TWI820712B - Chromatography - Google Patents

Abstract

A chromatography is used to solve the detecting inconveniences of conventional chromatography. The chromatography includes: a casing with a chamber; a detector module located in the chamber and having a reaction area; a temperature-controlling module located in the chamber and having a temperature sensor and a heater, which is located in the detector module and electrically connected to the temperature sensor; and a capture module located in the chamber and having a light source and a imaging unit, wherein the light source and the imaging unit are arranged toward the reaction area.

Description

Chromatograph

The invention relates to a detection device, in particular to a chromatograph.

Chromatography is a separation technology that can be used to analyze the purity of unknown mixtures and test substances. It drops the mixture onto a paper-based wafer and places the paper-based wafer on one side of the chromatograph. The separation system uses the different adhesion of each component in the mixed solution to the stationary phase and the different solubility to the mobile phase, resulting in differences in the movement rates of each component, that is, it can be based on the area of precipitation of various solutes. and position analysis of the composition and component ratio of the mixed liquid to achieve the purpose of separating the mixed liquid.

However, the above-mentioned conventional chromatograph is not equipped with a relevant device for controlling temperature, which makes it impossible to maintain a constant temperature during the chromatography process, making it difficult for subsequent detection operations to proceed smoothly, resulting in poor detection convenience, and the conventional chromatography Analyzers are usually relatively large instruments, making them inconvenient to carry.

In order to solve the above problems, the object of the present invention is to provide a chromatograph that can maintain constant temperature operation during the entire chromatography process, thereby enabling subsequent detection operations to proceed smoothly.

A secondary object of the present invention is to provide a chromatograph that is portable and convenient for operators.

Another object of the present invention is to provide a chromatograph that is easy to assemble.

Another object of the present invention is to provide a chromatograph that can reduce manufacturing costs.

Directionality or similar terms are used throughout the present invention, such as "front", "back", "left", "right", "upper (top)", "lower (bottom)", "inner", "outer" , "side", etc. mainly refer to the directions of the attached drawings. Each directionality or its approximate terms are only used to assist in explaining and understanding the various embodiments of the present invention, and are not intended to limit the present invention.

The use of the quantifier "a" or "an" in the elements and components described throughout the present invention is only for convenience of use and to provide a common sense of the scope of the present invention; in the present invention, it should be interpreted as including one or at least one, and single The concept of also includes the plural unless it is obvious that something else is meant.

Approximate terms such as "combination", "combination" or "assembly" used throughout the present invention mainly include forms that can be separated without damaging the components after being connected, or components that are inseparable after being connected, and are based on common knowledge in this field. You can choose according to the material of the components to be connected or the assembly requirements.

The chromatograph of the present invention includes: a shell base with a chamber; a detection module located in the chamber; the detection module has a reaction area; the detection module has a body and a carrier, The stage is combined with the frame, the reaction area is located on the stage, the reaction area has at least one heat conduction space, the heat conduction space is recessed on the surface of the stage; a temperature control module is located in the chamber, the temperature The control module has a temperature sensor and a heating element. The temperature sensor is electrically connected to the heating element. The heating element is located in the detection module; and a capture module is located in the chamber. The capture module The module has a light source and an imaging part, and the light source and the imaging part face the reaction area.

Accordingly, in the chromatograph of the present invention, the temperature sensor can sense the temperature of the reaction zone. If the temperature of the reaction zone is insufficient, the heating element can instantly heat the reaction zone so that the entire reaction zone can be heated. Constant temperature operation can be maintained during the chromatography process, thus allowing subsequent detection operations to proceed smoothly. In addition, the chromatograph of the present invention can integrate various components for detection in the chamber, so that the chromatograph can be easily carried, used and operated, and has the function of convenient detection. In addition, the thermal energy of the heating element can be transferred to the reaction zone through the heat conduction space, which has good heat conduction efficiency.

Wherein, the frame body may have several support members and a platform, the platform is combined above the several support members, and the platform is used to be combined with the platform. In this way, the system can effectively utilize space.

Wherein, the frame body may have two first coupling parts, the stage may have two second coupling parts, and the two second coupling parts may be coupled to the two first coupling parts respectively. In this way, the structure is simple and easy to assemble, and has the effect of convenient assembly.

Wherein, the shell base may have a ring wall, and the ring wall may have an opening groove, and the opening groove communicates the accommodation chamber with the outside of the shell base. In this way, the carrier can be pulled out from the opening slot or placed into the chamber, which is convenient for use.

Wherein, the detection module may have a carrier, and the cross-sectional shape of the carrier may match the shape of the opening slot. In this way, when the carrier is placed into the chamber through the opening slot, the carrier can slide to the platform along the opening slot and be positioned, thereby achieving smooth detection.

Wherein, the shell seat may have a bottom plate and a top plate opposite to each other, and a ring wall may be connected between the top plate and the bottom plate. The bottom plate, the top plate and the ring wall may jointly surround the chamber. In this way, the structure is simple and easy to assemble, and has the effect of convenient assembly.

