UA106212C2 - Гени дельта-8-десатурази, ферменти, що ними кодуються, та їх застосування - Google Patents

Гени дельта-8-десатурази, ферменти, що ними кодуються, та їх застосування

Info

Publication number
UA106212C2
UA106212C2 UAA201105291A UAA201105291A UA106212C2 UA 106212 C2 UA106212 C2 UA 106212C2 UA A201105291 A UAA201105291 A UA A201105291A UA A201105291 A UAA201105291 A UA A201105291A UA 106212 C2 UA106212 C2 UA 106212C2
Authority
UA
Ukraine
Prior art keywords
delta
desaturase
enzymed
genes
coded
Prior art date
Application number
UAA201105291A
Other languages
English (en)
Russian (ru)
Inventor
Тапас ДАС
Прадіп Мукерджі
Сюзет Перейра
Падмаваті Крішнан
Original Assignee
Ебботт Лебораторіз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ебботт Лебораторіз filed Critical Ебботт Лебораторіз
Publication of UA106212C2 publication Critical patent/UA106212C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Даний винахід належить до виділеної нуклеїнової кислоти, що містить нуклеотидну послідовність, яка кодує поліпептид, що має десатуразну активність, при цьому зазначена послідовність кодує функціонально активний Δ8-десатуразний фермент, що використовує як субстрат ω6-ейкозадієнову кислоту або ω3-ейкозатриєнову кислоту. Також винахід належить до вектора експресії, що містить виділену нуклеїнову кислоту, клітини-хазяїна, що містить вектор експресії, і до способу продукування (8-десатуразного ферменту і способу одержання поліненасиченої жирної кислоти.
UAA201105291A 2008-10-06 2009-10-06 Гени дельта-8-десатурази, ферменти, що ними кодуються, та їх застосування UA106212C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10310708P 2008-10-06 2008-10-06
PCT/US2009/059689 WO2010042510A1 (en) 2008-10-06 2009-10-06 Delta-8 desaturase genes, enzymes encoded thereby and uses thereof

Publications (1)

Publication Number Publication Date
UA106212C2 true UA106212C2 (uk) 2014-08-11

Family

ID=41571636

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201105291A UA106212C2 (uk) 2008-10-06 2009-10-06 Гени дельта-8-десатурази, ферменти, що ними кодуються, та їх застосування

Country Status (15)

Country Link
US (1) US8247653B2 (uk)
EP (1) EP2358869B1 (uk)
JP (1) JP5723281B2 (uk)
CN (1) CN102239254B (uk)
AR (1) AR073779A1 (uk)
AU (1) AU2009302522B2 (uk)
CA (1) CA2739836A1 (uk)
ES (1) ES2466365T3 (uk)
MX (1) MX2011003700A (uk)
MY (1) MY178930A (uk)
NZ (1) NZ592147A (uk)
RU (1) RU2517615C2 (uk)
UA (1) UA106212C2 (uk)
WO (1) WO2010042510A1 (uk)
ZA (1) ZA201103132B (uk)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2768082C (en) * 2009-07-17 2020-07-21 Basf Plant Science Company Gmbh Novel fatty acid desaturases and uses thereof
US8188335B2 (en) * 2009-07-17 2012-05-29 Abbott Laboratories Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
WO2016163454A1 (ja) * 2015-04-08 2016-10-13 株式会社ユーグレナ 関節リウマチ抑制剤，関節リウマチ予防剤，関節リウマチ治療剤及び関節リウマチ抑制用食品

