CN109957475A - A kind of contact lenses preservation liquid of phosphoric acid choline polymer - Google Patents
A kind of contact lenses preservation liquid of phosphoric acid choline polymer Download PDFInfo
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- CN109957475A CN109957475A CN201811601187.5A CN201811601187A CN109957475A CN 109957475 A CN109957475 A CN 109957475A CN 201811601187 A CN201811601187 A CN 201811601187A CN 109957475 A CN109957475 A CN 109957475A
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- CN
- China
- Prior art keywords
- contact lenses
- phosphoric acid
- polymer
- acid choline
- phosphocholine
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/02—Inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/02—Inorganic compounds
- C11D7/04—Water-soluble compounds
- C11D7/08—Acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/02—Inorganic compounds
- C11D7/04—Water-soluble compounds
- C11D7/10—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/265—Carboxylic acids or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/32—Organic compounds containing nitrogen
- C11D7/3281—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/36—Organic compounds containing phosphorus
Abstract
The present invention relates to a kind of contact lenses to save liquid, it is a kind of contact lenses preservation liquid of phosphoric acid choline polymer, it is formulated following (weight percent): phosphocholine polymer 0.05%~10%, osmotic pressure regulator 0.5~15%, pH adjusting agent 0.1%~5%, color developing agent 0%~1%, pure water content 69%~99.35%；Configured solution osmotic pressure is in 240~340mOsm/Kg, and the range of pH value is 6.4~7.8；Wherein, phosphocholine polymer is polymethyl trimethylammonium-trimethyl-(2- phosphonooxyethyl) ammonium salt.The solution has certain lubricant effect, be stored in the solution eyeglass, when wearing will not feel that eyes are dry and astringent.
Description
Technical field
The present invention relates to contact lens art, the contact lenses of especially a kind of phosphoric acid choline polymer are saved with stealthy
Glasses save liquid.
Background technique
Commercially available contact lenses are generally all stored in perhaps PP glasss of glass tube vial (material polypropylene) in vial or PP
The preservation liquid that a certain amount of buffer solution regards eyeglass is added in cup.Some in addition to containing osmotic pressure regulator (such as sodium chloride),
PH adjusting agent (such as disodium hydrogen phosphate, sodium dihydrogen phosphate or boric acid, borax) is also added some such as poloxamer, polyethylene
Alcohol, polyvinylpyrrolidone, cyclodextrin, hydroxypropyl methyl cellulose, Sodium Hyaluronate etc, primarily to preventing eyeglass
It sticks in glass tube vial or PP glasss, glasses are dry and astringent when these cannot all prevent consumer from wearing eyeglass, eyeglass dehydration deformation.Cause
This researches and develops a new contact lenses and saves liquid, consumer by contact lenses from save taken out in liquid after put on after a period of time not
It can feel that eyes are dry and astringent, wear also more comfortable.
Phosphocholine is a kind of chemical group found in natural phospholipid, it is the main composition part of cell membrane.Carefully
For after birth using two layers of lipid molecular as skeleton, main component is phospholipid amphipathic molecule (containing hydrophobic tail and hydrophilic head).
It is saved in liquid in contact lenses, Thermodynamic effect makes the hydrophobic tail of amphipathic molecule and the effect minimum of water, and hydrophilic radical is most
Limits it is exposed and is contacted with water, so as to forms double membrane structure.Phosphorylcholine is the substantially single of composition cell membrane
The terminal hydrophyllic group of first (such as lecithin), is the outermost layer group in extracellular tunic.Nakabayashi and Chapman research
Group is relatively early respectively to propose the concept of imitative membrane structure, and design has synthesized MPC, and by itself and hydrophilic acrylate's class monomer
Copolymerization obtains the copolymer with hydrophilic and oleophilic amphiphilic performance.Research shows that being imitated with MPC polymer biomaterial surface
The modification of cell membrane layer structure can dramatically increase the biocompatibility of material.
Summary of the invention
The present invention provides a kind of new contact lenses preservation liquid for contact lenses consumer, and contact lens storage is at it
In, it can make feel that eyes are dry and astringent when consumer's contact lens wear.The preservation liquid contains phosphocholine polymer, infiltration
Press the ingredients such as regulator, pH adjusting agent, color developing agent.Contact lenses are immersed in the preservation liquid of phosphoric acid choline polymer, hidden
Shape lens surface has good wetability, and there are fine lubricity and performance of keeping humidity in when wearing.
