TW202325315A - Solution for ophthalmic lens capable of making the ophthalmic lens have long-term rehydration, moisture retention and lubrication effects when the solution is used in the ophthalmic lens - Google Patents

Abstract

A solution for ophthalmic lens comprises a first hyaluronic acid or its salt, a second hyaluronic acid or its salt, and a solvent. The molecular weight of the first hyaluronic acid or its salt is between 100 kDA and 6000 kDA. The molecular weight of the second hyaluronic acid or its salt is less than 100 kDA. The solution is applied to the surface of the ophthalmic lens. Before the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C1. After the solution is applied to the ophthalmic lens and used for a period of time, the contact angle of the ophthalmic lens is C2 and the solution satisfies the following range of 16% < (C1-C2)/C1*100% < 61%. In this way, when the solution is used in the ophthalmic lens, it can prolong the effect of the ophthalmic lens in maintaining rehydration and moisture retention so that the wearer can still maintain the comfortable wearing effect after wearing the ophthalmic lens for a long time. The solvent is a buffer solution. The total content of the first hyaluronic acid or its salt and the second hyaluronic acid or its salt is 0.005 wt% to 1 wt% of the total content of the solution. The content of the first hyaluronic acid or its salt is 1/3 to 3 times the content of the second hyaluronic acid or its salt. The first hyaluronic acid or its salt and the second hyaluronic acid or its salt can be sodium hyaluronate, potassium hyaluronate or a combination thereof. The solution for ophthalmic lens comprises cellulose mixed ether.

Description

Solutions for Ophthalmic Lenses

The invention relates to a solution; in particular, it refers to a solution applied to ophthalmic lenses. The solution can make the ophthalmic lenses have long-term moisturizing, moisturizing and lubricating effects that do not have originally.

In today's society where electronic products are prevalent, the proportion of suffering from myopia remains high. Patients with myopia usually wear glasses or contact lenses to correct myopia. Among them, contact lenses, in addition to being easy to carry, are not easy to wear. It will affect the appearance of the face, and even increase the visual beauty of the user, making contact lenses the choice of many people.

However, when wearing contact lenses for a long time, it is easy to cause the wearer's eyes to feel dry, and the dust or particulate matter in the environment adheres to the contact lenses, which may easily cause the wearer's eyes to have a foreign body sensation or eye allergies, etc. Symptoms, and the moisture contained in the contact lens itself will be lost with the wearing time. It is easy to have the problem of dry eyes.

In order to improve the wearing discomfort of contact lenses, such as dryness, foreign body sensation, etc., some related companies can use a solution with moisturizing effect to maintain the moisture contained in the contact lenses. This solution will make the contact lenses have a layer of The moisturizing layer can be replenished to improve wearing comfort. In addition, the lubricating effect provided by the solution can be used to moisten the particulate matter on the contact lens, thereby reducing the foreign body sensation generated during the wearing process.

However, the current ophthalmic aqueous solution specially designed for contact lenses on the market mostly uses wetting ingredients containing macromolecular polymers to increase the wetting effect of contact lenses. Although it can solve the dry feeling caused by wearing contact lenses, But most of them only have short-term moisturizing effects, and cannot effectively provide long-term moisturizing, moisturizing and lubricating effects. For wearers who wear contact lenses for a long time, they cannot improve the problem of dry eyes caused by wearing contact lenses.

In view of this, the object of the present invention is to provide a solution applied to ophthalmic lenses. When the solution is used in the ophthalmic lenses, the ophthalmic lenses can have long-term hydrating, moisturizing and lubricating effects, so that the ophthalmic lenses can be worn After wearing ophthalmic lenses for a long time, it provides the effect of maintaining comfortable wearing.

In order to achieve the above object, the solution for ophthalmic lenses provided by the present invention includes a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent, the first hyaluronic acid The molecular weight of the second hyaluronic acid or its salts is between 100kDA~6000kDA, and the molecular weight of the second hyaluronic acid or its salts is less than 100kDA.