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57501692A (uk) 1980-09-24 1982-09-16
DE3381518D1 (de) 1982-01-22 1990-06-07 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4582788A (en) * 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5420034A (en) * 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
US4943674A (en) * 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
GB8507058D0 (en) 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8524276D0 (en) * 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
GB8524275D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5107065A (en) * 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5188958A (en) * 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US5004863B2 (en) * 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5416011A (en) * 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
IE63225B1 (en) 1988-09-13 1995-04-05 Efamol Holdings Use of fatty acids in the treatment of myalgic encephalomyelitis
US5231020A (en) * 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5106739A (en) * 1989-04-18 1992-04-21 Calgene, Inc. CaMv 355 enhanced mannopine synthase promoter and method for using same
US5175095A (en) * 1989-07-19 1992-12-29 Calgene, Inc. Ovary-tissue transcriptional factors
US5518908A (en) * 1991-09-23 1996-05-21 Monsanto Company Method of controlling insects
US5912120A (en) * 1992-04-09 1999-06-15 The United States Of America As Represented By The Department Of Health And Human Services, Cloning, expression and diagnosis of human cytochrome P450 2C19: the principal determinant of s-mephenytoin metabolism
ATE193729T1 (de) * 1993-02-26 2000-06-15 Calgene Llc Geminivirus-basiertes-genexpressionsystem
WO1995024488A1 (en) * 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
NZ279676A (en) 1994-03-09 1998-04-27 Abbott Lab Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates
US5750176A (en) * 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
US5631152A (en) 1994-10-26 1997-05-20 Monsanto Company Rapid and efficient regeneration of transgenic plants
DE19941609A1 (de) * 1999-09-01 2001-03-08 Inst Pflanzenbiochemie Ipb Fettsäure-Desaturase-Gen aus Pflanzen
CA3056110C (en) * 2004-04-22 2020-07-14 Surinder Pal Singh Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
US7943823B2 (en) * 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US8916361B2 (en) * 2006-11-17 2014-12-23 Abbott Laboratories Elongase gene and uses thereof
US7709239B2 (en) * 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids

Also Published As

Publication number Publication date
AU2009302522A1 (en) 2010-04-15
RU2517615C2 (ru) 2014-05-27
US8247653B2 (en) 2012-08-21
WO2010042510A1 (en) 2010-04-15
MX2011003700A (es) 2011-11-29
CN102239254A (zh) 2011-11-09
US20100154080A1 (en) 2010-06-17
RU2011114558A (ru) 2012-11-20
MY178930A (en) 2020-10-23
CA2739836A1 (en) 2010-04-15
NZ592147A (en) 2012-10-26
JP5723281B2 (ja) 2015-05-27
ZA201103132B (en) 2012-04-18
CN102239254B (zh) 2014-02-26
EP2358869A1 (en) 2011-08-24
JP2012504960A (ja) 2012-03-01
ES2466365T3 (es) 2014-06-10
AU2009302522B2 (en) 2015-03-26
AR073779A1 (es) 2010-12-01
EP2358869B1 (en) 2014-03-26

Similar Documents

Publication Publication Date Title
IN2012DN00469A (uk)
WO2010108114A3 (en) Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof
IN2014CN04586A (uk)
MX2012006096A (es) Polipeptidos que tienen actividad glucoamilasa y polinucleotidos que codifican para los mismos.
ATE466091T1 (de) Verfahren zur herstellung mehrfach ungesaettigter fettsaeuren, neue biosynthesegene sowie neue pflanzliche expressionskonstrukte
ATE524161T1 (de) Zusammensetzung mit einem gekoppelten enzymsystem
MY185473A (en) Method for decoding video by considering skip and split order
WO2010023202A3 (en) Nucleic acids encoding desaturases and modified plant oil
WO2003064596A8 (en) Desaturase genes, enzymes encoded thereby, and uses thereof
MX342150B (es) Codificacion y decodificacion de señales de audio.
EP3805348A3 (en) Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EA201290443A1 (ru) ХИМЕРНЫЕ И ГИБРИДНЫЕ ПОЛИПЕПТИДЫ ФАКТОРА VIII-Fc И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2327307A4 (en) Water that expresses pathogen-resistance genes (pr gene clusters) to encode plant immunoproteins, a method of preventing plant diseases using the water, and a device for producing the water
EP3792352A3 (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
WO2008040787A3 (de) Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
MY163985A (en) Image processing apparatus and method
MX2013004892A (es) Polipeptidos que tienen actividad de fosfolipasa c y polinucleotidos que codifican los mismos.
WO2012052468A3 (en) Novel fatty acid desaturases, elongases, elongation components and uses therof
WO2011155799A3 (ko) 탄화수소 생성능을 가지는 변이 미생물 및 이를 이용한 탄화수소의 제조방법
WO2014020533A3 (en) Novel enzymes, enzyme components and uses thereof
MX2012006095A (es) Polipeptidos que tienen actividad glucoamilasa y polinucleotidos que codifican para los mismos.
UA106212C2 (uk) Гени дельта-8-десатурази, ферменти, що ними кодуються, та їх застосування
MY163070A (en) Process to produce valerolactone from levulinic acid
BR112014020852B8 (pt) Método para a produção de um hidrocarboneto
IN2012DN05162A (uk)