CN114045187A - Preservative-free composition and application thereof - Google Patents
Preservative-free composition and application thereof Download PDFInfo
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- CN114045187A CN114045187A CN202111388415.7A CN202111388415A CN114045187A CN 114045187 A CN114045187 A CN 114045187A CN 202111388415 A CN202111388415 A CN 202111388415A CN 114045187 A CN114045187 A CN 114045187A
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- China
- Prior art keywords
- preservative
- acid
- composition
- free composition
- osmotic pressure
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- 239000000203 mixture Substances 0.000 title claims abstract description 30
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 18
- 230000003204 osmotic effect Effects 0.000 claims abstract description 14
- 239000006172 buffering agent Substances 0.000 claims abstract description 11
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000011780 sodium chloride Substances 0.000 claims abstract description 9
- 235000018324 Shepherdia canadensis Nutrition 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 5
- 229930195725 Mannitol Natural products 0.000 claims abstract description 5
- 239000000594 mannitol Substances 0.000 claims abstract description 5
- 235000010355 mannitol Nutrition 0.000 claims abstract description 5
- 239000001103 potassium chloride Substances 0.000 claims abstract description 5
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 3
- 229910021538 borax Inorganic materials 0.000 claims abstract description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000004327 boric acid Substances 0.000 claims abstract description 3
- 235000010338 boric acid Nutrition 0.000 claims abstract description 3
- 239000001110 calcium chloride Substances 0.000 claims abstract description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 3
- 239000008103 glucose Substances 0.000 claims abstract description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 claims abstract description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 3
- 239000008213 purified water Substances 0.000 claims abstract description 3
- 239000001509 sodium citrate Substances 0.000 claims abstract description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 3
- 239000001488 sodium phosphate Substances 0.000 claims abstract description 3
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 3
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims abstract description 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims abstract description 3
- 235000019801 trisodium phosphate Nutrition 0.000 claims abstract description 3
- 229960000281 trometamol Drugs 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 240000003377 Shepherdia canadensis Species 0.000 claims abstract 2
- 230000001050 lubricating effect Effects 0.000 claims description 12
- 235000002639 sodium chloride Nutrition 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 150000001642 boronic acid derivatives Chemical group 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000008181 tonicity modifier Substances 0.000 claims 1
- 238000005461 lubrication Methods 0.000 abstract description 5
- 239000003755 preservative agent Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 230000002335 preservative effect Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 241000694414 Sapindus saponaria Species 0.000 description 6
- 239000007788 liquid Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 201000009310 astigmatism Diseases 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010020675 Hypermetropia Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000029091 Refraction disease Diseases 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- 241000580938 Sapindus Species 0.000 description 1
- 241000580955 Sapindus mukorossi Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000004430 ametropia Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000003225 biodiesel Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000000882 contact lens solution Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000005536 corrosion prevention Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229940054534 ophthalmic solution Drugs 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000014733 refractive error Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/042—Acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/06—Phosphates, including polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
- C11D2111/14—Hard surfaces
- C11D2111/18—Glass; Plastics
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Eyeglasses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Detergent Compositions (AREA)
Abstract
A preservative-free composition and its application are provided. The invention relates to a composition used in cooperation with contact lens lubrication and application thereof. The components and contents are as follows: 0.05-5% of soapberry extract; 0.1-2.0% of acid-base buffering agent; the osmotic pressure regulator regulates the osmotic pressure of the composition to be 20-400 mOsmol/kg; the balance of purified water; the pH value of the composition is maintained at 6-8 by the acid-base buffering agent; the buffering agent is one or more of boric acid, borax, trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, hydrochloric acid, tromethamine and sodium hydroxide; the osmotic pressure regulator is one or more of sodium chloride, potassium chloride, magnesium chloride, calcium chloride, mannitol, glucose and polyvinyl alcohol.
Description
Technical Field
The invention relates to a composition used in cooperation with contact lens lubrication and application thereof.
Background
Contact lenses, or contact lenses, are lenses that are worn on the cornea of the eye to correct vision or protect the eye. The contact lenses not only bring great improvement to ametropia patients with myopia, hyperopia, astigmatism and the like from the aspects of appearance and convenience, but also have wide visual field and vivid visual objects, and also play special effects in the aspects of controlling the development of juvenile myopia and astigmatism, treating special ophthalmopathy and the like.
The contact lens has many advantages compared with the frame lens, and the most outstanding problem is the foreign body sensation, especially the hard contact lens, and the contact lens lubricating liquid is based on solving various discomfort caused by the foreign body sensation of the contact lens. The mechanism of action of the lubricating fluid is to add surfactants or viscosity-increasing thickeners to the product to reduce friction of the lens with the cornea. Such products are generally divided into single dose and multi-dose uses: the single dose product does not contain preservative, but the packing material and the liquid medicine are not necessary to be wasted too much when in use, and the cost is high; multi-dose products typically contain preservatives, and no preservative products have been available; in view of the technical development, in the future, the product which can be used in multiple doses through the special design on the packing material but has no preservative can be realized, and the overall cost of the product is high; there is a need for an economical preservative-free product of this type to meet the needs of the individual. Since preservatives are now a reliable way to ensure that such products are protected from microbial contamination over multiple uses, the long term contact and accumulation on the eye of a contact lens wearer can further exacerbate this foreign body sensation, which can be a vicious circle. The natural plant extract is added into the product, so that the preservative is not added on the basis of effective lubrication, two purposes are achieved, and the economic and safe preservative-free contact lens lubricating liquid is provided for contact lens wearers.
