TWM642999U - Embedded structure containing honeysuckle, [beta]-glucan, lactobacillus and maslinic acid compound - Google Patents

Abstract

This creation provides an embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound, including a fungal core; a human nutrient layer, which is wrapped around the outer layer of the fungal core; a plant extract The essence layer is wrapped in the outer layer of the human nutrition layer; and a compound Chinese herbal medicine layer is wrapped in the outer layer of the plant extract layer to form an embedding structure. The embedding structure contains Lactobacillus, Bacillus, bovine colostrum protein, β-glucan, catechin, curcumin, quercetin, maslinic acid, honeysuckle, Houttuynia cordata, licorice, perilla, olive leaf, Siberian ginseng, peppermint, lily, garlic and other ingredients have the effects of fighting new coronavirus infection, improving immunity, and reducing allergic symptoms.

Description

Embedded structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound

This creation provides an embedded structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound, which is a health food for improving immunity, reducing human allergic symptoms and strengthening the human body's effect against the new coronavirus.

In today's society, in addition to the ongoing ravages of the novel coronavirus that has caused hundreds of millions of people to be diagnosed and millions of people to die, there are still a variety of viruses and pathogenic bacteria that can endanger human health. Therefore, strengthening the immune system is an urgent task. However, because the function of the immune system is a very complex and detailed mechanism, an imbalance of the immune system, whether it is too weak or too strong, will affect the whole body and cause different diseases, ranging from allergic rhinitis, atopic dermatitis, allergic conjunctivitis etc., as large as systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, etc. Therefore, in addition to facing the virus with caution, it is also necessary to improve your own immune system.

Although modern medicine has done in-depth research on the operation of the new coronavirus and the human immune system, and there are corresponding treatments for viral infections and immune system imbalances, but because the existing treatments have different effects and have different degrees of Side effects, so there is still considerable room for growth and improvement.

It has been a long time since scientific research and analysis confirmed the health-care efficacy and safety of health-care functional ingredients to assist in the adjustment of human health, and more new raw materials and new functions used in human health care have been continuously discovered to improve the human immune system. The operation of is also one of the items. Therefore, it has become a new trend to use different high-quality health care ingredients to adjust human health to achieve the purpose of fighting viral infections, improving immunity, and reducing allergic symptoms.

In addition, the lactic acid bacteria in the health-care functional ingredients are not easy to preserve, and after eating, they are easily damaged by gastric acid and choline in the digestive tract, and lose their activity before reaching the intestinal tract, making it impossible for the supplemented lactic acid bacteria to colonize in the intestinal tract. The original effect of lactic acid bacteria may limit the development of its products.

In addition, acid and alkali-resistant crystal structures are often seen in products containing lactic acid bacteria on the market, which have good protection, so that lactic acid bacteria with embedded crystals can reach the intestinal tract for colonization, but the improvement process of intestinal flora takes time. If Excessive release rate in the intestinal tract may cause lactic acid bacteria to compete with each other and rob each other of nutrient sources, resulting in a reduction in the number and types of lactic acid bacteria that have already colonized. In addition, if different health-care functional ingredients can be released according to their most suitable absorption environment or action location, then they can exert the greatest comprehensive effect. Therefore, the structural composition that can change the release rate in response to environmental changes has become an important trend.

Honeysuckle, Lonicera japonica, is abundant in China. Its dried flowers and buds are called honeysuckle. It is a precious Chinese medicinal material with a history of more than 1500 years. It is currently known to be used to treat arthritis, diabetes, fever and viral infections. In addition, a total of 140 compounds have been isolated from honeysuckle through extraction and analysis techniques, including essential oils, organic acids, flavonoids, saponins, and cycloalkene ethers. Honeysuckle extract is rich in chlorogenic acid (CHA), which can act on upper respiratory tract infection to treat influenza virus, parainfluenza virus, and respiratory syncytial virus. At present, relevant experimental results have shown that CHA, as a neuraminidase inhibitor, can inhibit influenza virus in cells and animal models. In the silico bioinformatics workflow, the database predicts that honeysuckle and Astragalus membranaceus have potential anti-SARS-CoV-2 (Covid-19) effects. The cell experiments of these two plant extracts found that they can regulate microRNA including let-7a, miR-148b and miR-146a, etc., so as to reduce the pathogenesis of SARS-CoV-2. In addition, it can also inhibit pro-inflammatory cytokines including IL-6 and TNF-α that lead to cytokine storm. Cytokine storm is the main cause of death caused by COVID-19 caused by acute respiratory distress syndrome.

