TWM555729U - Nerve catheter containing highly-biocompatible micro scaffold used in minimally invasive neurosurgery - Google Patents

Description

Minimally invasive nerve catheter with high biocompatibility microscaffold for neurosurgery

This creation is a minimally invasive neurocatheter containing a highly biocompatible microstent in neurosurgery, especially a nerve conduit that can be used for neurosurgical reconstruction.

In clinical surgery, it is often necessary to repair tissue defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic, and metallic materials are used in tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. Among them, tissue engineering involves three main strategies: the use of in vitro cells or cell substitutes to replace limited tissue functions; the induction of tissue production, such as the utilization of growth factors; the development of biological scaffolds for tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. Used in minimally invasive surgery, different forms of defects are developed in different repair ways, and different functional stents are applied to the application. A bed is necessary. Peripheral nerve injury is a difficult problem in clinical treatment. Autologous nerve transplantation is a traditional method for the treatment of nerve defects. It is also the most important and best repair technique at present, but it is difficult to obtain nerves in the supply area and obtain nerves in the supply area. It may cause problems such as damage to the function of the supply site. The nerve catheterization can solve this problem. The two nerve ends are placed inside the two ends of the nerve catheter and then fixed by suture, and the nerve conduit is used to guide nerve regeneration. This step can simplify the procedure and time of the operation, and also avoid the pulling injury of the nerve by the surgical suture. The nerve catheter is implanted to avoid the proliferation of connective tissue and affect the normal nerve growth. The nerve conduit must have good biocompatibility and better mechanical strength, and the biodegradable nerve conduit material can avoid secondary surgery problems. In view of this, the applicant has been engaged in biomedical engineering and materials for many years of experience. Through continuous research and experimentation, he has developed a neurocatheter for neurosurgery minimally invasive micro-stent with high biocompatibility, which can be used for medical treatment. Equipment and biomedical materials are pledged for clinical use.

The present invention relates to a neurocatheter for neurosurgery minimally invasive bioconducting microscaffolds comprising a tubular body having a nerve guiding channel extending through the nerve ends of the tubular body and respectively disposed at The tubular body corresponds to two nerve connection ports at both ends; the tube wall of the tubular body comprises a plurality of uniformly distributed high biocompatibility micro-stents and a plurality of micro-interspersed between the high biocompatible micro-stents The channel, wherein the microchannels each have a microchannel through hole connected to the external environment, and the high biocompatible micro-frames each include a void space for accommodating a plurality of functional particles.

Preferably, the tubular system consists of a biodegradable selected from the group consisting of collagen, collagen peptide, collagen-derived gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Composition of polymers.

More preferably, the tubular body is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, decellularized cartilage collagen, and decellularized. Small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen peptide, collagen multipeptide and combinations thereof Collagen.

Most preferably, the tubular body is a collagen obtained by hydrolytically cutting animal tissue and supercritical carbon dioxide degreasing, enzyme treatment.

Preferably, the highly biocompatible microscaffold is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, and decellularized cartilage collagen. Protein, acellular small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen peptide, collagen multi-win Collagen and its combination of collagen.

More preferably, the highly biocompatible microscaffold is a collagen obtained by hydrolyzing animal tissue and supercritical carbon dioxide degreasing and enzymatic treatment.

1‧‧‧Nervous catheter

10‧‧‧High biocompatible micro scaffold

11‧‧‧ void space

20‧‧‧Tube body

25‧‧‧Microchannel

27‧‧‧Microchannel through hole

50‧‧‧Neural guiding channel

55‧‧‧Neural connection

1000‧‧‧ lesion nerve ending

Fig. 1 is a schematic view showing the structure of a first embodiment (A) for a minimally invasive nerve catheter containing a highly biocompatible microstent in neurosurgery and (B) a schematic diagram of clinical application.

In order to make the above and other objects, features and advantages of the present invention more comprehensible, the preferred embodiments of the present invention are described in detail below with reference to the accompanying drawings.