One embodiment of the present invention provides a solution applied to an ophthalmic lens. The solution is applied to the surface of an ophthalmic lens. The solution is applied in front of the ophthalmic lens. The contact angle of the ophthalmic lens is C1. The solution is applied to the surface of the ophthalmic lens. After the ophthalmic lens is used for a period of time, the contact angle of the ophthalmic lens is C2, and the solution applied to the ophthalmic lens satisfies the following range: 16%<(C1-C2)/C1*100% <61%.

Another embodiment of the present invention provides a solution applied to an ophthalmic lens. The solution is applied to the surface of an ophthalmic lens, wherein the solution is applied in front of the ophthalmic lens. The coefficient of friction of the ophthalmic lens is M1. The solution is applied After the ophthalmic lens, the coefficient of friction of the ophthalmic lens is M2, and the solution applied to the ophthalmic lens further satisfies the following range: 5%<(M1-M2)/M1*100%<70%.

The effect of the present invention is that when the solution is used in the ophthalmic lens, the combination of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts with different molecular weights can prolong the ophthalmic lens. The timeliness of maintaining hydration and moisturizing allows the wearer to maintain the comfortable wearing effect after wearing ophthalmic lenses for a long time.

The present invention is applied to a solution for ophthalmic lenses, the solution mainly includes a first hyaluronic acid or its salts, a second hyaluronic acid or its salts, a cellulose mixed ethers and a solvent, in this embodiment Among them, the ophthalmic lens is a contact lens, but not limited thereto.

The first hyaluronic acid or its salts and the second hyaluronic acid or its salts can be one of sodium hyaluronate, potassium hyaluronate or a combination of more than one, which is to provide the ophthalmic lens with hydration and moisturizing In this embodiment, the molecular weight of the first hyaluronic acid or its salts is greater than the molecular weight of the second hyaluronic acid or its salts, wherein the molecular weight of the first hyaluronic acid or its salts is between 100kDA~6000kDA, the molecular weight of the second hyaluronic acid or its salts is less than 100kDA. Specifically, the first hyaluronic acid or its salts have a relatively large molecular volume and can form a thin film on the surface of ophthalmic lenses. To prevent water loss of the ophthalmic lens, the second hyaluronic acid or its salts have a small molecular volume and can penetrate deep into the surface of the ophthalmic lens as water replenishment to increase the moisture content of the ophthalmic lens, and this embodiment will The mixed use of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts can further prolong the timeliness of maintaining moisture for the ophthalmic lens.

To further illustrate, the total weight of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to 1wt% of the total weight of the solution. In a preferred embodiment, the second hyaluronic acid or its salts The total weight of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to 0.012wt% of the total weight of the solution.

In addition, the weight of the first hyaluronic acid or its salts is 1/3 to 3 times of the weight of the second hyaluronic acid or its salts.

In this embodiment, the solution is applied to the surface of the ophthalmic lens, wherein the solution is applied to the ophthalmic lens, and the contact angle of the ophthalmic lens is C1. After the solution is applied to the ophthalmic lens, it is used for a period of After time, the contact angle of the ophthalmic lens is C2, and the solution applied to the ophthalmic lens more satisfies the following range: (1). When the solution is applied to the ophthalmic lens and used for 1 hour, the solution applied to the ophthalmic lens satisfies 16%<(C1-C2)/C1*100%<70%; (2). When the solution is applied to the ophthalmic lens and used for 2 hours, the solution applied to the ophthalmic lens satisfies 16%<(C1-C2)/C1*100%<70%; (3). When the solution is applied to the ophthalmic lens and used for 3 hours, the solution applied to the ophthalmic lens satisfies 16%<(C1-C2)/C1*100%<68%; (4). When the solution is applied to the ophthalmic lens and used for 4 hours, the solution applied to the ophthalmic lens satisfies 16%<(C1-C2)/C1*100%<68%; (5). When the solution is applied to the ophthalmic lens and used for 8 hours, the solution applied to the ophthalmic lens satisfies 16%<(C1-C2)/C1*100%<61%.

