CN110769844B - 用于治疗上皮屏障功能紊乱的蛋白质 - Google Patents

用于治疗上皮屏障功能紊乱的蛋白质 Download PDF

Info

Publication number
CN110769844B
CN110769844B CN201880037987.0A CN201880037987A CN110769844B CN 110769844 B CN110769844 B CN 110769844B CN 201880037987 A CN201880037987 A CN 201880037987A CN 110769844 B CN110769844 B CN 110769844B
Authority
CN
China
Prior art keywords
seq
protein
amino acid
therapeutic
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201880037987.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN110769844A (zh
Inventor
A·W·韩
A·W·古德耶
T·古亚
T·Z·德桑蒂斯
K·达巴
T·竹内
Y·金
M·I·威尔科匈
S·巴纳斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geneva Co
Original Assignee
Geneva Co
Second Genome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneva Co, Second Genome Inc filed Critical Geneva Co
Publication of CN110769844A publication Critical patent/CN110769844A/zh
Application granted granted Critical
Publication of CN110769844B publication Critical patent/CN110769844B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Prostheses (AREA)
CN201880037987.0A 2017-04-07 2018-04-06 用于治疗上皮屏障功能紊乱的蛋白质 Expired - Fee Related CN110769844B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762482963P 2017-04-07 2017-04-07
US62/482,963 2017-04-07
US201762607706P 2017-12-19 2017-12-19
US62/607,706 2017-12-19
US201762611334P 2017-12-28 2017-12-28
US62/611,334 2017-12-28
PCT/US2018/026447 WO2018187682A1 (en) 2017-04-07 2018-04-06 Proteins for the treatment of epithelial barrier function disorders

Publications (2)

Publication Number Publication Date
CN110769844A CN110769844A (zh) 2020-02-07
CN110769844B true CN110769844B (zh) 2025-01-21

Family

ID=63710147

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880037987.0A Expired - Fee Related CN110769844B (zh) 2017-04-07 2018-04-06 用于治疗上皮屏障功能紊乱的蛋白质

Country Status (12)

Country Link
US (3) US11207376B2 (enExample)
EP (1) EP3606542B1 (enExample)
JP (2) JP7789303B2 (enExample)
KR (2) KR20200003821A (enExample)
CN (1) CN110769844B (enExample)
AU (2) AU2018248324B2 (enExample)
CA (1) CA3059354A1 (enExample)
IL (1) IL269853A (enExample)
MX (2) MX393998B (enExample)
SG (1) SG11201909334TA (enExample)
TW (1) TWI797116B (enExample)
WO (1) WO2018187682A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207376B2 (en) 2017-04-07 2021-12-28 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2019195859A1 (en) * 2018-04-06 2019-10-10 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2020077010A1 (en) * 2018-10-09 2020-04-16 Second Genome, Inc. Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders
JP2022544992A (ja) * 2019-08-21 2022-10-24 アストラゼネカ・コラボレイション・ベンチャーズ・リミテッド・ライアビリティ・カンパニー クローン病を治療するためのブラジクマブの使用
WO2021139766A1 (en) * 2020-01-10 2021-07-15 Huang Chih Hung Peptide interacting with toll-like receptor 2 and the composition comprising the same
CN113773364B (zh) * 2021-08-25 2023-04-28 无锡市儿童医院 小分子肽及其制备方法和应用
EP4611774A2 (en) * 2022-11-04 2025-09-10 MiNK Therapeutics, Inc. B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5856457A (en) 1991-03-29 1999-01-05 Genentech, Inc. Nucleic acids encoding a human IL-8 receptor
US6734289B2 (en) 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US20060189526A1 (en) 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
AR053579A1 (es) * 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
ES2568938T3 (es) 2009-04-28 2016-05-05 Vanderbilt University Composiciones y procedimientos de tratamiento de trastornos que implican apoptosis de células epiteliales
JP2014093482A (ja) 2012-11-06 2014-05-19 Toshiba Corp 固体撮像装置の製造方法および固体撮像装置
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2015014973A2 (en) * 2013-07-31 2015-02-05 Institut National De La Recherche Agronomique Use of specific glycoside phosphorylases for the implementation of phosphorolysis or reverse phosphorolysis reactions
EP3662917A1 (en) 2015-06-15 2020-06-10 4D Pharma Research Limited Compositions comprising bacterial strains
US11666627B2 (en) * 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11207376B2 (en) 2017-04-07 2021-12-28 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11174293B2 (en) 2017-06-02 2021-11-16 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2019195859A1 (en) 2018-04-06 2019-10-10 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G2T1E5.UniProtKB，https://www.uniprot.org/uniprotkb/G2T1E5/entry#sequences.2011,第1-2页第第25-256个氨基酸. *

Also Published As

Publication number Publication date
IL269853A (en) 2019-11-28
MX393998B (es) 2025-03-24
KR20230144097A (ko) 2023-10-13
US20240066095A1 (en) 2024-02-29
KR20200003821A (ko) 2020-01-10
US20180289770A1 (en) 2018-10-11
EP3606542B1 (en) 2026-06-10
US10251933B2 (en) 2019-04-09
US12661383B2 (en) 2026-06-23
JP2024037834A (ja) 2024-03-19
CN110769844A (zh) 2020-02-07
WO2018187682A1 (en) 2018-10-11
TWI797116B (zh) 2023-04-01
SG11201909334TA (en) 2019-11-28
AU2023202844A1 (en) 2023-07-06
TW201841649A (zh) 2018-12-01
US11207376B2 (en) 2021-12-28
MX2019012051A (es) 2020-02-12
MX2022008842A (es) 2022-08-02
JP7789303B2 (ja) 2025-12-22
EP3606542A4 (en) 2021-01-20
US20200148728A1 (en) 2020-05-14
CA3059354A1 (en) 2018-10-11
AU2018248324B2 (en) 2023-02-09
EP3606542A1 (en) 2020-02-12
AU2018248324A1 (en) 2019-10-31
JP2020516615A (ja) 2020-06-11
KR102903277B1 (ko) 2025-12-23

Similar Documents

Publication Publication Date Title
US20240066095A1 (en) Proteins for the treatment of epithelial barrier function disorders
US12168677B2 (en) Proteins for the treatment of epithelial barrier function disorders
US11505583B2 (en) Proteins for the treatment of epithelial barrier function disorders
US12186364B2 (en) Proteins for the treatment of epithelial barrier function disorders
US20210380994A1 (en) Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders
US11534482B2 (en) C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency
US11666627B2 (en) Proteins for the treatment of epithelial barrier function disorders
WO2019213105A1 (en) Methods and compositions involving plantaricin ef (plnef)
US12371456B2 (en) Proteins for the treatment of epithelial barrier function disorders
WO2012156811A2 (en) Compositions useful for the treatment of inflammatory disease or disorders
EP4367217A1 (en) Recombinant microorganism-based methods and compositions for treatment of disease

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20240826

Address after: California, USA

Applicant after: Geneva Co.

Country or region after: U.S.A.

Address before: California, USA

Applicant before: Second genome Co.,Ltd.

Country or region before: U.S.A.

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20250121

CF01 Termination of patent right due to non-payment of annual fee