TWI804758B - Bone density measuring device and bone density measuring method - Google Patents

Abstract

The present invention provides a bone density measuring device and bone density measuring method for measuring the bone density of an area under test of a bone. The bone density measuring device includes a plurality of light sources, an image capturing device and a processing unit. Each of the plurality of light sources is a light-emitting diode. One of the light sources emits a first light beam of a first wavelength towards the area under test, and another one of the light sources emits a second light beam of a second wavelength towards the area under test. The image capturing device receives the first light beam and the second light beam penetrating the area under test and emitted therefrom so as to generate an image information. The processing unit is electrically connected and receives the image information from the image capturing device, and calculates a bone density measured information based on the image information.

Description

Bone density detection device and bone density detection method

The invention relates to a detection device and a detection method, in particular to a bone density detection device and a bone density detection method.

Bones are vital organs in the human body that support the body, protect internal organs, and perform a variety of daily activities and sports. Therefore, it is very important to promote bone growth and prevent osteoporosis at all ages. However, due to unbalanced diet, high life pressure and lack of exercise, modern people are quite common, and these conditions are likely to cause the bone loss rate to be greater than the bone growth rate. Especially after the age of 30 to 35, the metabolic rate of the human body decreases, and the bone mass will gradually be lost. Therefore, it is very important for the prevention of osteoporosis in the elderly to strengthen the bone density during the development period and youth.

For this reason, osteoporosis is no longer the common belief that only the elderly are high-risk patients, but people of all ages need to regularly check their bone health to adjust their lifestyle at any time. The current bone density testing techniques are mainly based on Dual Energy X-ray Absorptiometry (DEXA) and Ultrasound Densitometry. Bone density detection using X-rays has high accuracy, but there are concerns about radiation hazards, high cost, and large equipment space, so the mobility is low, and frequent detection cannot be performed. The detection method using ultrasound is easily affected by skin, muscle or other soft tissues in the body, so the accuracy is relatively low. Therefore, the bone density detection technology in the prior art is still insufficient and there is room for improvement.

Based on the above, one of the objectives of the present invention is to provide a bone density detection device and method, which uses a light-emitting diode with high safety, low cost, and small space as a detection light source, and uses a multi-band light source for detection. Detection, in order to achieve high mobility, high safety, high accuracy and low cost bone density detection device and method.

One of the technical proposals of the present invention provides a bone density detection device for detecting the bone density of a bone to be measured. The bone density detection device includes a plurality of light sources, an image capture unit and a processing unit. Each light source is a light-emitting diode, wherein one of the plurality of light sources is used to emit a first light with a first wavelength toward the site to be measured, and the other one of the plurality of light sources is used to emit a first light with a second wavelength. Two rays. The image capture unit is used for receiving the first light and the second light that penetrate the part to be measured to generate image information. The processing unit is electrically connected to the image capture unit for receiving image information from the image capture unit and calculating bone density measurement information according to the image information.

Another technical solution of the present invention provides a method for detecting bone density, which is used to detect the bone density of a part of a bone to be measured. The method for detecting bone density includes: emitting a first light with a first wavelength toward the part to be measured through a first light source and emit second light with a second wavelength toward the site to be measured through the second light source, wherein the first light source and the second light source are light-emitting diodes; receive the first light and the second light that penetrate the site to be measured to generate image information; and calculating bone density measurement information according to the image information.

In order to further understand the features and technical content of the present invention, please refer to the following detailed description and drawings related to the present invention. However, the provided drawings are only for reference and description, and are not intended to limit the present invention.

Z: Bone density detection device

1: light source

2: Image capture unit

3: Processing unit

S1: the first light source

S2: Second light source

S3: The third light source

L1,L1': first ray

L2, L2': second ray

M: Image Information

D1, D2: display

C1, C2: control signal

B: Bracket

P: support platform

H: open

S: light source substrate

A: The area to be tested

Fig. 1 is a schematic diagram of implementation of a bone density detection device according to an embodiment of the present invention.