In particular, the above-mentioned range is the reduction rate of the contact angle of the ophthalmic lens, which is measured before the solution is applied to the ophthalmic lens, the value of the contact angle of the ophthalmic lens, and the measured value of the ophthalmic lens when the solution is applied to the ophthalmic lens. After the lens is used for a period of time, the value of each contact angle of the ophthalmic lens is used to obtain the reduction rate of the contact angle of the ophthalmic lens. Wherein, the greater the reduction rate of the contact angle of the ophthalmic lens is, the better it is. In particular, the greater the reduction rate of the contact angle means that the solution can make the ophthalmic lens have better hydrating and moisturizing properties.

In this embodiment, after the solution is applied to the ophthalmic lens and used for 8 hours, the reduction rate of the contact angle of the ophthalmic lens is maintained above 30%. However, when the reduction rate of contact angle is maintained above 16%, it still has the expected moisturizing properties. It can be deduced accordingly, preferably, after the solution is applied to the ophthalmic lens and used for 8 hours, the reduction rate of the contact angle of the ophthalmic lens is maintained above 16%. Preferably, after the solution is applied to the ophthalmic lens and used for 8 hours, the reduction rate of the contact angle of the ophthalmic lens is maintained above 30%.

The cellulose mixed ethers provide the lubricating effect of the ophthalmic lens. The cellulose mixed ethers are mixed with the first hyaluronic acid or its salts and the second hyaluronic acid or its salts. The cellulose The types of mixed ethers include one or a combination of methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose , the content of the cellulose mixed ethers accounts for 0.08wt% to 0.12wt% of the total content of the solution.

Wherein the solution is applied to the surface of the ophthalmic lens, wherein before the solution is applied to the ophthalmic lens, the friction coefficient of the ophthalmic lens is M1, and after the solution is applied to the ophthalmic lens, the friction coefficient of the ophthalmic lens is M2, the solution applied to ophthalmic lenses satisfies the following range: 5%<(M1-M2)/M1*100%<70%; in particular, the above condition is that the coefficient of friction of the ophthalmic lenses is reduced The ratio is to measure the coefficient of friction of the ophthalmic lens before the solution is applied to the ophthalmic lens, and to measure the friction coefficient of the ophthalmic lens after the solution is applied to the ophthalmic lens to obtain the coefficient of friction of the ophthalmic lens. Coefficient of friction reduction rate. Among them, it is particularly stated that the greater the reduction rate of the friction coefficient, the better, and the greater the reduction rate of the friction coefficient, it means that the solution can make the lubricating properties of the ophthalmic lens better. In this embodiment, after the solution is applied to the ophthalmic lens, the reduction rate of the friction coefficient of the ophthalmic lens remains at least 7%. However, when the reduction rate of the friction coefficient of the ophthalmic lens is maintained above 5%, it still has the expected lubricating properties. It can be deduced accordingly that, preferably, after the solution is applied to the ophthalmic lens, the reduction rate of the friction coefficient of the ophthalmic lens is maintained above 5%. Preferably, after the solution is applied to the ophthalmic lens, the reduction rate of the friction coefficient of the ophthalmic lens is maintained above 7%.

The solvent provides the ophthalmic lens in a stable pH value and osmotic pressure environment, and the solvent can be a borate buffer solution or a phosphate buffer solution. For example, boric acid, sodium tetraborate, potassium chloride, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium monohydrogen phosphate, and the like may be contained.

In order to fully understand the purpose, characteristics and efficacy of the present invention, the composition formula of the solution is described, and the friction coefficient and contact angle are tested for the application of the solution to the ophthalmic lens, so as to illustrate the application of the solution in this embodiment to the ophthalmic lens Has moisturizing and lubricating effects.