Houttuynia cordata, Houttuynia cordata, is a creeping aromatic herb rhizome. The total length is about 20-50 cm. The leaves are 4-8 cm long and 3-6 cm wide. They are oval and heart-shaped and are widely distributed in Asia. Because its above-ground stems and leaves have a long history of medicinal use in China, in clinical treatment, it can usually be combined with other drugs to treat dysentery, cold, fever, mumps and other diseases. The chemical composition of Houttuynia cordata contains abundant alkaloids, while volatile oils and flavonoids are mainly pharmacologically active components. Among them, decanoyl acetaldehyde (decanoyl acetaldehyde) has a fishy smell, so it is named Houttuynia cordata in Chinese. This ingredient also has antibacterial effect, and it will be converted into 2-undecanone (2-undecanone) at high temperature. It is called methyl nonyl ketone (methyl n-nonanone), so it can be used as an indicator component for evaluating the quality of Houttuynia cordata. The water extract of Houttuynia cordata has immunomodulatory effects and reduces severe acute respiratory syndrome (SARS). In addition, experiments have found that it can also stimulate the proliferation of mouse spleen lymphocytes in a dose-dependent manner. The detection of mouse spleen lymphocytes by flow cytometry showed that Houttuynia cordata increased the ratio of CD4+ and CD8+ T cells and promoted a significant increase of IL-2 and IL-10. In terms of anti-virus, the water extract of Houttuynia cordata can significantly inhibit SARS coronavirus (SARS-CoV) 3C-like protease (3C-like protease) and RNA-dependent RNA polymerase (RNA dependent RNA polymerase).

Licorice, Glycyrrhiza uralensis, grows in China, Mongolia and Russia. Licorice is a perennial plant belonging to the Fabacaea family, with a plant height of 40 to 100 cm. It blooms in mid-to-late June and bears fruit in mid-July and August. Licorice root contains about 27 flavonoids (3-4%) and glycyrrhizin acid is biologically active. Glycyrrhizic acid, also known as glycyrrhizin (glycyrrhizin), is the water extract of licorice root, which is composed of one molecule of glycyrrhetinic acid and two glucuronic acids. Commonly used in sweeteners and flavoring agents, and glycyrrhetinic acid has a corticosteroid structure, and has been proven to have a variety of beneficial pharmacological activities, such as anti-inflammatory activity, antioxidant activity to protect the liver; it can perform immune regulation, promote Produce interleukin (interleukin) IL-1, IL-2 and IL-12 to enhance the production of antibodies; induce T cells to produce γ-interferon to inhibit virus replication and other effects. Glycyrrhizic acid has the effect of inhibiting SARS-associated coronavirus. In vitro cell experiments simulating SARS infection showed that infected cells treated with glycyrrhizic acid at concentrations of 1000 mg/L and 4000 mg/L significantly inhibited SARS in them. Therefore glycyrrhizic acid has the effect of suppressing SARS-associated coronavirus. The report of silico docking studies shows that glycyrrhizic acid and glycyrrhetinic acid may directly affect the internalization and replication of Covid-19 virus. At the same time, according to in vitro data, glycyrrhizic acid can interfere with virus entry by directly interacting with (angiotensin-converting enzyme 2, ACE2) and spike protein to avoid host cell infection.

Perilla, Perilla frutescens, Lamiaceae, is an edible plant often used in Asian countries such as: China, Korea, Japan and Thailand. It is an aromatic plant with a strong minty smell. The phytochemical constituents in perilla include apigenin, ascorbic acid, β-carotene, caffeic acid, citral, dilapiole, elemicin, limonene, and mignonette Myristin, perillaldehyde, protocatechuic acid, quercetin, rosmarinic acid, perillone, elsholzia ketone, isoegomaketone, 3-methyl-2-butanol naginata ketone, sassafras, anthocyanins (eg perillanin chloride) and polyphenols (eg flavonoids). Perilla leaf extract had an EC50 of 0.12 ± 0.06 mg/mL against SARS-CoV-2 (Covid-19)-infected Vero E6 cells, and was able to block Covid-19 viral RNA and protein synthesis. In the Calu-3 epithelial cell experiment, it can significantly reduce the virus-induced cytokine (cytokine) release and reduce the amount of viral protein and RNA. In addition, studies have shown that when perilla leaf extract is used in combination with remdesivir, an additive synergistic effect can inhibit Covid-19.