First embodiment

The first embodiment of the present invention for neurosurgery minimally invasive nerve catheters containing highly biocompatible microscaffolds and their clinical applications will be described with reference to FIG. The present invention is for neurosurgery minimally invasive nerve catheter 1 containing a highly biocompatible micro-scaffold, comprising a tubular body 20 having a nerve guiding channel 50 penetrating through the center and two corresponding to the tubular body 20 respectively. The two neural connection ports 55 of the end can be used to connect the lesion nerve end 1000, the tube wall of the tubular body 20 comprises a plurality of uniformly distributed highly biocompatible micro-scaffolds 10 and a plurality of interspersed in the high biocompatible The microchannels 25 between the micro-frames 10, wherein the micro-channels 25 each have a micro-channel through-hole 27 connected to the external environment, and the high bio-compatible micro-frames 10 each include a void space 11 for receiving Set up several functional particles. In clinical application, the two nerve endings 1000 are placed in the inner end of the nerve connecting port 55 of the present invention by nerve conduit splicing, and then sutured and fixed by the nerve conduit 1 of the present invention. Guide nerve regeneration. Preferably, the tubular body 20 is made of a bio-selectable material selected from the group consisting of collagen, collagen peptide, collagen-derived gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Decomposes the composition of the polymer. More preferably, the tubular body 20 is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, decellularized cartilage collagen, and Cell small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen peptide, collagen polypeptide and group Combined with collagen. Most preferably, the tubular body 20 is a collagen obtained by hydrolyzing animal tissue and supercritical carbon dioxide degreasing and enzymatic treatment. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, and decellularized cartilage. Collagen, acellular small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen peptide, collagen Collagen and its combination of collagen. More preferably, the highly biocompatible microscaffold 10 is a collagen obtained by hydrolyzing animal tissue and supercritical carbon dioxide degreasing and enzymatic treatment.

The creators of this case have rich experience in the development and research of biomedical and cosmetic related products and biomedical engineering materials. In view of this, the creators of this case have conducted in-depth discussions on the above-mentioned shortcomings based on their years of research and development experience in related fields, and Demand is actively seeking solutions, and after a long period of hard work and multiple tests, this work has finally been completed. Although the present invention has been disclosed by the above-described preferred embodiments, it is not intended to limit the present invention, and it is still within the spirit and scope of the present invention to make various changes and modifications to the above embodiments. The technical scope of the protection is created, so the scope of protection of this creation is subject to the definition of the patent application scope attached.

1‧‧‧Nervous catheter

10‧‧‧High biocompatible micro scaffold

11‧‧‧ void space

20‧‧‧Tube body

25‧‧‧Microchannel

27‧‧‧Microchannel through hole

50‧‧‧Neural guiding channel

55‧‧‧Neural connection

1000‧‧‧ lesion nerve ending

Claims (6)

The invention relates to a neurosurgery minimally invasive nerve catheter with a high biocompatibility microscaffold, comprising a tubular body having a nerve guiding channel passing through the nerve connection at both ends of the tubular body and correspondingly disposed on the tubular body Two nerve ends of the two ends can be used to connect the nerve endings of the lesion; the wall of the tubular body comprises a plurality of highly biocompatible micro-stents uniformly distributed and a plurality of interspersed in the highly biocompatible micro-scaffold An inter-microchannel, wherein each of the microchannels has a microchannel through-hole connected to the external environment, and the high biocompatibility micro-stent comprises a void space for accommodating a plurality of functional particles. The nerve conduit of claim 1, wherein the tubular system is selected from the group consisting of collagen, collagen peptide, collagen-derived gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, Polylactic acid ester and a combination thereof are composed of biodegradable polymers. The nerve conduit of claim 2, wherein the tubular body is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, and decellularized animal tissue collagen. Protein, acellular cartilage collagen, acellular small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen Collagen with peptides, collagen peptides and combinations thereof. The nerve conduit of claim 3, wherein the tubular body is a hydrophilic Sexual vibration cutting animal tissue and supercritical carbon dioxide degreasing, enzymatic treatment of the resulting collagen. The nerve conduit of claim 1, wherein the highly biocompatible microscaffold is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, and acellular dermal collagen. Decellularized animal tissue collagen, acellular cartilage collagen, acellular small intestinal membrane collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen Collagen, peptide collagen peptide, collagen peptide and combinations thereof. The nerve conduit of claim 5, wherein the highly biocompatible microscaffold is a collagen obtained by hydrolyzing animal tissue and supercritical carbon dioxide degreasing and enzymatic treatment.