TWI711474B - Use of a gum tragacanth composition for reducing skin sagging and improving skin brightness - Google Patents

Abstract

The present invention provides uses of a gum tragacanth composition for manufacture of composition for reducing skin sagging or improving skin brightness. The gum tragacanth composition, including a gum tragacanth and a pharmaceutically acceptable carrier, is effective in skin tightening, moisturizing, and brightening while being topically administered to skin at least once a day.

Description

Use of snow swallow composition for reducing skin laxity and enhancing skin luster

The present invention relates to the use of a snow swallow composition, in particular to the use of a snow swallow composition to prepare a composition for reducing skin laxity or enhancing skin luster.

Skin is the primary line of defense for the human body to isolate the human body from damage in the external environment, such as ultraviolet rays, pathogens, friction, etc., and to prevent moisture loss. The skin includes the epidermis layer, the dermis layer mainly composed of connective tissue, and the subcutaneous tissue from the outside to the inside. As we age, wrinkles, fine lines, sagging, sunken, and enlarged pores will appear on the skin. The formation of these skin aging phenomena is related to many factors, such as the lack of hyaluronic acid in the dermis, the lack of collagen and elastin, etc., which will reduce the fullness and elasticity of the skin.

The methods on the market to improve the aforementioned skin aging phenomenon include direct injection of collagen or hyaluronic acid into the dermis, and oral supplementation of collagen or hyaluronic acid. However, collagen or hyaluronic acid injected into the skin is easily decomposed by enzymes in the body over time, so that these substances must be administered regularly, which is costly; oral supplementation of collagen or hyaluronic acid will cause these macromolecules to be digested in the gastrointestinal tract Amino acids or monosaccharides are small molecules. Although the body can use these amino acids or monosaccharides to synthesize proteins or polysaccharides, it is not limited to collagen or hyaluronic acid. Therefore, the effect of supplementing collagen or hyaluronic acid is actually limited.

In order to effectively maintain the elasticity and firmness of the skin or increase the moisture content of the skin, researchers have tried to develop novel topical skin care compositions. Considering that modern people pay attention to the use of natural ingredients in skin care products as much as possible, it is really necessary for the auto plant community to find new materials that are safe and can fight skin aging.

The snow swallow tree ( Gum tragacanth ) is native to the dry areas of eastern Mediterranean and plateaus or deserts in southwest and north Asia. It is also distributed in a small amount in Southeast Asia. Its pith secretion is white and transparent, and is generally called snow swallow. Studies have found that snow swallows are rich in polysaccharides and galacturonic acid, which are known to be used to enhance immunity, fight upper respiratory tract infections, and improve diarrhea. However, its effect on skin care remains to be clarified.

Therefore, an object of the present invention is to provide a use of a snow swallow composition for preparing a composition for reducing skin laxity, wherein the snow swallow composition comprises a snow swallow and a pharmaceutically acceptable carrier.

In an embodiment of the present invention, the snow swallow composition comprises snow swallows at a concentration of 1% (w/v) or more; the pharmaceutically acceptable carrier system is water, organic solvent, or a combination thereof in any ratio; The snow swallow composition is topically applied to the skin at least once a day.

In an embodiment of the present invention, the composition for reducing skin laxity is a medicine, a skin care product, or a cosmetic, which can be cream, lotion, dispersion, foam, gel, ointment, powder, It is presented in the form of a patch or mask, and may further include hydroquinone, arbutin, salicylic acid, fruit acid, or any combination thereof.

Another object of the present invention is to provide a use of the snow swallow composition for preparing a composition for enhancing skin luster.

The present invention discloses that the snow swallow composition can significantly reduce skin laxity, and increase skin moisture content and luster, thereby achieving the effect of skin tightening and helping to improve skin aging phenomena such as wrinkles, sagging, depression, and enlarged pores. Therefore, the snow swallow composition can be used to prepare a safe and effective composition for reducing skin laxity or enhancing skin luster.

The following will further illustrate the implementation of the present invention in conjunction with the drawings. The following examples are used to illustrate the inventive features and applications of the present invention, rather than limiting the scope of the present invention. Anyone familiar with the art will not depart from Within the spirit and scope of the present invention, some changes and modifications can be made. Therefore, the protection scope of the present invention shall be subject to those defined by the appended patent scope.

