TWI827745B - 膠囊調配物 - Google Patents

膠囊調配物 Download PDF

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Publication number
TWI827745B
TWI827745B TW108143799A TW108143799A TWI827745B TW I827745 B TWI827745 B TW I827745B TW 108143799 A TW108143799 A TW 108143799A TW 108143799 A TW108143799 A TW 108143799A TW I827745 B TWI827745 B TW I827745B
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TW
Taiwan
Prior art keywords
peg
solid solution
compound
polyethylene glycol
polyoxyethylene
Prior art date
Application number
TW108143799A
Other languages
English (en)
Chinese (zh)
Other versions
TW202038952A (zh
Inventor
曼摩漢 瑞迪 賴勒提
傑 P 包爾斯
Original Assignee
美商卡默森屈有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70849818&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI827745(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 美商卡默森屈有限公司 filed Critical 美商卡默森屈有限公司
Publication of TW202038952A publication Critical patent/TW202038952A/zh
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833Encapsulating processes; Filling of capsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW108143799A 2018-11-30 2019-11-29 膠囊調配物 TWI827745B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862773848P 2018-11-30 2018-11-30
US62/773,848 2018-11-30

Publications (2)

Publication Number Publication Date
TW202038952A TW202038952A (zh) 2020-11-01
TWI827745B true TWI827745B (zh) 2024-01-01

Family

ID=70849818

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108143799A TWI827745B (zh) 2018-11-30 2019-11-29 膠囊調配物

Country Status (31)

Country Link
US (4) US20200170957A1 (https=)
EP (3) EP4487915A3 (https=)
JP (1) JP7342124B2 (https=)
KR (1) KR102586747B1 (https=)
CN (1) CN113164403A (https=)
AR (1) AR117219A1 (https=)
AU (1) AU2019389031B2 (https=)
BR (1) BR112021010285A2 (https=)
CA (1) CA3120999C (https=)
CL (1) CL2021001389A1 (https=)
CY (1) CY1126079T1 (https=)
DK (2) DK3886820T3 (https=)
ES (2) ES2998858T3 (https=)
FI (2) FI3886820T3 (https=)
HR (2) HRP20230551T1 (https=)
HU (2) HUE069633T2 (https=)
IL (1) IL283450B2 (https=)
LT (2) LT4233850T (https=)
MA (2) MA54318B1 (https=)
MD (2) MD3886820T2 (https=)
MX (1) MX2021006242A (https=)
NZ (1) NZ776554A (https=)
PL (2) PL4233850T3 (https=)
PT (2) PT4233850T (https=)
RS (2) RS64250B1 (https=)
SG (1) SG11202105572UA (https=)
SI (2) SI4233850T1 (https=)
SM (2) SMT202400521T1 (https=)
TW (1) TWI827745B (https=)
WO (1) WO2020112961A1 (https=)
ZA (1) ZA202103820B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020112961A1 (en) 2018-11-30 2020-06-04 Chemocentryx, Inc. Capsule formulations
US11603356B2 (en) 2019-11-08 2023-03-14 Chemocentryx, Inc. Amorphous form of a complement component C5a receptor
CN116529241A (zh) * 2020-10-28 2023-08-01 坎莫森特里克斯公司 治疗化脓性汗腺炎的方法
JP7839157B2 (ja) * 2020-10-28 2026-04-01 ケモセントリックス, インコーポレイテッド 化膿性汗腺炎を処置する方法
WO2022140258A1 (en) * 2020-12-21 2022-06-30 Chemocentryx, Inc. Treatment of c3 glomerulopathy using a c5a inhibitor
CN119031903A (zh) * 2022-05-19 2024-11-26 陶氏环球技术有限责任公司 基于peg的聚合物间复合物用于改善bcs ii类药物的增溶的用途
WO2025203055A1 (en) * 2024-03-26 2025-10-02 Council Of Scientific And Industrial Research Encapsulated dihydrofolate formulation for dietary supplementation as effective nutraceutical supplement and method of preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1633307A (zh) * 2002-02-14 2005-06-29 索尔瓦药物有限公司 水溶性差的活性物质的口服固溶体配方
CN103068385A (zh) * 2010-06-24 2013-04-24 凯莫森特里克斯股份有限公司 C5aR拮抗剂

