CN114555589B - 用于抑制ezh2的化合物和组合物 - Google Patents

用于抑制ezh2的化合物和组合物 Download PDF

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Publication number
CN114555589B
CN114555589B CN202180005903.7A CN202180005903A CN114555589B CN 114555589 B CN114555589 B CN 114555589B CN 202180005903 A CN202180005903 A CN 202180005903A CN 114555589 B CN114555589 B CN 114555589B
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China
Prior art keywords
amino
methyl
chloro
methylquinolin
cyclohexyl
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CN202180005903.7A
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Chinese (zh)
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CN114555589A (zh
Inventor
代璇
迈克·多尔
顾祥巨
李玲
刘康志
麦星洋
米沅
欧阳孔德
朱利恩·帕皮伦
费琦
严小霞
郁征天
张继跃
赵克浩
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Novartis AG
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Novartis AG
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Priority to CN202411371645.6A priority Critical patent/CN119431341A/zh
Publication of CN114555589A publication Critical patent/CN114555589A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202180005903.7A 2020-08-10 2021-08-10 用于抑制ezh2的化合物和组合物 Active CN114555589B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411371645.6A CN119431341A (zh) 2020-08-10 2021-08-10 用于抑制ezh2的化合物和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020108213 2020-08-10
CNPCT/CN2020/108213 2020-08-10
PCT/CN2021/111910 WO2022033492A1 (en) 2020-08-10 2021-08-10 Quinoline compounds and compositions for inhibiting ezh2

Related Child Applications (1)

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CN202411371645.6A Division CN119431341A (zh) 2020-08-10 2021-08-10 用于抑制ezh2的化合物和组合物

Publications (2)

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CN114555589A CN114555589A (zh) 2022-05-27
CN114555589B true CN114555589B (zh) 2024-10-25

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CN202180005903.7A Active CN114555589B (zh) 2020-08-10 2021-08-10 用于抑制ezh2的化合物和组合物
CN202411371645.6A Pending CN119431341A (zh) 2020-08-10 2021-08-10 用于抑制ezh2的化合物和组合物

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Country Status (12)

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US (1) US12473273B2 (https=)
EP (1) EP4041725B1 (https=)
JP (1) JP7768880B2 (https=)
KR (1) KR20230051116A (https=)
CN (2) CN114555589B (https=)
AR (1) AR123185A1 (https=)
AU (1) AU2021323828A1 (https=)
CA (1) CA3180139A1 (https=)
ES (1) ES2985111T3 (https=)
IL (1) IL297332B2 (https=)
TW (1) TWI910207B (https=)
WO (1) WO2022033492A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR123185A1 (es) 2020-08-10 2022-11-09 Novartis Ag Compuestos y composiciones para inhibir ezh2
CA3243621A1 (en) * 2022-02-01 2023-08-10 Eli Lilly And Company METHODS FOR PREPARING SELECTIVE ESTROGEN RECEPTOR DEGRADING AGENTS
CN117384153A (zh) * 2022-07-12 2024-01-12 上海赛岚生物科技有限公司 一类甲基转移酶抑制剂及其用途
CN118515653B (zh) * 2024-07-23 2024-12-10 西湖制药(杭州)有限公司 一种ezh2特异性抑制剂及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021057853A1 (en) * 2019-09-26 2021-04-01 Novartis Ag Aza-quinoline compounds and uses thereof

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US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
EP1143957A3 (en) 1998-12-16 2002-02-27 Warner-Lambert Company Treatment of arthritis with mek inhibitors
JP3811775B2 (ja) 2000-07-19 2006-08-23 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
CN1653059A (zh) 2002-03-08 2005-08-10 卫材株式会社 用作医药品的大环化合物
KR100984595B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
SE0202134D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Therapeutic agents
JP2006124387A (ja) * 2004-09-30 2006-05-18 Taisho Pharmaceut Co Ltd 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CA2618218C (en) 2005-07-21 2015-06-30 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
EP2205242B1 (en) 2007-09-12 2015-04-15 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
JP5348725B2 (ja) 2007-10-25 2013-11-20 ジェネンテック， インコーポレイテッド チエノピリミジン化合物の製造方法
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
US20130310379A1 (en) * 2010-11-19 2013-11-21 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
TN2016000529A1 (en) * 2014-06-17 2018-04-04 Pfizer Substituted dihydroisoquinolinone compounds
EP3472166A1 (en) * 2016-06-20 2019-04-24 Novartis AG Imidazopyrimidine compounds useful for the treatment of cancer
CN110621316B (zh) * 2017-04-21 2024-01-26 Epizyme股份有限公司 用ehmt2抑制剂进行的组合疗法
CN109912576B (zh) * 2019-03-20 2021-11-19 华东理工大学 环状或螺环二胺类嘧啶-异羟肟酸及其用途
AR123185A1 (es) 2020-08-10 2022-11-09 Novartis Ag Compuestos y composiciones para inhibir ezh2

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021057853A1 (en) * 2019-09-26 2021-04-01 Novartis Ag Aza-quinoline compounds and uses thereof

Also Published As

Publication number Publication date
JP7768880B2 (ja) 2025-11-12
JP2023538159A (ja) 2023-09-07
US20230167100A1 (en) 2023-06-01
EP4041725B1 (en) 2024-03-27
WO2022033492A1 (en) 2022-02-17
TW202220979A (zh) 2022-06-01
TWI910207B (zh) 2026-01-01
ES2985111T3 (es) 2024-11-04
IL297332B2 (en) 2026-02-01
EP4041725A1 (en) 2022-08-17
IL297332A (en) 2022-12-01
KR20230051116A (ko) 2023-04-17
US12473273B2 (en) 2025-11-18
IL297332B1 (en) 2025-10-01
AU2021323828A1 (en) 2022-05-19
CN119431341A (zh) 2025-02-14
CN114555589A (zh) 2022-05-27
AR123185A1 (es) 2022-11-09
CA3180139A1 (en) 2022-02-17

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