Figure 1 shows the skin laxity changes of the snow swallow mask filled with 1% snow swallow composition before and 60 minutes after application to the subject's skin, with the subject's skin laxity before application being 100%.

Figure 2 shows the change of skin laxity before and after the 1% snow swallow composition was continuously applied to the skin of the subject for 28 days, with the skin laxity of the subject before the application being 100%.

Figure 3 shows the changes in skin moisture content before and after the 1% snow swallow composition was continuously applied to the skin of the subject for 28 days, taking the subject's skin moisture content as 100% before application.

Figure 4 shows the change in skin gloss before and after the 1% snow swallow composition was continuously applied to the skin of the subject for 28 days, with the skin gloss of the subject before the application being 100%.

The present invention provides a use of a snow swallow composition for preparing a composition for reducing skin laxity or enhancing skin luster. The so-called snow swallow composition of the present invention comprises a snow swallow and a pharmaceutically acceptable carrier. The snow swallow refers to any form of snow swallow tree pith secretions, such as gelled, massive or powdered snow swallows. The pharmaceutically acceptable carrier system is water, organic solvent, or a combination in any ratio. The following examples prove through skin laxity, skin moisture content, and skin gloss tests that continuous application of snow swallow composition to the skin can effectively reduce skin laxity, and increase skin moisture content and gloss.

definition

The numerical values used herein are approximate values, and all experimental data are expressed in the range of 20%, preferably in the range of 10%, and most preferably in the range of 5%.

Materials and Methods Preparation of snow swallow composition

Grind the snow swallows from Myanmar into powder, then dissolve 0.1-10g snow swallow powder in 1-100mL solvent, and mix homogeneously to obtain a snow swallow composition with a concentration of 0.1-10% (w/v) . The solvent can be water, an organic solvent, or a combination thereof in any ratio, wherein the organic solvent can be an alcohol, such as ethanol, propylene glycol, and glycerol.

Skin laxity test

The skin laxity was measured using a skin elasticity tester Cutometer Dual MPA 580 (Courage+Khazaka electronic GmbH, Germany). During the test, the skin elasticity probe connected to the skin elasticity tester is in contact with the subject’s skin area to be tested. A closed space is formed on the skin surface and negative pressure is applied to pull up the skin, and then air is introduced to make the skin rebound. To the normal state, at the same time, the light reflection is used to detect the height of the skin being pulled up, and the skin laxity parameter of the area to be measured is calculated. Because the external temperature and humidity and other factors will affect the skin relaxation, the subject must first enter the constant temperature and humidity room to balance for 10 minutes before testing. The environmental conditions of the test are temperature 20℃±1℃, relative humidity 50%±5%.

Skin moisture test

The skin moisture content was measured using the DermaLab Combo (Cortex Technologies, Denmark) moisturizing module of an ultrasonic skin quality analyzer. During the test, the probe of the ultrasonic skin quality analyzer is used to press the test area of the subject's skin, and the skin moisture content of the test area is measured by the change in conductivity. Because the external temperature and humidity and other factors will affect the skin moisture content, the subject must first enter the constant temperature and humidity room to balance for 20 minutes before testing. The environmental conditions of the test are temperature 20℃±1℃, relative humidity 50%±5%.

Skin gloss test

The skin gloss is obtained by using a high-resolution single-lens camera with two light sources (light sources with full-range wavelength and polarized wavelength) to photograph the subject’s facial skin in a closed studio. After obtaining a clear image file, it is analyzed by image software. Got.

Statistical Analysis

Statistically significant differences are determined by the student t test of Excel software.

Example 1 Skin firming effect of snow swallow composition

This example examines the skin tightening effect of the snow swallow composition. A snow swallow mask filled with 1% snow swallow composition (containing a base solvent, and its ingredients include water, cinnamon, hexanediol, 1,3-butanediol, sanxian gum, thickener, and triethanolamine) And the control mask filled with only the base solvent was applied to the skin of the inner arm of 5 subjects for 20 minutes, and the applied area was slightly massaged with the fingertips to promote the absorption of the snow swallow composition or the base solvent, and then applied Before and 60 minutes after application, the skin relaxation of the subjects was measured with a skin elasticity tester. The results of the experiment are shown in Figure 1. After 60 minutes of applying the snow swallow mask to the skin, the subject’s skin laxity decreased by about 14%. Compared with the control mask, the subject’s skin laxity was only reduced by about 8%. The results prove that the snow swallow composition significantly improves skin firmness.

