TWI922280B - 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法 - Google Patents

包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法

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Publication number
TWI922280B
TWI922280B TW114114410A TW114114410A TWI922280B TW I922280 B TWI922280 B TW I922280B TW 114114410 A TW114114410 A TW 114114410A TW 114114410 A TW114114410 A TW 114114410A TW I922280 B TWI922280 B TW I922280B
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TW
Taiwan
Prior art keywords
cells
antibody
ser
lymphoma
leu
Prior art date
Application number
TW114114410A
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English (en)
Chinese (zh)
Other versions
TW202547555A (zh
Inventor
珍 恩德爾
雷納 博克斯哈默
多明尼克 普雷切爾
Original Assignee
美商英塞特公司
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Publication of TW202547555A publication Critical patent/TW202547555A/zh
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Publication of TWI922280B publication Critical patent/TWI922280B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW114114410A 2019-10-31 2020-10-30 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法 TWI922280B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19206479 2019-10-31
EP19206479.8 2019-10-31

Publications (2)

Publication Number Publication Date
TW202547555A TW202547555A (zh) 2025-12-16
TWI922280B true TWI922280B (zh) 2026-04-11

Family

ID=68424789

Family Applications (2)

Application Number Title Priority Date Filing Date
TW114114410A TWI922280B (zh) 2019-10-31 2020-10-30 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法
TW109137982A TWI883067B (zh) 2019-10-31 2020-10-30 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法

Family Applications After (1)

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TW109137982A TWI883067B (zh) 2019-10-31 2020-10-30 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法

Country Status (23)

Country Link
US (1) US20210130461A1 (enExample)
EP (2) EP4706673A3 (enExample)
JP (2) JP7688025B2 (enExample)
KR (1) KR20220116154A (enExample)
CN (1) CN115151565A (enExample)
AU (1) AU2020372646A1 (enExample)
DK (1) DK4051710T3 (enExample)
ES (1) ES3062643T3 (enExample)
FI (1) FI4051710T3 (enExample)
HR (1) HRP20251630T1 (enExample)
IL (1) IL292213A (enExample)
LT (1) LT4051710T (enExample)
MA (1) MA69251B1 (enExample)
MD (1) MD4051710T2 (enExample)
MX (1) MX2022005033A (enExample)
PH (1) PH12022551009A1 (enExample)
PL (1) PL4051710T3 (enExample)
PT (1) PT4051710T (enExample)
RS (1) RS67602B1 (enExample)
SI (1) SI4051710T1 (enExample)
SM (1) SMT202600082T1 (enExample)
TW (2) TWI922280B (enExample)
WO (1) WO2021084063A1 (enExample)

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AU2016311136B2 (en) 2015-08-21 2022-02-17 Incyte Corporation Combinations and uses thereof
ES2981046T3 (es) 2016-05-30 2024-10-07 Incyte Corp Métodos para predecir el beneficio terapéutico de una terapia anti-CD19 en pacientes
SMT202100317T1 (it) 2016-06-27 2021-07-12 Morphosys Ag Formulazioni di anticorpi anti-cd19
WO2018078123A1 (en) 2016-10-28 2018-05-03 Morphosys Ag Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
KR102617497B1 (ko) 2022-09-15 2023-12-27 주식회사 엘지에너지솔루션 음극용 자성 정렬 장치 및 이를 이용한 음극의 제조방법

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Also Published As

Publication number Publication date
MA69251B1 (fr) 2025-12-31
TW202547555A (zh) 2025-12-16
WO2021084063A1 (en) 2021-05-06
DK4051710T3 (da) 2025-12-15
AU2020372646A1 (en) 2022-05-12
PH12022551009A1 (en) 2023-03-20
SI4051710T1 (sl) 2026-01-30
KR20220116154A (ko) 2022-08-22
ES3062643T3 (en) 2026-04-13
TWI883067B (zh) 2025-05-11
IL292213A (en) 2022-06-01
JP7688025B2 (ja) 2025-06-03
EP4706673A3 (en) 2026-05-20
EP4051710B1 (en) 2025-11-26
LT4051710T (lt) 2026-03-10
CA3158984A1 (en) 2021-05-06
US20210130461A1 (en) 2021-05-06
MX2022005033A (es) 2022-09-09
RS67602B1 (sr) 2026-01-30
SMT202600082T1 (it) 2026-03-09
JP2022554324A (ja) 2022-12-28
CN115151565A (zh) 2022-10-04
PL4051710T3 (pl) 2026-04-20
JP2025134705A (ja) 2025-09-17
HRP20251630T1 (hr) 2026-02-13
TW202131949A (zh) 2021-09-01
PT4051710T (pt) 2026-02-09
EP4051710A1 (en) 2022-09-07
EP4706673A2 (en) 2026-03-11
MD4051710T2 (ro) 2026-04-30
FI4051710T3 (fi) 2026-01-12

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