TWI835166B - 靶向pd-1和/或ox40的特異性結合蛋白及其應用 - Google Patents

靶向pd-1和/或ox40的特異性結合蛋白及其應用 Download PDF

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TWI835166B
TWI835166B TW111122111A TW111122111A TWI835166B TW I835166 B TWI835166 B TW I835166B TW 111122111 A TW111122111 A TW 111122111A TW 111122111 A TW111122111 A TW 111122111A TW I835166 B TWI835166 B TW I835166B
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antibody
amino acid
seq
antigen
acid sequence
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TW111122111A
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TW202305011A (zh
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杰森 盧恩
木勝 包
戎一平
尹躍翔
羅海山
黄冰
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大陸商和鉑醫藥(上海)有限責任公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW111122111A 2021-06-17 2022-06-15 靶向pd-1和/或ox40的特異性結合蛋白及其應用 TWI835166B (zh)

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CN202110673515 2021-06-17
CN202110673515.8 2021-06-17

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TW202305011A TW202305011A (zh) 2023-02-01
TWI835166B true TWI835166B (zh) 2024-03-11

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CN (1) CN117460746A (fr)
TW (1) TWI835166B (fr)
WO (1) WO2022262749A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110734493A (zh) * 2018-07-20 2020-01-31 厦门大学 抗pd-1抗体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623685B (zh) * 2017-03-25 2022-07-01 信达生物制药(苏州)有限公司 抗ox40抗体及其用途
CN109053889B (zh) * 2018-07-25 2019-06-21 博奥信生物技术(南京)有限公司 一种抗人pd1单克隆抗体及用途
EP3837285A1 (fr) * 2018-08-13 2021-06-23 Inhibrx, Inc. Polypeptides se liant à ox40 et utilisations associées
KR20210107058A (ko) * 2018-12-21 2021-08-31 오제 이뮈노테라프틱스 인간 pd-1에 대항하는 이작용성 분자
CN111303285B (zh) * 2019-12-27 2023-06-02 百力司康生物医药(杭州)有限公司 靶向ox40的抗体及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110734493A (zh) * 2018-07-20 2020-01-31 厦门大学 抗pd-1抗体及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
期刊 Ying Ma et al , "Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer", Gastroenterology. 2020 Jul; 159(1): 306- 319.; *
期刊 Zhihui Kuang et al, "A Novel Bispecific Antibody with PD-L1-assisted OX40 Activation for Cancer Treatment", Mol Cancer Ther. 2020 Dec;19 (12): 2564-2574. *

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CN117460746A (zh) 2024-01-26
WO2022262749A1 (fr) 2022-12-22
TW202305011A (zh) 2023-02-01

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