Example 2 Long-term effects of snow swallow composition on skin firmness, skin moisturization, and skin luster

In order to verify whether the skin tightening effect caused by the snow swallow composition can be maintained for a long time, in this example, 8 subjects aged 25 to 40 years old were asked to apply 1% on their left and right faces every morning and evening after cleansing their faces. Snow swallow composition (contains a base solvent, its ingredients include water, cinnamon, hexanediol, 1,3-butanediol, sanxian gum, thickener, and triethanolamine) and a base solvent (the ingredients include water, Xanthanone, hexylene glycol, 1,3-butanediol, sanxian gum, thickener and triethanolamine), massage the face with fingertips to promote the absorption of snow swallow composition or base solvent, and The skin laxity of the subjects was measured before application and after continuous application for 28 days. The experimental results are shown in Figure 2. Compared with using the base solvent alone, the skin laxity can only be reduced by about 8.2%. The application of 1% snow swallow composition in the morning and evening for 28 consecutive days can reduce the skin laxity of subjects by about 22.7%. This result shows that the Xueyan composition can continuously improve skin sagging.

In order to further evaluate the effect of Xueyan composition on skin moisturizing and skin luster, this example also measured the skin moisture content and skin luster of the left and right faces of the aforementioned subjects before application and 28 days after continuous application. Figure 3 shows the changes in skin moisture content of the aforementioned subjects; Figure 4 shows the changes in skin gloss of the aforementioned subjects. According to Figure 3, compared to using a base solvent, the skin moisture content will be increased by about 8.1%. Applying 1% snow swallow composition in the morning and evening for 28 consecutive days can increase the subject’s skin moisture content by 22.7%, showing that the snow swallow composition has skin Moisturizing effect. According to Fig. 4, compared with the use of a base solvent to significantly improve skin luster, applying 1% snow swallow composition in the morning and evening for 28 consecutive days can significantly increase the skin luster of subjects, which proves that the snow swallow composition has a skin lightening effect.

In summary, the present invention proves that the snow swallow composition can effectively reduce skin laxity, and increase skin moisture content and luster, thereby achieving the effect of skin tightening. Based on the obvious improvement of the skin laxity of the Xueyan composition, it is presumed that its skin tightening effect can be attributed to the increase in the content of elastin in the skin. Therefore, the snow swallow composition can be used to prepare a composition that reduces skin laxity or enhances skin luster, such as a medicine, skin care product, or cosmetic for topical application to the skin, which can be cream, emulsion, dispersion, foam, gel It is presented in the form of glue, ointment, powder, patch, or mask, and may further contain hydroquinone, arbutin, salicylic acid, fruit acid, or any combination thereof.

Claims (10)

A use of a snow swallow composition for preparing a composition for reducing skin laxity, wherein the snow swallow composition is prepared from a snow swallow powder and a base solvent, and the snow swallow composition contains a concentration of 1% (w /v) Snow swallow, the base solvent includes at least one of water, alcohol, thickener, antibacterial agent and pH balance agent or a combination in any ratio. The use described in item 1 of the scope of patent application, wherein the composition is topically applied to the skin at least once a day. The use as described in item 1 of the scope of patent application, wherein the composition is a skin care product or a cosmetic. The use described in item 1 of the scope of patent application, wherein the composition is presented in the form of cream, lotion, dispersion, foam, gel, ointment, powder, or mask. The use according to item 1 of the scope of patent application, wherein the composition further comprises hydroquinone, arbutin, salicylic acid, fruit acid, or any combination thereof. A use of a snow swallow composition for preparing a composition for enhancing skin luster, wherein the snow swallow composition is prepared from a snow swallow powder and a base solvent, and the snow swallow composition contains a concentration of 1% (w/ v) Snow swallow, the base solvent includes at least one of water, alcohol, thickener, antibacterial agent and pH balance agent or a combination in any ratio. The use described in item 6 of the scope of patent application, wherein the composition is topically applied to the skin at least once a day. The use as described in item 6 of the scope of patent application, wherein the composition is a skin care product or a cosmetic. The use described in item 6 of the scope of patent application, wherein the composition is presented in the form of cream, lotion, dispersion, foam, gel, ointment, powder, or mask. The use according to item 6 of the scope of patent application, wherein the composition further comprises hydroquinone, arbutin, salicylic acid, fruit acid, or any combination thereof.

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