TWI825029B - 針對突變ras之hla第ii類限制性t細胞受體 - Google Patents

針對突變ras之hla第ii類限制性t細胞受體 Download PDF

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TWI825029B
TWI825029B TW107133221A TW107133221A TWI825029B TW I825029 B TWI825029 B TW I825029B TW 107133221 A TW107133221 A TW 107133221A TW 107133221 A TW107133221 A TW 107133221A TW I825029 B TWI825029 B TW I825029B
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TW201920251A (zh
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拉彌 約瑟夫
蓋爾 卡夫利
保羅 Ｆ 羅賓斯
史帝文 Ａ 羅森伯格
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美國衛生與公眾服務部
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TW107133221A 2017-09-20 2018-09-20 針對突變ras之hla第ii類限制性t細胞受體 TWI825029B (zh)

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US201762560930P 2017-09-20 2017-09-20
US62/560,930 2017-09-20

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TW201920251A TW201920251A (zh) 2019-06-01
TWI825029B true TWI825029B (zh) 2023-12-11

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GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
CA3127673A1 (en) * 2019-01-25 2020-07-30 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting mutant ras
US20220291215A1 (en) * 2019-07-30 2022-09-15 University Health Network Methods of identifying t cell receptors
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
JP2023507432A (ja) 2019-12-20 2023-02-22 インスティル バイオ （ユーケイ） リミテッド 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用
MX2022009825A (es) * 2020-02-14 2022-10-13 Us Health Receptores de células t restringidas por hla de la clase i contra ras con mutación g12v.
US20230090247A1 (en) * 2020-02-19 2023-03-23 Aelin Therapeutics Molecules targeting ras protein
US20230159614A1 (en) * 2020-02-26 2023-05-25 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class ii-restricted t cell receptors against ras with g12v mutation
US20230312672A1 (en) * 2020-06-24 2023-10-05 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class i-restricted t cell receptors against cd20
CA3185241A1 (en) 2020-07-13 2022-01-20 Noam LEVIN Hla class ii?restricted drb t cell receptors against ras with g12d mutation
WO2022015922A1 (en) * 2020-07-16 2022-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted drb t cell receptors against ras with g12v mutation
CN112300269B (zh) * 2020-09-29 2022-12-09 中国科学院微生物研究所 Kras突变特异性t细胞受体筛选及抗肿瘤用途
AU2021351710A1 (en) * 2020-10-02 2023-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
JP2023550515A (ja) * 2020-11-24 2023-12-01 シャンハイ、ケンパーソー、バイオテクノロジー、カンパニー、リミテッド Ｒａｓ突然変異体エピトープペプチドおよびｒａｓ突然変異体を認識するｔ細胞受容体
JP2024507929A (ja) 2021-02-25 2024-02-21 アラウノス セラピューティクス インコーポレイテッド 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN114835800B (zh) * 2022-05-27 2023-10-13 重庆医科大学 Tcr或其抗原结合片段及其应用
CN117264043B (zh) * 2022-06-14 2024-05-10 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
WO2024072954A1 (en) * 2022-09-29 2024-04-04 Jerome Canady Research Institute for Advanced Biological and Technological Sciences Cold atmopsheric plasma treated pan-cancer epitope peptide within the collagen type vi a-3 (col6a3) protein as cancer vaccine
WO2026019786A1 (en) * 2024-07-16 2026-01-22 Board Of Regents, The University Of Texas System Peptides and engineered t cell receptors targeting brachyury antigen and methods of use
WO2026024602A2 (en) * 2024-07-22 2026-01-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors against ras with g12d, g12v, g13d or q61r mutation

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WO2016085904A1 (en) * 2014-11-26 2016-06-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mutated kras t cell receptors
WO2017048593A1 (en) * 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing hla-cw8 restricted mutated kras

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JP6869947B2 (ja) * 2015-07-22 2021-05-12 アラクセス ファーマ エルエルシー 置換キナゾリン化合物ならびにそのｇ１２ｃ変異ｋｒａｓ、ｈｒａｓおよび／またはｎｒａｓタンパク質の阻害剤としての使用
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WO2016085904A1 (en) * 2014-11-26 2016-06-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mutated kras t cell receptors
WO2017048593A1 (en) * 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing hla-cw8 restricted mutated kras

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MX2024004610A (es) 2024-04-30
JP7256794B2 (ja) 2023-04-12
IL273254B1 (en) 2024-05-01
IL273254A (en) 2020-04-30
CN111201237A (zh) 2020-05-26
AU2025202532A1 (en) 2025-05-01
WO2019060349A1 (en) 2019-03-28
US12304940B2 (en) 2025-05-20
EA202090652A1 (ru) 2020-08-21
US20250250318A1 (en) 2025-08-07
TW201920251A (zh) 2019-06-01
EP3684799B1 (en) 2026-07-08
IL273254B2 (en) 2024-09-01
CR20240019A (es) 2024-02-15
KR102777370B1 (ko) 2025-03-10
CR20200150A (es) 2020-08-15
KR20250037592A (ko) 2025-03-17
MA50180A (fr) 2021-05-26
SG11202002425PA (en) 2020-04-29
AU2018335274A1 (en) 2020-04-09
US20190085046A1 (en) 2019-03-21
EP3684799A1 (en) 2020-07-29
US20220204584A1 (en) 2022-06-30
BR112020005469A2 (pt) 2020-09-29
CN111201237B (zh) 2025-03-25
CA3076339A1 (en) 2019-03-28
KR20200051804A (ko) 2020-05-13
AU2018335274B2 (en) 2025-02-13
AU2025202532A9 (en) 2025-09-04
CN120082603A (zh) 2025-06-03
US11306132B2 (en) 2022-04-19
AR112902A1 (es) 2019-12-26
JP2020534828A (ja) 2020-12-03
MX2020003117A (es) 2020-08-20

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