TWI826361B - 投與抗纖維化療法之方法 - Google Patents

投與抗纖維化療法之方法 Download PDF

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Publication number
TWI826361B
TWI826361B TW106141628A TW106141628A TWI826361B TW I826361 B TWI826361 B TW I826361B TW 106141628 A TW106141628 A TW 106141628A TW 106141628 A TW106141628 A TW 106141628A TW I826361 B TWI826361 B TW I826361B
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TW
Taiwan
Prior art keywords
compound
administration
food
ppi
hours
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TW106141628A
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English (en)
Chinese (zh)
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TW201825093A (zh
Inventor
林 潘
桃樂絲 紫芸 鐘
傑佛瑞 馬克 哈里斯
印第安娜 史東布
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美商基因科技公司
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Publication of TW201825093A publication Critical patent/TW201825093A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW106141628A 2016-11-30 2017-11-29 投與抗纖維化療法之方法 TWI826361B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662428163P 2016-11-30 2016-11-30
US62/428,163 2016-11-30
US201662432425P 2016-12-09 2016-12-09
US62/432,425 2016-12-09

Publications (2)

Publication Number Publication Date
TW201825093A TW201825093A (zh) 2018-07-16
TWI826361B true TWI826361B (zh) 2023-12-21

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Family Applications (2)

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TW106141628A TWI826361B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法
TW112145288A TWI891129B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法

Family Applications After (1)

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TW112145288A TWI891129B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法

Country Status (11)

Country Link
US (3) US11207304B2 (enExample)
EP (2) EP4470624A3 (enExample)
JP (3) JP2020502054A (enExample)
KR (3) KR20190089862A (enExample)
CN (1) CN110087651A (enExample)
AU (3) AU2017366881A1 (enExample)
CA (2) CA3045455A1 (enExample)
IL (3) IL299447A (enExample)
MX (3) MX2019006143A (enExample)
TW (2) TWI826361B (enExample)
WO (1) WO2018102323A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020502054A (ja) 2016-11-30 2020-01-23 ジェネンテック, インコーポレイテッド 抗線維化療法を投与する方法
CN114129517A (zh) * 2020-09-03 2022-03-04 苏州爱科百发生物医药技术有限公司 一种ak3287制剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153683A1 (en) * 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP2020502054A (ja) 2016-11-30 2020-01-23 ジェネンテック, インコーポレイテッド 抗線維化療法を投与する方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153683A1 (en) * 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 PA WINSTANLEY ET AL he effects of food on drug bioavailability BRITISH JOURNAL OF CLINICAL PHARMACOLOGY vol. 28, no. 6 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 1989 pages 621 – 628 *

Also Published As

Publication number Publication date
TW202412795A (zh) 2024-04-01
US20240197693A1 (en) 2024-06-20
KR20230129628A (ko) 2023-09-08
EP3548025A1 (en) 2019-10-09
IL289544B2 (en) 2023-06-01
US12310951B2 (en) 2025-05-27
JP2022058873A (ja) 2022-04-12
AU2023263548A1 (en) 2023-11-30
AU2025238129A1 (en) 2025-10-23
KR20190089862A (ko) 2019-07-31
MX2019006143A (es) 2019-10-17
TW201825093A (zh) 2018-07-16
WO2018102323A1 (en) 2018-06-07
KR102575344B1 (ko) 2023-09-06
JP2020502054A (ja) 2020-01-23
JP7495951B2 (ja) 2024-06-05
EP4470624A3 (en) 2025-01-08
IL266480A (en) 2019-07-31
US11925624B2 (en) 2024-03-12
KR20220139450A (ko) 2022-10-14
AU2023263548B2 (en) 2025-10-16
US20190321344A1 (en) 2019-10-24
MX2023003924A (es) 2023-04-26
CA3247781A1 (en) 2025-07-09
EP4470624A2 (en) 2024-12-04
US20220184046A1 (en) 2022-06-16
AU2017366881A1 (en) 2019-05-30
JP2023139157A (ja) 2023-10-03
IL289544A (en) 2022-03-01
CA3045455A1 (en) 2018-06-07
IL299447A (en) 2023-02-01
US11207304B2 (en) 2021-12-28
MX2020011766A (es) 2020-11-24
CN110087651A (zh) 2019-08-02
TWI891129B (zh) 2025-07-21

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