TWI905129B - 作為5-羥基色胺受體7 之調節劑之新穎官能化內醯胺及其使用方法 - Google Patents

作為5-羥基色胺受體7 之調節劑之新穎官能化內醯胺及其使用方法

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Publication number
TWI905129B
TWI905129B TW109139761A TW109139761A TWI905129B TW I905129 B TWI905129 B TW I905129B TW 109139761 A TW109139761 A TW 109139761A TW 109139761 A TW109139761 A TW 109139761A TW I905129 B TWI905129 B TW I905129B
Authority
TW
Taiwan
Prior art keywords
group
alkyl
unsubstituted
cycloalkyl
compound
Prior art date
Application number
TW109139761A
Other languages
English (en)
Chinese (zh)
Other versions
TW202132301A (zh
Inventor
丹尼爾 Ｊ 坎尼
班傑明 Ｅ 布雷斯
凱文 Ｍ 布拉嫩
道格拉斯 Ａ 皮賓
Original Assignee
美國坦普大學 高等教育聯邦系統
美商普雷凡堤斯責任有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 美國坦普大學 高等教育聯邦系統, 美商普雷凡堤斯責任有限公司 filed Critical 美國坦普大學 高等教育聯邦系統
Publication of TW202132301A publication Critical patent/TW202132301A/zh
Application granted granted Critical
Publication of TWI905129B publication Critical patent/TWI905129B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW109139761A 2019-11-13 2020-11-13 作為5-羥基色胺受體7 之調節劑之新穎官能化內醯胺及其使用方法 TWI905129B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962934997P 2019-11-13 2019-11-13
US62/934,997 2019-11-13

Publications (2)

Publication Number Publication Date
TW202132301A TW202132301A (zh) 2021-09-01
TWI905129B true TWI905129B (zh) 2025-11-21

Family

ID=74068668

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109139761A TWI905129B (zh) 2019-11-13 2020-11-13 作為5-羥基色胺受體7 之調節劑之新穎官能化內醯胺及其使用方法

Country Status (12)

Country Link
US (1) US20230002383A1 (OSRAM)
EP (1) EP4058455A1 (OSRAM)
JP (2) JP7730811B2 (OSRAM)
KR (1) KR20220113702A (OSRAM)
CN (1) CN115003675A (OSRAM)
AU (1) AU2020381460A1 (OSRAM)
BR (1) BR112022009374A2 (OSRAM)
CA (1) CA3160801A1 (OSRAM)
IL (1) IL292811A (OSRAM)
MX (1) MX2022005820A (OSRAM)
TW (1) TWI905129B (OSRAM)
WO (1) WO2021097116A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10961249B2 (en) 2017-03-21 2021-03-30 Temple University-Of The Commonwealth System Of Higher Education Modulators of the sigma-2 receptor and their method of use
BR112020023072A2 (pt) 2018-05-11 2021-02-02 Temple University-Of The Commonwealth System Of Higher Education novos lactâmicos funcionalizados como moduladores do receptor 7 de 5-hidroxitriptamina e seu método de uso

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018093818A1 (en) * 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
TW202016072A (zh) * 2018-05-11 2020-05-01 美國坦普大學 高等教育聯邦系統 作為5-羥基色胺受體7之調節劑之新穎官能化內醯胺及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201002563D0 (en) * 2010-02-15 2010-03-31 Cambridge Entpr Ltd Compounds
WO2014164756A1 (en) * 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
EP3200589B1 (en) * 2014-09-10 2026-03-11 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
JP7365238B2 (ja) * 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
US11365195B2 (en) * 2017-11-13 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018093818A1 (en) * 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
TW202016072A (zh) * 2018-05-11 2020-05-01 美國坦普大學 高等教育聯邦系統 作為5-羥基色胺受體7之調節劑之新穎官能化內醯胺及其使用方法
TWI856012B (zh) * 2018-05-11 2024-09-21 美國坦普大學 高等教育聯邦系統 作為5-羥基色胺受體7之調節劑之新穎官能化內醯胺及其使用方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Entered STN： 08 Jun 2017至11 Jun 2019 *
網路文獻 STN CAS Registry Number: 2329051-37-6、2326236-28-4、2326132-57-2、2326123-00-4、2326069-23-0、 2325959-08-6、2325081-00-1、2324954-11-0、2199317-75-2、2097863-94-8 *
網路文獻 STN CAS Registry Number: 2329051-37-6、2326236-28-4、2326132-57-2、2326123-00-4、2326069-23-0、 2325959-08-6、2325081-00-1、2324954-11-0、2199317-75-2、2097863-94-8。 Entered STN： 08 Jun 2017至11 Jun 2019。

Also Published As

Publication number Publication date
AU2020381460A1 (en) 2022-06-09
KR20220113702A (ko) 2022-08-16
JP7730811B2 (ja) 2025-08-28
US20230002383A1 (en) 2023-01-05
MX2022005820A (es) 2022-08-16
BR112022009374A2 (pt) 2022-08-09
EP4058455A1 (en) 2022-09-21
CN115003675A (zh) 2022-09-02
JP2023501577A (ja) 2023-01-18
WO2021097116A1 (en) 2021-05-20
JP2025161894A (ja) 2025-10-24
CA3160801A1 (en) 2021-05-20
IL292811A (en) 2022-07-01
TW202132301A (zh) 2021-09-01

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