AU2018335274B2 - HLA class II–restricted T cell receptors against mutated RAS - Google Patents

HLA class II–restricted T cell receptors against mutated RAS Download PDF

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AU2018335274B2
AU2018335274B2 AU2018335274A AU2018335274A AU2018335274B2 AU 2018335274 B2 AU2018335274 B2 AU 2018335274B2 AU 2018335274 A AU2018335274 A AU 2018335274A AU 2018335274 A AU2018335274 A AU 2018335274A AU 2018335274 B2 AU2018335274 B2 AU 2018335274B2
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AU2018335274A1 (en
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Gal CAFRI
Paul F. Robbins
Steven A. Rosenberg
Rami Yoseph
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US Department of Health and Human Services
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A—HUMAN NECESSITIES
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    • A61K35/14—Blood; Artificial blood
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4253—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2740/10011—Retroviridae
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    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

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  • Urology & Nephrology (AREA)
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AU2018335274A 2017-09-20 2018-09-19 HLA class II–restricted T cell receptors against mutated RAS Active AU2018335274B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025202532A AU2025202532A1 (en) 2017-09-20 2025-04-09 HLA Class II-restricted T cell receptors against mutated RAS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560930P 2017-09-20 2017-09-20
US62/560,930 2017-09-20
PCT/US2018/051641 WO2019060349A1 (en) 2017-09-20 2018-09-19 CLASS II HLA RESTRICTED T LYMPHOCYTE RECEPTORS AGAINST KRAS MUTATED

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AU2025202532A Division AU2025202532A1 (en) 2017-09-20 2025-04-09 HLA Class II-restricted T cell receptors against mutated RAS

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AU2018335274A1 AU2018335274A1 (en) 2020-04-09
AU2018335274B2 true AU2018335274B2 (en) 2025-02-13

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AU2025202532A Pending AU2025202532A1 (en) 2017-09-20 2025-04-09 HLA Class II-restricted T cell receptors against mutated RAS

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GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US20220088190A1 (en) * 2019-01-25 2022-03-24 The Trustees Of The University Of Pennsylvania Compositions and Methods for Targeting Mutant RAS
CA3146290A1 (en) * 2019-07-30 2021-02-04 Naoto Hirano Methods of identifying t cell receptors
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
WO2021163477A1 (en) * 2020-02-14 2021-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class i-restricted t cell receptors against ras with g12v mutation
IL295634A (en) * 2020-02-19 2022-10-01 Aelin Therapeutics Molecules targeting ras protein
CN115244075A (zh) * 2020-02-26 2022-10-25 美国卫生和人力服务部 针对含有g12v突变的ras的hla ii类限制性t细胞受体
WO2021262829A2 (en) * 2020-06-24 2021-12-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class i-restricted t cell receptors against cd20
US20230272038A1 (en) * 2020-07-13 2023-08-31 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class ii-restricted drb t cell receptors against ras with g12d mutation
EP4182029A1 (en) * 2020-07-16 2023-05-24 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class ii-restricted drb t cell receptors against ras with g12v mutation
CN112300269B (zh) * 2020-09-29 2022-12-09 中国科学院微生物研究所 Kras突变特异性t细胞受体筛选及抗肿瘤用途
AU2021351710A1 (en) * 2020-10-02 2023-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
JP2023550515A (ja) * 2020-11-24 2023-12-01 シャンハイ、ケンパーソー、バイオテクノロジー、カンパニー、リミテッド Ｒａｓ突然変異体エピトープペプチドおよびｒａｓ突然変異体を認識するｔ細胞受容体
US20240175047A1 (en) 2021-02-25 2024-05-30 Alaunos Therapeutics, Inc. Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN114835800B (zh) * 2022-05-27 2023-10-13 重庆医科大学 Tcr或其抗原结合片段及其应用
CN117264043B (zh) * 2022-06-14 2024-05-10 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
WO2024072954A1 (en) * 2022-09-29 2024-04-04 Jerome Canady Research Institute for Advanced Biological and Technological Sciences Cold atmopsheric plasma treated pan-cancer epitope peptide within the collagen type vi a-3 (col6a3) protein as cancer vaccine

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US20190085046A1 (en) 2019-03-21
AR112902A1 (es) 2019-12-26
JP2020534828A (ja) 2020-12-03
MX2020003117A (es) 2020-08-20
CN120082603A (zh) 2025-06-03
US12304940B2 (en) 2025-05-20
EP3684799A1 (en) 2020-07-29
AU2025202532A1 (en) 2025-05-01
IL273254B2 (en) 2024-09-01
CN111201237A (zh) 2020-05-26
MX2024004610A (es) 2024-04-30
KR20200051804A (ko) 2020-05-13
CR20240019A (es) 2024-02-15
TW201920251A (zh) 2019-06-01
WO2019060349A1 (en) 2019-03-28
KR102777370B1 (ko) 2025-03-10
JP7256794B2 (ja) 2023-04-12
IL273254B1 (en) 2024-05-01
US11306132B2 (en) 2022-04-19
CA3076339A1 (en) 2019-03-28
SG11202002425PA (en) 2020-04-29
MA50180A (fr) 2021-05-26
EA202090652A1 (ru) 2020-08-21
US20220204584A1 (en) 2022-06-30
BR112020005469A2 (pt) 2020-09-29
AU2025202532A9 (en) 2025-09-04
KR20250037592A (ko) 2025-03-17
CN111201237B (zh) 2025-03-25
TWI825029B (zh) 2023-12-11
AU2018335274A1 (en) 2020-04-09
IL273254A (en) 2020-04-30
US20250250318A1 (en) 2025-08-07

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