TWI821845B - Solutions for ophthalmic lenses - Google Patents

Abstract

A solution applied to ophthalmic lenses, including a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent, the molecular weight of the first hyaluronic acid or its salts is between 100kDA ~6000kDA, the molecular weight of the second hyaluronic acid or its salt is less than 100kDA, the solution is applied to the surface of the ophthalmic lens, wherein before the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C1, the After the solution is applied to the ophthalmic lens and used for a period of time, the contact angle of the ophthalmic lens is C2, and the solution meets the following range: 16%＜(C1-C2)/C1*100%＜61%; Borrow Therefore, when the solution is used in the ophthalmic lens, it can prolong the timeliness of the ophthalmic lens to maintain hydration and moisturizing, so that the wearer can still maintain the comfortable wearing effect after wearing the ophthalmic lens for a long time.

Description

Solutions for ophthalmic lenses

The present invention is a solution; in particular, it refers to a solution applied to ophthalmic lenses. The solution can make the ophthalmic lenses have long-lasting hydrating, moisturizing and lubricating effects that are not originally available.

In today's society where electronic products are prevalent, the proportion of myopia remains high. Patients with myopia usually wear glasses or contact lenses to correct myopia. For contact lenses, in addition to being easy to carry, wearing contact lenses is not easy. It will affect the appearance of the face and even increase the visual beauty of the user, making contact lenses the choice of many people.

However, wearing contact lenses for a long time can easily cause the wearer's eyes to feel dry, and dust or particulate matter in the environment can adhere to the contact lenses, which can easily cause the wearer's eyes to have a foreign body sensation or eye allergies. Symptoms, and the moisture contained in the contact lens itself will be lost over time. That is to say, when the contact lens is worn for a period of time, the lens of the contact lens will absorb moisture from the eye to maintain the moisture content of the lens. Therefore, It is easy to have dry eyes.

In order to improve the problems of wearing discomfort caused by contact lenses such as dryness and foreign body sensation in the eyes, some relevant manufacturers can use solutions with hydrating and moisturizing effects to maintain the moisture contained in the contact lenses themselves. This solution will make the contact lenses have a layer of The hydrating and moisturizing layer improves wearing comfort. In addition, the lubricating effect provided by the solution can be used to remove particulate matter on the contact lens, thereby reducing the foreign body sensation generated during the wearing process.

However, the ophthalmic aqueous solutions currently on the market specifically designed for contact lenses mostly use wetting ingredients containing macromolecular polymers to increase the wetting effect of contact lenses. Although they can solve the dryness caused by wearing contact lenses, However, most of them only have a short-term moisturizing effect and are not able to effectively provide long-term hydration, moisturizing and lubricating effects. For wearers who wear contact lenses for a long time, they also cannot improve the problem of dry eyes caused by wearing contact lenses.

In view of this, the object of the present invention is to provide a solution applied to ophthalmic lenses. When the solution is used in the ophthalmic lenses, the ophthalmic lenses can have long-lasting hydrating, moisturizing and lubricating effects, making it easier to wear. It provides the effect of maintaining wearing comfort after wearing eye lenses for a long time.

In order to achieve the above object, the solution provided by the present invention for use in ophthalmic lenses includes a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent. The first hyaluronic acid Or the molecular weight of its salts is between 100kDA and 6000kDA, and the molecular weight of the second hyaluronic acid or its salts is less than 100kDA.

One embodiment of the present invention provides a solution applied to an ophthalmic lens. The solution is applied to the surface of an ophthalmic lens. The solution is applied in front of the ophthalmic lens. The contact angle of the ophthalmic lens is C1. The solution is applied to the surface of the ophthalmic lens. After using the ophthalmic lens for a period of time, the contact angle of the ophthalmic lens is C2, and the solution applied to the ophthalmic lens further satisfies the following range: 16% < (C1-C2)/C1*100% <61%.