Olive leaves and olive trees (Olea europaea L.) are planted in many parts of the world, and the Mediterranean region is the main area of its agricultural production, accounting for about 98% of the planted area. There are currently five types of phenolic compounds in the chemical components identified from olive trees: oleuropeosides (oleuropein and verbascoside ); and diosmetin); flavonols (rutin); catechins (flavan-3-ols) and substituted phenols (tyrosol, hydroxytyrosol, vanillin, vanillic acid and caffeic acid). Oleuropein is the most abundant phenolic compound in olive leaves, followed by hydroxytyrosol, luteolin-7-O-glucosides, apigenin-7-glucosides ) and verbascoside (verbascoside). The total flavonoid and polyphenol content of olive leaf was determined to be 2.058 mg GAE (gallic acid equivalent) per 100 g and 858 mg CTE (catechin equivalent) per 100 g, values similar to red grapes. Taking poultry Newcastle disease virus (New castle disease virus) as the research object, it was found that olive leaf extract can inhibit the production of two structural proteins (matrix protein M and fusion protein F) by the virus, blocking the replication ability of the virus. It can also be found in the hemagglutinin experiment that the number of viruses in infected cells has dropped significantly, blocking the subsequent infectivity of the virus. A randomized controlled trial of thirty-two high school students in the United States who played for elite teams in the United States was assigned to a daily placebo or olive leaf extract (equivalent to 20 grams of olive leaves, containing 100 mg of oleuropein) two groups, Supplement for nine weeks during the competitive season. After analysis, it was found that there was no significant difference in the incidence rate between the two groups, but the number of sick days in the olive leaf extract group was significantly reduced by 28%, which means that taking olive leaf extract can shorten the recovery time of respiratory diseases.

Siberian ginseng, also known as Acanthopanax, Acanthopanax senticosus, Araliaceae. It is a cold-resistant shrub with a height of about six meters. It is native to China, Korea, Northeast Japan, the Far East and Russia. It is a widely used traditional Chinese medicinal material with active effects such as anti-ulcer, anti-radiation, anti-cancer, anti-inflammation and liver protection. It can relieve the symptoms of transient ischemic attack, cerebral arteriosclerosis, cerebral thrombosis and cerebral embolism. In addition, it is also used to treat coronary heart disease, angina pectoris, combined neurosis and menopausal syndrome, etc. Modern pharmacological studies have shown that the ingredients of traditional Chinese medicine are effective in clearing away heat and detoxification, relieving surface moisture, thereby inhibiting viruses. Two ways as an antiviral drug. The first is to directly inhibit the virus, mainly to clear away heat and detoxify, and it is used with honeysuckle, Radix Radix and Scutellaria baicalensis to inhibit the virus. The second is to indirectly play an antiviral effect or inhibit virus-mediated inflammatory response by regulating the immune function of the body. Combined with astragalus, salvia, eleuthero and gentian can be used as an antiviral drug and induce the effect of interferon and immunoglobulin.