Wherein, the heating element can be a heating sheet. In this way, the system has the effect of reducing manufacturing costs.

Wherein, the capture module may have a signal transmission unit, the signal transmission unit is coupled to the imaging part, and the signal transmission unit may transmit the captured information to a client. In this way, the user can view the retrieval results through the client, which is convenient to use.

[Invention]

1: Shell base

11: Bottom plate

12:Top plate

13: Surround wall

2:Detection module

21: Frame

211:Support

212:Platform

213:First joint

22: Carrier platform

221:Second joint part

23:Reaction zone

23a:Heat conduction space

3:Temperature control module

31:Temperature sensor

32:Heating element

4: Capture module

41:Light source

42: Image acquisition department

43: Signal transmission unit

P: Paper-based wafer

S: room

U: client

[Figure 1] An exploded perspective view of a preferred embodiment of the present invention.

[Figure 2] An exploded perspective view of a preferred embodiment of the present invention.

In order to make the above and other objects, features and advantages of the present invention more obvious and understandable, preferred embodiments of the present invention are illustrated below and described in detail with reference to the accompanying drawings; in addition, the same symbols are used in different drawings. are considered to be the same and their description will be omitted.

Please refer to Figure 2, which is a preferred embodiment of the chromatograph of the present invention. It includes a housing 1, a detection module 2, a temperature control module 3 and a capture module 4. The detection module 2, the temperature control module 3 and the capture module 4 are located in the housing 1.

Please refer to Figures 1 and 2. The housing 1 can be a hollow object of various geometric shapes, which is not limited in the present invention. In this embodiment, the housing 1 can have an opposite bottom plate 11 and A top plate 12, and a ring wall 13 is connected between the top plate 12 and the bottom plate 11. The bottom plate 11, the top plate 12 and the ring wall 13 can jointly enclose a chamber S, and the chamber S can be used to accommodate The detection module 2, the temperature control module 3 and the capture module 4 can thereby prevent external light sources from interfering with the detection results in the chamber S. In addition, the ring wall 13 can have an opening groove 14 , and the opening groove 14 can communicate with the outside of the housing S and the housing 1 .

The detection module 2 is located in the chamber S. The detection module 2 may have a frame 21 and a carrier 22. The frame 21 may have a plurality of supporting members 211 and a platform 212. The plurality of supporting members 211 One end of the platform 212 can be fixed to the base plate 11 by locking or gluing, which is not limited by the present invention. The platform 212 is combined with the other ends of the supports 211. The frame 21 can have two first joints. The two first joint parts 213 can be located on the platform 212. The two first joint parts 213 can be two guide rails. The stage 22 can have two second joint parts 221. The two second joint parts 221 can be As two sides, the two second coupling parts 221 can be coupled to the two first coupling parts 213 respectively, so that the stage 22 can be slidably coupled to the frame 21 .

In addition, the detection module 2 has a reaction area 23 located on the stage 22. The reaction area 23 is used to accommodate a paper-based wafer P. The stage 22 can be drawn out from the opening slot 14, so that The user can place a paper-based wafer P in the reaction area 23, and the carrier 22 can be placed in the chamber S through the opening slot 14, so that the carrier 22 can be located on the frame 21. The cross-sectional shape of the carrier 22 preferably matches the shape of the opening groove 14. Therefore, when the carrier 22 is placed in the chamber S through the opening groove 14, the carrier 22 can follow the opening. The slot 14 slides to the platform 212 and is positioned. In addition, the reaction zone 23 may have at least one heat conduction space 23a, and the heat conduction space 23a may be recessed on the surface of the stage 22. In this embodiment, the reaction zone 23 has several heat conduction spaces 23a.

The temperature control module 3 is located in the chamber S. The temperature control module 3 has a temperature sensor 31 and a heating element 32. The temperature sensor 31 can be located under the platform 212. The temperature sensor 31 For sensing the temperature of the reaction zone 23, the heating element 32 is electrically connected to the temperature sensor 31. The heating element 32 can be located on the platform 212, and the heating element 32 can be located below the stage 22, so that The heating element 32 can heat the reaction zone 23, and the temperature of the reaction zone 23 can be maintained at 40~50°C, preferably at 45°C. The shape of the heating element 32 is based on the principle that the reaction zone 23 can be smoothly heated to the required temperature. The invention is not limited thereto. In this embodiment, the heating element 32 can be a heating plate. .

The capture module 4 is located in the chamber S. The capture module 4 can be located above the reaction area. In this embodiment, the capture module 4 is combined with the top plate 12. The capture module 4 It has a light source 41 and an imaging part 42. The light source 41 can face the reaction area 23. The light source 41 can For example, it is a UV lamp. The light source 41 is electrically connected to a circuit board or other power supply device and can supply power to emit ultraviolet light. This is understood by those in the art and will not be described in detail here. In addition, the image capturing part 42 can face the reaction area 23. The image capturing part 42 can be, for example, a lens or an absorbance detection device. The image capturing part 42 can capture information on the paper-based wafer P, such as the The imaging unit 42 may be electrically connected to a computer device to display or analyze the acquisition results.