Another embodiment of the present invention provides a solution applied to an ophthalmic lens. The solution is applied to the surface of an ophthalmic lens. The solution is applied in front of the ophthalmic lens. The friction coefficient of the ophthalmic lens is M1. The solution is applied After the ophthalmic lens, the friction coefficient of the ophthalmic lens is M2, and the solution applied to the ophthalmic lens further satisfies the following range: 5%<(M1-M2)/M1*100%<70%.

The effect of the present invention is that when the solution is used in the ophthalmic lens, the combination of the first hyaluronic acid or its salt and the second hyaluronic acid or its salt with different molecular weights can extend the length of the ophthalmic lens. Maintaining the timeliness of hydrating and moisturizing allows the wearer to maintain the comfortable wearing effect of eye lenses after wearing them for a long time.

The present invention is applied to a solution for ophthalmic lenses. The solution mainly includes a first hyaluronic acid or its salts, a second hyaluronic acid or its salts, a cellulose mixed ether and a solvent. In this embodiment , the ophthalmic lens is a contact lens, but is not limited to this.

The first hyaluronic acid or its salts and the second hyaluronic acid or its salts can be one of sodium hyaluronate and potassium hyaluronate or a combination of more than one, which provide hydration and moisturizing for the ophthalmic lens. In this embodiment, the molecular weight of the first hyaluronic acid or its salts is greater than the molecular weight of the second hyaluronic acid or its salts, wherein the molecular weight of the first hyaluronic acid or its salts is between 100kDA~6000kDA. The molecular weight of the second hyaluronic acid or its salts is less than 100kDA. Specifically, the first hyaluronic acid or its salts have a larger molecular volume and can form a thin film on the surface of the ophthalmic lens. To prevent water loss from the ophthalmic lens, the second hyaluronic acid or its salt has a small molecular volume and can penetrate deeply into the surface of the ophthalmic lens as a replenishing water to provide the moisture content of the ophthalmic lens, and this embodiment will The mixed use of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts can further prolong the timeliness of maintaining hydration and moisturizing of the ophthalmic lens.

To further explain, the total weight of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to 1wt% of the total weight of the solution. In a preferred embodiment, the The total weight of one hyaluronic acid or its salt and the second hyaluronic acid or its salt accounts for 0.005wt% to 0.012wt% of the total weight of the solution.

In addition, the weight of the first hyaluronic acid or its salts is 1/3 to 3 times the weight of the second hyaluronic acid or its salts.

In this embodiment, the solution is applied to the surface of the ophthalmic lens. Before the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C1. After the solution is applied to the ophthalmic lens, it is used for a period of time. After time, the contact angle of the ophthalmic lens is C2, and the solution applied to the ophthalmic lens meets the following range: (1). When the solution is applied to the ophthalmic lens and used for 1 hour, the solution applied to the ophthalmic lens satisfies 16%＜(C1-C2)/C1*100%＜70%; (2). When the solution is applied to the ophthalmic lens and used for 2 hours, the solution applied to the ophthalmic lens satisfies 16%＜(C1-C2)/C1*100%＜70%; (3). When the solution is applied to the ophthalmic lens and used for 3 hours, the solution applied to the ophthalmic lens satisfies 16%＜(C1-C2)/C1*100%＜68%; (4). When the solution is applied to the ophthalmic lens and used for 4 hours, the solution applied to the ophthalmic lens satisfies 16%＜(C1-C2)/C1*100%＜68%; (5). When the solution is applied to the ophthalmic lens and used for 8 hours, the solution applied to the ophthalmic lens satisfies 16%＜(C1-C2)/C1*100%＜61%.

