CN109266457A - A kind of contact lens multifunction nursing liquid and preparation method thereof - Google Patents

A kind of contact lens multifunction nursing liquid and preparation method thereof Download PDF

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Publication number
CN109266457A
CN109266457A CN201811156248.1A CN201811156248A CN109266457A CN 109266457 A CN109266457 A CN 109266457A CN 201811156248 A CN201811156248 A CN 201811156248A CN 109266457 A CN109266457 A CN 109266457A
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contact lens
conditioning liquid
sodium
surfactant
alkyl glycosides
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曹天中
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Zhenjiang Austria Optics Co Ltd
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Zhenjiang Austria Optics Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/83Mixtures of non-ionic with anionic compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/042Acids
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/046Salts
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2075Carboxylic acids-salts thereof
    • C11D3/2086Hydroxy carboxylic acids-salts thereof
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/22Carbohydrates or derivatives thereof
    • C11D3/221Mono, di- or trisaccharides or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/22Carbohydrates or derivatives thereof
    • C11D3/222Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C11D3/225Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/28Heterocyclic compounds containing nitrogen in the ring
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/33Amino carboxylic acids
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3703Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3703Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707Polyethers, e.g. polyalkyleneoxides
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3746Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3753Polyvinylalcohol; Ethers or esters thereof
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/008Polymeric surface-active agents
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/04Carboxylic acids or salts thereof
    • C11D1/10Amino carboxylic acids; Imino carboxylic acids; Fatty acid condensates thereof
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/667Neutral esters, e.g. sorbitan esters
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/72Ethers of polyoxyalkylene glycols

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Abstract

The invention discloses a kind of contact lens conditioning liquid and preparation method thereof, the raw material of the conditioning liquid includes: alkyl glycosides, lubrication humectant, surfactant, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate, distilled water.Preparation method is to add to alkyl glycosides, lubrication humectant, surfactant, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate in distilled water, dispersion.Conditioning liquid of the invention can alleviate asthenopia, nutrition eyes under the premise of guaranteeing has good moisturizing and fungistatic effect, and examination wearer is comfortable on;And there is excellent grease removal and removing protein effect to eyeglass.