One, the property quality measurement of this solution:

The properties of the solution must meet the applicable range of the eye, otherwise the ophthalmic lens is soaked in the solution and then worn on the eye, which will cause irritation or foreign body sensation to the eye, so the viscosity, pH value and osmotic pressure of the solution will be different. Affect the comfort of wearing the ophthalmic lens on the eyes.

(1) The viscosity condition of this solution:

The viscosity of the solution is between 1~10mPas, which is in line with the acceptable viscosity range of the human eye, so that the solution will not cause irritation or discomfort after entering the human eye. The viscosity of the solution is measured using a rotary viscometer (model : LVDV-1) to measure.

(2) The pH value condition of this solution:

The pH value of the solution is between 5.0 and 9.0 to meet the pH value that the human eye can adapt to, so that the solution will not cause irritation or discomfort after entering the human eye. The viscosity of the solution is measured by a pH meter (model : pH-510) to measure.

(3) The osmotic pressure condition of this solution:

The osmotic pressure of the solution is between 300±40mOsm/Kg to meet the adaptable osmotic pressure of the human eye, so that the solution will not cause irritation or discomfort after entering the human eye. The viscosity of the solution is determined by using a freezing point osmometer (Model: 33200) to measure.

2. Measure the value of the coefficient of friction (COF) of the solution applied to the ophthalmic lens. The measurement steps are as follows:

Soak the ophthalmic lens in standard saline solution for balance, take out the ophthalmic lens and remove the excess liquid on the surface with lens tissue, and place the ophthalmic lens on the friction machine (model: CETR-UMT-2) on stage.

Firstly, a standard saline solution was attached to the ophthalmic lens for numerical measurement of friction force, which was used as a control group.

Next, the same ophthalmic lens is soaked in the solution for balance, the ophthalmic lens is taken out and the excess liquid on the surface is removed with a lens tissue, and then the ophthalmic lens is placed on the stage of the friction machine.

Then use the solution to attach to the ophthalmic lens for numerical measurement of the friction force, as an experimental group.

Specifically, the aforementioned control group is ophthalmic lenses treated with standard saline solution, and the aforementioned experimental groups are divided into experimental group 1-1, experimental group 1-2 and experimental group 1-3, wherein experimental group 1-1, experimental group Groups 1-2 and experimental groups 1-3 are ophthalmic lenses soaked with the solution, the cellulose mixed ethers in the solution are hydroxypropyl methylcellulose, and the cellulose mixed ethers in each experimental group are The weight percentages are adjusted to 0.08wt%~0.12wt%, the first hyaluronic acid or its salts are high-molecular-weight sodium hyaluronate, and the second hyaluronic acid or its salts are low-molecular-weight sodium hyaluronate , and the experimental group 1-1 to the experimental group 1-3 respectively obtained the friction coefficient reduction rate of the ophthalmic lens by the following formula. Friction coefficient reduction rate=(M1-M2)/M1*100%, wherein M1 is the friction coefficient of the ophthalmic lens before the solution is applied to the ophthalmic lens, and M2 is the friction coefficient of the ophthalmic lens after the solution is applied to the ophthalmic lens. Coefficient of friction of ophthalmic lenses.

The composition and friction coefficient reduction rate analysis results of each experimental group and control group are shown in Table 1 below: Table 1 is the lubricating efficiency analysis table of ophthalmic lenses Composition (weight percentwt%) control group Experimental group 1-1 Experimental group 1-2 Experimental group 1-3 Cellulose Mixed Ethers 0wt% 0.08wt% 0.1wt% 0.12wt% The first hyaluronic acid or its salts 0wt% 0.004wt% 0.004wt% 0.004wt% Second hyaluronic acid or its salts 0wt% 0.008wt% 0.008wt% 0.008wt% solvent 100wt% 99.908wt% 99.888wt% 99.868wt% Coefficient of friction (COF) 0.2066 0.1852 0.0613 0.1923 Friction coefficient reduction rate% - 10.4% 70.3% 6.9%