Fig. 2 is a flow chart of a bone density detection method according to an embodiment of the present invention.

Fig. 3 is a functional block diagram of a bone density detection device according to an embodiment of the present invention.

Fig. 4 is a schematic diagram of a variant embodiment of the bone density detection device of the embodiment of the present invention.

Fig. 5 is a schematic diagram of a variation embodiment of a plurality of light sources of the bone density detection device according to the embodiment of the present invention.

Fig. 6 is a flow chart of a variation example of the bone density detection method of the embodiment of the present invention.

Fig. 7 is a flow chart of another variation embodiment of the bone density detection method of the embodiment of the present invention.

Fig. 8 is a flow chart of another variation embodiment of the bone density detection method of the embodiment of the present invention.

9 is a multiple regression model of the bone density measured by the bone density detection device and method of the embodiment of the present invention and the bone density measured by the dual energy X-ray absorptiometry.

The bone density detection device and the bone density detection method disclosed in the present invention are described below through specific specific embodiments and with reference to FIGS. 1 to 9 . Those skilled in the art can understand the advantages and effects of the present invention from the content disclosed in this specification. However, the content disclosed below is not intended to limit the protection scope of the present invention. Those skilled in the art can implement the present invention in other different embodiments based on different viewpoints and applications without departing from the spirit of the present invention.

Please refer to Figure 1 and Figure 2 together. FIG. 1 shows a bone density detection device Z provided by an embodiment of the present invention, which is used to perform bone density detection on a part A of a bone to be measured. Specifically, As shown in FIG. 1 , in this embodiment, bone density detection is performed on the distal radius and distal ulna in the wrist; however, the present invention is not limited thereto. FIG. 2 shows a bone density detection method according to an embodiment of the present invention, which uses a bone density detection device Z as shown in FIG. 1 . The bone density detection device Z includes a plurality of light sources 1 , an image capture unit 2 and a processing unit 3 . In this embodiment, the plurality of light sources 1 are light emitting diodes, including a first light source S1 and a second light source S2. The first light source S1 is used to emit a first light L1 with a first wavelength; the second light source S2 is used to emit a second light L2 with a second wavelength. As shown in FIG. 1 , the processing unit 3 of this embodiment is realized by a computer electrically connected to the image capturing unit 2 , however, the present invention is not limited thereto. In other embodiments, it may be, for example, a notebook computer or other portable device with a microprocessor.

Please refer to FIG. 1 and FIG. 2 together. The method for detecting bone density in this embodiment includes at least the following steps. Step S100: send out the first light L1 with the first wavelength and the second light L2 with the second wavelength toward the part A to be tested; Step S102: receive the first light L1' and the second light L2 that penetrate the part A to be tested ', to generate image information M; and step S104: calculating bone density measurement information according to the image information M. As shown in FIG. 1 , the first light L1' and the second light L2' passing through the part A to be measured are received by the image capture unit 2 to generate image information M through the image capture unit 2 . In this embodiment, the processing unit 3 receives the image information M from the image capturing unit 2 and calculates the bone density measurement information according to the image information M. The processing unit 3 may include a storage element for storing the images of the part A to be tested captured by the image capture unit 2 at different time points. As shown in FIG. 1 , the processing unit 3 of this embodiment may have a display D1 for displaying the calculated bone density measurement information.

As shown in FIG. 3 , in a variant embodiment, the processing unit 3 can actively transmit the first control signal C1 to the image capture unit 2 to control the exposure time of the image capture unit 2 and the wavelength band of the sensed light. And shooting parameters such as the time point of capturing the image. In the embodiment shown in FIG. 3 , the processing unit 3 can be further electrically connected to a plurality of light sources 1 , and independently controls the light sources 1 of different wavelength bands to emit light with the second control signal C2 .