Specifically, the above range is the contact angle reduction rate of the ophthalmic lens, the contact angle value of the ophthalmic lens is measured before the solution is applied to the ophthalmic lens, and the contact angle value of the ophthalmic lens is measured before the solution is applied to the ophthalmic lens. After the lens is used for a period of time, each contact angle value of the ophthalmic lens is used to obtain the contact angle reduction rate of the ophthalmic lens. Among them, the greater the contact angle reduction rate of the ophthalmic lens, the better. In particular, the greater the contact angle reduction rate means that the solution can make the ophthalmic lens have better hydrating and moisturizing properties.

In this embodiment, after 8 hours of use after the solution was applied to the ophthalmic lens, the contact angle reduction rate of the ophthalmic lens was maintained at more than 30%. However, when the contact angle reduction rate is maintained above 16%, it still has the expected hydrating and moisturizing properties. It can be deduced from this that preferably, after 8 hours of use after the solution is applied to the ophthalmic lens, the contact angle reduction rate of the ophthalmic lens is maintained at above 16%. Preferably, after 8 hours of use after the solution is applied to the ophthalmic lens, the contact angle reduction rate of the ophthalmic lens is maintained at more than 30%.

The cellulose mixed ethers provide the lubricating effect of the ophthalmic lens. The cellulose mixed ethers are mixed with the first hyaluronic acid or its salts and the second hyaluronic acid or its salts. The cellulose mixed ethers The types of mixed ethers include one or more combinations of methylcellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose, and carboxyethylcellulose. , the content of the cellulose mixed ethers accounts for 0.08wt% to 0.12wt% of the total content of the solution.

The solution is applied to the surface of the ophthalmic lens. Before the solution is applied to the ophthalmic lens, the friction coefficient of the ophthalmic lens is M1. After the solution is applied to the ophthalmic lens, the friction coefficient of the ophthalmic lens is M2, the solution applied to ophthalmic lenses further satisfies the following range: 5%＜(M1-M2)/M1*100%＜70%; specifically, the above conditions are to reduce the friction coefficient of the ophthalmic lenses The rate is to measure the friction coefficient of the ophthalmic lens before the solution is applied to the ophthalmic lens, and to measure the friction coefficient of the ophthalmic lens after the solution is applied to the ophthalmic lens, to obtain the coefficient of friction of the ophthalmic lens. Friction coefficient reduction rate. Among them, it is particularly noted that the greater the friction coefficient reduction rate, the better. The greater the friction coefficient reduction rate means that the solution can make the lubricating properties of ophthalmic lenses better. In this embodiment, after the solution is applied to the ophthalmic lens, the friction coefficient reduction rate of the ophthalmic lens is maintained at least 7%. However, when the friction coefficient reduction rate of the ophthalmic lens is maintained above 5%, it still has the expected lubrication properties. It can be deduced from this that preferably, after the solution is applied to the ophthalmic lens, the friction coefficient reduction rate of the ophthalmic lens is maintained at more than 5%. Preferably, after the solution is applied to the ophthalmic lens, the friction coefficient reduction rate of the ophthalmic lens is maintained at more than 7%.

The solvent provides the ophthalmic lens with a stable pH value and osmotic pressure environment, and the solvent can be a borate buffer solution or a phosphate buffer solution. For example, it may include boric acid, sodium tetraborate, potassium chloride, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium monohydrogen phosphate, etc.

In order to fully understand the purpose, characteristics and efficacy of the present invention, the composition and formula of the solution are described, and the friction coefficient and contact angle of the solution are tested when applied to the ophthalmic lens to illustrate the application of the solution to the ophthalmic lens in this embodiment. It has the effect of hydrating, moisturizing and lubricating.

1. Quality test of the solution:

The properties of the solution must comply with the scope of application for the eyes. Otherwise, the ophthalmic lenses will be irritated or have a foreign body sensation in the eyes after being soaked with the solution. Therefore, the viscosity, pH value and osmotic pressure of the solution will be affected. Affects the comfort of wearing the ophthalmic lenses on the eyes.