A kind of contact lenses preservation liquid of phosphoric acid choline polymer, is formulated following (weight percent):
Phosphocholine polymer 0.05%~10%,
Osmotic pressure regulator 0.5~15%,
PH adjusting agent 0.1%~5%,
Color developing agent 0%~1%,
Pure water content 69%~99.35%；
Wherein, osmotic pressure regulator can be one or more of sodium chloride, potassium chloride, magnesium chloride；
PH value adjustment can be one of disodium hydrogen phosphate, sodium dihydrogen phosphate, boric acid, borax, citric acid, sodium citrate
Or it is a variety of；
Color developing agent can be one of vitamin B2, vitamin B12；
Configured solution osmotic pressure is in 240~340mOsm/Kg, and the range of pH value is 6.4~7.8.
Detailed description of the invention
Fig. 1 is surface wettability test chart.
Fig. 2 is water lock performance test figure.
Specific embodiment
Embodiment 1[embodiment is rearranged according to the increase of phosphocholine polymer]
Phosphocholine polymer contains 0.05%, osmotic pressure regulator: sodium chloride 0.81%, pH adjusting agent: biphosphate
Sodium 0.54%, disodium hydrogen phosphate 0.61%, color developing agent: vitamin B12 contains 0.01%, pure water 97.98%.
Embodiment 2
Phosphocholine polymer contains 0.08%, osmotic pressure regulator: sodium chloride 0.85%, pH adjusting agent: a hydration phosphorus
Acid dihydride sodium 0.08%, disodium hydrogen phosphate dodecahydrate 0.62%, color developing agent: vitamin B2 contains 0.01%, pure water 98.36%.
Embodiment 3
Phosphocholine polymer contains 0.1%, osmotic pressure regulator: sodium chloride 0.82%, pH adjusting agent a: hypophosphite monohydrate
Sodium dihydrogen 0.05%, disodium hydrogen phosphate dodecahydrate 0.59%, color developing agent: vitamin B12 contains 0.01%, pure water 98.43%.
Embodiment 4
Phosphocholine polymer contains 0.15%, osmotic pressure regulator: sodium chloride 0.80%, pH adjusting agent: boric acid
0.24%, borax 0.01%, color developing agent: vitamin B12 contains 0.005%, pure water 98.792%.
Embodiment 5
Phosphocholine polymer contains 10%, osmotic pressure regulator: sodium chloride 0.75%, pH adjusting agent: sodium dihydrogen phosphate
0.50%, disodium hydrogen phosphate 0.60%, color developing agent: vitamin B12 contains 0.01%, pure water 88.14%.
Prepared contact lenses save liquid osmotic pressure in 240~340mOsm/Kg, and the range of pH value is 6.4~7.8.
Show that the concentration of phosphocholine polymer is higher according to the test of the phosphocholine polymer solution of various concentration, soaks
Bubble is better in the moistening effect of eyeglass wherein, and consumer's wearing is comfortable, and eyes are without sensation of dryness.
In order to verify eyeglass after impregnating containing phosphocholine polymer solution, with good performance of keeping humidity and lubrication
Effect is now tested as follows: surface wettability test and water lock performance test；
Surface wettability test: contact lenses are immersed in the preservation solution containing heterogeneity, are blank control respectively
Phosphate buffer (hereinafter referred to as " PBS ") (number 1), contains polyvinylpyrrolidone at the PBS (number 2) containing Sodium Hyaluronate
The PBS (number 3) of ketone, the PBS (number 4) containing hydroxypropyl methyl cellulose, PBS (number 5), phosphoric acid gallbladder containing poloxamer
Alkali polymer P BS (number 6) impregnates half an hour, then tests rupture time (the water-film break up of moisture film
Time writes a Chinese character in simplified form WBUT).The basic recipe of phosphate buffer (PBS) is as follows: sodium chloride 8.30g, a hypophosphite monohydrate sodium dihydrogen
0.467g, disodium hydrogen phosphate dodecahydrate 5.993g, pure water 1000ml；
The solution of 6 kinds of heterogeneities, by test: the solution of phosphoric acid choline polymer has the moisture film of maximum duration broken
The time is split, shows it with good surface wettability.Test results are shown in figure 1.
Water lock performance test: the solution of 4 kinds of heterogeneities is blank control PBS respectively, phosphoric acid choline polymer
PBS, the PBS containing poloxamer, the PBS containing hydroxypropyl methyl cellulose take out after eyeglass is impregnated half an hour in the solution,
It is placed in air 10 minutes (environment: 20 DEG C of temperature, humidity 35%), visually observes the deformation of eyeglass.Test result such as Fig. 2
It is shown.