Please refer to FIG. 3 and FIG. 4 together. In a variant embodiment, the bone density detection device Z shown in FIG. 1 can be integrated into the bone density detection device Z shown in FIG. The light source S1 and the second light source S2 are disposed on the light source substrate S, and the light source 1 is disposed in the support platform P as a whole. In this embodiment, the image capture unit 2 is erected above the light source 1 through the bracket B, so that when the subject puts his wrist on the support platform P in such a way that the area A to be measured is aligned with the light source 1, the image capture unit 2 The unit 2 is located on the other side of the area to be measured A opposite to the light source 1 to receive the first light L1 ′ and the second light L2 ′ penetrating the area A to be tested. In one embodiment, the bracket B can be built with a height adjustment mechanism to adjust the distance between the image capture unit 2 and the part A to be tested according to the thickness of the wrist of different subjects. In the embodiment of FIG. 4 , the processing unit 3 can be integrated in the supporting platform P or the bracket B, and display the calculated bone density measurement information on the display D2. Furthermore, the display D2 can be, for example, a touch screen, and the display D2 can be used as a man-machine interface to receive and transmit the first control signal C1 and the second control signal C2 to the image capture unit 2 and the light source 1 . Or, for example, in one embodiment, the position of the display D2 on the bracket B in FIG. Interface of light source 1.

In the embodiment of FIG. 4 , the light source 1 is embedded in the opening H on the support platform P to reduce the influence of external ambient light. In other embodiments, the bone density detection device Z may further include an optical isolation unit, such as a black cloth, a shielding box, etc., to accommodate the image capture unit 2, the bracket B, and the support platform P, so as to reduce the ambient light during bone density detection. Impact.

The light source 1 in this embodiment is preferably a near-infrared light emitting diode. Due to the good penetration of near-infrared light into several bones, such as the distal radius, distal ulna, and calcaneus, this Embodiment Using the light source 1 of near-infrared light-emitting diodes to measure the bone density of the distal radius is an ideal low-radiation, low-cost, and high-safety bone density measurement method. Furthermore, the light with a wavelength between 750nm and 950nm is less susceptible to the influence of collagen and fat, that is, when the measurement light with a wavelength between 750nm and 950nm penetrates the part where the bone density is to be measured, the measurement The bones of the site absorb most of the measurement light. For example, in this embodiment, the first wavelength of the first light source S1 and the second wavelength of the second light source S2 are selected from any two of 770±10 nm, 850±10 nm and 940±10 nm. In a preferred embodiment, the measured bone may be one of the distal radius, distal ulna and calcaneus. However, the present invention is not limited thereto; in other embodiments, it can also be applied to other bones that are easier for near-infrared light to penetrate.

Please refer to FIG. 5 and FIG. 6 , in a variant embodiment of the present invention, the plurality of light sources 1 may further include a third light source S3. The third light source S3 is used for emitting a third light with a third wavelength. In the embodiment shown in FIG. 5 , the light source 1 includes a plurality of first light sources S1 , a plurality of second light sources S2 and a plurality of third light sources S3 disposed on the light source substrate S. As shown in FIG. In order to make the part A to be measured receive the measuring light of uniform intensity, the first light source S1 , the second light source S2 and the third light source S3 are arranged in a matrix-like manner. Specifically, in this embodiment, the first wavelength, the second wavelength and the third wavelength are 770±10 nm, 850±10 nm and 940±10 nm, respectively. Since the third wavelength is longer and the energy is lower, in the light source array in Fig. 5, each row and each column uses one of the first light source S1, the third light source S3, the second light source S2, the third light source S3... The order is staggered so as to increase the ratio of the third light source S3 and achieve the purpose of emitting light of different wavelengths uniformly at the same time.

Please refer to FIG. 5 and FIG. 6 , the bone density measurement method in this variation embodiment may include step S200: send out a first light with a first wavelength, a second light with a second wavelength, and a third light with a third wavelength toward the site to be measured. The third light with a wavelength; step S202: receiving the first light, the second light and the third light that penetrate the part to be measured, so as to generate image information according to the first light, the second light and the third light; Step S204: Calculate bone density measurement information according to the image information. In this modified embodiment, since the measurement light of three wavelengths in the range of 750nm to 950nm is used to detect the bone density, the parameters of the optical information are added to improve the measurement accuracy of the bone density.

