TWI898161B - 異野漆樹苷及其衍生物用於促進神經修復的用途 - Google Patents

異野漆樹苷及其衍生物用於促進神經修復的用途

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Publication number
TWI898161B
TWI898161B TW111140498A TW111140498A TWI898161B TW I898161 B TWI898161 B TW I898161B TW 111140498 A TW111140498 A TW 111140498A TW 111140498 A TW111140498 A TW 111140498A TW I898161 B TWI898161 B TW I898161B
Authority
TW
Taiwan
Prior art keywords
isorhoifolin
nerve
brain
neurons
regeneration
Prior art date
Application number
TW111140498A
Other languages
English (en)
Chinese (zh)
Other versions
TW202320806A (zh
Inventor
陳令儀
廖彣玲
王翊
李育棠
呂亭萱
李家維
陳裕仁
陳方儀
焦傳金
Original Assignee
國立清華大學
台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 國立清華大學, 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 filed Critical 國立清華大學
Publication of TW202320806A publication Critical patent/TW202320806A/zh
Application granted granted Critical
Publication of TWI898161B publication Critical patent/TWI898161B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Otolaryngology (AREA)
TW111140498A 2021-10-25 2022-10-25 異野漆樹苷及其衍生物用於促進神經修復的用途 TWI898161B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163271411P 2021-10-25 2021-10-25
US63/271,411 2021-10-25

Publications (2)

Publication Number Publication Date
TW202320806A TW202320806A (zh) 2023-06-01
TWI898161B true TWI898161B (zh) 2025-09-21

Family

ID=86159046

Family Applications (2)

Application Number Title Priority Date Filing Date
TW111140498A TWI898161B (zh) 2021-10-25 2022-10-25 異野漆樹苷及其衍生物用於促進神經修復的用途
TW111140500A TW202317142A (zh) 2021-10-25 2022-10-25 異丙基－ｄ－吡喃葡萄糖苷衍生物及其製備方法和用於促進神經修復的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW111140500A TW202317142A (zh) 2021-10-25 2022-10-25 異丙基－ｄ－吡喃葡萄糖苷衍生物及其製備方法和用於促進神經修復的用途

Country Status (7)

Country Link
US (2) US20250255893A1 (https=)
EP (2) EP4424695A4 (https=)
JP (2) JP2024541121A (https=)
KR (2) KR20240090983A (https=)
CN (2) CN118139869A (https=)
TW (2) TWI898161B (https=)
WO (2) WO2023072069A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101045072A (zh) * 2007-05-08 2007-10-03 胡军 山香圆叶提取物及其医药用途
CN102617658B (zh) * 2012-03-09 2014-08-20 中国烟草总公司郑州烟草研究院 β-紫罗兰醇-β-D-葡糖苷的制备方法及其在烟草加香中的应用
CN102617659A (zh) * 2012-03-09 2012-08-01 中国烟草总公司郑州烟草研究院 α-紫罗兰醇葡糖苷的合成方法及其在卷烟中的加香应用
CN106167508A (zh) * 2016-07-13 2016-11-30 上海应用技术学院 一种具有紫罗兰香味的葡萄糖苷化合物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Hong Shi,et al. "Demyelination as a rational therapeutic target for ischemic or traumatic brain injury", Exp Neurol, 272: 17-25, 2015.

Also Published As

Publication number Publication date
TW202317142A (zh) 2023-05-01
US20240415859A1 (en) 2024-12-19
JP2024541121A (ja) 2024-11-06
CN118215669A (zh) 2024-06-18
KR20240090982A (ko) 2024-06-21
WO2023072085A1 (zh) 2023-05-04
EP4424694A1 (en) 2024-09-04
EP4424695A1 (en) 2024-09-04
EP4424694A4 (en) 2026-03-11
JP2024539499A (ja) 2024-10-28
EP4424695A4 (en) 2025-10-22
TW202320806A (zh) 2023-06-01
WO2023072069A1 (zh) 2023-05-04
CN118139869A (zh) 2024-06-04
US20250255893A1 (en) 2025-08-14
KR20240090983A (ko) 2024-06-21

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