UA112857C2

UA112857C2 - Препарат, що містить 2-аміно-2-[2-(4-октилфеніл)етил]пропан-1,3-діол

Препарат, що містить 2-аміно-2-[2-(4-октилфеніл)етил]пропан-1,3-діол Download PDF

Info

Publication number: UA112857C2
Authority: UA; Ukraine
Prior art keywords: cyclodextrin; composition according; ethyl; octylphenyl; amino
Prior art date: 2011-04-01

Application number

UAA201310656A

Other languages

English (en)

Ukrainian (uk)

Inventor

Супрія Ране

Original Assignee

Новартіс Аг

Priority date

2011-04-01

Filing date

2012-03-30

Publication date

2016-11-10

2012-03-30 Application filed by Новартіс Аг filed Critical Новартіс Аг

2012-03-30 Priority claimed from PCT/US2012/031340 external-priority patent/WO2012135561A1/en

2016-11-10 Publication of UA112857C2 publication Critical patent/UA112857C2/uk

Links

-1 4-OCTYLPHENYL Chemical class 0.000 title claims abstract description 16
238000002360 preparation method Methods 0.000 title description 9
QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 133
229920000858 Cyclodextrin Polymers 0.000 claims abstract description 64
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 36
150000003839 salts Chemical class 0.000 claims abstract description 23
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
239000003381 stabilizer Substances 0.000 claims abstract description 20
150000001875 compounds Chemical class 0.000 claims abstract description 14
239000007787 solid Substances 0.000 claims abstract description 5
125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims abstract 5
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FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 67
229930195725 Mannitol Natural products 0.000 claims description 67
235000010355 mannitol Nutrition 0.000 claims description 67
YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 46
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 21
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
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