Further, please refer to FIG. 7 , in step S104 in FIG. 1 and step S204 in FIG. 6 , the step of calculating bone density measurement information according to image information may further include step S300: calculating bone mass according to light intensity values in image information Density prediction information; and step S302 : obtaining bone density measurement information corresponding to the bone density prediction information according to the prediction model. Taking the functional block diagram in FIG. 3 as an example, in the embodiment of the present invention, when the processing unit 3 receives the image information M, the processing unit 3 first calculates the bone density prediction information according to the light intensity in the image information M, and then calculates the bone density prediction information according to a prediction model to obtain bone density measurement information corresponding to the bone density prediction information. Since different bone densities have different degrees of absorption of the measured light, the prediction information of the bone density can be calculated according to the light intensity of the image information M. Next, the processing unit 3 substitutes the bone density prediction information into the prediction model. In this embodiment, the prediction model is a logarithmic function, which can be pre-stored in the storage element in the processing unit 3 . In step S302, the bone density prediction information is input into the prediction model as a variable to obtain the corresponding bone density measurement information.

Furthermore, in this embodiment, the prediction model is a regression model. In one embodiment, the bone density detection method of the present invention may include step S400: measure the bone density reference information of the site to be measured by the bone density measurement device; and step S402: use the regression analysis step to obtain Density forecasting information to build forecasting models. In detail, the bone density measurement device in step S400 is a high-precision bone density detector, and the bone density of the part A to be measured measured by the bone density measurement device is the bone density reference information. In this embodiment, the bone density measuring device is a dual-energy X-ray absorptiograph, however, the present invention is not limited thereto. In step S402, use multiple groups of bone density prediction information obtained using the bone density detection device Z of the present invention and multiple groups of bone density measurement devices Based on the obtained bone density benchmark information, multiple linear regression scale analysis is performed to establish the prediction model in step S302.

Please refer to FIG. 9 , which shows an experimental example of the present invention, wherein the vertical axis is the bone density measurement information measured by the bone density detection device and method of the embodiment of the present invention on the site A to be measured in FIG. 1 , and the horizontal axis is It is the baseline information of bone density measured on the same site using dual-energy X-ray absorptiometry. It can be seen from FIG. 9 that, compared with the high-precision dual-energy X-ray absorptiometry, the bone density detection device and method of the embodiment of the present invention can obtain quite close measurement results.

Based on the above, the bone density detection device and bone density detection method provided by the embodiments of the present invention achieve high-precision bone density measurement through the technical means of "the plurality of light sources are light-emitting diodes" and the light source has multiple bands. In addition, the bone density detection device and bone density detection method provided by the embodiments of the present invention use light-emitting diodes as light sources, which can prevent the subject from being affected by ionizing radiation, and at the same time achieve low-cost, high-mobility bone density measurements. It can also improve the service life of the bone density detection device Z.

The content disclosed above is only the preferred feasible embodiment of the present invention, and does not limit the patent scope of the present invention. Therefore, all equivalent technical changes made by using the description and drawings of the present invention fall into the application of the present invention. within the scope of the patent.