It can be seen from the results in Table 1 above that the solution applied to ophthalmic lenses satisfies the following range: 7%<(M1-M2)/M1*100%<70%, which refers to the reduction rate of the friction coefficient of the ophthalmic lenses Between 7% and 70%, wherein the friction coefficient reduction rate of 5% or more can meet the lubricating effect of the ophthalmic lens, and the friction coefficient reduction rate of the experimental group 1-2 is compared with the experimental group 1-1 and the experimental group 1-3 can reach more than 70%, wherein the higher the friction coefficient reduction rate, the better the lubricating effect of the ophthalmic lens; therefore, the solution composition applied to the ophthalmic lens can provide excellent lubricating performance, and the Experimental group 1-2 has a better lubricating effect.

In addition, this embodiment further collects the ophthalmic lens try-in feedback to prove that the solution has a lubricating effect, wherein the same try-wearer wears the experimental group 1-1, the experimental group 1-2 and the experimental group 1-3 on different days, And scored the wearing comfort of the ophthalmic lens after wearing for 4 hours and 8 hours respectively. The wearing comfort includes dry feeling and lubricating feeling. Comfortable to wear, less than 5 points means uncomfortable to wear, the feedback results are shown in Table 2 below: Table 2 is the feedback form of wearing comfort for each experimental group Wearing Time/Comfort Feedback Score Experimental group 1-1 Experimental group 1-2 Experimental group 1-3 4 hours 8.8±0.7 9.3±0.7 8.8±0.5 8 hours 8.3±0.9 9.0±0.5 8.1±0.8

It can be seen from the above Table 2 that the comfort feedback scores of the experimental groups 1-1 to 1-3 are all above 6 points after wearing for 4 to 8 hours, which means that the experimental groups 1-1 to 1-3 have good wearing comfort , wherein the comfort feedback score of the experimental group 1-2 is more than 9 points, which means that when the content of the cellulose mixed ether in the solution is 0.1 wt%, it can provide better lubricating performance for the ophthalmic lens.

3. Measure the contact angle reduction rate of the solution applied to the ophthalmic lens. The measurement steps are as follows:

Immerse the ophthalmic lens in standard saline solution for 30 minutes to balance, take out the ophthalmic lens and flatten it on a glass slide, and remove excess liquid from the surface of the ophthalmic lens with lens tissue and place it on the contact angle measurement The lens contact angle of the ophthalmic lens is measured first on the instrument (model: Phoenix MT(A)), as a control group.

Next, after soaking the same ophthalmic lens in the solution for a period of time, make the solution fully adhere to the ophthalmic lens, take out the ophthalmic lens and remove excess liquid on the surface with lens tissue, and then the ophthalmic lens The lens was placed on the contact angle measuring instrument to measure the contact angle at hour 0, which was used as the experimental group.

Subsequently, the ophthalmic lenses of the aforementioned experimental group were soaked in a standard saline solution to simulate the use time and state of the ophthalmic lenses worn by the wearer. Measure the contact angle value of the ophthalmic lens after the ophthalmic lens is soaked in standard saline for 1, 2, 3, 4, and 8 hours, and then soak the ophthalmic lens to a new In the standard saline solution, wait for the next time point before taking out the measurement.

Specifically, the aforementioned experimental groups are experimental group 2-1 to experimental group 2-5, experimental group 3 and experimental group 4, wherein the cellulose mixed ethers in the solutions of experimental group 2-1 to experimental group 2-5 is hydroxypropyl methylcellulose, the first hyaluronic acid or its salts are high molecular weight sodium hyaluronate, and the second hyaluronic acid or its salts are low molecular weight sodium hyaluronate; in addition, The weight of the first hyaluronic acid or its salts in experimental groups 2-1 to 2-5 is 1/3, 1/2, 1, 2 and 3 of the weight of the second hyaluronic acid or its salts In addition, the sum of the content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts is 0.012wt%.