Mint, Mentha haplocalyx, Lamiaceae (Lamiaceae), is a perennial herb widely distributed in Southwest China and widely used in food, cosmetics and medicines. As a traditional Chinese medicine, it is clinically used to treat diseases of the nervous center, respiratory, reproductive and digestive systems. Pharmacological studies have revealed multiple biological activities such as antibacterial, anti-inflammatory, antioxidant, antitumor, gastrointestinal protective and hepatoprotective activities. Peppermint extract contains a large number of volatile compounds, as well as some polyphenolic acids, flavonoids, monoterpenoids and glycosides. The research team of Academia Sinica published in 2021, from more than 3,000 existing drugs, identified 5 potential drugs that have the effect of inhibiting the activity of the new coronavirus, including the anti-malarial drug Mefloquine and the anti-AIDS drug nelfinavir (Nelfinavir), Chinese herbal medicine Ganoderma lucidum polysaccharide RF3, extracts of whole mint and whole perilla. Through the inhibition of viral protein activity, cell and animal experiments, female golden Syrian hamsters were intranasally instilled with SAR-CoV-2 (Covid-19) on day 0 after infection, and the drug and extract were orally administered twice a day (drug 30 mg /kg/d, extract 200 mg/kg/d) for 3 consecutive days. Three days later, the lungs were taken to measure the viral load (titer). The results showed that the viral load decreased significantly in the experimental group of melquinine, nelfinavir, Ganoderma lucidum polysaccharide RF3, peppermint and perilla extract. Therefore, melquinine, nelfinavir, Ganoderma lucidum polysaccharide RF3, peppermint and perilla extracts have inhibitory effects on Covid-19.

Lilium, Lilium brownii var. viridulum, belongs to the Liliaceae family and is widely distributed in northern and eastern Asia. It is included in the "Chinese Pharmacopoeia" in the traditional Chinese medicine theory that it has the effect of nourishing yin, nourishing the lungs and clearing the stomach, so it has long been used to treat chronic gastritis, whooping cough, pneumonia, bronchitis and cough. In animal experiments, it was found that lily extract can inhibit inflammation through NF-κB, MAPKs pathway (pathway), and reduce the expression of TNF-α, IL-6, and IL-1β inflammatory factors.

Garlic, Allium sativum L., is a widely edible plant in the world. Garlic contains a variety of bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide (diallyl trisulfide), ajoene (ajoene) and S-allyl-cysteine (S-allyl-cysteine). Many studies have found that garlic and its bioactive components have antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardiovascular protective, anticancer, hepatoprotective, digestive system protective, antidiabetic, antiobesity, neuroprotective, and renal protective properties And so on. In the experiment of allicin on SARS-CoV-2 (Covid-19) infected Vero E6 and Calu-3 cells, the infected Vero E6 and Calu-3 cells were exposed to biocompatible doses of allicin, resulting in Viral RNA and infectivity are reduced by about 60-70% of virus particles and the content of N, M, S and ORF3 in the viral proteome is reduced, which indicates that allicin has the ability to resist Covid-19 virus.

Catechin is a natural polyphenolic compound found in many fruits, vegetables and plant-based foods and beverages. Green tea extract is recognized as a rich source of catechins, containing a large amount of catechins, epicatechin (EC), epicatechin-3-gallate (epicatechin-3-gallate ( ECG)), epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG). Catechins possess a wide range of pharmacological activities, including antiviral and renoprotective activities, as well as anti-inflammatory and antioxidant properties. EGCG binds with high affinity to the SARS-CoV-2-S protein. 1 mM EGCG can reduce the infection of SARS-CoV-2 (Covid-19) by binding to S protein and weakening the interaction between S protein and ACE2 receptor. In addition, EGCG is an NSP15 inhibitor and effectively blocks SARS-CoV-2 viral replication. In addition to EGCG, ECG can also bind to the N protein of SARS-CoV-2 to inhibit the replication of SARS-CoV-2 virus.

Curcumin (curcumin), turmeric, Curcuma longa, is a rhizome herbaceous perennial plant, often used as a medicinal herb in Asian countries, with antioxidant, anti-inflammatory, antimutagenic, antibacterial and anticancer effects. Curcumin is a polyphenol with a structure of (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), (1,7-bis(4-hydroxy-3 -methoxyphenyl)-1,6-heptadiene-3,5-dione), also known as diferuloylmethane (diferuloylmethane), is found in the rhizomes of turmeric and its Curcuma spp plants The main natural polyphenols found in . Studies have shown that turmeric helps control oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety and hyperlipidemia through its antioxidant and anti-inflammatory mechanisms. Evidence shows that curcumin can fight various viral infections, including vesicular stomatitis virus, parainfluenza virus type 3, flock house virus, herpes simplex virus virus) and respiratory syncytial virus (respiratory syncytial virus). The pleiotropic effects of curcumin on viruses stem from its ability to interact with various molecular targets, including DNA polymerase, thioredoxin reductase, focal adhesion kinase (FAK), protein kinase (PK), tubulin And lipoxygenase and so on. In addition, curcumin modulates intercellular signaling cascades, such as NF-κB and PI3K/Akt signal transduction, which are important for virus replication. It also affects cellular post-transcriptional and post-translational modifications, thereby inhibiting Covid-19 virus infection and viral replication by interfering with key steps in the viral replication cycle. In addition, curcumin can also reduce the cytokine storm (cytokine storm) induced by COVID-19, and reduce inflammation by reducing the gene expression of pro-inflammatory cytokines (pro-inflammatory cytokines), IFNγ, MCP-1, IL-6 and IL-10 Response, treatment of lung inflammation, edema and fibrosis and avoid damage to cardiovascular and kidney and other organs.