(1) Viscosity conditions of the solution:

The viscosity of the solution is between 1 and 10 mPas, in line with the acceptable viscosity range of human eyes, so that the solution will not cause irritation or discomfort after entering the human eyes. The viscosity of the solution is measured using a rotary viscometer (model : LVDV-1) to measure.

(2) pH value conditions of the solution:

The pH value of the solution is between 5.0 and 9.0, in line with the pH value that human eyes can adapt to, so that the solution will not cause irritation or discomfort after entering the human eyes. The viscosity of the solution is measured using a pH meter (model : pH-510) to measure.

(3) Osmotic pressure conditions of the solution:

The osmotic pressure of the solution is between 300±40mOsm/Kg, which is in line with the osmotic pressure that the human eye can adapt to, so that the solution will not cause irritation or discomfort after entering the human eye. The viscosity of the solution is measured using a freezing point osmometer. (Model: 33200) to measure.

2. Measure the coefficient of friction (COF) value of the solution applied to the ophthalmic lens. The measurement steps are as follows:

Soak the ophthalmic lens in standard saline solution for equilibrium, take out the ophthalmic lens and use lens wiping paper to remove excess liquid on the surface, and place the ophthalmic lens on the friction machine (model: CETR-UMT-2) On stage.

First, a standard saline solution was used to adhere to the ophthalmic lens to measure the friction force as a control group.

Next, the same ophthalmic lens is immersed in the solution for equilibrium, the ophthalmic lens is taken out and excess liquid on the surface is removed with lens paper, and then the ophthalmic lens is placed on the stage of the friction machine.

The solution was then attached to the ophthalmic lens for numerical measurement of friction force to serve as an experimental group.

Specifically, the aforementioned control group uses ophthalmic lenses treated with standard saline solution, and the aforementioned experimental groups are divided into experimental group 1-1, experimental group 1-2 and experimental group 1-3, among which experimental group 1-1, experimental group Groups 1-2 and experimental groups 1-3 are ophthalmic lenses infiltrated with this solution. The cellulose mixed ether in the solution is hydroxypropyl methylcellulose, and the cellulose mixed ether in each experimental group is The weight percentages are respectively adjusted to 0.08wt%~0.12wt%. The first hyaluronic acid or its salts are high molecular sodium hyaluronate, and the second hyaluronic acid or its salts are low molecular sodium hyaluronate. , and experimental groups 1-1 to 1-3 respectively obtained the friction coefficient reduction rate of the ophthalmic lens through the following formulas. Friction coefficient reduction rate = (M1-M2)/M1*100%, where M1 is the friction coefficient of the ophthalmic lens before the solution is applied to the ophthalmic lens, and M2 is the friction coefficient of the ophthalmic lens after the solution is applied to the ophthalmic lens. Friction coefficient of ophthalmic lenses.

The analysis results of the composition and friction coefficient reduction rate of each experimental group and the control group are shown in Table 1 below: Table 1 is an analysis table of the lubrication efficiency of ophthalmic lenses. Ingredients (wt%) control group Experimental group 1-1 Experimental group 1-2 Experimental group 1-3 Cellulose mixed ethers 0wt% 0.08wt% 0.1wt% 0.12wt% First hyaluronic acid or its salts 0wt% 0.004wt% 0.004wt% 0.004wt% Second hyaluronic acid or its salts 0wt% 0.008wt% 0.008wt% 0.008wt% Solvent 100wt% 99.908wt% 99.888wt% 99.868wt% Coefficient of friction (COF) 0.2066 0.1852 0.0613 0.1923 Friction coefficient reduction rate % - 10.4% 70.3% 6.9%

It can be seen from the results in Table 1 above that the solution applied to ophthalmic lenses meets the following range: 7%＜(M1-M2)/M1*100%＜70%, which refers to the friction coefficient reduction rate of the ophthalmic lenses Between 7% and 70%, the friction coefficient reduction rate of more than 5% can meet the lubrication effect of the ophthalmic lens, and the friction coefficient reduction rate of experimental group 1-2 is compared with experimental group 1-1 and experimental group 1-3 can reach more than 70%. The higher the friction coefficient reduction rate, the better the lubrication effect of the ophthalmic lens; therefore, the solution composition can provide excellent lubrication performance when applied to the ophthalmic lens, and Experimental group 1-2 has better lubrication effect.

