UA104677C2 - Производные мочевины и их терапевтическое применение при лечении, среди прочего, заболеваний дыхательных путей - Google Patents
Производные мочевины и их терапевтическое применение при лечении, среди прочего, заболеваний дыхательных путейInfo
- Publication number
- UA104677C2 UA104677C2 UAA201213918A UAA201213918A UA104677C2 UA 104677 C2 UA104677 C2 UA 104677C2 UA A201213918 A UAA201213918 A UA A201213918A UA A201213918 A UAA201213918 A UA A201213918A UA 104677 C2 UA104677 C2 UA 104677C2
- Authority
- UA
- Ukraine
- Prior art keywords
- diseases
- treatment
- inter alia
- respiratory tract
- therapeutic use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Соединения формулы (I) представляют собой ингибиторы МАРК р38, применяемые в качестве противовоспалительных средств при лечении, среди прочих, заболеваний дыхательных путей, где Rпредставляет собой радикал формулы (IA) или (IB), или (IC); Y представляет собой -О- или -S(O)-, где р равняется 0, 1 или 2; А представляет собой необязательно замещенный циклоалкиленовый радикал, который имеет 5, 6 или 7 атомов кольца, конденсированных с фенильным кольцом; и R, Rи Rявляются такими, как определено в формуле изобретения.(I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1009731.9A GB201009731D0 (en) | 2010-06-10 | 2010-06-10 | Kinase inhibitors |
PCT/GB2011/051076 WO2011154738A1 (en) | 2010-06-10 | 2011-06-09 | Urea derivatives and their therapeutic use in the treatment of, inter alia, diseases of the respiratory tract |
Publications (1)
Publication Number | Publication Date |
---|---|
UA104677C2 true UA104677C2 (ru) | 2014-02-25 |
Family
ID=42471455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201213918A UA104677C2 (ru) | 2010-06-10 | 2011-06-09 | Производные мочевины и их терапевтическое применение при лечении, среди прочего, заболеваний дыхательных путей |
Country Status (17)
Country | Link |
---|---|
US (1) | US8916708B2 (ru) |
EP (1) | EP2580212B1 (ru) |
JP (1) | JP5791708B2 (ru) |
KR (1) | KR20130086944A (ru) |
CN (1) | CN103140489B (ru) |
AU (1) | AU2011263492B2 (ru) |
BR (1) | BR112012031226A2 (ru) |
CA (1) | CA2802010A1 (ru) |
GB (1) | GB201009731D0 (ru) |
IL (1) | IL223463A (ru) |
MX (1) | MX2012014371A (ru) |
MY (1) | MY159239A (ru) |
RU (1) | RU2586223C2 (ru) |
SG (1) | SG186228A1 (ru) |
UA (1) | UA104677C2 (ru) |
WO (1) | WO2011154738A1 (ru) |
ZA (1) | ZA201209289B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2788348B1 (en) * | 2011-12-09 | 2016-10-19 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
PE20141370A1 (es) * | 2011-12-09 | 2014-10-17 | Chiesi Farma Spa | Inhibidores de quinasa |
EP2788345B1 (en) * | 2011-12-09 | 2020-06-10 | Chiesi Farmaceutici S.p.A. | Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphtalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract |
WO2014033447A2 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
EP2890460B1 (en) | 2012-08-29 | 2017-02-22 | Respivert Limited | Kinase inhibitors |
EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
EA030483B1 (ru) | 2013-04-02 | 2018-08-31 | Респайверт Лимитед | Производные мочевины, полезные в качестве ингибиторов киназы |
US9573949B2 (en) | 2013-06-06 | 2017-02-21 | Chiesi Farmaceutici S.P.A. | Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors |
CN105308046A (zh) * | 2013-06-06 | 2016-02-03 | 奇斯药制品公司 | 激酶抑制剂 |
KR20160018567A (ko) | 2013-06-06 | 2016-02-17 | 키에시 파르마슈티시 엣스. 피. 에이. | 키나아제 억제제 |
AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
WO2018199210A1 (ja) * | 2017-04-27 | 2018-11-01 | 日本農薬株式会社 | 縮合複素環化合物又はその塩類、及びそれらの化合物を含有する農園芸用殺虫剤並びにその使用方法 |
US10364245B2 (en) * | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
KR20200067170A (ko) | 2017-10-05 | 2020-06-11 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제 |
US11407771B2 (en) | 2018-05-30 | 2022-08-09 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
US11475172B2 (en) | 2019-03-15 | 2022-10-18 | International Business Machines Corporation | Adjustable viewing angle for a computer privacy filter |
EP3868368A1 (en) * | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
JPH11508583A (ja) | 1995-07-06 | 1999-07-27 | ゼネカ・リミテッド | ペプチド系のフィブロネクチン阻害薬 |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
YU25500A (sh) | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