Quercetin is a phenolic flavonol compound found in many fruits and vegetables. The chemical structure of quercetin contains four phenolic groups, making it a strong scavenger of reactive oxygen species (ROS), antioxidant, immune enhancer and anti-inflammatory substance. In silico studies using SARS-CoV-2 protease proteins demonstrated that quercetin inhibits some residues of SARS-CoV-2 protease 6LU7 (His164, Glu166, Asp187, Gln192, and Thr190) by forming hydrogen bonds. Quercetin also reduced the expression of many SARS-CoV-2 proteins in human genes and reduced the severity of SARS-CoV-2 infection. It has an inhibitory effect on the expression of human ACE2 receptors and SARS-CoV-2 enzymes (MPro, PLPro and RdRp). Phospholipid complexes of quercetin (a delivery form of quercetin from bioavailable phospholipids) were disclosed in clinical trials. A 2-week trial was conducted in 21 outpatients receiving standard care using a combination of quercetin-phospholipid complex (200 mg, 3 times/day). As a result, the recovery time and severity of COVID-19 was shortened. Another group of researchers administered quercetin-phospholipid complex (1 g/day) to 153 COVID-19 outpatients. The result is reduced recovery time, oxygen requirements and hospitalization requirements.

Maslinic acid, also known as crategolic acid or (2α,3β)-2,3-dihydroxyolean-12-en-28-oic acid, is a pentacyclic triterpene found in a variety of natural sources, including traditional Herbs in Asian medicine to edible vegetables and fruits such as olives in the Mediterranean diet. In recent years, many studies have proved that maslinic acid has a wide range of biological activities, namely anti-tumor, anti-diabetic, antioxidant, cardioprotective, neuroprotective, anti-parasitic and growth-stimulating effects. Oleanolic acid and maslinic acid were isolated from olive oil pomace and evaluated by molecular docking analysis, and found that both had site binding to the main protease of Covid-19. Thus it was shown that oleanolic acid and maslinic acid and their derivatives are inhibitory to the main protease of SARS-CoV-2 (Covid-19). Antiviral screening showed that one of the maslinic acid derivatives-17 compounds was inhibitory to the main protease of Covid-19.

Colostrum, colostrum is the colostrum secreted by cows during parturition and the first few days after delivery. It is used to protect newborn calves. It helps to boost the immune system and provides passive immunity against pathogens. It has many bioactive substances such as components I and II (IGF-I and IGF-II) such as insulin-like growth factor, lactoferrin, lysozyme, lactoperoxidase and bioactive components, containing high levels of immunoglobulin Protein G (IgG), etc. Clinical tests on bovine colostrum supplementation against COVID-19 have shown that bovine colostrum food supplements are beneficial to COVID-19 patients and are helpful in the recovery of mild, moderate and severe categories of patients.

β-glucan (β-glucan), present in several yeast and bacterial cell walls. Oral administration of β-glucan can activate immune cells such as monocytes, macrophages, neutrophils, dendritic cells and T lymphocytes by activating Dectin-1. β-glucan can also stimulate the toxic activity of natural killer cells (Natural Killer Cell, NK) as part of the innate immune response. Oral administration of β-glucan can also reduce tumors in the spleen and lymph nodes by activating dendritic cells and activating antigen-specific CD4 and CD8 T cells, and induce the production of IFN-γ, as well as induce B lymphocytes to produce antibodies and improve salivary immunity Globulins (sIgM, sIgG, and sIgA), maintain immunity against infection. According to the list released by the European Commission, β-(1,3)-(1,6)-glucan is considered to be the most effective and safest adjuvant, with no side effects, no toxicity, and no adverse reactions. Oral use as an adjuvant can enhance the effect of the vaccine while relieving the symptoms of the disease, so β-glucan can improve the effectiveness of various vaccines against COVID-19 currently on sale.

