UA114360C2 - Спосіб лікування та/або зменшення інтенсивності неалкогольної жирової хвороби печінки (нжхп) - Google Patents

Info

Publication number

UA114360C2

UA114360C2 UAA201509744A UAA201509744A UA114360C2 UA 114360 C2 UA114360 C2 UA 114360C2 UA A201509744 A UAA201509744 A UA A201509744A UA A201509744 A UAA201509744 A UA A201509744A UA 114360 C2 UA114360 C2 UA 114360C2

Authority

UA

Ukraine

Prior art keywords

formula

sodium

liver

cellulose

nafld

Prior art date

2013-04-22

Links

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• Global Dossier
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• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 title claims abstract description 83
• 239000000203 mixture Substances 0.000 title claims abstract description 15
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims abstract description 54
• 238000000034 method Methods 0.000 claims abstract description 37
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
• 210000004185 liver Anatomy 0.000 claims abstract description 22
• 208000010706 fatty liver disease Diseases 0.000 claims abstract description 19
• 206010016654 Fibrosis Diseases 0.000 claims abstract description 18
• 208000019425 cirrhosis of liver Diseases 0.000 claims abstract description 16
• 231100000240 steatosis hepatitis Toxicity 0.000 claims abstract description 16
• 230000007882 cirrhosis Effects 0.000 claims abstract description 15
• 230000007863 steatosis Effects 0.000 claims abstract description 14
• 230000002265 prevention Effects 0.000 claims abstract description 7
• -1 poly(vinylpyrrolidone) Polymers 0.000 claims description 59
• 150000003839 salts Chemical class 0.000 claims description 30
• 239000003814 drug Substances 0.000 claims description 20
• 238000011282 treatment Methods 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 19
• 201000010099 disease Diseases 0.000 claims description 16
• 229940079593 drug Drugs 0.000 claims description 16
• 210000005229 liver cell Anatomy 0.000 claims description 15
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 13
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
• 150000002632 lipids Chemical class 0.000 claims description 10
• 235000006708 antioxidants Nutrition 0.000 claims description 8
• 210000003494 hepatocyte Anatomy 0.000 claims description 8
• GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 8
• 239000002904 solvent Substances 0.000 claims description 8
• 239000000126 substance Substances 0.000 claims description 8
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
• 239000013543 active substance Substances 0.000 claims description 7
• 239000003963 antioxidant agent Substances 0.000 claims description 7
• 239000011230 binding agent Substances 0.000 claims description 7
• 239000011575 calcium Substances 0.000 claims description 7
• 239000002775 capsule Substances 0.000 claims description 7
• 239000003381 stabilizer Substances 0.000 claims description 7
• 241000416162 Astragalus gummifer Species 0.000 claims description 6
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
• 229920002472 Starch Polymers 0.000 claims description 6
• 229920001615 Tragacanth Polymers 0.000 claims description 6
• 125000003545 alkoxy group Chemical group 0.000 claims description 6
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
• 235000012000 cholesterol Nutrition 0.000 claims description 6
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
• 230000009467 reduction Effects 0.000 claims description 6
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 6
• 235000019698 starch Nutrition 0.000 claims description 6
• 235000000346 sugar Nutrition 0.000 claims description 6
• 235000010487 tragacanth Nutrition 0.000 claims description 6
• 239000000196 tragacanth Substances 0.000 claims description 6
• 229940116362 tragacanth Drugs 0.000 claims description 6
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
• 239000004743 Polypropylene Substances 0.000 claims description 5
• 235000021355 Stearic acid Nutrition 0.000 claims description 5
• 125000002252 acyl group Chemical group 0.000 claims description 5
• 125000004104 aryloxy group Chemical group 0.000 claims description 5
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 5
• 235000013539 calcium stearate Nutrition 0.000 claims description 5
• 239000008116 calcium stearate Substances 0.000 claims description 5
• 239000002738 chelating agent Substances 0.000 claims description 5
• 239000007884 disintegrant Substances 0.000 claims description 5
• 150000002148 esters Chemical class 0.000 claims description 5
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 5
• 229940126601 medicinal product Drugs 0.000 claims description 5
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
• 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
• 239000008117 stearic acid Substances 0.000 claims description 5
• 239000000080 wetting agent Substances 0.000 claims description 5
• 102000009027 Albumins Human genes 0.000 claims description 4