In addition, this embodiment further collects trial-fit feedback of the ophthalmic lens to prove that the solution has a lubricating effect, in which the same try-on wearer wears experimental group 1-1, experimental group 1-2 and experimental group 1-3 on different days. The wearing comfort of the ophthalmic lens was scored after 4 hours and 8 hours of wearing respectively. The wearing comfort includes dryness and lubrication. The scoring standard is based on 10 points as a full score, and a score of 6 or above is considered a good fit. It is comfortable to wear. A score of 5 or below indicates uncomfortable wearing. The feedback results are shown in Table 2 below: Table 2 is the feedback table of wearing comfort for each experimental group. Wearing time/comfort feedback score Experimental group 1-1 Experimental group 1-2 Experimental group 1-3 4 hours 8.8±0.7 9.3±0.7 8.8±0.5 8 hours 8.3±0.9 9.0±0.5 8.1±0.8

As can be seen from Table 2 above, the comfort feedback scores of experimental groups 1-1 to 1-3 after wearing for 4 to 8 hours are all above 6 points, indicating that experimental groups 1-1 to 1-3 have good wearing comfort. , among which the comfort feedback score of experimental groups 1-2 is more than 9 points, which means that when the content of the cellulose mixed ether in the solution is 0.1wt%, it can provide better lubrication performance for the ophthalmic lens.

3. Measure the contact angle reduction rate of the solution applied to the ophthalmic lens. The measurement steps are as follows:

Immerse the ophthalmic lens in standard saline solution and equilibrate for 30 minutes. Take out the ophthalmic lens and flatten it on a glass slide. Use lens paper to remove excess liquid from the surface of the ophthalmic lens and place it for contact angle measurement. The lens contact angle of the ophthalmic lens was first measured on the instrument (model: Phoenix MT(A)) as a control group.

Then, after the same ophthalmic lens is immersed in the solution for a period of time, the solution is fully adhered to the ophthalmic lens, the ophthalmic lens is taken out, and excess liquid on the surface is removed with lens paper, and then the ophthalmic lens is The lens was placed on the contact angle measuring instrument and the contact angle at hour 0 was measured to serve as the experimental group.

Subsequently, the ophthalmic lenses of the aforementioned experimental group were immersed in a standard saline solution to simulate the wearer's use time and state of wearing the ophthalmic lenses. The contact angle value of the ophthalmic lens is measured respectively after immersing the ophthalmic lens in standard saline for 1, 2, 3, 4, and 8 hours. After the measurement at each time point, the ophthalmic lens is immersed to a new value. into the standard saline solution and wait for the next time point before taking it out for measurement.

Specifically, the aforementioned experimental groups are divided into experimental group 2-1 to experimental group 2-5, experimental group 3 and experimental group 4, in which the cellulose mixed ethers are in the solutions of experimental group 2-1 to experimental group 2-5. is hydroxypropyl methylcellulose, the first hyaluronic acid or its salts is high molecular weight sodium hyaluronate, and the second hyaluronic acid or its salts is low molecular weight sodium hyaluronate; in addition, The weight of the first hyaluronic acid or its salts in experimental groups 2-1 to 2-5 is 1/3, 1/2, 1, 2 and 3 of the weight of the second hyaluronic acid or its salts. times; in addition, the total content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts is 0.012wt%.