Description

A kind of contact lens multifunction nursing liquid and preparation method thereof
Technical field
The invention belongs to optical mirror slip technical fields, and in particular to a kind of contact lens conditioning liquid and its preparation side Method.
Background technique
Contact lenses are a kind of are worn on cornea with protection eyes and the ophthalmic medical instrument corrected defects of vision.Because of its side Just, beautiful advantage and the favor by young consumers.
Contact lenses are directly worn on the cornea tissue of eyeball and eyeball composition is unified has as medical device product Body, sterilization problems, cleaning problems and the comfort problem of eyeglass require to pay attention to.Contact lens care solution is exactly special lancet to hidden Shape eyeglass sanitation and hygiene and design, mainly have the multiple functions such as cleaning, sterilization, removing protein, disinfection, storage, moisturizing, It is that contact lens wearers must match nursing materials.
Multifunction nursing liquid is maximum contact lens care products of usage amount currently on the market, can be used to include clear simultaneously The nursing process of the contact lenses such as clean, flushing, disinfection or antibacterial, storage, ravine cunning.It is most of to impregnate multi-functional conditioning liquid nursing Contact lenses can directly wear.Multifunction nursing liquid contains the characteristics such as the pH of suitable eyes, osmotic pressure, also containing effective Bacterium while Efficient antibacterial agent again not irritant to human eye and nontoxic on killing eyeglass, quick removing albumen and lipid Surfactant, easy operating method make multifunction nursing liquid by consumers.
With the application of the development of contact lens, especially silicone hydrogel lenses, the requirement to conditioning liquid is also gradually mentioned Height, therefore it is badly in need of Devoting Major Efforts To Developing with the silicone hydrogel contact lens conditioning liquid for efficiently removing lipid function, to meet the need in market It asks.
Summary of the invention
Present invention aim to address above-mentioned the deficiencies in the prior art provide a kind of contact lens conditioning liquid and its Preparation method, the conditioning liquid can alleviate asthenopia, nutrition eyes under the premise of guaranteeing has good moisturizing and fungistatic effect, Examination wearer is comfortable on.
A kind of contact lens conditioning liquid, raw material include: alkyl glycosides 0.1-0.5% by percentage to the quality, lubrication Moisturizer 0.1-0.2%, surfactant 0.05-0.2%, EDTA 0.01-0.08%, sodium citrate 0.05-0.2%, boric acid 0.05-0.1%, Boratex 0.05-0.2%, sodium chloride 0.2-0.8%, polyaminopropyl biguanide 0.001-003%, Sodium Hyaluronate 0.05-0.2%, surplus are distilled water;The sum of mass percent of all raw materials is 100%.
Further, above-mentioned contact lens conditioning liquid, raw material include: alkyl glycosides by percentage to the quality 0.3%, lubrication humectant 0.15%, surfactant 0.1%, EDTA 0.05%, sodium citrate 0.1%, boric acid 0.07%, Boratex 0.1%, sodium chloride 0.5%, polyaminopropyl biguanide 0.002%, Sodium Hyaluronate 0.1%, surplus is distilled water;The quality of all raw materials The sum of percentage is 100%.
Further, the lubrication humectant is selected from polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol or hydroxypropyl first Base cellulose.
Further, the alkyl glycosides is C8-C12 straight chained alkyl glucosides.
Further, the surfactant is selected from poloxamer188, polysorbate or sodium lauroyl glutamate.
The preparation method of above-mentioned contact lens conditioning liquid is by alkyl glycosides, lubrication humectant, surface-active Agent, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate add in distilled water, dispersion, ?.
Conditioning liquid of the invention can alleviate asthenopia, nutrition under the premise of guaranteeing has good moisturizing and fungistatic effect Eyes, examination wearer are comfortable on;And there is excellent grease removal and removing protein effect to eyeglass.
Specific embodiment
Embodiment 1
A kind of contact lens conditioning liquid, raw material include: alkyl glycosides 0.1%, lubrication humectant by percentage to the quality 0.1%, surfactant 0.05%, EDTA 0.01%, sodium citrate 0.05%, boric acid 0.05%, Boratex 0.05%, sodium chloride 0.2%, polyaminopropyl biguanide 0.001%, Sodium Hyaluronate 0.05%, surplus is distilled water;The sum of the mass percent of all raw materials It is 100%.
The lubrication humectant is polyvinylpyrrolidone.
The alkyl glycosides is Dodecyl Glucoside.
The surfactant is poloxamer188.
The preparation method of above-mentioned contact lens conditioning liquid is by alkyl glycosides, lubrication humectant, surface-active Agent, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate add in distilled water, dispersion, ?.
Through detecting, gained conditioning liquid pH is 7.4, osmotic pressure 298mOsm/kg, viscosity 2.24, surface tension 30.
According to national standards in the hygienic requirements of GB19192-2003 contact lens care solution sterilizing test method to large intestine bar Bacterium, staphylococcus aureus, green crafty bacillus and Candida albicans carry out bacteriostatic test, and bacteriostasis rate is all satisfied requirement.
Embodiment 2
A kind of contact lens conditioning liquid, raw material include: alkyl glycosides 0.4%, lubrication humectant by percentage to the quality 0.2%, surfactant 0.12%, EDTA 0.04%, sodium citrate 0.15%, boric acid 0.07%, Boratex 0.15%, sodium chloride 0.7%, polyaminopropyl biguanide 0.002%, Sodium Hyaluronate 0.12%, surplus is distilled water;The sum of the mass percent of all raw materials It is 100%.
The lubrication humectant is polyvinylpyrrolidone.
The alkyl glycosides is Dodecyl Glucoside.
The surfactant is poloxamer188.
The preparation method of above-mentioned contact lens conditioning liquid is by alkyl glycosides, lubrication humectant, surface-active Agent, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate add in distilled water, dispersion, ?.
Through detecting, gained conditioning liquid pH is 7.4, osmotic pressure 298mOsm/kg, viscosity 2.24, surface tension 30.
According to national standards in the hygienic requirements of GB19192-2003 contact lens care solution sterilizing test method to large intestine bar Bacterium, staphylococcus aureus, green crafty bacillus and Candida albicans carry out bacteriostatic test, and bacteriostasis rate is all satisfied requirement.Embodiment 3
A kind of contact lens conditioning liquid, raw material include: alkyl glycosides 0.3%, lubrication humectant by percentage to the quality 0.15%, surfactant 0.1%, EDTA 0.05%, sodium citrate 0.1%, boric acid 0.07%, Boratex 0.1%, sodium chloride 0.5%, Polyaminopropyl biguanide 0.002%, Sodium Hyaluronate 0.1%, surplus are distilled water;The sum of the mass percent of all raw materials is 100%。
The lubrication humectant is hydroxypropyl methyl cellulose.
The alkyl glycosides is Dodecyl Glucoside.
The surfactant is polysorbate.
The preparation method of above-mentioned contact lens conditioning liquid is by alkyl glycosides, lubrication humectant, surface-active Agent, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate add in distilled water, dispersion, ?.
Through detecting, gained conditioning liquid pH is 7.4, osmotic pressure 298mOsm/kg, viscosity 2.24, surface tension 30.
According to national standards in the hygienic requirements of GB19192-2003 contact lens care solution sterilizing test method to large intestine bar Bacterium, staphylococcus aureus, green crafty bacillus and Candida albicans carry out bacteriostatic test, and bacteriostasis rate is all satisfied requirement.Embodiment 4
A kind of contact lens conditioning liquid, raw material include: alkyl glycosides 0.5%, lubrication humectant by percentage to the quality 0.2%, surfactant 0.2%, EDTA 0.08%, sodium citrate 0.2%, boric acid 0.1%, Boratex 0.2%, sodium chloride 0.8%, gather Aminopropyl biguanides 003%, Sodium Hyaluronate 0.2%, surplus are distilled water;The sum of mass percent of all raw materials is 100%.
The lubrication humectant is polyethylene glycol.
The alkyl glycosides is Dodecyl Glucoside.
The surfactant is sodium lauroyl glutamate.
The preparation method of above-mentioned contact lens conditioning liquid is by alkyl glycosides, lubrication humectant, surface-active Agent, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate add in distilled water, dispersion, ?.
Through detecting, gained conditioning liquid pH is 7.4, osmotic pressure 298mOsm/kg, viscosity 2.24, surface tension 30.
According to national standards in the hygienic requirements of GB19192-2003 contact lens care solution sterilizing test method to large intestine bar Bacterium, staphylococcus aureus, green crafty bacillus and Candida albicans carry out bacteriostatic test, and bacteriostasis rate is all satisfied requirement.

