TWI831764B - 眼科疾病之治療 - Google Patents

眼科疾病之治療 Download PDF

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Publication number
TWI831764B
TWI831764B TW108104518A TW108104518A TWI831764B TW I831764 B TWI831764 B TW I831764B TW 108104518 A TW108104518 A TW 108104518A TW 108104518 A TW108104518 A TW 108104518A TW I831764 B TWI831764 B TW I831764B
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TW
Taiwan
Prior art keywords
weeks
treatment
vegf
seq
antibody
Prior art date
Application number
TW108104518A
Other languages
English (en)
Chinese (zh)
Other versions
TW202000700A (zh
Inventor
羅柏特 詹姆士 威克特
亞倫 奧斯本
嘉亞許瑞 沙尼
Original Assignee
美商建南德克公司
瑞士商赫孚孟拉羅股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 美商建南德克公司, 瑞士商赫孚孟拉羅股份公司 filed Critical 美商建南德克公司
Publication of TW202000700A publication Critical patent/TW202000700A/zh
Application granted granted Critical
Publication of TWI831764B publication Critical patent/TWI831764B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW108104518A 2018-02-06 2019-02-11 眼科疾病之治療 TWI831764B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862627103P 2018-02-06 2018-02-06
US62/627,103 2018-02-06
US201862729333P 2018-09-10 2018-09-10
US62/729,333 2018-09-10

Publications (2)

Publication Number Publication Date
TW202000700A TW202000700A (zh) 2020-01-01
TWI831764B true TWI831764B (zh) 2024-02-11

Family

ID=65352014

Family Applications (3)

Application Number Title Priority Date Filing Date
TW114116623A TW202535932A (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW113103154A TWI885720B (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW108104518A TWI831764B (zh) 2018-02-06 2019-02-11 眼科疾病之治療

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TW114116623A TW202535932A (zh) 2018-02-06 2019-02-11 眼科疾病之治療
TW113103154A TWI885720B (zh) 2018-02-06 2019-02-11 眼科疾病之治療

Country Status (12)

Country Link
US (2) US20210139576A1 (enExample)
EP (1) EP3749359A1 (enExample)
JP (5) JP7005772B2 (enExample)
KR (3) KR20240093772A (enExample)
CN (4) CN119770646A (enExample)
AU (3) AU2019219004B2 (enExample)
CA (1) CA3088355A1 (enExample)
IL (1) IL276383B2 (enExample)
MX (1) MX2020007527A (enExample)
SG (1) SG11202006712XA (enExample)
TW (3) TW202535932A (enExample)
WO (1) WO2019154776A1 (enExample)

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US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CA3010056A1 (en) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Antibodies and conjugates thereof
EA202091786A1 (ru) 2018-01-26 2020-10-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Способы и композиции для лечения ангиогенных расстройств с применением агентов против фрэс
CN112203679A (zh) 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
JP7403553B2 (ja) * 2019-08-06 2023-12-22 エフ． ホフマン－ラ ロシュ アーゲー 眼科の疾患の個別化された治療
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
KR20220104756A (ko) 2019-11-25 2022-07-26 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 안구내 신생혈관형성을 위한 장기지속형 vegf 억제제
KR20230061458A (ko) 2020-09-04 2023-05-08 에프. 호프만-라 로슈 아게 Vegf-a 및 ang2에 결합하는 항체 및 사용 방법
WO2022057888A1 (zh) * 2020-09-17 2022-03-24 江苏恒瑞医药股份有限公司 特异性结合vegf和ang-2的双特异性抗原结合分子
US20240158489A1 (en) * 2021-03-30 2024-05-16 Abpro Corporation Methods for treating choroidal neovascularization using anti-ang2 x vegf multi-specific antibodies
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
CN118139628A (zh) * 2021-08-23 2024-06-04 阿维麦克思生物制药公司 用于转基因表达的组合物和方法
CN117100845A (zh) * 2022-10-24 2023-11-24 景泽生物医药(合肥)股份有限公司 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途

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Also Published As

Publication number Publication date
TW202535932A (zh) 2025-09-16
JP2025084976A (ja) 2025-06-03
IL276383A (en) 2020-09-30
JP7273204B2 (ja) 2023-05-12
AU2025220842A1 (en) 2025-09-11
AU2019219004A1 (en) 2020-07-16
WO2019154776A1 (en) 2019-08-15
JP2022046738A (ja) 2022-03-23
TW202419464A (zh) 2024-05-16
JP2021506947A (ja) 2021-02-22
CN111699004A (zh) 2020-09-22
JP2025084977A (ja) 2025-06-03
EP3749359A1 (en) 2020-12-16
KR20250166355A (ko) 2025-11-27
TW202000700A (zh) 2020-01-01
MX2020007527A (es) 2020-09-09
JP7646727B2 (ja) 2025-03-17
AU2019219004B2 (en) 2025-06-05
CN119733046A (zh) 2025-04-01
IL276383B2 (en) 2024-01-01
SG11202006712XA (en) 2020-08-28
IL276383B1 (en) 2023-09-01
AU2025220841A1 (en) 2025-09-11
KR20200119274A (ko) 2020-10-19
US20210139576A1 (en) 2021-05-13
US20230416353A1 (en) 2023-12-28
KR20240093772A (ko) 2024-06-24
CN119770646A (zh) 2025-04-08
CN119909169A (zh) 2025-05-02
JP7005772B2 (ja) 2022-02-10
CA3088355A1 (en) 2019-08-15
JP2023099094A (ja) 2023-07-11
TWI885720B (zh) 2025-06-01

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