In addition, experimental group 3 only added the second hyaluronic acid or its salts, which were low molecular weight sodium hyaluronate, while experimental group 4 only added the first hyaluronic acid or its salts, which were high molecular weight. Sodium hyaluronate. The components of experimental groups 2-1 to 2-5 and experimental groups 3 and 4, as well as the performance analysis of viscosity, pH value and osmotic pressure are shown in Table 3 below: Table 3 is the composition and performance analysis table of each experimental group Ingredients (wt%) Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 Cellulose mixed ethers 0.100wt% First hyaluronic acid or its salts 0.006wt% 0.008wt% 0.009wt% 0.004wt% 0.003wt% 0 0.012wt% Second hyaluronic acid or its salts 0.006wt% 0.004wt% 0.003wt% 0.008wt% 0.009wt% 0.012wt% 0 The weight of the first hyaluronic acid or its salts is a multiple of the weight of the second hyaluronic acid or its salts 1 2 3 1/2 1/3 NA NA Solvent 99.888% Average viscosity (mPas) 2.25 2.30 2.35 2.16 2.16 2.17 2.48 pH value 7.35 7.34 7.31 7.33 7.31 7.39 7.32 Osmotic pressure (mOsm/Kg) 299 299 299 298 298 297 296

From the above Table 3, it can be seen that the hydroxypropyl methylcellulose content of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 is 0.1wt%, and the first hyaluronic acid or other hyaluronic acid in experimental group 2-1 The content of salts is 0.006wt%, and the content of the second hyaluronic acid or its salts is 0.006wt%; the content of the first hyaluronic acid or its salts in experimental group 2-2 is 0.008wt%, and the content of the second hyaluronic acid or its salts is 0.008wt%. The content of hyaluronic acid or its salts is 0.004wt%; the content of the first hyaluronic acid or its salts in experimental groups 2-3 is 0.009wt%, and the content of the second hyaluronic acid or its salts is 0.003 wt%; the content of the first hyaluronic acid or its salts in experimental groups 2-4 is 0.004wt%, and the content of the second hyaluronic acid or its salts is 0.008wt%; the content of the first hyaluronic acid or its salts in experimental groups 2-5 The content of the first hyaluronic acid or its salts is 0.003wt%, the content of the second hyaluronic acid or its salts is 0.009wt%; the content of the first hyaluronic acid or its salts in experimental group 3 is 0, The content of the second hyaluronic acid or its salts is 0.012wt%; the content of the first hyaluronic acid or its salts in experimental group 4 is 0.012wt%, and the content of the second hyaluronic acid or its salts is 0 , and the performance of viscosity, pH value and osmotic pressure measured in experimental groups 2-1 to 2-5 and experimental groups 3 and 4 are within the range of conditions that the human eye can adapt to.

Next, the combination of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts in different content ratios is discussed, as well as the single use of the first hyaluronic acid or its salts or the single use of the second hyaluronic acid or its salts. In the case of salts, will it affect the long-lasting hydrating and moisturizing performance of the solution composition when applied to the ophthalmic lens? Therefore, experimental groups 2-1 to 2-5 and experimental groups 3 and 4 respectively obtained the contact angle reduction rates of the ophthalmic lenses at different time points through the following formulas. Before the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C1, and after the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C2, where The contact angle reduction rate = (C1-C2)/C1*100%.

The analysis results of the contact angle reduction rate of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 are shown in Table 4 below: Table 4 is an analysis table of the contact angle reduction rate of each experimental group Contact angle reduction rate % Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 0 hours 65.0% 68.9% 65.3% 67.8% 69.3% 64.3% 62.2% 1 hour 64.3% 65.9% 65.2% 65.9% 69.1% 62.5% 61.4% 2 hours 61.0% 65.9% 64.9% 63.5% 68.9% 61.2% 59.6% 3 hours 60.4% 65.5% 61.9% 57.4% 67.9% 60.5% 57.8% 4 hours 57.5% 61.5% 59.0% 56.5% 67.2% 49.1% 43.3% 8 hours 30.4% 51.4% 50.5% 55.8% 60.6% 15.2% 4.8%