In addition, the experimental group 3 only added the second hyaluronic acid or its salts to form a low-molecular-weight sodium hyaluronate, while the experimental group 4 only added the first hyaluronic acid or its salts to form a high-molecular-weight sodium hyaluronate. Sodium hyaluronate. The composition of experimental groups 2-1 to 2-5 and experimental groups 3 and 4, as well as the performance analysis of viscosity, pH value and osmotic pressure are shown in Table 3 below: Table 3 is the composition and performance analysis table of each experimental group Composition (weight percentwt%) Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 Cellulose Mixed Ethers 0.100wt% The first hyaluronic acid or its salts 0.006 wt% 0.008wt% 0.009 wt% 0.004wt% 0.003 wt% 0 0.012wt% Second hyaluronic acid or its salts 0.006 wt% 0.004wt% 0.003 wt% 0.008wt% 0.009 wt% 0.012wt% 0 The weight of the first hyaluronic acid or its salts is the multiple of the weight of the second hyaluronic acid or its salts 1 2 3 1/2 1/3 NA NA solvent 99.888% Average viscosity (mPas) 2.25 2.30 2.35 2.16 2.16 2.17 2.48 pH value 7.35 7.34 7.31 7.33 7.31 7.39 7.32 Osmotic pressure (mOsm/Kg) 299 299 299 298 298 297 296

It can be seen from the above Table 3 that the hydroxypropyl methylcellulose content of the experimental groups 2-1 to 2-5 and the experimental groups 3 and 4 is 0.1wt%, wherein the first hyaluronic acid or the first hyaluronic acid in the experimental group 2-1 The content of the salt is 0.006wt%, the content of the second hyaluronic acid or its salt is 0.006wt%; the content of the first hyaluronic acid or its salt in the experimental group 2-2 is 0.008wt%, the second The content of hyaluronic acid or its salts is 0.004wt%; the content of the first hyaluronic acid or its salts in the experimental group 2-3 is 0.009wt%, and the content of the second hyaluronic acid or its salts is 0.003 wt%; the content of the first hyaluronic acid or its salts in the experimental group 2-4 is 0.004wt%, and the content of the second hyaluronic acid or its salts is 0.008wt%; the first hyaluronic acid or its salts in the experimental group 2-5 The content of the first hyaluronic acid or its salts is 0.003wt%, the content of the second hyaluronic acid or its salts is 0.009wt%; the content of the first hyaluronic acid or its salts in the experimental group 3 is 0, The content of the second hyaluronic acid or its salts is 0.012wt%; the content of the first hyaluronic acid or its salts in the experimental group 4 is 0.012wt%, and the content of the second hyaluronic acid or its salts is 0 , and the performance of viscosity, pH value and osmotic pressure measured in experimental groups 2-1 to 2-5 and experimental groups 3 and 4 are all within the range of conditions that human eyes can adapt to.

Next, discuss the combination of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts in different content ratios, and the single use of the first hyaluronic acid or its salts or the single use of the second hyaluronic acid or its salts. In the case of salts, whether it will affect the long-term moisturizing effect of the solution composition applied to the ophthalmic lens. Therefore, experimental groups 2-1 to 2-5 and experimental groups 3 and 4 respectively obtained the contact angle reduction rates of the ophthalmic lenses at different time points by the following formulas. Before the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C1, and after being used for a period of time after the solution is applied to the ophthalmic lens, the contact angle of the ophthalmic lens is C2, wherein the ophthalmic lens The reduction rate of contact angle=(C1-C2)/C1*100%.

