TWI773205B - Edible composition, food and use for relieving visual fatigue and preventing glaucoma - Google Patents

Abstract

The present invention provides an edible composition, food and use thereof for relieving visual fatigue and preventing glaucoma. The composition comprises, in parts by weight, 1-10 parts of turmeric powder, 1-12 parts of whole coffee fruit extract, 1-20 parts of phospholipid complex, 1-15 parts of DHA, 0.5-5 parts of phospholipids Serine and 0.1-5 servings of vitamin C. The edible composition provided by the present invention has the effect of relieving visual fatigue. After the test subjects for 1 week, the persistence of photopic vision is improved and has a significant difference with that before the test; There was a significant difference before the test; after 8 weeks of the test, the visual field of the subjects increased significantly, indicating that this formula can prevent the occurrence of glaucoma. The combination of the whole coffee fruit extract of the present invention and the other five raw materials has a better synergistic effect.

Description

Edible composition, food and same for relieving visual fatigue and preventing glaucoma use

The invention belongs to the technical field of food, and relates to an edible composition, food and use thereof for relieving visual fatigue and preventing glaucoma.

Visual fatigue is a common eye disease characterized by dry eyes, soreness, double vision (diplopia), and intermittent blurred vision. In severe cases, nausea, vomiting, dizziness, headache, and neck muscles can occur Systemic symptoms such as tightness and shoulder pain reduce the work efficiency of adults, lead to learning disabilities in adolescents and children, and directly affect people's work and life. Mild visual fatigue is often not taken seriously by people, leading to aggravation of visual fatigue symptoms. Long-term repeated visual fatigue may cause a variety of eye diseases, such as dry eye syndrome, refractive error, VDT (visual display terminal) syndrome, computer Visual syndrome, which exacerbates the occurrence of age-related eye diseases.

Modern nutrition and medical research show that the causes of visual fatigue mainly include the following theories:

(1) Free radical theory: When the eyeball is in the search and gaze state for a long time, the metabolism of extraocular muscles and ciliary muscles increases, resulting in an increase in the production and accumulation of metabolic wastes (including oxygen free radicals), resulting in structural damage and functional decline of muscle cells. Studies have shown that free radicals can cause and exacerbate a variety of retinal diseases.

(2) The theory of visual cell nutrient depletion: the excessive consumption of visual cells and the untimely supply of required nutrients will prolong the recovery time of the macula and retina. Nutrients in visual cells mainly include lutein, VA, polyunsaturated fatty acids, VB1, VB2, trace minerals and so on.

(3) The theory of retinal damage: the focusing of visible light on the retina produces high oxygen pressure and high concentration of light, which is prone to lipid peroxidation and its products phagocytose retinal pigment epithelial cells, resulting in retinal damage.

(4) Retinal cell senescence theory: Retinal pigment epithelial cell senescence leads to aging of the eyes, which in turn leads to age-related eye diseases, such as decreased macular pigment optical density (MPOD).

Based on the problems in the prior art, the purpose of the present invention is to provide an edible composition for relieving visual fatigue and its application, which can effectively relieve visual fatigue and prevent the occurrence of glaucoma.

The object of the present invention is achieved through the following technical features: On the one hand, the present invention provides an edible composition, which comprises in parts by weight:

In the edible composition of the present invention, the phospholipid complex does not contain phosphatidylserine.

There is no report on the visual fatigue and optic nerve protection of the whole coffee fruit extract in the prior art. The inventor creatively found in the long-term experiment that the whole coffee fruit extract is combined with turmeric powder, phospholipid complex, DHA, phosphatidylserine. The acid and vitamin C mixed and eaten have the effect of relieving visual fatigue. Specifically, the composition obtained by these 6 raw materials was used for eating. The study found that after the test for 1 week, the visual endurance of the subjects improved and there was a significant difference from that before the test. The total score of visual fatigue symptoms decreased after the test for 2 weeks. And there is a significant difference from before the test; at the same time, the study found that when only consuming the single raw material whole coffee berry extract in this composition or only using the composition of the other 5 raw materials except the whole coffee berry extract, the subjects clearly There was no significant change in the visual persistence and the total score of visual fatigue symptoms, and the combination of the 6 raw materials had a synergistic effect on relieving visual fatigue; at the same time, it was found that after 8 weeks of consumption, the visual field of the subjects increased significantly, showing that This formula prevents the occurrence of glaucoma.