WO2001036403A1 (en) * | 1999-11-16 | 2001-05-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Urea derivatives as anti-inflammatory agents |
CN1388802A (zh) | 2000-09-06 | 2003-01-01 | 大赛璐化学工业株式会社 | 3-氨基-1-茚满醇、其合成方法和对映体的拆分 |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
EP1241176A1 (en) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Purine derivatives for the treatment of ischemia |
CA2445003A1 (en) * | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
CA2446193C (en) * | 2001-06-05 | 2011-11-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused cycloalkyl urea compounds |
DE60214428T2 (de) | 2001-12-20 | 2007-09-20 | Bayer Healthcare Ag | 1, 4-dihydro-1, 4-diphenylpyridin-derivate |
DE602004001676T2 (de) | 2003-02-14 | 2007-08-30 | Pfizer Products Inc., Groton | Triazolo-Pyridine als entzündungshemmende Verbindungen |
SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
JP2007514791A (ja) * | 2003-12-18 | 2007-06-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | P38mapキナーゼインヒビターであるbirb796の多形 |
EP1609789A1 (en) | 2004-06-23 | 2005-12-28 | Eli Lilly And Company | Ureido-pyrazole derivatives and their use as kinase inhibitors |
ES2308523T3 (es) | 2004-06-23 | 2008-12-01 | Eli Lilly And Company | Inhibidores de quinasa. |
GB0418015D0 (en) * | 2004-08-12 | 2004-09-15 | Pfizer Ltd | New compounds |
US20090215817A1 (en) | 2004-08-18 | 2009-08-27 | Pfizer Inc | Novel Triazolopyridine Compounds for the Treatment of Inflammation |
GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
DOP2006000051A (es) | 2005-02-24 | 2006-08-31 | Lilly Co Eli | Inhibidores de vegf-r2 y métodos |
CA2620254A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
EP1984363A1 (en) | 2006-02-09 | 2008-10-29 | Pfizer Limited | Triazolopyridine compounds |
CL2007002867A1 (es) | 2006-10-04 | 2008-06-27 | Pharmacopeia Inc | Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras. |
MX2011006219A (es) * | 2008-12-11 | 2011-06-28 | Respivert Ltd | Inhibidores de la proteina cinasa activada por el mitogeno p38. |
WO2010094956A1 (en) * | 2009-02-17 | 2010-08-26 | Pulmagen Therapeutics (Inflammation) Limited. | Triazolopyridine derivatives as p38 map kinase inhibitors |
GB201005589D0 (en) * | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
-
2010
- 2010-06-10 GB GBGB1009731.9A patent/GB201009731D0/en not_active Ceased
-
2011
- 2011-06-09 EP EP11729655.8A patent/EP2580212B1/en active Active
- 2011-06-09 BR BR112012031226A patent/BR112012031226A2/pt not_active IP Right Cessation
- 2011-06-09 CN CN201180026836.3A patent/CN103140489B/zh not_active Expired - Fee Related
- 2011-06-09 KR KR1020127031394A patent/KR20130086944A/ko active IP Right Grant
- 2011-06-09 MX MX2012014371A patent/MX2012014371A/es unknown
- 2011-06-09 RU RU2012153164/04A patent/RU2586223C2/ru not_active IP Right Cessation
- 2011-06-09 US US13/701,989 patent/US8916708B2/en not_active Expired - Fee Related
- 2011-06-09 MY MYPI2012005302A patent/MY159239A/en unknown
- 2011-06-09 UA UAA201213918A patent/UA104677C2/ru unknown
- 2011-06-09 WO PCT/GB2011/051076 patent/WO2011154738A1/en active Application Filing
- 2011-06-09 JP JP2013513759A patent/JP5791708B2/ja not_active Expired - Fee Related
- 2011-06-09 SG SG2012090239A patent/SG186228A1/en unknown
- 2011-06-09 AU AU2011263492A patent/AU2011263492B2/en not_active Ceased
- 2011-06-09 CA CA2802010A patent/CA2802010A1/en not_active Abandoned
-
2012
- 2012-12-06 IL IL223463A patent/IL223463A/en active IP Right Grant
- 2012-12-07 ZA ZA2012/09289A patent/ZA201209289B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2012014371A (es) | 2013-01-29 |
US8916708B2 (en) | 2014-12-23 |
WO2011154738A1 (en) | 2011-12-15 |
AU2011263492A1 (en) | 2013-01-10 |
JP5791708B2 (ja) | 2015-10-07 |
AU2011263492B2 (en) | 2015-11-12 |
SG186228A1 (en) | 2013-01-30 |
GB201009731D0 (en) | 2010-07-21 |
BR112012031226A2 (pt) | 2018-03-06 |
CN103140489A (zh) | 2013-06-05 |
US20130143914A1 (en) | 2013-06-06 |
IL223463A (en) | 2016-12-29 |
JP2013528205A (ja) | 2013-07-08 |
RU2586223C2 (ru) | 2016-06-10 |
EP2580212A1 (en) | 2013-04-17 |
ZA201209289B (en) | 2014-02-26 |
KR20130086944A (ko) | 2013-08-05 |
CN103140489B (zh) | 2016-05-18 |
RU2012153164A (ru) | 2014-06-20 |
CA2802010A1 (en) | 2011-12-15 |
MY159239A (en) | 2016-12-30 |
EP2580212B1 (en) | 2015-01-28 |
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