism 1786C was determined in blood serum. The content of thrombomodulin, pyridinoline, homocysteine was determined by immunoenzymatic method. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 18.1 ng/ml, pyridinoline - 14.8 ng/ml, homocysteine - 29 μmol/l. The development of atherosclerosis was diagnosed.

Arteriographic confirmation of the diagnosis was obtained after 13 months.

Thus, the proposed method of diagnosing the development of atherosclerosis is informative.

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Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by that in the blood serum of the patient, the polymorphism of the EMO5 gene T786C, the content of thrombomodulin, pyridinoline, and homocysteine are determined, in the case of homozygous carrier 786-SS, the levels of thrombomodulin 25 ng/ml, pyridinoline 28 ng/ml, and homocysteine 220 μmol/l diagnose the development of atherosclerosis.