The analysis results of the contact angle reduction rates of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 are shown in Table 4 below: Table 4 is the analysis table of the contact angle reduction rates of each experimental group Contact angle reduction rate% Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 0 hours 65.0% 68.9% 65.3% 67.8% 69.3% 64.3% 62.2% 1 hour 64.3% 65.9% 65.2% 65.9% 69.1% 62.5% 61.4% 2 hours 61.0% 65.9% 64.9% 63.5% 68.9% 61.2% 59.6% 3 hours 60.4% 65.5% 61.9% 57.4% 67.9% 60.5% 57.8% 4 hours 57.5% 61.5% 59.0% 56.5% 67.2% 49.1% 43.3% 8 hours 30.4% 51.4% 50.5% 55.8% 60.6% 15.2% 4.8%

In this embodiment, the calculation of the contact angle reduction rate of the ophthalmic lenses of experimental groups 2-1 to 2-5 and experimental groups 3 and 4 is as follows: in experimental group 2-5, the solution is applied to the ophthalmic lens Before the lens, the contact angle detected by the ophthalmic lens was 30.61. After the solution was applied to the ophthalmic lens in experimental group 2-5 and used for 8 hours, the contact angle detected by the ophthalmic lens was 12.07. The formula calculation of the contact angle reduction rate is to obtain the contact angle reduction rate of the ophthalmic lenses of the experimental group 2-5 after the 8th hour of use is 60.6%, the same as the experimental group 2-1 to 2-4 and the experimental group 3 4 The reduction rate of the contact angle at each time point can also be obtained through the above method.

From the above results in Table 4, it can be seen that the ophthalmic lenses of the experimental groups 2-1 to 2-5 and the experimental groups 3 and 4, after being used for up to 8 hours, the ophthalmic lenses of the experimental groups 2-1 to 2-5 The reduction rate of the contact angle ranged from 30% to 61%. On the other hand, the reduction rate of the contact angle of the ophthalmic lenses of the experimental group 3 was 15.2%, and the reduction rate of the contact angle of the ophthalmic lenses of the experimental group 4 was 4.8%; obviously , the contact angle reduction rates of the ophthalmic lenses of experimental groups 2-1 to 2-5 were all higher than those of the ophthalmic lenses of experimental groups 3 and 4. In the above description, when the contact angle reduction rate is maintained above 16%, it is considered to have the expected moisturizing properties. Therefore, the ophthalmic lenses of the experimental groups 2-1 to 2-5 after using The reduction rate of the contact angle after 1 hour is in the range of points (1) to (5), which means that the solutions in the experimental groups 2-1 to 2-5 can all maintain long-lasting moisturizing effects.

In addition, this example further collects the ophthalmic lens try-in feedback to support the moisturizing effect of the solution, wherein the same try-wearer wears experimental groups 2-1 to 2-5 and experimental groups 3 and 4 on different days , and scored the wearing comfort of the ophthalmic lens after wearing it for 4 hours and 8 hours respectively. Comfortable, the feedback results are shown in Table 5 below: Table 5 is the wearing comfort feedback table of each experimental group Wearing Time/Comfort Feedback Score Experimental group 2-1 Experimental group 2-2 Experimental group 2-3 Experimental group 2-4 Experimental group 2-5 Experimental group 3 Experimental group 4 4 hours 9.0±0.9 8.8±0.7 8.8±0.5 9.0±0.9 9.3±0.7 7.4±1.2 4.6±1.1 8 hours 7.4±1.3 8.3±0.9 8.1±0.8 7.9±1.1 9.0±0.5 3.4±0.9 1.4±1.5

It can be seen from the above Table 5 that the comfort feedback scores of the experimental groups 2-1 to 2-5 are all above 7 points after wearing for 4 to 8 hours, indicating that the experimental groups 2-1 to 2-5 have good wearing comfort ; On the other hand, the comfort feedback scores of experimental groups 3 and 4 after wearing for 8 hours are all lower than 5 points, which means that experimental groups 3 and 4 will cause dry eyes after wearing for 8 hours; therefore, the The combination of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts in the solution can prolong the moisturizing effect of the ophthalmic lens, allowing the wearer to wear the ophthalmic lens for a long time. , providing the effect of maintaining comfortable wearing.