Z: Bone density detection device

1: light source

S1: the first light source

S2: Second light source

2: Image capture unit

3: Processing unit

M: Image information

L1,L1': first ray

L2, L2': second ray

A: The area to be tested

D: monitor

Claims (13)

A bone density detection device, used to detect the bone density of a part of a bone to be measured, the bone density detection device includes: a plurality of light sources, each of the plurality of light sources is a light-emitting diode, wherein, among the plurality of light sources One of them is used to emit a first light with a first wavelength toward the part to be measured, and the other one of the plurality of light sources is used to emit a second light with a second wavelength; an image capture unit , for receiving the first light and the second light penetrating through the part to be tested to generate an image information; and a processing unit, electrically connected to the image capture unit, for generating The image information is received, and bone density measurement information is calculated according to the image information. The bone density detection device according to claim 1, wherein the first wavelength and the second wavelength are selected from any two of 770±10 nm, 850±10 nm and 940±10 nm. The bone density detection device according to claim 1, wherein another one of the plurality of light sources is used to emit a third light with a third wavelength toward the part to be measured, and the image capture unit is used to receive The first light, the second light and the third light that pass through the portion to be tested generate the image signal. The bone density detection device according to claim 3, wherein the first wavelength, the second wavelength and the third wavelength are 770±10 nm, 850±10 nm and 940±10 nm, respectively. A method for detecting bone density, used for detecting the bone density of a part of a bone to be measured, the method for detecting bone density comprises: A first light source emits a first light with a first wavelength toward the portion to be tested and a second light source emits a second light with a second wavelength toward the portion to be measured, wherein the first light source and the second light source is a light emitting diode; receiving the first light and the second light passing through the part to be measured to generate an image information; and calculating a bone density measurement information according to the image information. The bone density detection method according to claim 5, wherein the first wavelength and the second wavelength are any two of 770±10 nm, 850±10 nm and 940±10 nm. The method for detecting bone density according to claim 5, wherein the step of emitting the first light with the first wavelength and the second light with the second wavelength toward the site to be tested further includes: passing through a The third light source emits a third light with a third wavelength towards the part to be tested, and the third light source is a light emitting diode; and receives the first light and the second light that penetrate the part to be tested to generate The step of the image information further includes: receiving the third light penetrating through the part to be tested, so as to generate the image information according to the first light, the second light and the third light. The bone density detection method according to claim 7, wherein the first wavelength, the second wavelength and the third wavelength are 770±10 nm, 850±10 nm and 940±10 nm, respectively. The bone density detection method as described in claim 5, wherein the step of calculating the bone density measurement information according to the image information includes: calculating a bone density prediction information according to a light intensity value in the image information; and The bone density measurement information corresponding to the bone density prediction information is obtained according to a prediction model. The bone density detection method as described in Claim 9, further comprising: measuring a bone density reference information of the site to be measured by a bone density measurement device; Density forecast information builds the forecast model. The method for detecting bone density according to claim 5, wherein the bone is one of the distal radius, distal ulna and calcaneus. A bone density detection device, used to detect the bone density of a part of a bone to be measured, the bone density detection device includes: a plurality of light sources, each of which is a light-emitting diode, wherein the plurality of light sources are used to emit a first ray with a first wavelength, a second ray with a second wavelength, and a third ray with a third wavelength toward the site to be measured; wherein, the first ray, the second ray And the third light rays form a light source array, in the light source array, the first light rays, the third light rays, the second light rays, and the third light rays are arranged alternately in each row and column; an image capture an acquisition unit for receiving the first light, the second light and the third light that penetrate the part to be tested to generate image information; and a processing unit that is electrically connected to the image acquisition unit for The image information is received from the image capture unit, and bone density measurement information is calculated according to the image information. A method for detecting bone density, used for detecting the bone density of a part of a bone to be measured, the method for detecting bone density comprises: A first light source with a first wavelength is emitted toward the portion to be measured by a first light source, a second light with a second wavelength is emitted by a second light source toward the portion to be measured, and a second light beam with a second wavelength is emitted by a third light source toward the portion to be measured. The part to be tested emits a third light with a third wavelength, wherein the first light source, the second light source and the third light source are light-emitting diodes; wherein the first light, the second light and The third light rays form a light source array, and in the light source array, the first light rays, the third light rays, the second light rays, and the third light rays are arranged alternately in each row and each column; The first light, the second light and the third light source of the part to be measured are used to generate an image information; and a bone density measurement information is calculated according to the image information.

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