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BRPI0518484A2 (pt) 2004-11-24 2008-11-18 Merck & Co Inc composiÇço, cÁpsula, e, processo para preparar a mesma
DE102005053066A1 (de) 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
CA2689137C (en) * 2007-05-29 2017-05-02 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
RS54998B1 (sr) 2008-12-22 2016-11-30 Chemocentryx Inc Antagonisti c5ar
NZ602288A (en) * 2010-03-10 2014-02-28 Abbvie Bahamas Ltd Solid compositions comprising amorphous (2r,6s,13as,14ar,16as,z)-n-(cyclopropylsulfonyl)-6-(5-methylpyrazine-2-carboxamido)-5,16-dioxo-2-(phenanthridin-6-yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9074470B2 (en) 2010-12-27 2015-07-07 Seven Generations Energy Ltd. Methods for drilling and stimulating subterranean formations for recovering hydrocarbon and natural gas resources
WO2015118015A1 (en) 2014-02-05 2015-08-13 Lek Pharmaceuticals D.D. Solid pharmaceutical compositions of androgen receptor antagonists
DK3200791T3 (da) 2014-09-29 2020-05-25 Chemocentryx Inc Fremgangsmåder og mellemprodukter i fremstilling af C5AR- antagonister
JP7339733B2 (ja) 2016-01-14 2023-09-06 ケモセントリックス,インコーポレイティド C3腎症を処置する方法
EP3439658B1 (en) 2016-04-04 2021-11-24 ChemoCentryx, Inc. Soluble c5ar antagonists
TWI826364B (zh) 2017-04-03 2023-12-21 德商因夫萊亞斯有限公司 活性抑制劑於發炎性疾病之治療
CA3077395A1 (en) 2017-10-30 2019-05-09 Chemocentryx, Inc. Deuterated compounds as immunomodulators
CA3078732A1 (en) 2017-10-31 2019-05-09 Chemocentryx, Inc. C5ar inhibitor reduction of urinary scd163
US11191756B2 (en) 2018-06-07 2021-12-07 Chemocentryx, Inc. Dosing and effect of C5a antagonist with ANCA-associated vasculitis
WO2020112961A1 (en) 2018-11-30 2020-06-04 Chemocentryx, Inc. Capsule formulations

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1633307A (zh) * 2002-02-14 2005-06-29 索尔瓦药物有限公司 水溶性差的活性物质的口服固溶体配方
CN103068385A (zh) * 2010-06-24 2013-04-24 凯莫森特里克斯股份有限公司 C5aR拮抗剂

Also Published As

Publication number Publication date
EP4487915A3 (en) 2025-03-19
SG11202105572UA (en) 2021-06-29
US20220233453A1 (en) 2022-07-28
IL283450A (en) 2021-07-29
HRP20241735T1 (hr) 2025-02-28
IL283450B2 (en) 2024-06-01
WO2020112961A1 (en) 2020-06-04
US20200170957A1 (en) 2020-06-04
BR112021010285A2 (pt) 2021-08-17
JP2022510304A (ja) 2022-01-26
CN113164403A (zh) 2021-07-23
JP7342124B2 (ja) 2023-09-11
US20240299306A1 (en) 2024-09-12
AU2019389031B2 (en) 2023-06-15
DK3886820T3 (da) 2023-05-15
CA3120999C (en) 2025-04-01
EP3886820B1 (en) 2023-04-12
LT3886820T (lt) 2023-06-12
PT3886820T (pt) 2023-05-24
MA62992B1 (fr) 2025-01-31
KR20210098489A (ko) 2021-08-10
MX2021006242A (es) 2021-09-10
EP3886820A4 (en) 2022-08-24
CY1126079T1 (el) 2023-11-15
MD4233850T2 (ro) 2025-02-28
PL4233850T3 (pl) 2025-03-17
KR102586747B1 (ko) 2023-10-06
MA54318B1 (fr) 2023-08-31
LT4233850T (lt) 2025-01-27
PL3886820T3 (pl) 2023-08-14
EP3886820B8 (en) 2023-05-17
HUE069633T2 (hu) 2025-04-28
EP4233850A3 (en) 2023-09-20
HUE062551T2 (hu) 2023-11-28
FI4233850T3 (fi) 2024-12-30
EP3886820A1 (en) 2021-10-06
ES2943492T3 (es) 2023-06-13
FI3886820T3 (fi) 2023-05-25
MA54318A (fr) 2021-10-06
RS66362B1 (sr) 2025-01-31
MD3886820T2 (ro) 2023-07-31
ES2998858T3 (en) 2025-02-21
US20250375385A1 (en) 2025-12-11
TW202038952A (zh) 2020-11-01
CA3120999A1 (en) 2020-06-04
AR117219A1 (es) 2021-07-21
HRP20230551T1 (hr) 2023-08-18
EP4487915A2 (en) 2025-01-08
SMT202400521T1 (it) 2025-01-14
US11951214B2 (en) 2024-04-09
ZA202103820B (en) 2026-03-25
AU2019389031A1 (en) 2021-06-17
IL283450B1 (en) 2024-02-01
NZ776554A (en) 2024-12-20
DK4233850T3 (da) 2025-01-02
EP4233850B1 (en) 2024-10-02
SI3886820T1 (sl) 2023-07-31
SMT202300153T1 (it) 2023-09-06
SI4233850T1 (sl) 2025-03-31
RS64250B1 (sr) 2023-06-30
EP4233850A2 (en) 2023-08-30
CL2021001389A1 (es) 2021-12-24
PT4233850T (pt) 2024-12-30

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