Raw materials such as turmeric powder, whole coffee fruit extract, phospholipid complex, DHA, phosphatidylserine and vitamin C used in the present invention can be obtained commercially, and can also be prepared according to the prior art. Each raw material should meet the relevant industry standard quality requirements.

In some specific embodiments, in the edible composition of the present invention, the content of the main active ingredient curcumin of the turmeric powder is more than 20%, for example: more than 30%, more than 40%, more than 50%, more than 60%, 70% or more % or more, more than 80%, or even more than 90%. The dosage of turmeric powder in the edible composition of the present invention can be appropriately adjusted according to the level of curcumin content in the turmeric powder.

In some specific embodiments, in the edible composition of the present invention, the whole coffee berry extract is a mixture extracted from the whole coffee fruit. be made of. 100% of the quality of whole coffee fruit extract In total, the active ingredients in the whole coffee fruit extract include 20%-50% of total chlorogenic acid and 0.5%-5% of proanthocyanidins; wherein, the total chlorogenic acid includes neochlorogenic acid, and the new green The proportion of ortho acids in the whole coffee fruit extract is 1%-20%.

In some specific embodiments, in the edible composition of the present invention, the main active ingredients in the phospholipid complex include phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol and ceramide, and the mass of the phospholipid complex is 100 %, wherein the content of phosphatidylethanolamine is 5%-5.5%, the content of phosphatidylcholine is 4%-5.5%, the content of phosphatidylinositol is 0.5%-1.8%, and the content of ceramide is 1.5% %-2.5%, the rest of the phospholipid complex also includes most of the protein and other components. The phospholipid complex used in the present invention can be purchased from Lecico GmbH, or can be prepared by itself according to the prior art.

In the above edible composition, preferably, the composition is composed of turmeric powder, whole coffee fruit extract, phospholipid complex, DHA, phospholipid serine and vitamin C.

In the edible composition of the present invention, according to the theory of free radicals and the theory of retinal depletion, adding turmeric powder can inhibit the lipid peroxidation mediated by metal ions, and protect the DNA inside the cells from the damage of oxidized lipids; vitamin C is an important nutritional component of crystals, Its content in crystals is much higher than other tissues. Insufficient intake of vitamin C will lead to turbid crystals, and in severe cases, cataracts may be caused. At the same time, vitamin C has strong antioxidant properties and can scavenge free radicals and reduce lipid peroxide levels. The present invention Adding vitamin C can effectively alleviate age-related eye diseases and visual damage; whole coffee fruit extract mainly contains total chlorogenic acid, neochlorogenic acid and proanthocyanidins, which can reduce the damage of lipid peroxides to the retina. According to the theory of visual cell nutrient depletion, DHA, phospholipid complex and phosphatidylserine are supplemented in the formula of the edible composition of the present invention. DHA is one of the most abundant polyunsaturated fatty acids in the retina, which can provide the nutrients needed for the growth of visual cells. By adding phospholipid complexes It can improve cognition and memory. The phospholipid choline in the phospholipid complex can generate choline through hydrolysis in the body, which is the precursor of the neurotransmitter acetylcholine synthesis; acetylcholine is the interaction between nerve cells in the brain. Transfer information, establish stable connections, and form the basic material for thinking and thinking ability; adequate intake of phosphatidylcholine is conducive to the formation of more neurotransmitter acetylcholine, which makes the brain more energetic and memory is enhanced. , thereby contributing to the improvement of intelligence. Phosphatidylserine can reduce excessive levels of stress hormones in the body, reduce stress, relieve brain fatigue, promote concentration, improve alertness and memory, and relieve negative emotions. According to the research in the specific embodiment of the present invention, it is shown that the composition of the six raw materials of the present invention has a synergistic effect, which is helpful for relieving visual fatigue and preventing the occurrence of glaucoma.

In addition, the effect of the whole coffee fruit extract in the present invention when matched with other five raw materials is better than that of bilberry extract, blueberry extract, grape seed extract and other extracts containing proanthocyanidins and the other five raw materials.

According to a specific embodiment of the present invention, preferably, the composition comprises in parts by weight:

In another aspect, the present invention also provides the use of the above edible composition in relieving visual fatigue. Specifically, the use of the edible composition in the preparation of food with the effect of relieving visual fatigue is provided.

In another aspect, the present invention also provides the use of the above edible composition for preventing glaucoma. Specifically, there is provided the use of the edible composition in the preparation of a food having a glaucoma preventive effect.

According to a specific embodiment of the present invention, in the above application, the food includes an effective amount of the above edible composition, and may optionally include auxiliary materials.