Sapindusukorosis (Sapindusmukurossi) is a deciduous tree of Sapindusukorosis genus of Sapindaceae family, widely distributed abroad in Japan, Korea and other countries, and distributed in domestic provinces. Sapindus have different names in different places, and are called as Haidao tree in Taiwan, bitter tree in Hainan, and Feizhu beads in Jiangxi, Guangdong and Hunan. The soapberry has very wide application value, and the tree shape is attractive and can absorb the automobile exhaust; the kernel has high oil content, and is a novel raw material for preparing the biodiesel; the saponin in the fruit has strong nonionic surface activity, and can be used as natural detergent. Modern researches show that the peel of Chinese soapberry contains a large amount of saponins, mainly triterpenoid saponins.
Disclosure of Invention
It is an object of the present invention to overcome the above-mentioned deficiencies of the prior art and to provide a preservative-free composition for use in conjunction with the lubrication of contact lenses and uses thereof.
The specific technical scheme of the invention is as follows:
a preservative-free composition comprises the following components in percentage by weight: (weight percent)
0.05-5% of soapberry extract;
0.1-2.0% of acid-base buffering agent;
the osmotic pressure regulator regulates the osmotic pressure of the composition to be 20-400 mOsmol/kg;
the balance of purified water;
the pH value of the composition is maintained at 6-8 by the acid-base buffering agent; the buffering agent is one or more of boric acid, borax, trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, hydrochloric acid, tromethamine and sodium hydroxide;
the osmotic pressure regulator is one or more of sodium chloride, potassium chloride, magnesium chloride, calcium chloride, mannitol, glucose and polyvinyl alcohol.
Furthermore, the buffering system of the present invention should preferably maintain the pH of the composition at 6.0-8.0, and the buffering agent may be one or more of borate, phosphate, citrate, carbonate, etc. Preferably a borate salt, which is a system with a strong buffering capacity over a wide range of temperatures.
Further, the tonicity adjusting agent is capable of adjusting the tonicity of the composition of the present invention: when used in soft lenses, should be adjusted to approximate the natural tear fluid, i.e., to correspond to the osmotic pressure of a 0.9% sodium chloride solution. Changes in the optical parameters of the contact lens can be caused by both hypotonic and hypertonic conditions; when applied to a hard lens, there is little specific requirement for osmotic pressure because hard contact lenses are non-hydrophilic materials. In general, a commonly used osmotic pressure regulator such as sodium chloride, potassium chloride or mannitol is used. The invention selects sodium chloride preferably, and the content of the sodium chloride is 20-400 mOsmol/kg for regulating the osmotic pressure of the whole composition system.
Furthermore, the composition contains a surfactant (soapberry extract), and also contains an acid-base buffering agent and an osmotic pressure regulator, and has the advantages of remarkable lubricating effect and no damage caused by direct contact of preservative and eyes compared with the common contact lens lubricating liquid.
The invention also provides the use of a preservative-free composition as a lubricating fluid and disinfectant in combination with various contact lenses, including day-wear lenses, extended-wear lenses, periodically-replaced lenses, and disposable lenses.
The composition has the obvious advantages of strong lubricating capability on various contact lenses, no preservative and no additional damage to eyes.
The composition solution of the present invention can also be used as an ophthalmic solution for achieving other functions by adding other ingredients such as a viscosity-increasing humectant, a refreshing agent, a nutritional agent, etc. It is to be understood that the invention is not so limited and that the addition and modification of certain other materials will be apparent to those skilled in the art.
Detailed Description
The invention is further illustrated by the following specific examples. It is to be understood that the following examples are illustrative only and are not intended to limit the scope of the invention, which is to be given numerous insubstantial modifications and adaptations by those skilled in the art based on the teachings set forth above.
With respect to the formulation of the composition shown in the following table 1, a concentration gradient solution A, B, C, D of the soapberry extract was prepared by using the existing contact lens solution manufacturing equipment, contact lenses were treated for a predetermined period of time, and the comfort level of the contact lenses after treatment was comparatively tested and compared.
The lenses were soaked with the following solutions and the comfort of wear of the treated lenses was recorded. Randomly selecting 30 volunteers who do not wear contact lenses and frequently wear contact lenses, respectively trying on the left eye and the right eye for 4 hours, recording the comfort level of each lens in the wearing process, respectively performing 4 groups of tests with different concentrations on 1, 2, 3 and 4 days by the trying-on person, and recording the test results, wherein the results are shown in Table 1
TABLE 1
As a result, the lens treated with the solution B, C, D was found to have a good feeling of lubrication in the hand; the post-treatment lens feel A, B, C, D is sequentially lifted. It is apparent that the contact lens lubricating fluid containing the soapberry fruit extract has significantly improved lubricating performance. The contribution of the soapberry extract to the lubricating performance of the solution was found, and the lubricating sensation was found to increase with the increase of the added concentration.