In this embodiment, the calculation of the contact angle reduction rate of the ophthalmic lenses of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 is as follows: In experimental group 2-5, the solution is applied to the ophthalmic lenses Before the lens, the contact angle detected by the ophthalmic lens was 30.61. In experimental group 2-5, after the solution was applied to the ophthalmic lens and used for 8 hours, the contact angle detected by the ophthalmic lens was 12.07. Through the above-mentioned The formula for calculating the contact angle reduction rate is to obtain the contact angle reduction rate of the ophthalmic lenses of experimental group 2-5 after 8 hours of use, which is 60.6%. The same is true for experimental groups 2-1 to 2-4 and experimental groups 3 and 3. 4The contact angle reduction rate at each time point can also be obtained through the above method.

It can be seen from the results in Table 4 above that after using the ophthalmic lenses of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 for 8 hours, the ophthalmic lenses of experimental groups 2-1 to 2-5 have The contact angle reduction rate ranged from 30% to 61%; on the other hand, the contact angle reduction rate of the ophthalmic lenses of experimental group 3 was 15.2%, and the contact angle reduction rate of the ophthalmic lenses of experimental group 4 was 4.8%; obviously , the contact angle reduction rates of the ophthalmic lenses of experimental groups 2-1 to 2-5 are all higher than the contact angle reduction rates of the ophthalmic lenses of experimental groups 3 and 4. As mentioned above, when the contact angle reduction rate is maintained above 16%, it is considered to have the expected moisturizing and moisturizing properties. Therefore, the ophthalmic lenses of experimental groups 2-1 to 2-5 have been used after using 1, 2, 3, 4, and 8. The contact angle reduction rate after hours ranges from points (1) to (5), which means that the solutions in experimental groups 2-1 to 2-5 can maintain long-term hydrating and moisturizing effects.

In addition, this embodiment further collects trial-wearing feedback of the ophthalmic lens to prove that the solution has a hydrating and moisturizing effect. The same trial wearer wore experimental groups 2-1 to 2-5 and experimental groups 3 and 4 on different days. , and rated the wearing comfort of the ophthalmic lenses after 4 hours and 8 hours of wearing respectively. The scoring standard is based on 10 points as the full score. A score of 6 or more means comfortable to wear, and a score of less than 5 means it is not comfortable to wear. Comfort, the feedback results are shown in Table 5 below: Table 5 is the feedback table of wearing comfort for each experimental group Wearing time/comfort feedback score Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 4 hours 9.0±0.9 8.8±0.7 8.8±0.5 9.0±0.9 9.3±0.7 7.4±1.2 4.6±1.1 8 hours 7.4±1.3 8.3±0.9 8.1±0.8 7.9±1.1 9.0±0.5 3.4±0.9 1.4±1.5

As can be seen from Table 5 above, the comfort feedback scores of experimental groups 2-1 to 2-5 after wearing for 4 to 8 hours are all above 7 points, indicating that experimental groups 2-1 to 2-5 have good wearing comfort. ; On the other hand, the comfort feedback scores of experimental groups 3 and 4 after wearing for 8 hours were both lower than 5 points, which means that experimental groups 3 and 4 will cause dryness to human eyes after wearing for 8 hours; therefore, the The combination of the first hyaluronic acid or its salt and the second hyaluronic acid or its salt in the solution can prolong the hydrating and moisturizing effect of the ophthalmic lens, allowing the wearer to wear the ophthalmic lens for a long time. , providing the effect of maintaining wearing comfort.

Through the design of the present invention, when the solution is used in the ophthalmic lens, the solution utilizes a combination of different molecular weights of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts to prolong the wear of the eye. The lenses are used to maintain the timeliness of hydration and moisturizing, so that the wearer can still maintain the comfortable wearing effect of eye lenses after wearing them for a long time.