Lactobacillus (Lactobacillus), is a group of probiotics (Probiotics) that exist in the human body. Lactobacillus, named for its ability to ferment carbohydrates into lactic acid, is used to make yogurt, cheese, sauerkraut, beer, wine, sauerkraut, pickles, and other fermented foods. In addition to being known to be effective in reducing various allergic symptoms, Lactobacillus also has a significant effect in modulating the immune response. For example, during COVID-19 infection, ACE2 will link with the virus and lead to the destruction of the tight junction (TJ) of intestinal epithelial cells, resulting in intestinal leaks (leak) that allow pathogens to invade and cause secondary pathogen infection, resulting in systemic Sexual inflammation promotes a cytokine storm, causing excessive activation of immune cells to release a large number of intracellular inflammatory factors, including IL-6, IL-1β, TNF-α, IFN and complement proteins. Finally, immune cells launch a storm-like suicide attack on pathogens and infected cells, causing multiple damages to healthy cells and tissues. Lactobacillus and its metabolites can reduce the cytokine storm caused by COVID-19 infection through the gut-lung axis. Supplementation with Lactobacillus and their metabolites significantly decreased pro-inflammatory markers (hs-C-reactive protein, TNF-α, IL-6, IL-12, IL-4, and TNF-α) and increased anti-inflammatory cytokines ( IL-10). Therefore, Lactobacillus can accelerate the recovery of patients by regulating intestinal immune response and inflammatory signaling pathways, avoiding hyperinflammation and improving intestinal malnutrition caused by COVID-19.

Bacillus, a Gram-positive bacterium, is distributed in various environments. Under adverse conditions that are not suitable for survival, Bacillus can transform into endospores (endospores, also known as endospores or spores) to enter a dormant state. This endospore state can be maintained for a long time and has strong resistance to adversity, and has strong tolerance to acid, alkali, heat, hyperosmotic pressure and radiation. Bacillus coagulans In a clinical trial, ten healthy subjects were first exposed to influenza A virus (H3N2 Texas strain), resulting in significant pro-inflammatory factors IL-6, IL-8 and TNF-α in vivo After consuming one capsule containing Lactobacillus sporogenes every day for 28 days, the pro-inflammatory factors IL-6, IL-8 and TNF-α decreased significantly, while increasing the number of CD3+ CD69+ cells and IFN-γ, and reducing influenza A virus quantity. And the production of Type 1 Interferons (IFNs) Type 1 interferon is the direct medium to prevent virus infection, especially against SARS-CoV-2 (Covid-19) infection, so lactic acid bacteria spores have the potential to be used in the treatment of SARS-CoV-2 ( Covid-19). Natto bacteria (Bacillus subtilis) can produce surfactin (Surfactin), which can effectively anti-virus, anti-tumor and anti-bacterial. Due to the interaction of Surfactin's amphiphilicity (hydrophilicity, hydrophobicity) with the outer membrane of the virus, resulting in permeability disruption or inactivation of the virus by forming ion channels to interfere with the assembly of the Covid-19 spike protein and lipid envelope protein . At the same time, Surfactin is a natural cyclic lipopeptide that can activate heme oxygenase-1 (heme oxygenase-1) and T helper type 1 macrophage cells to inhibit the production of NF-κB to achieve anti-inflammatory effects and reduce the occurrence of cytokines storm.

A brief summary of the disclosure is presented below to facilitate readers' basic understanding of the disclosure. This summary is not an extensive overview of the disclosure, nor is it intended to identify key/critical elements of the disclosure or to delineate the scope of the disclosure. Its sole purpose is to present some concepts of this disclosure in a simplified form as a prelude to the more detailed description that is presented later.

In view of this, this creation provides an embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound, which can effectively fight against new coronavirus infection, improve immunity and reduce allergic symptoms after oral administration by users .

