TWI797116B - 用於治療上皮細胞屏障功能病症的蛋白質 - Google Patents

用於治療上皮細胞屏障功能病症的蛋白質 Download PDF

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Publication number
TWI797116B
TWI797116B TW107112165A TW107112165A TWI797116B TW I797116 B TWI797116 B TW I797116B TW 107112165 A TW107112165 A TW 107112165A TW 107112165 A TW107112165 A TW 107112165A TW I797116 B TWI797116 B TW I797116B
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Taiwan
Prior art keywords
seq
protein
amino acid
acid sequence
disease
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TW107112165A
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English (en)
Chinese (zh)
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TW201841649A (zh
Inventor
安德魯 源熙 韓
安德魯 惠特曼 固德易
特朗密 古吉拉爾
陶德 柴克里 德桑提斯
卡里姆 達布巴
俊彥 竹內
秦業
米基 和泉 威爾卡森
史蒂芬妮 巴納斯
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美商第二基因體公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Prostheses (AREA)
TW107112165A 2017-04-07 2018-04-09 用於治療上皮細胞屏障功能病症的蛋白質 TWI797116B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762482963P 2017-04-07 2017-04-07
US62/482,963 2017-04-07
US201762607706P 2017-12-19 2017-12-19
US62/607,706 2017-12-19
US201762611334P 2017-12-28 2017-12-28
US62/611,334 2017-12-28

Publications (2)

Publication Number Publication Date
TW201841649A TW201841649A (zh) 2018-12-01
TWI797116B true TWI797116B (zh) 2023-04-01

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TW107112165A TWI797116B (zh) 2017-04-07 2018-04-09 用於治療上皮細胞屏障功能病症的蛋白質

Country Status (12)

Country Link
US (3) US11207376B2 (enExample)
EP (1) EP3606542B1 (enExample)
JP (2) JP7789303B2 (enExample)
KR (2) KR20200003821A (enExample)
CN (1) CN110769844B (enExample)
AU (2) AU2018248324B2 (enExample)
CA (1) CA3059354A1 (enExample)
IL (1) IL269853A (enExample)
MX (2) MX393998B (enExample)
SG (1) SG11201909334TA (enExample)
TW (1) TWI797116B (enExample)
WO (1) WO2018187682A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207376B2 (en) 2017-04-07 2021-12-28 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2019195859A1 (en) * 2018-04-06 2019-10-10 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2020077010A1 (en) * 2018-10-09 2020-04-16 Second Genome, Inc. Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders
JP2022544992A (ja) * 2019-08-21 2022-10-24 アストラゼネカ・コラボレイション・ベンチャーズ・リミテッド・ライアビリティ・カンパニー クローン病を治療するためのブラジクマブの使用
WO2021139766A1 (en) * 2020-01-10 2021-07-15 Huang Chih Hung Peptide interacting with toll-like receptor 2 and the composition comprising the same
CN113773364B (zh) * 2021-08-25 2023-04-28 无锡市儿童医院 小分子肽及其制备方法和应用
EP4611774A2 (en) * 2022-11-04 2025-09-10 MiNK Therapeutics, Inc. B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌
CN105407908A (zh) * 2013-04-10 2016-03-16 4D制药研究有限公司 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控

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US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5856457A (en) 1991-03-29 1999-01-05 Genentech, Inc. Nucleic acids encoding a human IL-8 receptor
US6734289B2 (en) 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US20060189526A1 (en) 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
AR053579A1 (es) * 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
ES2568938T3 (es) 2009-04-28 2016-05-05 Vanderbilt University Composiciones y procedimientos de tratamiento de trastornos que implican apoptosis de células epiteliales
JP2014093482A (ja) 2012-11-06 2014-05-19 Toshiba Corp 固体撮像装置の製造方法および固体撮像装置
WO2015014973A2 (en) * 2013-07-31 2015-02-05 Institut National De La Recherche Agronomique Use of specific glycoside phosphorylases for the implementation of phosphorolysis or reverse phosphorolysis reactions
EP3662917A1 (en) 2015-06-15 2020-06-10 4D Pharma Research Limited Compositions comprising bacterial strains
US11666627B2 (en) * 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11207376B2 (en) 2017-04-07 2021-12-28 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11174293B2 (en) 2017-06-02 2021-11-16 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2019195859A1 (en) 2018-04-06 2019-10-10 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌
CN105407908A (zh) * 2013-04-10 2016-03-16 4D制药研究有限公司 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
網路文獻 UniProtKB G2T1E5 2011/11/16 *

Also Published As

Publication number Publication date
IL269853A (en) 2019-11-28
MX393998B (es) 2025-03-24
KR20230144097A (ko) 2023-10-13
US20240066095A1 (en) 2024-02-29
KR20200003821A (ko) 2020-01-10
US20180289770A1 (en) 2018-10-11
EP3606542B1 (en) 2026-06-10
US10251933B2 (en) 2019-04-09
US12661383B2 (en) 2026-06-23
JP2024037834A (ja) 2024-03-19
CN110769844A (zh) 2020-02-07
CN110769844B (zh) 2025-01-21
WO2018187682A1 (en) 2018-10-11
SG11201909334TA (en) 2019-11-28
AU2023202844A1 (en) 2023-07-06
TW201841649A (zh) 2018-12-01
US11207376B2 (en) 2021-12-28
MX2019012051A (es) 2020-02-12
MX2022008842A (es) 2022-08-02
JP7789303B2 (ja) 2025-12-22
EP3606542A4 (en) 2021-01-20
US20200148728A1 (en) 2020-05-14
CA3059354A1 (en) 2018-10-11
AU2018248324B2 (en) 2023-02-09
EP3606542A1 (en) 2020-02-12
AU2018248324A1 (en) 2019-10-31
JP2020516615A (ja) 2020-06-11
KR102903277B1 (ko) 2025-12-23

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