TWI797116B - 用於治療上皮細胞屏障功能病症的蛋白質 - Google Patents

用於治療上皮細胞屏障功能病症的蛋白質 Download PDF

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Publication number
TWI797116B
TWI797116B TW107112165A TW107112165A TWI797116B TW I797116 B TWI797116 B TW I797116B TW 107112165 A TW107112165 A TW 107112165A TW 107112165 A TW107112165 A TW 107112165A TW I797116 B TWI797116 B TW I797116B
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Taiwan
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seq
protein
amino acid
acid sequence
disease
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TW107112165A
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English (en)
Chinese (zh)
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TW201841649A (zh
Inventor
安德魯 源熙 韓
安德魯 惠特曼 固德易
特朗密 古吉拉爾
陶德 柴克里 德桑提斯
卡里姆 達布巴
俊彥 竹內
秦業
米基 和泉 威爾卡森
史蒂芬妮 巴納斯
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美商第二基因體公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2/00Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
TW107112165A 2017-04-07 2018-04-09 用於治療上皮細胞屏障功能病症的蛋白質 TWI797116B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762482963P 2017-04-07 2017-04-07
US62/482,963 2017-04-07
US201762607706P 2017-12-19 2017-12-19
US62/607,706 2017-12-19
US201762611334P 2017-12-28 2017-12-28
US62/611,334 2017-12-28

Publications (2)

Publication Number Publication Date
TW201841649A TW201841649A (zh) 2018-12-01
TWI797116B true TWI797116B (zh) 2023-04-01

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TW107112165A TWI797116B (zh) 2017-04-07 2018-04-09 用於治療上皮細胞屏障功能病症的蛋白質

Country Status (12)

Country Link
US (3) US10251933B2 (enExample)
EP (1) EP3606542A4 (enExample)
JP (2) JP7789303B2 (enExample)
KR (2) KR102903277B1 (enExample)
CN (1) CN110769844B (enExample)
AU (2) AU2018248324B2 (enExample)
CA (1) CA3059354A1 (enExample)
IL (1) IL269853A (enExample)
MX (2) MX393998B (enExample)
SG (1) SG11201909334TA (enExample)
TW (1) TWI797116B (enExample)
WO (1) WO2018187682A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251933B2 (en) 2017-04-07 2019-04-09 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
EP3773644A4 (en) * 2018-04-06 2021-06-02 Second Genome, Inc. PROTEINS FOR TREATMENT OF EPITHELIAL BARRIER FUNCTION DISORDERS
JP2022512639A (ja) * 2018-10-09 2022-02-07 セカンド ゲノム インコーポレイテッド 上皮バリア機能障害の治療に有効なタンパク質を送達するためのラクトコッカス・ラクティス発現系
US20210079086A1 (en) * 2019-08-21 2021-03-18 Astrazeneca Collaboration Ventures, Llc Use of Brazikumab to Treat Crohn's Disease
EP4087859A4 (en) * 2020-01-10 2024-02-14 National Taipei University of Technology PEPTIDE INTERACTING WITH THE TOLL-LIKE RECEPTOR 2 AND COMPOSITION THEREOF
CN113773364B (zh) * 2021-08-25 2023-04-28 无锡市儿童医院 小分子肽及其制备方法和应用
JP2025542567A (ja) * 2022-11-04 2025-12-26 ミンク セラピューティクス,インコーポレイティッド B細胞成熟抗原(bcma)キメラ抗原受容体インバリアントナチュラルキラーt細胞及びその用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌
CN105407908A (zh) * 2013-04-10 2016-03-16 4D制药研究有限公司 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5571702A (en) 1991-03-29 1996-11-05 Genentech, Inc. Amplification method for detection of human PF4A receptors
AR053579A1 (es) * 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
ES2568938T3 (es) 2009-04-28 2016-05-05 Vanderbilt University Composiciones y procedimientos de tratamiento de trastornos que implican apoptosis de células epiteliales
JP2014093482A (ja) 2012-11-06 2014-05-19 Toshiba Corp 固体撮像装置の製造方法および固体撮像装置
WO2015014973A2 (en) * 2013-07-31 2015-02-05 Institut National De La Recherche Agronomique Use of specific glycoside phosphorylases for the implementation of phosphorolysis or reverse phosphorolysis reactions
WO2016203221A1 (en) * 2015-06-15 2016-12-22 4D Pharma Research Limited Compositions comprising bacterial strains
US10251933B2 (en) 2017-04-07 2019-04-09 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) * 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11174293B2 (en) 2017-06-02 2021-11-16 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌
CN105407908A (zh) * 2013-04-10 2016-03-16 4D制药研究有限公司 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
網路文獻 UniProtKB G2T1E5 2011/11/16 *

Also Published As

Publication number Publication date
JP2024037834A (ja) 2024-03-19
JP2020516615A (ja) 2020-06-11
EP3606542A4 (en) 2021-01-20
SG11201909334TA (en) 2019-11-28
AU2023202844A1 (en) 2023-07-06
MX393998B (es) 2025-03-24
US20240066095A1 (en) 2024-02-29
US20180289770A1 (en) 2018-10-11
CA3059354A1 (en) 2018-10-11
KR20230144097A (ko) 2023-10-13
WO2018187682A1 (en) 2018-10-11
AU2018248324B2 (en) 2023-02-09
US10251933B2 (en) 2019-04-09
CN110769844B (zh) 2025-01-21
EP3606542A1 (en) 2020-02-12
AU2018248324A1 (en) 2019-10-31
US20200148728A1 (en) 2020-05-14
US11207376B2 (en) 2021-12-28
CN110769844A (zh) 2020-02-07
MX2022008842A (es) 2022-08-02
IL269853A (en) 2019-11-28
KR102903277B1 (ko) 2025-12-23
TW201841649A (zh) 2018-12-01
KR20200003821A (ko) 2020-01-10
MX2019012051A (es) 2020-02-12
JP7789303B2 (ja) 2025-12-22

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