The adjuvant may be a common adjuvant in the food field, such as, but not limited to, a combination of one or more of sorbitol, maltodextrin, magnesium stearate, lactose, and whole milk powder.

According to a specific embodiment of the present invention, in the above application, the food is in the form of tablet, capsule, powder or granule, but not limited thereto. The preparation of the tablet, capsule, powder or granule can be carried out with reference to the prior art.

In yet another aspect, the present invention also provides a food, calculated on the basis of the total mass of the food as 100%, comprising:

In the above-mentioned food, in addition to 6 kinds of nutrients, it also includes common auxiliary materials in the food field, such as: sorbitol, maltodextrin, magnesium stearate, lactose, whole milk powder in one or more combinations, but Not limited to this.

According to a specific embodiment of the present invention, preferably, the total mass of the food is 100%, including:

In another aspect, the present invention also provides the use of the above food for relieving visual fatigue.

In another aspect, the present invention also provides the use of the above food in preventing glaucoma.

The edible composition provided by the present invention has the effect of relieving visual fatigue. After the test subjects for 1 week, the persistence of photopic vision is improved and has a significant difference with that before the test; There was a significant difference before the test; after 8 weeks of the test, the visual field of the subjects increased significantly, indicating that this formula can prevent the occurrence of glaucoma. The combination of the whole coffee fruit extract of the present invention and the other five raw materials has a better synergistic effect.

Figure 1 is a comparison diagram of changes in the visual field range of subjects before and after consumption of different groups of compositions in Example 1 of the present invention.

In order to have a clearer understanding of the technical features, purposes and beneficial effects of the present invention, the technical solutions of the present invention are now described in detail below, but should not be construed as limiting the scope of implementation of the present invention. The raw materials in the following examples are generally commercially available unless otherwise specified.

Embodiment 1: This embodiment provides an edible composition for relieving visual fatigue, the composition comprises in parts by weight:

Among them, the curcumin content in turmeric powder is about 20%-30%, the total chlorogenic acid content in the whole coffee fruit extract is about 30%-40%, the neochlorogenic acid content is about 10%-20%, and the proanthocyanidin content is about 10%-20%. 1%-5%. The content of phospholipid ethanolamine in the phospholipid complex is about 5%-5.5%, and the content of phospholipid choline is about 5%-5.5%. The content is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide is about 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, whole coffee fruit extract (from coffee fruit extracted by ethanol aqueous solution, concentrated and dried), phospholipid complex (purchased from Lecico GmbH), DHA, Phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose and whole milk powder are uniformly mixed and pressed into tablets to prepare an edible composition for relieving visual fatigue.

The composition prepared in this example was given to the test subjects (4.8g/day consumption), and the control group adopted the placebo group (except for other identical auxiliary materials and contents, 6 kinds of active ingredients and contents were supplemented with maltodextrin). ), to investigate the changes in photopic persistence (Table 1) and the total score of visual fatigue symptoms (Table 2) during the trial period of different groups. The results are as follows:

Note: P<0.01 compared with before food test; P<0.05 compared with a before test food; P<0.01 compared with B compared with placebo group, P<0.05 compared with b compared with placebo group, the same is true in the table below.

From Table 1 and Table 2, it can be seen that there was no significant difference in the visual acuity persistence and total score of visual fatigue symptoms among subjects before the food test (P>0.05), which was comparable between groups. After 8 weeks of trial food, compared with the total score of visual fatigue symptoms in the placebo group before and after the trial food, there was no statistical significance (P>0.05). There were significant differences (P<0.05) after 1 week of trial food compared with those before trial food and the placebo group, and the improvement rate of photopic vision persistence in the composition group of Example 1 was greater than 10%; at the same time, the composition group of Example 1 The total score of visual fatigue symptoms decreased, which was significantly different from that before the food test (P<0.05). Therefore, the composition group of Example 1 helped to relieve visual fatigue.

In addition, the initial symptom of glaucoma is reduced visual field. It can be seen from Figure 1 that after 8 weeks of eating the composition of Example 1, the visual field of the subjects increased significantly, indicating that this formula can prevent the occurrence of glaucoma.

