TWI910207B - 用於抑制ezh2之化合物及組成物 - Google Patents
用於抑制ezh2之化合物及組成物Info
- Publication number
- TWI910207B TWI910207B TW110129535A TW110129535A TWI910207B TW I910207 B TWI910207 B TW I910207B TW 110129535 A TW110129535 A TW 110129535A TW 110129535 A TW110129535 A TW 110129535A TW I910207 B TWI910207 B TW I910207B
- Authority
- TW
- Taiwan
- Prior art keywords
- amino
- methyl
- chloro
- cyclohexyl
- methylquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020108213 | 2020-08-10 | ||
| CNPCT/CN2020/108213 | 2020-08-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202220979A TW202220979A (zh) | 2022-06-01 |
| TWI910207B true TWI910207B (zh) | 2026-01-01 |
Family
ID=77520462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110129535A TWI910207B (zh) | 2020-08-10 | 2021-08-10 | 用於抑制ezh2之化合物及組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12473273B2 (https=) |
| EP (1) | EP4041725B1 (https=) |
| JP (1) | JP7768880B2 (https=) |
| KR (1) | KR20230051116A (https=) |
| CN (2) | CN114555589B (https=) |
| AR (1) | AR123185A1 (https=) |
| AU (1) | AU2021323828A1 (https=) |
| CA (1) | CA3180139A1 (https=) |
| ES (1) | ES2985111T3 (https=) |
| IL (1) | IL297332B2 (https=) |
| TW (1) | TWI910207B (https=) |
| WO (1) | WO2022033492A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR123185A1 (es) | 2020-08-10 | 2022-11-09 | Novartis Ag | Compuestos y composiciones para inhibir ezh2 |
| CA3243621A1 (en) * | 2022-02-01 | 2023-08-10 | Eli Lilly And Company | METHODS FOR PREPARING SELECTIVE ESTROGEN RECEPTOR DEGRADING AGENTS |
| CN117384153A (zh) * | 2022-07-12 | 2024-01-12 | 上海赛岚生物科技有限公司 | 一类甲基转移酶抑制剂及其用途 |
| CN118515653B (zh) * | 2024-07-23 | 2024-12-10 | 西湖制药(杭州)有限公司 | 一种ezh2特异性抑制剂及其制备方法和用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012068589A2 (en) * | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN110621316A (zh) * | 2017-04-21 | 2019-12-27 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| WO2021057853A1 (en) * | 2019-09-26 | 2021-04-01 | Novartis Ag | Aza-quinoline compounds and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2779780A (en) | 1955-03-01 | 1957-01-29 | Du Pont | 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation |
| EP0647450A1 (en) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| EP1143957A3 (en) | 1998-12-16 | 2002-02-27 | Warner-Lambert Company | Treatment of arthritis with mek inhibitors |
| JP3811775B2 (ja) | 2000-07-19 | 2006-08-23 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル |
| CN1653059A (zh) | 2002-03-08 | 2005-08-10 | 卫材株式会社 | 用作医药品的大环化合物 |
| KR100984595B1 (ko) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체 |
| SE0202134D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Therapeutic agents |
| JP2006124387A (ja) * | 2004-09-30 | 2006-05-18 | Taisho Pharmaceut Co Ltd | 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CA2618218C (en) | 2005-07-21 | 2015-06-30 | Ardea Biosciences, Inc. | N-(arylamino)-sulfonamide inhibitors of mek |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| EP2205242B1 (en) | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| JP5348725B2 (ja) | 2007-10-25 | 2013-11-20 | ジェネンテック， インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| TN2016000529A1 (en) * | 2014-06-17 | 2018-04-04 | Pfizer | Substituted dihydroisoquinolinone compounds |
| EP3472166A1 (en) * | 2016-06-20 | 2019-04-24 | Novartis AG | Imidazopyrimidine compounds useful for the treatment of cancer |
| CN109912576B (zh) * | 2019-03-20 | 2021-11-19 | 华东理工大学 | 环状或螺环二胺类嘧啶-异羟肟酸及其用途 |
| AR123185A1 (es) | 2020-08-10 | 2022-11-09 | Novartis Ag | Compuestos y composiciones para inhibir ezh2 |
-
2021
- 2021-08-09 AR ARP210102216A patent/AR123185A1/es unknown
- 2021-08-10 IL IL297332A patent/IL297332B2/en unknown
- 2021-08-10 JP JP2022530800A patent/JP7768880B2/ja active Active
- 2021-08-10 CA CA3180139A patent/CA3180139A1/en active Pending
- 2021-08-10 CN CN202180005903.7A patent/CN114555589B/zh active Active
- 2021-08-10 WO PCT/CN2021/111910 patent/WO2022033492A1/en not_active Ceased
- 2021-08-10 US US17/919,490 patent/US12473273B2/en active Active
- 2021-08-10 KR KR1020227019646A patent/KR20230051116A/ko active Pending
- 2021-08-10 CN CN202411371645.6A patent/CN119431341A/zh active Pending
- 2021-08-10 AU AU2021323828A patent/AU2021323828A1/en active Pending
- 2021-08-10 ES ES21762334T patent/ES2985111T3/es active Active
- 2021-08-10 TW TW110129535A patent/TWI910207B/zh active
- 2021-08-10 EP EP21762334.7A patent/EP4041725B1/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012068589A2 (en) * | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN110621316A (zh) * | 2017-04-21 | 2019-12-27 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| WO2021057853A1 (en) * | 2019-09-26 | 2021-04-01 | Novartis Ag | Aza-quinoline compounds and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Yunlong Wu, et al "Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays." Bioorg Med Chem Lett 26(15) 2016 Aug 1 3813-3817. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7768880B2 (ja) | 2025-11-12 |
| JP2023538159A (ja) | 2023-09-07 |
| US20230167100A1 (en) | 2023-06-01 |
| EP4041725B1 (en) | 2024-03-27 |
| WO2022033492A1 (en) | 2022-02-17 |
| TW202220979A (zh) | 2022-06-01 |
| ES2985111T3 (es) | 2024-11-04 |
| IL297332B2 (en) | 2026-02-01 |
| EP4041725A1 (en) | 2022-08-17 |
| IL297332A (en) | 2022-12-01 |
| KR20230051116A (ko) | 2023-04-17 |
| US12473273B2 (en) | 2025-11-18 |
| IL297332B1 (en) | 2025-10-01 |
| AU2021323828A1 (en) | 2022-05-19 |
| CN119431341A (zh) | 2025-02-14 |
| CN114555589A (zh) | 2022-05-27 |
| CN114555589B (zh) | 2024-10-25 |
| AR123185A1 (es) | 2022-11-09 |
| CA3180139A1 (en) | 2022-02-17 |
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