JP2019535295A - がんの診断における後成的染色体相互作用の応用 - Google Patents

がんの診断における後成的染色体相互作用の応用 Download PDF

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JP2019535295A
JP2019535295A JP2019528462A JP2019528462A JP2019535295A JP 2019535295 A JP2019535295 A JP 2019535295A JP 2019528462 A JP2019528462 A JP 2019528462A JP 2019528462 A JP2019528462 A JP 2019528462A JP 2019535295 A JP2019535295 A JP 2019535295A
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chromosomal
sequence
nucleic acids
cancer
ligated
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JP2019535295A5 (https=
Inventor
ヘクター グランド，フランシス
ヘクター グランド，フランシス
セルヴァム ラマダス，アラウル
セルヴァム ラマダス，アラウル
アコウリチェフ，アレクサンドル
ハンター，ユアン
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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Priority to JP2022183117A priority Critical patent/JP7579003B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301—Endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/101—Crosslinking agents, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019528462A 2016-12-01 2017-11-30 がんの診断における後成的染色体相互作用の応用 Pending JP2019535295A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022183117A JP7579003B2 (ja) 2016-12-01 2022-11-16 がんの診断における後成的染色体相互作用の応用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428893P 2016-12-01 2016-12-01
US62/428,893 2016-12-01
PCT/GB2017/053615 WO2018100381A1 (en) 2016-12-01 2017-11-30 Application of epigenetic chromsomal interactions in cancer diagnostics

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JP2022183117A Division JP7579003B2 (ja) 2016-12-01 2022-11-16 がんの診断における後成的染色体相互作用の応用

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JP2019535295A true JP2019535295A (ja) 2019-12-12
JP2019535295A5 JP2019535295A5 (https=) 2021-01-14

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JP2019528462A Pending JP2019535295A (ja) 2016-12-01 2017-11-30 がんの診断における後成的染色体相互作用の応用
JP2022183117A Active JP7579003B2 (ja) 2016-12-01 2022-11-16 がんの診断における後成的染色体相互作用の応用

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US (2) US11560597B2 (https=)
EP (2) EP4357463A3 (https=)
JP (2) JP2019535295A (https=)
KR (1) KR102481242B1 (https=)
CN (1) CN110234769B (https=)
AU (1) AU2017367245B2 (https=)
CA (1) CA3045070A1 (https=)
ES (1) ES2971286T3 (https=)
MY (1) MY190153A (https=)
PL (1) PL3548633T3 (https=)
TW (1) TWI865427B (https=)
WO (1) WO2018100381A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532108A (ja) * 2019-05-08 2022-07-13 オックスフォード バイオダイナミックス ピーエルシー 前立腺がんおよびリンパ腫の染色体コンフォメーションマーカー

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118506860B (zh) * 2024-07-18 2024-10-08 广州女娲生命科技有限公司 药物表观遗传安全性评价的检测分析方法及系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009500031A (ja) * 2005-07-04 2009-01-08 エラスムス ユニバーシティ メディカル センター 染色体コンフォメーションキャプチャ−オン−チップ（４ｃ）アッセイ
JP2010515449A (ja) * 2007-01-11 2010-05-13 エラスムス ユニバーシティ メディカル センター 環状染色体コンホメーション捕捉（４ｃ）

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GB0603251D0 (en) * 2006-02-17 2006-03-29 Isis Innovation DNA conformation
CA2609172A1 (en) * 2007-10-31 2009-04-30 University Of Utah Research Foundation Immunotherapy compositions for use with targeted therapy in the treatment of cancer
GB0810051D0 (en) 2008-06-02 2008-07-09 Oxford Biodynamics Ltd Method of diagnosis
US9434985B2 (en) * 2008-09-25 2016-09-06 University Of Massachusetts Methods of identifying interactions between genomic loci
WO2010059742A1 (en) * 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
WO2012005595A2 (en) * 2010-07-09 2012-01-12 Wouter Leonard De Laat V3-d genomic region of interest sequencing strategies
EP2678359A4 (en) * 2011-02-24 2015-01-28 Merrimack Pharmaceuticals Inc COMBINATION THERAPIES WITH ANTI-ERBB3 MEDIUM
US8663919B2 (en) * 2011-05-18 2014-03-04 Life Technologies Corporation Chromosome conformation analysis
JP6280546B2 (ja) * 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
CN102827935B (zh) * 2012-08-29 2013-12-18 北京大学人民医院 定量检测FIP1L1-PDGFRA融合基因mRNA水平的试剂盒
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
US11802305B2 (en) 2015-06-24 2023-10-31 Oxford BioDynamics PLC Detection processes using sites of chromosome interaction
WO2017106290A1 (en) 2015-12-14 2017-06-22 The General Hospital Corporation Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof
GB201608000D0 (en) 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2009500031A (ja) * 2005-07-04 2009-01-08 エラスムス ユニバーシティ メディカル センター 染色体コンフォメーションキャプチャ−オン−チップ（４ｃ）アッセイ
JP2010515449A (ja) * 2007-01-11 2010-05-13 エラスムス ユニバーシティ メディカル センター 環状染色体コンホメーション捕捉（４ｃ）

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532108A (ja) * 2019-05-08 2022-07-13 オックスフォード バイオダイナミックス ピーエルシー 前立腺がんおよびリンパ腫の染色体コンフォメーションマーカー
JP7617029B2 (ja) 2019-05-08 2025-01-17 オックスフォード バイオダイナミックス ピーエルシー 前立腺がんおよびリンパ腫の染色体コンフォメーションマーカー

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Publication number Publication date
EP3548633B1 (en) 2024-01-24
NZ753716A (en) 2024-05-31
US11560597B2 (en) 2023-01-24
JP7579003B2 (ja) 2024-11-07
JP2023027076A (ja) 2023-03-01
AU2017367245B2 (en) 2020-09-24
KR20190086569A (ko) 2019-07-22
EP3548633A1 (en) 2019-10-09
PL3548633T3 (pl) 2024-04-02
US20190338367A1 (en) 2019-11-07
CN110234769B (zh) 2024-06-07
EP3548633C0 (en) 2024-01-24
AU2017367245A1 (en) 2019-06-06
TWI865427B (zh) 2024-12-11
TW201842190A (zh) 2018-12-01
US20230082230A1 (en) 2023-03-16
ES2971286T3 (es) 2024-06-04
MY190153A (en) 2022-03-31
KR102481242B1 (ko) 2022-12-23
EP4357463A3 (en) 2024-07-17
CN110234769A (zh) 2019-09-13
EP4357463A2 (en) 2024-04-24
WO2018100381A1 (en) 2018-06-07
CA3045070A1 (en) 2018-06-07

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