The above are only the best possible embodiments of the present invention. Any equivalent changes made by applying the description and patent scope of the present invention should be included in the patent scope of the present invention.

[Invention] without

without

Claims (14)

A solution applied to ophthalmic lenses, including a first hyaluronic acid or its salts, a second hyaluronic acid or its salts, a cellulose mixed ether and a solvent, the first hyaluronic acid or its salts The molecular weight of the salts is between 100kDA and 6000kDA, the molecular weight of the second hyaluronic acid or its salts is less than 100kDA, the solvent is a buffer solution, and after the solution is applied to the ophthalmic lens, the friction coefficient of the surface of the ophthalmic lens Between 0.0613~0.1923. The solution applied to ophthalmic lenses as described in claim 1, wherein the total content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to the total content of the solution. 1wt%. The solution applied to ophthalmic lenses as described in claim 1, wherein the content of the first hyaluronic acid or its salts is 1/3 to 3 times the content of the second hyaluronic acid or its salts. The solution applied to ophthalmic lenses as described in any one of claims 1 to 3, wherein the first hyaluronic acid or its salts and the second hyaluronic acid or its salts can be sodium hyaluronate, One or a combination of more than one potassium hyaluronate. The solution applied to ophthalmic lenses as described in any one of claims 1 to 3, wherein the content of the cellulose mixed ethers accounts for 0.08wt% to 0.12wt% of the total content of the solution. The solution applied to ophthalmic lenses as described in claim 5, wherein the cellulose mixed ethers include methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, One or a combination of more than one hydroxyethylcellulose. A solution applied to ophthalmic lenses, including a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent, the molecular weight of the first hyaluronic acid or its salts is between 100kDA ~6000kDA, the molecular weight of the second hyaluronic acid or its salt is less than 100kDA, the solvent is a buffer solution, wherein the solution is applied to the surface of the ophthalmic lens, and the solution is applied before the ophthalmic lens, the ophthalmic lens The contact angle of the lens surface is C1; After the solution is applied to the ophthalmic lens, and after the ophthalmic lens is used for a period of time, the contact angle on the surface of the ophthalmic lens is C2; the solution applied to the ophthalmic lens further satisfies the following range: 16%< (C1-C2)/C1*100%<61%. The solution applied to ophthalmic lenses as described in claim 7, which contains a cellulose mixed ether, and the content of the cellulose mixed ether accounts for 0.08wt% to 0.12wt% of the total content of the solution. The solution applied to ophthalmic lenses as described in claim 7 or 8, wherein the total content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt of the total content of the solution % to 1wt%. The solution applied to ophthalmic lenses as described in claim 7 or 8, wherein the content of the first hyaluronic acid or its salts is 1/3 to 3 times the content of the second hyaluronic acid or its salts. A solution applied to ophthalmic lenses, including a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent, the molecular weight of the first hyaluronic acid or its salts is between 100kDA ~6000kDA, the molecular weight of the second hyaluronic acid or its salt is less than 100kDA, the solvent is a buffer solution, wherein the solution is applied to the surface of the ophthalmic lens, and the solution is applied before the ophthalmic lens, the ophthalmic lens The friction coefficient of the surface of the lens is M1; after the solution is applied to the ophthalmic lens, the friction coefficient of the surface of the ophthalmic lens is M2; the solution applied to the ophthalmic lens further satisfies the following range: 5%<( M1-M2)/M1*100%<70%. The solution applied to ophthalmic lenses as described in claim 11, which contains a cellulose mixed ether, and the content of the cellulose mixed ether accounts for 0.08wt% to 0.12wt% of the total content of the solution. A solution for use in ophthalmic lenses as described in claim 11 or 12, which The total content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to 1wt% of the total content of the solution. The solution applied to ophthalmic lenses as described in claim 11 or 12, wherein the content of the first hyaluronic acid or its salts is 1/3 to 3 times the content of the second hyaluronic acid or its salts.