At the same time, solution A, B, C, D was tested for preservative effectiveness (ophthalmic optical contact lens care products), requiring:
the average reduction of the number of bacteria per ml of the test bacteria in 14 days is not less than 3.0 lgs. After 14 days of re-inoculation, the concentration of each test bacterium should be reduced again at 28 days, with an average reduction of at least 3.0 lgs;
the number of bacteria for restoring growth per ml of each test bacteria should be maintained at or below the initial concentration of the mold and yeast at 14 days; at 28 days, the concentration of each test bacterium should be maintained at or below that of the respective test bacterium after inoculation.
3 kinds of bacteria (staphylococcus aureus, pseudomonas aeruginosa and escherichia coli), 1 kind of mould (aspergillus niger) and 1 kind of yeast (candida albicans) are selected to evaluate the preservative effectiveness of the solution, and the result shows that the preservative effectiveness of each solution meets the requirement.
Table 2 comparison table for corrosion prevention effectiveness evaluation of each solution
The maximum use concentration is specified when the ophthalmic preparation is used, considering that an excessive addition causes a yellowish or darker color of the solution, affects the consumer acceptance, and even affects the light transmittance of a contact lens for a short time.
Claims (7)
1. A preservative-free composition is characterized by comprising the following components in percentage by weight: (weight percent)
0.05-5% of soapberry extract;
0.1-2.0% of acid-base buffering agent;
the osmotic pressure regulator regulates the osmotic pressure of the composition to be 20-400 mOsmol/kg;
the balance of purified water;
the pH value of the composition is maintained at 6-8 by the acid-base buffering agent; the buffering agent is one or more of boric acid, borax, trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, hydrochloric acid, tromethamine and sodium hydroxide;
the osmotic pressure regulator is one or more of sodium chloride, potassium chloride, magnesium chloride, calcium chloride, mannitol, glucose and polyvinyl alcohol.
2. A preservative-free composition as claimed in claim 1, wherein the acid-base buffer is selected from one or more of borate, phosphate, citrate, carbonate and the like.
3. A preservative-free composition according to claim 2, wherein the acid-base buffer is borate.
4. The preservative-free composition of claim 1, wherein the tonicity adjusting agent adjusts the tonicity of the composition to: when used in soft lenses, the osmolality of the 0.9% sodium chloride solution should be adjusted.
5. A preservative-free composition according to claim 1, wherein sodium chloride, potassium chloride or mannitol is used as the tonicity modifier.
6. Use of the preservative-free composition of claim 1 as a lubricating fluid and disinfectant for use with various contact lenses.
7. The use of a preservative-free composition according to claim 6, wherein the contact lens comprises a daily wear lens, a long wear lens, a replacement lens, or a disposable lens.
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| CN202111388415.7A CN114045187B (en) | 2021-11-22 | 2021-11-22 | Preservative-free composition and application thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005306779A (en) * | 2004-04-21 | 2005-11-04 | Mitsui Chemicals Inc | Plant-derived antimicrobial agent |
| CN101691479A (en) * | 2009-09-25 | 2010-04-07 | 海昌隐形眼镜有限公司 | Corneal contact lens preserving liquid composition and preparation method thereof |
| US20170020807A1 (en) * | 2013-12-08 | 2017-01-26 | Y&B Mother's Choice Ltd. | Preparations for suppressing or attenuating ocular irritancy |
| US20180153206A1 (en) * | 2016-11-08 | 2018-06-07 | Kamterter Products, Llc | Labile-Based Spray and Emissions for Food Applications |
| CN109957475A (en) * | 2018-12-26 | 2019-07-02 | 上海卫康光学眼镜有限公司 | A kind of contact lenses preservation liquid of phosphoric acid choline polymer |
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2021
- 2021-11-22 CN CN202111388415.7A patent/CN114045187B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005306779A (en) * | 2004-04-21 | 2005-11-04 | Mitsui Chemicals Inc | Plant-derived antimicrobial agent |
| CN101691479A (en) * | 2009-09-25 | 2010-04-07 | 海昌隐形眼镜有限公司 | Corneal contact lens preserving liquid composition and preparation method thereof |
| US20170020807A1 (en) * | 2013-12-08 | 2017-01-26 | Y&B Mother's Choice Ltd. | Preparations for suppressing or attenuating ocular irritancy |
| US20180153206A1 (en) * | 2016-11-08 | 2018-06-07 | Kamterter Products, Llc | Labile-Based Spray and Emissions for Food Applications |
| CN109957475A (en) * | 2018-12-26 | 2019-07-02 | 上海卫康光学眼镜有限公司 | A kind of contact lenses preservation liquid of phosphoric acid choline polymer |
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| CN114045187B (en) | 2024-07-26 |
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