Claims (6)

1. a kind of contact lens conditioning liquid, it is characterised in that: raw material includes: alkyl glycosides 0.1- by percentage to the quality 0.5%, lubrication humectant 0.1-0.2%, surfactant 0.05-0.2%, EDTA 0.01-0.08%, sodium citrate 0.05- 0.2%, boric acid 0.05-0.1%, Boratex 0.05-0.2%, sodium chloride 0.2-0.8%, polyaminopropyl biguanide 0.001-003% are transparent Matter acid sodium 0.05-0.2%, surplus is distilled water;The sum of mass percent of all raw materials is 100%.
2. contact lens conditioning liquid according to claim 1, it is characterised in that: raw material wraps by percentage to the quality It includes: alkyl glycosides 0.3%, lubrication humectant 0.15%, surfactant 0.1%, EDTA 0.05%, sodium citrate 0.1%, boric acid 0.07%, Boratex 0.1%, sodium chloride 0.5%, polyaminopropyl biguanide 0.002%, Sodium Hyaluronate 0.1%, surplus is distilled water;Institute Having the sum of mass percent of raw material is 100%.
3. contact lens conditioning liquid according to claim 1, it is characterised in that: the lubrication humectant is selected from poly- Vinylpyrrolidone, polyvinyl alcohol, polyethylene glycol or hydroxypropyl methyl cellulose.
4. contact lens conditioning liquid according to claim 1, it is characterised in that: the alkyl glycosides is C8-C12 Straight chained alkyl glucosides.
5. contact lens conditioning liquid according to claim 1, it is characterised in that: the surfactant is selected from pool Luo Shamu 407, polysorbate or sodium lauroyl glutamate.
6. the preparation method of contact lens conditioning liquid described in claim 1, it is characterised in that: by alkyl glycosides, profit Sliding moisturizer, surfactant, EDTA, sodium citrate, boric acid, Boratex, sodium chloride, polyaminopropyl biguanide, Sodium Hyaluronate It adds in distilled water, disperses.
CN201811156248.1A 2018-09-30 2018-09-30 A kind of contact lens multifunction nursing liquid and preparation method thereof Pending CN109266457A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110819464A (en) * 2019-10-11 2020-02-21 陕西仁康药业有限公司 Hard corneal contact lens care solution and preparation method thereof
TWI821845B (en) * 2021-12-29 2023-11-11 永勝光學股份有限公司 Solutions for ophthalmic lenses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390606A (en) * 2002-06-20 2003-01-15 上海卫康光学有限公司 Composition for treaitng contact lens and its application
CN104906619A (en) * 2015-06-19 2015-09-16 蔡婷婷 Contact lens care solution
CN106924799A (en) * 2015-12-29 2017-07-07 青岛智通四海家具设计研发有限公司 A kind of contact lens care solution

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390606A (en) * 2002-06-20 2003-01-15 上海卫康光学有限公司 Composition for treaitng contact lens and its application
CN104906619A (en) * 2015-06-19 2015-09-16 蔡婷婷 Contact lens care solution
CN106924799A (en) * 2015-12-29 2017-07-07 青岛智通四海家具设计研发有限公司 A kind of contact lens care solution

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110819464A (en) * 2019-10-11 2020-02-21 陕西仁康药业有限公司 Hard corneal contact lens care solution and preparation method thereof
TWI821845B (en) * 2021-12-29 2023-11-11 永勝光學股份有限公司 Solutions for ophthalmic lenses

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RJ01 Rejection of invention patent application after publication

Application publication date: 20190125

RJ01 Rejection of invention patent application after publication