According to the design of the present invention, when the solution is used in the ophthalmic lens, the solution can extend the ophthalmic The lenses are used to maintain the timeliness of moisturizing and moisturizing, so that the wearer can still maintain the comfortable wearing effect after wearing ophthalmic lenses for a long time.

The above description is only a preferred feasible embodiment of the present invention, and all equivalent changes made by applying the description of the present invention and the scope of the patent application should be included in the scope of the patent of the present invention.

[this invention] none

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Claims (10)

A solution for ophthalmic lenses, comprising a first hyaluronic acid or its salts, a second hyaluronic acid or its salts and a solvent, the molecular weight of the first hyaluronic acid or its salts is between 100kDA ~6000kDA, the molecular weight of the second hyaluronic acid or its salts is less than 100kDA, and the solvent is a buffer solution. The solution for ophthalmic lenses as described in Claim 1, wherein the total content of the first hyaluronic acid or its salts and the second hyaluronic acid or its salts accounts for 0.005wt% to 0.005wt% of the total content of the solution 1wt%. The solution for ophthalmic lenses according to claim 1, wherein the content of the first hyaluronic acid or its salts is 1/3 to 3 times that of the second hyaluronic acid or its salts. The solution applied to ophthalmic lenses as described in any one of claims 1 to 3, wherein the first hyaluronic acid or its salts and the second hyaluronic acid or its salts can be sodium hyaluronate, One or a combination of potassium hyaluronate. The solution applied to ophthalmic lenses as described in any one of Claims 1 to 3, comprising a cellulose mixed ether, the content of which is 0.08wt% to 0.12wt% of the total content of the solution . The solution applied to ophthalmic lenses as described in claim 5, wherein the cellulose mixed ethers include methylcellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose, One or a combination of more than one hydroxyethyl cellulose. The solution applied to an ophthalmic lens as described in any one of claims 1 to 3 is applied to the surface of an ophthalmic lens, and before the solution is applied to the ophthalmic lens, the contact angle of the surface of the ophthalmic lens is C1; after the solution is applied to the ophthalmic lens, and after the ophthalmic lens is used for a period of time, the contact angle of the surface of the ophthalmic lens is C2; the solution applied to the ophthalmic lens further satisfies the following range: 16%＜(C1-C2)/C1*100%＜61%. The solution applied to the ophthalmic lens as described in Claim 5 is applied to the surface of the ophthalmic lens, and before the solution is applied to the ophthalmic lens, the contact angle of the surface of the ophthalmic lens is C1; the solution is applied After the ophthalmic lens, after the ophthalmic lens is used for a period of time, the contact angle of the surface of the ophthalmic lens is C2; the solution applied to the ophthalmic lens further satisfies the following range: 16%<(C1- C2)/C1*100% <61%. The solution applied to an ophthalmic lens as described in any one of claims 1 to 3 is applied to the surface of an ophthalmic lens, and before the solution is applied to the ophthalmic lens, the coefficient of friction of the surface of the ophthalmic lens is M1; after the solution is applied to the ophthalmic lens, the friction coefficient of the surface of the ophthalmic lens is M2; the solution applied to the ophthalmic lens further satisfies the following range: 5%<(M1-M2)/M1 *100% <70%. The solution applied to the ophthalmic lens as described in Claim 5 is applied to the surface of the ophthalmic lens, and before the solution is applied to the ophthalmic lens, the friction coefficient of the surface of the ophthalmic lens is M1; the solution is applied After the ophthalmic lens, the friction coefficient of the surface of the ophthalmic lens is M2; the solution applied to the ophthalmic lens further satisfies the following range: 5%<(M1-M2)/M1*100%<70% .