• 108010088751 Albumins Proteins 0.000 claims description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
• 229920002261 Corn starch Polymers 0.000 claims description 4
• 108010010803 Gelatin Proteins 0.000 claims description 4
• 229920000881 Modified starch Polymers 0.000 claims description 4
• 239000004698 Polyethylene Substances 0.000 claims description 4
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
• 235000010443 alginic acid Nutrition 0.000 claims description 4
• 229920000615 alginic acid Polymers 0.000 claims description 4
• 125000004414 alkyl thio group Chemical group 0.000 claims description 4
• 125000005110 aryl thio group Chemical group 0.000 claims description 4
• 229910052791 calcium Inorganic materials 0.000 claims description 4
• 235000001465 calcium Nutrition 0.000 claims description 4
• 150000001768 cations Chemical class 0.000 claims description 4
• 239000001913 cellulose Substances 0.000 claims description 4
• 235000010980 cellulose Nutrition 0.000 claims description 4
• 229920002678 cellulose Polymers 0.000 claims description 4
• 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 4
• 239000008120 corn starch Substances 0.000 claims description 4
• 239000000945 filler Substances 0.000 claims description 4
• 239000008273 gelatin Substances 0.000 claims description 4
• 229920000159 gelatin Polymers 0.000 claims description 4
• 235000019322 gelatine Nutrition 0.000 claims description 4
• 235000011852 gelatine desserts Nutrition 0.000 claims description 4
• 239000000314 lubricant Substances 0.000 claims description 4
• 229910052751 metal Inorganic materials 0.000 claims description 4
• 239000002184 metal Substances 0.000 claims description 4
• 229920000609 methyl cellulose Polymers 0.000 claims description 4
• 235000010981 methylcellulose Nutrition 0.000 claims description 4
• 239000001923 methylcellulose Substances 0.000 claims description 4
• 230000001575 pathological effect Effects 0.000 claims description 4
• 229920001983 poloxamer Polymers 0.000 claims description 4
• 229920000573 polyethylene Polymers 0.000 claims description 4
• 229920001223 polyethylene glycol Polymers 0.000 claims description 4
• CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
• 235000010265 sodium sulphite Nutrition 0.000 claims description 4
• 239000008107 starch Substances 0.000 claims description 4
• 150000008163 sugars Chemical class 0.000 claims description 4
• 125000004001 thioalkyl group Chemical group 0.000 claims description 4
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 3
• 244000215068 Acacia senegal Species 0.000 claims description 3
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 3
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
• 235000013912 Ceratonia siliqua Nutrition 0.000 claims description 3
• 240000008886 Ceratonia siliqua Species 0.000 claims description 3
• 229920000084 Gum arabic Polymers 0.000 claims description 3
• 229910019142 PO4 Inorganic materials 0.000 claims description 3
• 235000010489 acacia gum Nutrition 0.000 claims description 3
• 239000000205 acacia gum Substances 0.000 claims description 3
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
• 239000000654 additive Substances 0.000 claims description 3
• 229940087168 alpha tocopherol Drugs 0.000 claims description 3
• 235000012216 bentonite Nutrition 0.000 claims description 3
• 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 3
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
• 239000003085 diluting agent Substances 0.000 claims description 3
• 239000000194 fatty acid Substances 0.000 claims description 3
• 229930195729 fatty acid Natural products 0.000 claims description 3
• 150000004665 fatty acids Chemical class 0.000 claims description 3
• 235000019359 magnesium stearate Nutrition 0.000 claims description 3
• 239000002480 mineral oil Substances 0.000 claims description 3
• 235000010446 mineral oil Nutrition 0.000 claims description 3
• 235000021317 phosphate Nutrition 0.000 claims description 3
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
• 229960000984 tocofersolan Drugs 0.000 claims description 3
• XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 3
• 239000002076 α-tocopherol Substances 0.000 claims description 3
• 235000004835 α-tocopherol Nutrition 0.000 claims description 3
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
• RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
• GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
• 102000008186 Collagen Human genes 0.000 claims description 2
• 108010035532 Collagen Proteins 0.000 claims description 2
• 244000303965 Cyamopsis psoralioides Species 0.000 claims description 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
• 239000001856 Ethyl cellulose Substances 0.000 claims description 2
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
• 229920002907 Guar gum Polymers 0.000 claims description 2
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
• 239000000783 alginic acid Substances 0.000 claims description 2