Embodiment 2: This embodiment provides an edible composition for relieving visual fatigue, the composition comprises in parts by weight:

Among them, the curcumin content in turmeric powder is about 20%-30%, the total chlorogenic acid content in the whole coffee fruit extract is about 30%-40%, the neochlorogenic acid content is about 10%-20%, and the proanthocyanidin content is about 10%-20%. 1%-5%. The content of phosphatidylethanolamine in the phospholipid complex is about 5%-5.5%, the content of phosphatidylcholine is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide About 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, whole coffee fruit extract (from coffee fruit extracted by ethanol aqueous solution, concentrated and dried), phospholipid complex (purchased from Lecico GmbH), DHA, Phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose and whole milk powder are uniformly mixed and pressed into tablets to prepare an edible composition for relieving visual fatigue.

Embodiment 3: This embodiment provides an edible composition for relieving visual fatigue, the composition comprises in parts by weight:

Among them, the curcumin content in turmeric powder is about 20%-30%, the total chlorogenic acid content in the whole coffee fruit extract is about 30%-40%, the neochlorogenic acid content is about 10%-20%, and the proanthocyanidin content is about 10%-20%. 1%-5%. The content of phosphatidylethanolamine in the phospholipid complex is about 5%-5.5%, the content of phosphatidylcholine is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide About 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, whole coffee fruit extract (from coffee fruit extracted by ethanol aqueous solution, concentrated and dried), phospholipid complex (purchased from Lecico GmbH), DHA, Phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose and whole milk powder are uniformly mixed and pressed into tablets to prepare an edible composition for relieving visual fatigue.

Comparative Example 1: This comparative example provides an edible composition for relieving visual fatigue, the composition comprising in parts by weight:

Among them, the total chlorogenic acid content in the whole coffee fruit extract is about 30%-40%, the neochlorogenic acid content is about 10%-20%, and the proanthocyanidin content is about 1%-5%.

The preparation method of the composition is as follows: weighing the whole coffee fruit extract (prepared by extracting the coffee fruit through ethanol aqueous solution, concentrating and drying), sorbitol, magnesium stearate, lactose, whole milk powder and wheat flour according to the weight ratio The buddyxtrin is uniformly mixed and tableted to prepare an edible composition for relieving visual fatigue.

Comparative Example 2: This comparative example provides an edible composition for relieving visual fatigue, the composition comprising in parts by weight:

Among them, the curcumin content in turmeric powder is about 20%-30%. The content of phosphatidylethanolamine in the phospholipid complex is about 5%-5.5%, the content of phosphatidylcholine is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide About 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, phospholipid complex (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, whole fat according to weight ratio The milk powder and maltodextrin are mixed uniformly and pressed into tablets to prepare an edible composition for relieving visual fatigue.

Comparative Example 1 Compared with Example 1 of the present invention, only one active ingredient, whole coffee berry extract, was added, and the amount of the active ingredient was the same. Compared with Example 1 of the present invention, Comparative Example 2 did not add the active ingredient whole coffee fruit extract, but added five other active ingredients, turmeric powder, phospholipid complex, DHA, phospholipid serine, and vitamin C. According to the experimental method of Example 1, the experimental results are shown in Table 3 and Table 4 below.

From Table 3 and Table 4, it can be seen that after 9 weeks of trial food, the composition group of Comparative Example 1 and the composition group of Comparative Example 2 have no significant changes in the duration of photopic vision and the total score of visual fatigue symptoms, and there is no significant change compared with the placebo group. sexual differences.

It can be seen that the effect of relieving visual fatigue can be achieved only after all the effective raw materials in the composition are mixed and eaten, and it is difficult to achieve the effect of relieving visual fatigue by using some of the raw materials.

Comparative Example 3: This comparative example provides an edible composition, which is different from Example 1 in that the whole coffee fruit extract is replaced with a commercially available grape seed extract, and the composition comprises in parts by weight:

Among them, the content of curcumin in turmeric powder is about 20%-30%, and the content of proanthocyanidins in grape seed extract is not less than 90%. The content of phosphatidylethanolamine in the phospholipid complex is about 5%-5.5%, the content of phosphatidylcholine is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide About 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, grape seed extract, phospholipid complex (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate according to weight ratio , lactose, whole milk powder and maltodextrin are evenly mixed and pressed into tablets to prepare an edible composition for relieving visual fatigue.

Comparative Example 4: This comparative example provides an edible composition, which is different from Example 1 in that the whole coffee berry extract is replaced with a commercially available blueberry extract, and the composition comprises in parts by weight:

Among them, the curcumin content in turmeric powder is about 20%-30%, and the anthocyanin content in blueberry extract is not less than 20%. The content of phosphatidylethanolamine in the phospholipid complex is about 5%-5.5%, the content of phosphatidylcholine is about 4%-5.5%, the content of phosphatidylinositol is about 0.5%-1.8%, and the content of ceramide About 1.5%-2.5%.

