TWI865427B - 測定癌症預後之方法 - Google Patents

測定癌症預後之方法 Download PDF

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Publication number
TWI865427B
TWI865427B TW106142279A TW106142279A TWI865427B TW I865427 B TWI865427 B TW I865427B TW 106142279 A TW106142279 A TW 106142279A TW 106142279 A TW106142279 A TW 106142279A TW I865427 B TWI865427 B TW I865427B
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Taiwan
Prior art keywords
dna
cancer
interactions
sequence
seq
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TW106142279A
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English (en)
Chinese (zh)
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TW201842190A (zh
Inventor
法蘭西斯 黑克特 葛藍德
阿洛爾 賽爾凡 瑞瑪達斯
艾力山卓 阿考里特雀夫
伊旺 杭特
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英商牛津生物力學公眾有限公司
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/30Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301Endonuclease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/50Other enzymatic activities
    • C12Q2521/501Ligase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/101Crosslinking agents, e.g. psoralen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50Detection characterised by immobilisation to a surface
    • C12Q2565/501Detection characterised by immobilisation to a surface being an array of oligonucleotides

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW106142279A 2016-12-01 2017-12-01 測定癌症預後之方法 TWI865427B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662428893P 2016-12-01 2016-12-01
US62/428,893 2016-12-01

Publications (2)

Publication Number Publication Date
TW201842190A TW201842190A (zh) 2018-12-01
TWI865427B true TWI865427B (zh) 2024-12-11

Family

ID=60702831

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106142279A TWI865427B (zh) 2016-12-01 2017-12-01 測定癌症預後之方法

Country Status (12)

Country Link
US (2) US11560597B2 (https=)
EP (2) EP4357463A3 (https=)
JP (2) JP2019535295A (https=)
KR (1) KR102481242B1 (https=)
CN (1) CN110234769B (https=)
AU (1) AU2017367245B2 (https=)
CA (1) CA3045070A1 (https=)
ES (1) ES2971286T3 (https=)
MY (1) MY190153A (https=)
PL (1) PL3548633T3 (https=)
TW (1) TWI865427B (https=)
WO (1) WO2018100381A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230049379A1 (en) * 2019-05-08 2023-02-16 Oxford BioDynamics PLC Chromosome conformation markers of prostate cancer and lymphoma
CN118506860B (zh) * 2024-07-18 2024-10-08 广州女娲生命科技有限公司 药物表观遗传安全性评价的检测分析方法及系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009147386A1 (en) * 2008-06-02 2009-12-10 Oxford Biodynamics Limited Methods of detecting long range chromosomal interactions

Family Cites Families (15)

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CA2614118C (en) * 2005-07-04 2013-11-26 Erasmus University Medical Center 4c
GB0603251D0 (en) * 2006-02-17 2006-03-29 Isis Innovation DNA conformation
US8642295B2 (en) * 2007-01-11 2014-02-04 Erasmus University Medical Center Circular chromosome conformation capture (4C)
CA2609172A1 (en) * 2007-10-31 2009-04-30 University Of Utah Research Foundation Immunotherapy compositions for use with targeted therapy in the treatment of cancer
US9434985B2 (en) * 2008-09-25 2016-09-06 University Of Massachusetts Methods of identifying interactions between genomic loci
WO2010059742A1 (en) * 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
WO2012005595A2 (en) * 2010-07-09 2012-01-12 Wouter Leonard De Laat V3-d genomic region of interest sequencing strategies
EP2678359A4 (en) * 2011-02-24 2015-01-28 Merrimack Pharmaceuticals Inc COMBINATION THERAPIES WITH ANTI-ERBB3 MEDIUM
US8663919B2 (en) * 2011-05-18 2014-03-04 Life Technologies Corporation Chromosome conformation analysis
JP6280546B2 (ja) * 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はahi1の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
CN102827935B (zh) * 2012-08-29 2013-12-18 北京大学人民医院 定量检测FIP1L1-PDGFRA融合基因mRNA水平的试剂盒
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
US11802305B2 (en) 2015-06-24 2023-10-31 Oxford BioDynamics PLC Detection processes using sites of chromosome interaction
WO2017106290A1 (en) 2015-12-14 2017-06-22 The General Hospital Corporation Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof
GB201608000D0 (en) 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009147386A1 (en) * 2008-06-02 2009-12-10 Oxford Biodynamics Limited Methods of detecting long range chromosomal interactions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Flavahan et al., "Insulator dysfunction and oncogene activation in IDH mutant gliomas", Nature, Vol. 529, 23 December 2015, Pages 110–114 *

Also Published As

Publication number Publication date
EP3548633B1 (en) 2024-01-24
NZ753716A (en) 2024-05-31
US11560597B2 (en) 2023-01-24
JP7579003B2 (ja) 2024-11-07
JP2019535295A (ja) 2019-12-12
JP2023027076A (ja) 2023-03-01
AU2017367245B2 (en) 2020-09-24
KR20190086569A (ko) 2019-07-22
EP3548633A1 (en) 2019-10-09
PL3548633T3 (pl) 2024-04-02
US20190338367A1 (en) 2019-11-07
CN110234769B (zh) 2024-06-07
EP3548633C0 (en) 2024-01-24
AU2017367245A1 (en) 2019-06-06
TW201842190A (zh) 2018-12-01
US20230082230A1 (en) 2023-03-16
ES2971286T3 (es) 2024-06-04
MY190153A (en) 2022-03-31
KR102481242B1 (ko) 2022-12-23
EP4357463A3 (en) 2024-07-17
CN110234769A (zh) 2019-09-13
EP4357463A2 (en) 2024-04-24
WO2018100381A1 (en) 2018-06-07
CA3045070A1 (en) 2018-06-07

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