The capture module 4 may also have a signal transmission unit 43. The signal transmission unit 43 is coupled to the imaging part 42. The signal transmission unit 43 is used to transmit and receive signals. For example, but not limited to, the signal transmission unit 43 can be a wireless transmission unit such as GSM, WiFi, Zigbee, NB-IoT, Sigfox or LoRa. The signal transmission unit 43 can transmit the captured information to a client U so that the user can view it through the client U Retrieve results, wherein the client U can be a mobile phone, a tablet, a personal computer or other device.

When the chromatograph of the present invention is used, the mixed liquid to be separated is dropped onto the paper-based wafer P, using the paper-based wafer P as a stationary phase, and a developing solution is dropped into it as a mobile phase, and then the paper-based wafer is P is placed on the stage 22, and the stage 22 is placed in the chamber S through the opening slot 14, so that the stage 22 can be located on the frame 21, and the components in the mixture interact with the stationary phase ( The different adhesion forces of the Stationary Phase and the different solubility of the mobile phase (Mobile Phase) cause differences in the movement rates of the mixed liquid to achieve separation. Among them, the temperature sensor 31 can sense the temperature of the reaction zone 23. If the temperature of the reaction zone 23 is insufficient, the heating element 32 can heat the reaction zone 23 immediately so that a constant temperature can be maintained during the entire chromatography process. operation, so that subsequent inspection operations can proceed smoothly. In addition, the chromatograph of the present invention can integrate various detection components into the chamber S to facilitate portability, use and operation, and has the effect of convenient detection. In addition, through the arrangement of the heat conduction space 23a, the heat energy of the heating element 32 can be transferred to the reaction zone 23 through the heat conduction space 23a, which has a good heat conduction effect.

To sum up, in the chromatograph of the present invention, the temperature sensor can sense the reaction zone If the temperature of the reaction zone is insufficient, the heating element can instantly heat the reaction zone, so that constant temperature operation can be maintained during the entire chromatography process, thereby allowing subsequent detection operations to proceed smoothly. In addition, the chromatograph of the present invention can integrate various detection components into the chamber to facilitate portability, use and operation, and has the effect of convenient detection.

Although the present invention has been disclosed using the above-mentioned preferred embodiments, they are not intended to limit the invention. Anyone skilled in the art can make various changes and modifications to the above-described embodiments without departing from the spirit and scope of the invention. The technical scope protected by the invention, therefore, the protection scope of the invention shall include all changes within the literal and equivalent scope described in the appended patent application scope.

1: Shell base

11: Bottom plate

12:Top plate

13: Surround wall

2:Detection module

21: Frame

211:Support

212:Platform

213:First joint

22: Carrier platform

221:Second joint part

23:Reaction zone

23a:Heat conduction space

3:Temperature control module

31:Temperature sensor

32:Heating element

4: Capture module

41:Light source

42: Image acquisition department

43: Signal transmission unit

P: Paper-based wafer

S: room

U: client

Claims (8)

A chromatograph, including: a shell base with a chamber; a detection module located in the chamber; the detection module has a reaction area; the detection module has a body and a carrier; the carrier The stage is combined with the frame, the reaction area is located on the stage, the reaction area has at least one heat conduction space, and the heat conduction space is recessed on the surface of the stage; a temperature control module is located in the chamber, and the temperature control module The set has a temperature sensor and a heating element, the temperature sensor is electrically connected to the heating element, the heating element is located in the detection module; and a capture module is located in the chamber, the capture module It has a light source and an imaging part, and the light source and the imaging part face the reaction area. The chromatograph of claim 1, wherein the frame has a plurality of supporting members and a platform, the platform is coupled to the top of the plurality of supporting members, and the stage is used to be coupled to the platform. The chromatograph of claim 1, wherein the frame has two first coupling parts, the stage has two second coupling parts, and the two second coupling parts are respectively coupled to the two first coupling parts. The chromatograph of claim 1, wherein the shell base has a ring wall, the ring wall has an opening groove, and the opening groove connects the chamber with the outside of the shell base. The chromatograph of claim 4, wherein the detection module has a carrier, and the cross-sectional shape of the carrier matches the shape of the opening groove. The chromatograph of claim 1, wherein the housing has a bottom plate and a top plate opposite each other, a ring wall is connected between the top plate and the bottom plate, and the bottom plate, the top plate and the ring wall jointly surround the chamber. . The chromatograph of claim 1, wherein the heating element is a heating plate. The chromatograph of claim 1, wherein the acquisition module has a signal transmission unit, the signal transmission unit is coupled to the imaging part, and the signal transmission unit transmits the acquired information to a client.

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