By test, relative to the eyeglass being immersed in other solution, it is immersed in the PBS solution of phosphoric acid choline polymer
In eyeglass it is more difficult deformed because of drying out, show phosphoric acid choline polymer PBS be easier lock moisture, prevent
Sealing divides drain evaporation.
The new contact lenses of one kind of the invention save liquid, so that consumer is immersed in contact lenses therein in wearing
When, eyes will not feel lubricant effect that is dry and astringent, while having certain.Phosphocholine polymer chemistry performance is stablized, biofacies
Capacitive is also fine, non-stimulated to eyes.Itself has excellent hydrophilicity, while also having certain moisturizing water lock function, energy
Enough it effectively prevent the drain evaporation of moisture.
Claims (7)
1. a kind of contact lenses of phosphoric acid choline polymer save liquid, which is characterized in that be formulated following (weight percent):
Phosphocholine polymer 0.05%~10%,
Osmotic pressure regulator 0.5~15%,
PH adjusting agent 0.1%~5%,
Color developing agent 0%~1%,
Pure water content 69%~99.35%；
Configured solution osmotic pressure is in 240~340mOsm/Kg, and the range of pH value is 6.4~7.8；
Wherein, phosphocholine polymer is polymethyl trimethylammonium-trimethyl-(2- phosphonooxyethyl) ammonium salt.
2. a kind of contact lenses of phosphoric acid choline polymer according to claim 1 save liquid, which is characterized in that infiltration
Pressing regulator is one or more of sodium chloride, potassium chloride, magnesium chloride.
3. a kind of contact lenses of phosphoric acid choline polymer according to claim 1 save liquid, which is characterized in that pH value
Adjustment is one or more of disodium hydrogen phosphate, sodium dihydrogen phosphate, boric acid, borax, citric acid or sodium citrate.
4. a kind of contact lenses of phosphoric acid choline polymer according to claim 1 save liquid, which is characterized in that colour developing
Agent is vitamin B2 or vitamin B12.
5. contact lenses as described in claim 1 save liquid, it is characterised in that: the structure of the phosphocholine polymer is such as
Under:
6. a kind of contact lenses as described in claim 1 save liquid, it is characterised in that: contain polymethyl acyloxy second
Base-trimethyl-(2- phosphonooxyethyl) ammonium salt 0.05~0.10% (weight percent).
7. a kind of preservation liquid as claimed in claim 5, it is characterised in that: poly- trimethyl-(2- phosphono oxygen in the composition
Base ethyl) ammonium salt, molecular weight is in 2000-300000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811601187.5A CN109957475A (en) | 2018-12-26 | 2018-12-26 | A kind of contact lenses preservation liquid of phosphoric acid choline polymer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811601187.5A CN109957475A (en) | 2018-12-26 | 2018-12-26 | A kind of contact lenses preservation liquid of phosphoric acid choline polymer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109957475A true CN109957475A (en) | 2019-07-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811601187.5A Pending CN109957475A (en) | 2018-12-26 | 2018-12-26 | A kind of contact lenses preservation liquid of phosphoric acid choline polymer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114045187A (en) * | 2021-11-22 | 2022-02-15 | 上海卫康光学眼镜有限公司 | Preservative-free composition and application thereof |
| CN115956574A (en) * | 2022-12-30 | 2023-04-14 | 烟台爱博诺德医用材料有限公司 | Care composition for optical devices |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101391111A (en) * | 2008-10-31 | 2009-03-25 | 广州科甫眼镜有限公司 | Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil |
| CN107541361A (en) * | 2016-06-27 | 2018-01-05 | 晶硕光学股份有限公司 | Solution for treating contact lenses |
-
2018
- 2018-12-26 CN CN201811601187.5A patent/CN109957475A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101391111A (en) * | 2008-10-31 | 2009-03-25 | 广州科甫眼镜有限公司 | Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil |
| CN107541361A (en) * | 2016-06-27 | 2018-01-05 | 晶硕光学股份有限公司 | Solution for treating contact lenses |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114045187A (en) * | 2021-11-22 | 2022-02-15 | 上海卫康光学眼镜有限公司 | Preservative-free composition and application thereof |
| CN115956574A (en) * | 2022-12-30 | 2023-04-14 | 烟台爱博诺德医用材料有限公司 | Care composition for optical devices |
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