• 229960001126 alginic acid Drugs 0.000 claims description 2
• 150000004781 alginic acids Chemical class 0.000 claims description 2
• 239000003125 aqueous solvent Substances 0.000 claims description 2
• 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
• 239000000378 calcium silicate Substances 0.000 claims description 2
• 229910052918 calcium silicate Inorganic materials 0.000 claims description 2
• 235000012241 calcium silicate Nutrition 0.000 claims description 2
• OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 2
• 239000005018 casein Substances 0.000 claims description 2
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
• 235000021240 caseins Nutrition 0.000 claims description 2
• 239000004359 castor oil Substances 0.000 claims description 2
• 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
• 229960003260 chlorhexidine Drugs 0.000 claims description 2
• 229960004106 citric acid Drugs 0.000 claims description 2
• 235000015165 citric acid Nutrition 0.000 claims description 2
• 229920001436 collagen Polymers 0.000 claims description 2
• 239000008387 emulsifying waxe Substances 0.000 claims description 2
• 239000004174 erythrosine Substances 0.000 claims description 2
• 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
• 229920001249 ethyl cellulose Polymers 0.000 claims description 2
• 235000003599 food sweetener Nutrition 0.000 claims description 2
• RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims description 2
• 239000000665 guar gum Substances 0.000 claims description 2
• 235000010417 guar gum Nutrition 0.000 claims description 2
• 229960002154 guar gum Drugs 0.000 claims description 2
• 239000000017 hydrogel Substances 0.000 claims description 2
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
• 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 2
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 2
• 235000010445 lecithin Nutrition 0.000 claims description 2
• 239000000787 lecithin Substances 0.000 claims description 2
• 229940067606 lecithin Drugs 0.000 claims description 2
• 239000000391 magnesium silicate Substances 0.000 claims description 2
• 235000019792 magnesium silicate Nutrition 0.000 claims description 2
• 229910052919 magnesium silicate Inorganic materials 0.000 claims description 2
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
• 239000011976 maleic acid Substances 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 235000019426 modified starch Nutrition 0.000 claims description 2
• PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 2
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 2
• 235000010987 pectin Nutrition 0.000 claims description 2
• 239000001814 pectin Substances 0.000 claims description 2
• 229920001277 pectin Polymers 0.000 claims description 2
• 229920001451 polypropylene glycol Polymers 0.000 claims description 2
• 229920001282 polysaccharide Polymers 0.000 claims description 2
• 239000005017 polysaccharide Substances 0.000 claims description 2
• 150000004804 polysaccharides Chemical class 0.000 claims description 2
• 229920001592 potato starch Polymers 0.000 claims description 2
• 229940069328 povidone Drugs 0.000 claims description 2
• 239000010703 silicon Substances 0.000 claims description 2
• 229910052710 silicon Inorganic materials 0.000 claims description 2
• 235000015424 sodium Nutrition 0.000 claims description 2
• 239000011734 sodium Substances 0.000 claims description 2
• 229910052708 sodium Inorganic materials 0.000 claims description 2
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
• 239000004299 sodium benzoate Substances 0.000 claims description 2
• 235000010234 sodium benzoate Nutrition 0.000 claims description 2
• 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
• 235000017550 sodium carbonate Nutrition 0.000 claims description 2
• HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
• 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
• 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
• 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
• 229940001482 sodium sulfite Drugs 0.000 claims description 2
• 239000000600 sorbitol Substances 0.000 claims description 2
• 239000003765 sweetening agent Substances 0.000 claims description 2
• 239000000454 talc Substances 0.000 claims description 2
• 229910052623 talc Inorganic materials 0.000 claims description 2
• 235000012222 talc Nutrition 0.000 claims description 2
• OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• 229920000591 gum Polymers 0.000 claims 2
• 238000011084 recovery Methods 0.000 claims 2
• 239000013589 supplement Substances 0.000 claims 2
• RGHNJXZEOKUKBD-NRXMZTRTSA-N (2r,3r,4r,5s)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-NRXMZTRTSA-N 0.000 claims 1
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
• 240000000467 Carum carvi Species 0.000 claims 1
• 235000005747 Carum carvi Nutrition 0.000 claims 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
• QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
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