The preparation method of the composition is as follows: weighing turmeric powder, blueberry extract, phospholipid complex (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, Lactose, whole milk powder and maltodextrin are uniformly mixed and tableted to prepare an edible composition for relieving visual fatigue.

90%)要遠高於本發明的全咖啡果實提取物中的有效成分原花青素(含量1%-5%)，且不含有全咖啡果實提取物的有效成分總綠原酸及新綠原酸；藍莓提取物中的有效成分為花青素(含量

20%)，其不同於本發明全咖啡果實提取物的有效成分。按照實施例1的實驗方法，將對比例3 和對比例4製備的組合物給予受試者試食(4.8g/天食用量)，考察不同組別試食期間明視覺持久度的變化，實驗結果如下述表5所示。 Comparative Example 3 and Comparative Example 4 are compared with Example 1 of the present invention, only the whole coffee fruit extract is replaced by grape seed extract and blueberry extract respectively, the amount of each extract is the same, and the active ingredient proanthocyanidin (content) in the grape seed extract is the same.

90%) is much higher than the active ingredient proanthocyanidins (content 1%-5%) in the whole coffee berry extract of the present invention, and does not contain the active ingredients total chlorogenic acid and neochlorogenic acid of the whole coffee berry extract; blueberry The active ingredient in the extract is anthocyanin (content

20%), which is different from the active ingredient of the whole coffee berry extract of the present invention. According to the experimental method of Example 1, the compositions prepared in Comparative Example 3 and Comparative Example 4 were given to subjects to test food (4.8 g/day consumption), and the changes in photopic vision persistence during the trial feeding of different groups were investigated. The experimental results are as follows shown in Table 5.

It can be seen from Table 5 that after 4 weeks of trial food, the composition group of Comparative Example 3 and the composition group of Comparative Example 4 have no obvious changes in the persistence of photopic vision. In combination with Table 1, it can be seen that the experimenter ate the combination of Example 1 for 1 week. The visual durability of Wuming has been significantly improved.

To sum up, it can be seen that the effect of relieving visual fatigue can be achieved only after all the effective raw materials in the composition of the present invention are mixed and eaten, and it is difficult to achieve the effect of relieving visual fatigue by using some of the raw materials. At the same time, the effect of the whole coffee fruit extract of the present invention when matched with other 5 kinds of raw materials is better than that of bilberry extract, blueberry extract, grape seed extract and other extracts containing proanthocyanidins and anthocyanins when matched with other 5 kinds of raw materials after effect.

Claims (13)

An edible composition for relieving visual fatigue and preventing glaucoma, the composition comprises in parts by weight:

The edible composition according to claim 1, wherein, based on the mass of the whole coffee fruit extract as 100%, the active ingredients in the whole coffee fruit extract include 20%-50% of total chlorogenic acid and 0.5% of total chlorogenic acid. %-5% of proanthocyanidins; wherein, the total chlorogenic acid includes neochlorogenic acid, and the proportion of the neochlorogenic acid in the whole coffee fruit extract is 1%-20%. The edible composition according to claim 1, wherein, based on the mass of the phospholipid complex as 100%, the active ingredients in the phospholipid complex include 5%-5.5% phospholipid ethanolamine, 4%-5.5% phospholipid ethanolamine Phosphatidylcholine, 0.5%-1.8% phosphatidylinositol and 1.5%-2.5% ceramide. The edible composition of claim 1, which consists of turmeric powder, whole coffee berry extract, phospholipid complex, DHA, phospholipid serine and vitamin C. The edible composition according to claim 1, comprising in parts by weight: 8 parts of turmeric powder,

Use of the edible composition according to any one of claims 1 to 5 in the preparation of food with the effect of relieving visual fatigue. A use of the edible composition according to any one of claims 1 to 5 in the preparation of food with glaucoma prevention efficacy. The use according to claim 6 or 7, wherein the food comprises an effective amount of the edible composition of any one of claims 1-5. The use according to claim 8, wherein the food further includes auxiliary materials. The use according to claim 9, wherein the adjuvant comprises a combination of one or more of sorbitol, maltodextrin, magnesium stearate, lactose, and whole milk powder. The use according to claim 9, wherein the food is in the form of tablets, capsules, powders or granules. A food for relieving visual fatigue and preventing glaucoma, based on 100% of the total mass of the food, comprising:

The food according to claim 12, wherein, based on the total mass of the food as 100%, comprising:

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