TWI814234B - 突變蛋白抑制劑的製備及其應用 - Google Patents
突變蛋白抑制劑的製備及其應用 Download PDFInfo
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- TWI814234B TWI814234B TW111103959A TW111103959A TWI814234B TW I814234 B TWI814234 B TW I814234B TW 111103959 A TW111103959 A TW 111103959A TW 111103959 A TW111103959 A TW 111103959A TW I814234 B TWI814234 B TW I814234B
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Classifications
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
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- Organic Chemistry (AREA)
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CN202110276073.3 | 2021-03-15 | ||
CN202110276073.3A CN115073450A (zh) | 2021-03-15 | 2021-03-15 | Krasg12c突变蛋白抑制剂的制备及其应用 |
CN202110374457.9 | 2021-04-07 | ||
CN202110374457.9A CN115160309B (zh) | 2021-04-07 | 2021-04-07 | Krasg12c突变蛋白杂环类抑制剂的制备及其应用 |
CN202110496041.4 | 2021-05-07 | ||
CN202110496041.4A CN115304603B (zh) | 2021-05-07 | 2021-05-07 | 喹唑啉类抑制剂的制备及其应用 |
CN202110672205.4 | 2021-06-17 | ||
CN202110672205.4A CN115490689B (zh) | 2021-06-17 | 2021-06-17 | 不可逆krasg12c抑制剂的制备及其应用 |
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US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
WO2023114733A1 (fr) * | 2021-12-13 | 2023-06-22 | Quanta Therapeutics, Inc. | Modulateurs de kras et leurs utilisations |
WO2023154766A1 (fr) | 2022-02-09 | 2023-08-17 | Quanta Therapeutics, Inc. | Modulateurs de kras et leurs utilisations |
CN118660891A (zh) * | 2022-02-14 | 2024-09-17 | 深圳福沃药业有限公司 | 作为kras g12c突变抑制剂的喹唑啉衍生物 |
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WO2016164675A1 (fr) * | 2015-04-10 | 2016-10-13 | Araxes Pharma Llc | Composés quinazoline substitués et leurs procédés d'utilisation |
WO2020239077A1 (fr) * | 2019-05-29 | 2020-12-03 | 上海翰森生物医药科技有限公司 | Régulateur dérivé hétérocyclique contenant de l'azote, son procédé de préparation et son application |
CN112110918A (zh) * | 2019-06-21 | 2020-12-22 | 劲方医药科技(上海)有限公司 | 螺环取代的嘧啶并环类化合物,其制法与医药上的用途 |
CN112142735A (zh) * | 2020-04-09 | 2020-12-29 | 上海凌达生物医药有限公司 | 一类稠和氰基吡啶类化合物、制备方法和用途 |
WO2021031952A1 (fr) * | 2019-08-16 | 2021-02-25 | 劲方医药科技(上海)有限公司 | Composé de pyrimidine cyclique à six chaînons substitué par oxygène, son procédé de préparation et son utilisation médicale |
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WO2021139678A1 (fr) * | 2020-01-07 | 2021-07-15 | 广州百霆医药科技有限公司 | Inhibiteur pyridopyrimidine de protéine mutante kras g12c |
WO2021168193A1 (fr) * | 2020-02-20 | 2021-08-26 | Beta Pharma, Inc. | Dérivés de pyridopyrimidine en tant qu'inhibiteurs de kras |
KR20230019101A (ko) * | 2020-04-29 | 2023-02-07 | 상하이 린진 바이오파마 씨오., 엘티디. | 벤조티아졸릴 비아릴 화합물, 제조 방법 및 용도 |
CN113754653A (zh) * | 2020-06-05 | 2021-12-07 | 明慧医药(上海)有限公司 | 一种kras g12c抑制剂化合物及其用途 |
US20230081426A1 (en) * | 2020-09-18 | 2023-03-16 | Plexxikon Inc. | Compounds and methods for kras modulation and indications therefor |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2016164675A1 (fr) * | 2015-04-10 | 2016-10-13 | Araxes Pharma Llc | Composés quinazoline substitués et leurs procédés d'utilisation |
WO2020239077A1 (fr) * | 2019-05-29 | 2020-12-03 | 上海翰森生物医药科技有限公司 | Régulateur dérivé hétérocyclique contenant de l'azote, son procédé de préparation et son application |
CN112110918A (zh) * | 2019-06-21 | 2020-12-22 | 劲方医药科技(上海)有限公司 | 螺环取代的嘧啶并环类化合物,其制法与医药上的用途 |
WO2021031952A1 (fr) * | 2019-08-16 | 2021-02-25 | 劲方医药科技(上海)有限公司 | Composé de pyrimidine cyclique à six chaînons substitué par oxygène, son procédé de préparation et son utilisation médicale |
CN112142735A (zh) * | 2020-04-09 | 2020-12-29 | 上海凌达生物医药有限公司 | 一类稠和氰基吡啶类化合物、制备方法和用途 |
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TW202237604A (zh) | 2022-10-01 |
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