This creation provides an embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound, which includes: a fungal core; a human nutrient layer, which is wrapped around the outer layer of the fungal core; The plant extract layer is wrapped in the outer layer of the human nutrition layer; and a Chinese herbal medicine compound layer is wrapped in the outer layer of the plant extract layer.

In one embodiment, the fungal core of the present invention includes Lactobacillus and Bacillus.

In one embodiment, the human nutrient layer of the present invention includes bovine colostrum protein and β-glucan.

In one embodiment, the plant extract layer of the present invention includes catechin, curcumin, quercetin and maslinic acid.

In one embodiment, the herbal compound layer of the present invention includes honeysuckle, houttuynia cordata, licorice, perilla, olive leaf, Siberian ginseng, mint, lily and garlic.

In one embodiment, the embedding structure of the invention containing honeysuckle, β-glucan, lactobacillus and maslinic acid can enhance immunity, provide passive immunity against pathogens and enhance immune response.

In one embodiment, the embedding structure of the invention containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound can reduce human allergic symptoms.

In one embodiment, the embedding structure of the invention containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound can strengthen the human body's anti-coronavirus effect.

In one embodiment, the embedding structure of the invention containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound can inhibit cell inflammatory factors, inhibit the entry of the new coronavirus into host cells, and inhibit the internalization and replication of the new coronavirus .

This creation will be fully understood by the following examples, so that those who are familiar with the art can complete it. However, the implementation of this case cannot be limited by the following examples. Those who are familiar with the art can still Other embodiments are deduced according to the spirit of the disclosed embodiments, and these embodiments shall all belong to the scope of the present invention.

This creation provides an embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound. After oral administration by users, it can effectively improve immunity, effectively fight against new coronavirus infection and reduce allergic symptoms .

This creation provides an embedding structure 1 containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound. Its structure is shown in Figure 1, which includes: a bacterial core 11, which includes a lactobacillus and a Bacillus; a human nutrient layer 12, which is wrapped in the outer layer of the fungus core 11, which includes a bovine colostrum white and a β-glucan; a plant extract layer 13, which is wrapped in the human nutrient layer 12 the outer layer, which contains a catechin, a curcumin, a quercetin and a maslinic acid; and a Chinese herbal medicine compound layer 14, which is wrapped in the plant extract layer 13 outer layer, which includes a honeysuckle, 1 houttuynia cordata, 1 licorice, 1 perilla, 1 olive leaf, 1 Siberian ginseng, 1 mint, 1 lily and 1 garlic.

1: Embedded structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound 11: Fungus core 12: Human nutrition layer 13: Plant extract layer 14: Chinese herbal medicine compound layer

Figure 1 is a cross-sectional view of the embedding structure of this invention containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound.

1: Embedded structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound

11: Fungus core

12: Human nutrition layer

13: Plant extract layer

14: Chinese herbal medicine compound layer

Claims (5)

An embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound, including: A microbial core, which includes a lactobacillus and a bacillus; A human nutrient layer, which is wrapped around the outer layer of the fungus core, which includes a bovine colostrum protein and a β-glucan; a plant extract layer, which is wrapped in the outer layer of the human nutrient layer, which contains a catechin, a curcumin, a quercetin and a maslinic acid; and A compound layer of Chinese herbal medicine, which is wrapped in the outer layer of the plant extract layer, which includes a honeysuckle, a houttuynia cordata, a licorice, a perilla, an olive leaf, a Siberian ginseng, a mint, a lily and a garlic . The embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound as described in claim 1, the embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound can be Boosts immunity, provides passive immunity against pathogens and enhances immune response. The embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound as described in claim 1, the embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound can be Reduce human allergic symptoms. The embedding structure containing the compound compound of honeysuckle, β-glucan, lactobacillus and maslinic acid as described in claim 2, wherein the enhancement of immunity can further strengthen the effect of the human body against the new coronavirus. The embedding structure containing honeysuckle, β-glucan, lactobacillus and maslinic acid compound as described in claim 4, wherein the anti-new coronavirus effect further includes inhibiting cell inflammatory factors, inhibiting the entry of new coronavirus into host cells and inhibiting Internalization and replication of 2019-nCoV.

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