TWI869410B - α－酮戊二酸鹽之持續釋放組合物 - Google Patents

α－酮戊二酸鹽之持續釋放組合物 Download PDF

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Publication number
TWI869410B
TWI869410B TW109119483A TW109119483A TWI869410B TW I869410 B TWI869410 B TW I869410B TW 109119483 A TW109119483 A TW 109119483A TW 109119483 A TW109119483 A TW 109119483A TW I869410 B TWI869410 B TW I869410B
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TW
Taiwan
Prior art keywords
composition
ketoglutarate
calcium
amount
weight
Prior art date
Application number
TW109119483A
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English (en)
Chinese (zh)
Other versions
TW202112362A (zh
Inventor
大衛 尤金 佩瑞拉
蘇瑪納 柯納
Original Assignee
愛爾蘭商龐賽德萊昂健康公司
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Application filed by 愛爾蘭商龐賽德萊昂健康公司 filed Critical 愛爾蘭商龐賽德萊昂健康公司
Publication of TW202112362A publication Critical patent/TW202112362A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
TW109119483A 2019-06-10 2020-06-10 α－酮戊二酸鹽之持續釋放組合物 TWI869410B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962859595P 2019-06-10 2019-06-10
US62/859,595 2019-06-10
US201962929024P 2019-10-31 2019-10-31
US62/929,024 2019-10-31

Publications (2)

Publication Number Publication Date
TW202112362A TW202112362A (zh) 2021-04-01
TWI869410B true TWI869410B (zh) 2025-01-11

Family

ID=73781275

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109119483A TWI869410B (zh) 2019-06-10 2020-06-10 α－酮戊二酸鹽之持續釋放組合物

Country Status (12)

Country Link
US (1) US20220265586A1 (https=)
EP (1) EP3980001B1 (https=)
JP (2) JP7751291B2 (https=)
KR (1) KR20220044478A (https=)
CN (1) CN114126601B (https=)
AU (1) AU2020292278B2 (https=)
BR (1) BR112021024952A2 (https=)
DK (1) DK3980001T3 (https=)
ES (1) ES3054304T3 (https=)
IL (1) IL288782B1 (https=)
TW (1) TWI869410B (https=)
WO (1) WO2020252014A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102833111B1 (ko) * 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
MX2024008182A (es) * 2021-12-29 2024-09-24 Jrs Pharma Gmbh & Co Kg Lubricante para productos farmacéuticos y nutracéuticos.
WO2024123738A1 (en) * 2022-12-06 2024-06-13 Ponce De Leon Health Designated Activity Company Compositions and methods for treating diseases responsive to akg-vitamin b coadministration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106246A1 (en) * 1998-05-28 2005-05-19 Byrd Edward A. Controlled release arginine alpha-ketoglutarate
WO2018200736A2 (en) * 2017-04-25 2018-11-01 The Buck Institute For Research On Aging Formulations for extending lifespan and healthspan

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US8293277B2 (en) * 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
CO5140079A1 (es) * 1998-10-14 2002-03-22 Novartis Ag Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
EP1512403A1 (en) * 1999-12-03 2005-03-09 Polichem S.A. Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
AU2002228955B2 (en) * 2000-12-20 2005-09-29 Alcon Inc. Solution for removing cataracts via liquefracture
US20060029668A1 (en) * 2002-10-24 2006-02-09 Ron Eyal S Sustained release L-arginine formulations and methods of manufacture and use
EP1778616A1 (en) * 2004-08-09 2007-05-02 Cancer Research Technology Limited Alpha-ketoglutarates and their use as therapeutic agents
FR2967578B1 (fr) * 2010-11-18 2012-12-28 Advicenne Pharma Composition pharmaceutique comportant des sels de citrate et de bicarbonate, et son utilisation pour le traitement de la cystinurie
ITBO20120226A1 (it) * 2012-04-24 2013-10-25 Alfa Wassermann Spa Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso.
US11331287B2 (en) * 2013-06-06 2022-05-17 Balchem Corporation Iron supplement
ITFI20130184A1 (it) * 2013-08-01 2015-02-02 Valpharma Internat S P A Una formulazione farmaceutica di gliclazide a rilascio modificato, somministrabile per via orale, e suo metodo di produzione.
CN108721242B (zh) * 2015-06-03 2021-03-02 南京三迭纪医药科技有限公司 药品剂型及其使用
EP3518915A4 (en) * 2016-09-30 2020-04-15 The Regents of the University of California ALPHA KETOBUTYRATE, ALPHA KETOGLUTARATE AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH
KR20180062063A (ko) * 2016-11-30 2018-06-08 (주) 메티메디제약 서방형 항암용 약학 조성물
MX2017004010A (es) * 2017-03-27 2018-02-09 Antonio Hernandez Miramontes Jorge Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106246A1 (en) * 1998-05-28 2005-05-19 Byrd Edward A. Controlled release arginine alpha-ketoglutarate
WO2018200736A2 (en) * 2017-04-25 2018-11-01 The Buck Institute For Research On Aging Formulations for extending lifespan and healthspan

Also Published As

Publication number Publication date
EP3980001B1 (en) 2025-08-27
BR112021024952A2 (pt) 2022-02-15
KR20220044478A (ko) 2022-04-08
TW202112362A (zh) 2021-04-01
JP2022537685A (ja) 2022-08-29
JP7751291B2 (ja) 2025-10-08
CN114126601A (zh) 2022-03-01
AU2020292278A1 (en) 2022-01-06
CA3142494A1 (en) 2020-12-17
AU2020292278B2 (en) 2026-02-12
IL288782B1 (en) 2026-04-01
CN114126601B (zh) 2025-07-15
IL288782A (en) 2022-02-01
WO2020252014A1 (en) 2020-12-17
EP3980001A4 (en) 2023-06-21
EP3980001A1 (en) 2022-04-13
US20220265586A1 (en) 2022-08-25
JP2025124683A (ja) 2025-08-26
ES3054304T3 (en) 2026-02-02
DK3980001T3 (da) 2025-12-01

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