UA108742C2

UA108742C2 - Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 Download PDF

Info

Publication number: UA108742C2
Authority: UA; Ukraine
Prior art keywords: group; pharmaceutical composition; hydrogen atom; alkyl group; amount
Prior art date: 2009-09-23

Application number

UAA201203482A

Other languages

English (en)

Ukrainian (uk)

Priority date

2009-09-23

Filing date

2010-03-09

Publication date

2015-06-10

2010-03-09 Application filed filed Critical

2015-06-10 Publication of UA108742C2 publication Critical patent/UA108742C2/uk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 33
102100021943 C-C motif chemokine 2 Human genes 0.000 title abstract 2
101710155857 C-C motif chemokine 2 Proteins 0.000 title abstract 2
201000010099 disease Diseases 0.000 title description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 7
230000001404 mediated effect Effects 0.000 title description 4
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims abstract description 23
239000003529 anticholesteremic agent Substances 0.000 claims abstract description 22
229940127226 anticholesterol agent Drugs 0.000 claims abstract description 21
AKQDXNFPEFHRLS-UHFFFAOYSA-N (1-benzylindazol-3-yl)methanol Chemical compound C12=CC=CC=C2C(CO)=NN1CC1=CC=CC=C1 AKQDXNFPEFHRLS-UHFFFAOYSA-N 0.000 claims abstract description 11
239000003638 chemical reducing agent Substances 0.000 claims abstract description 7
239000005541 ACE inhibitor Substances 0.000 claims description 29
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 29
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 17
150000002148 esters Chemical class 0.000 claims description 16
239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 15
150000001875 compounds Chemical class 0.000 claims description 15
229960002198 irbesartan Drugs 0.000 claims description 15
YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 15
239000002083 C09CA01 - Losartan Substances 0.000 claims description 13
229960004773 losartan Drugs 0.000 claims description 13
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims description 13
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 12
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 12
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HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims description 12
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RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 12
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HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 11
125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 10
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HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 8
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FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 5
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125000005843 halogen group Chemical group 0.000 claims description 4
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